There are two groups in this study so that we can compare how well different drugs work at stopping your body from rejecting your new kidney after transplant. Group 1 will take the study drugs belatacept and sirolimus. One of these is taken by mouth and the other is given through an IV in your arm. Group 2 will take the study drugs tacrolimus and MMF. Both are taken by mouth. You will be randomly assigned to one of the groups, like flipping a coin. If you/your child join this study, you will come to 18 study visits at Children's Hospital Colorado over the course of 1-2 years after you have a kidney transplant. At these study visits we will do a brief physical exam and ask you questions about your health. We will use a needle in your arm to take a blood sample. At some visits we will also ask you to give a urine and a stool sample. Three times during the study we will take a kidney biopsy to see how well the study drugs are working.

Who can Participate

You/your child can join this study if you are between 13 and 20 years old and are scheduled to have a kidney transplant at Children's Hospital Colorado. If you are interested in joining our study, we will do other tests to make sure you meet other requirements and that it is safe for you to join.

Study ID