If you qualify, you will be asked to participate in the study for 12 weeks. You will receive either equol or placebo during that time. You will come to the Renal Research Clinic on the Anschutz Medical Campus for 5 in-person visits. You will also have 3 remote, check-in visits. Visits will include vitals, blood draw, urine collection, and blood vessel function testing (via non-invasive ultrasound). There are other optional procedures that will be discussed prior to enrollment into the study.

Who can Participate

-Women aged ≥50 years who are post-menopausal -CKD stage 3 or 4 (eGFR of 15-59 mL/min/1.73m) -Weight stable in the prior 3 months (<2kg weight change) and willing to remain weight stable throughout the study Exclusions: -Uncontrolled blood pressure (>140/90) -Use of hormone replacement therapy -Current tobacco or nicotine use in the past 12 months -History of kidney transplant

Study ID