In this study we want to learn more about a new treatment called CD19x22 CAR T cells. We want to see how well it works as a treatment for B-cell Acute Lymphoblastic Leukemia (B-ALL) when the cancer has come back after treatment or hasn’t responded to previous treatments.
We want to learn how nightmares from trauma or posttraumatic stress disorder (PTSD) affect heart and artery health in women. We also want to see if a treatment called NightWare, which is used on a smartwatch, can help women with these nightmares sleep better and improve their heart and artery health.
Aim 1: Test the effectiveness of Rehabbing with Peloton on physical activity as measured by daily steps. Aim 2. Examine the effectiveness of Rehabbing with Peloton on secondary health outcomes. Aim 3. Assess the implementation of the Rehabbing with Peloton using the Reach, Effectiveness, Adoption, Implementation, and Maintenance Framework (RE-AIM).
Evaluate the safety and efficacy of the Cleaner™ Pro Thrombectomy System for aspiration thrombectomy in patients with acute pulmonary embolism (PE).
To determine the safety of targeted immunotherapy with daratumumab (DARA) IV after total body irradiation (TBI)-based myeloablative conditioning and allogeneic hematopoietic cell transplantation (HCT) for children, adolescents, and young adults (CAYA) with high-risk T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LLy).
The main goal of this study is to show that adding ianalumab (either a smaller or larger dose) to the usual first medicine, corticosteroids, helps people with a blood disease called primary ITP stay well for a longer time before their treatment stops working. This part of the study focuses on participants who had already gotten better from corticosteroids, sometimes with IVIG, before they were ran...
This study wants to learn how working at night or outside normal daytime hours affects women’s heart and reproductive health in women. We are looking for women who work night shifts, both day and night shifts, or only daytime shifts to see how different work hours may affect heart and reproductive health.
The primary study objective is to compare the clinical outcomes of patients treated with an interventional strategy using the ClotTriever System to achieve and maintain vessel patency (ClotTriever Intervention Arm) versus conservative medical management using anticoagulation therapy alone (Conservative Medical Management Arm) in the treatment of symptomatic unilateral iliofemoral DVT
Preserving endothelial function with pulsatility during CPB will be associated with less AKI after cardiac surgery.
This study wants to learn about the best way to take pictures of unborn babies' hearts to better identify certain heart health problems.
The primary objective of the BISON-PRO Database is to establish a prospective repository of real-world, longitudinally-collected patient-reported outcomes (PRO) and quality-of-life data for patients with both malignant and non-neoplastic blood disorders to support patient-centered research.
In this research we will learn more about blood clotting and drugs that modify blood clotting.
This study is testing a virtual physical activity program to improve the health and wellness of older family care partners. The virtual physical activity program will use Zoom to deliver exercise sessions, track physical activity and sleep using a Fitbit, and send motivational and encouraging text messages. The goal is to help older family care partners to improve their physical and mental health ...