This study plans to learn more about the effects of having too much acid in the blood as a result of having a kidney transplant. This study will look at how acid levels in the blood affect the function of blood vessels and the transplanted kidney.
Participation will last approximately 52 weeks and will include 3-7 in-person visits. Baseline, Month 6, and Month 12 visits will be held in person to assess blood vessel health. Baseline visits will be coordinated with patients' 1 year post-transplant biopsy. The Month 12 biopsy will occur for study purposes outside of standard of care. 24hr urine samples will be collected at Baseline and Month 12. Month 1, 3, and 9 visits can be conducted remotely to check safety labs and complete questions via phone. Blood pressure, weight, health, and medication changes will be assessed throughout the study.
-Age 18-80 years -Kidney transplant received 1 year prior to randomization into study -Kidney function of >/= 45 ml/min/1.73m2 (Using CKD-EPI eGFR equation) -Carbon dioxide blood levels of 16-24 mEq/L
Principal Investigator