A Study to Understand the Safety, Tolerability, and Activity of a Catch-Up Pneumococcal Vaccine in Children and Adolescents who may or may not have received prior doses of a pneumococcal vaccine.
The purpose of this study is to learn about the safety of a new pneumococcal vaccine and how the new pneumococcal vaccine helps to fight against germs that can cause pneumonia (lung infections), meningitis (brain infections), and otitis media (ear infections) in infants when compared to the pneumococcal vaccine that is currently in use, 20vPnC (Prevnar 20®).
This study plans to learn more about two commonly used minimally invasive techniques (US-guided percutaneous needle tenotomy vs percutaneous ultrasonic tenotomy) for the treatment of gluteal tendinosis. The goal of the study is to see which works better at reducing pain and improving movement in people with gluteal tendinosis (a condition that causes pain in the hip area).
This is a first-in-human study to learn about the study drug called BG-C9074 alone and in combination with tislelizumab in participants with advanced solid tumors.
To investigate a blood-flow restriction exercise-based intervention for people with Multiple Sclerosis (MS).
This project will test whether cyclic versus continuous estradiol administration differentially influences brain, metabolic, immune, and stress systems, as well as behavioral (mood, sleep, activity, perceived stress) and cognitive (memory, attention, decision-making, processing speed) outcomes in healthy early postmenopausal women.
This phase II/III trial tests whether adding trastuzumab and hyaluronidase-oysk (Herceptin Hylecta [TM]) or pertuzumab, trastuzumab and hyaluronidase-zzxf (Phesgo [TM]) to the usual chemotherapy (paclitaxel and carboplatin) works to shrink tumors in patients with HER2 positive endometrial cancer. Trastuzumab and pertuzumab are monoclonal antibodies and forms of targeted therapy that attach to spec...
The main goal of this study is to see how well two drugs, tirzepatide and retatrutide, work for treating metabolic dysfunction associated steatotic liver disease compared to placebo.
The purpose of this study is to measure the efficacy and safety of rilvegostomig with gemcitabine plus cisplatin vs. durvalumab with gemcitabine plus cisplatin as first line treatment for patients with advanced BTC.
This is a multi-center, open-label Phase 1/2 trial evaluating the safety and efficacy of AB-3028 in subjects with metastatic castration resistant prostate cancer (mCRPC).
The study will test whether GSK5460025 alone or in combination (potential combinations may be included in future amendments to the protocol) with other anti-cancer agents can decrease tumor size, is safe, well-tolerated, and how the drug is processed in the body over time.
This is an international, multicenter, randomized, double-blind, active-controlled, phase 3 clinical trial. The purpose of this trial is to compare the efficacy and safety of palazestrant in combination with ribociclib +letrozole -matching placebo (Arm A: investigational arm) with letrozole in combination with ribociclib + palazestrant-matching placebo (Arm B: control arm). This trial is seeking a...
This study wants to learn more about muvalaplin (LY3473329). Muvalaplin is being studied to treat high lipoprotein, which is a type of unhealthy fat in your blood. The goal of this study is to see if muvalaplin can lower the risk of serious health problems, such as heart attack or stroke, and see what side effects people may have.
This study plans to learn more about whether exercise can help protect the body from health problems that happen when a person’s sleep and daily schedule are out of sync with their natural body clock.
This is a Phase 2, open-label, global, multi-arm study to evaluate efficacy and safety of relacorilant in combination with other treatments in patients with gynecological cancers.
This study is looking at whether hormone therapy can help reduce hot flashes and night sweats in women living with HIV who are going through menopause or who recently finished menopause.
Non small cell lung carcinoma (NSCLC) is the most frequently occurring histologic subtype of lung cancer and is the leading cause of cancer-related deaths worldwide. The purpose of this study is to assess adverse events and change in disease activity when Telisotuzumab Adizutecan (ABBV-400) is given in combination with a programmed cell death receptor 1 (PD1) inhibitor (budigalimab) to adult parti...
This study wants to learn more about how the food we eat affects the reproductive hormones of adult women with obesity.
This study wants to find out if a glucose monitor can help detect type 1 diabetes early in people getting immune therapy for cancer treatment. It also wants to learn if certain genes or antibodies can help identify people at higher risk.
This study wants to learn more about whether a drug called sotagliflozin (SOTA) can slow down the loss of kidney function in people with type 1 diabetes and diabetic kidney disease.
We are studying adolescents who may be at higher risk of getting type 2 diabetes, as they go through puberty. Our goal is to identify early signs that might help predict who will develop the disease.
This study wants to see how blood sugar changes with sex hormones during regular menstrual cycles or when using hormonal birth control. We also want to learn how exercise and hormonal birth control affect blood sugar.
The goals of this study are to refine the implementation and pilot test the feasibility of an adapted cognitive behavioral therapy (CBT), the Balanced and Empowered EaTing in Diabetes (or the BEET Diabetes Program), compared with the original CBT program, delivered by behavioral health providers to treat disordered eating behaviors (DEBs) in patients with type 2 diabetes in real-world clinical set...
This study will look at two ways to prevent heart and blood vessel problems. It will test which treatment works better for people who may have hidden artery disease because of conditions like diabetes or metabolic syndrome. One way uses your risk factors, and the other way uses pictures of your heart arteries to guide care.
The primary outcome variables will be the change in hemoglobin A1c, and diabetes medications recorded at 4.5 month and 13.5 month follow-up assessments.
This research study is being conducted to examine the effects of dapagliflozin on kidney function, blood vessel function and heart function. We are studying the effects/impact of dapagliflozin (a SGLT2 inhibitor) on: - Kidney function - Protein in the urine - Blood vessel function - Heart function
This study wants to learn more about how exposures during pregnancy like infections, diet and growth, can affect a baby’s chances of developing type 1 diabetes later in life.
This study wants to learn more about CXA-10, a naturally occurring compound in the body. Researchers will test whether CXA-10 is safe and if it helps people who have asthma and are also living with obesity.
This study wants to learn more about how COVID-19 and diabetes are connected.
This study wants to learn how aerobic exercise affects people with Parkinson’s disease who have not started medication for their Parkinson’s symptoms. It will compare two types of treadmill exercise – moderate-intensity and high-intensity – to see how they impact Parkinson’s symptoms.
If your doctor has told you that you have diabetes, but it doesn’t seem like type 1 or type 2, you might be able to join our study. The goal of this study is to better understand different kinds of diabetes that are not common.
In this study we want to find out how the body’s immune system reacts to nuts and other foods and causes allergies. We also want to check how well a new test works that may help predict allergic reactions to peanuts
This study wants to learn more about factors in the body (called biomarkers) that are linked to preventable vision loss and changes in the retina. We will use artificial intelligence (AI) to help find signs of health problems in the body, such as high blood pressure, diabetes, Parkinson’s disease, and Alzheimer’s disease.
To determine the maximum tolerated dose of temozolomide followed by selinexor in recurrent glioblastoma patients as determined by dose-limiting toxicities (DLTs) and the total toxicity profile. (Phase I) II. To evaluate the efficacy of sequentially administering temozolomide and selinexor in recurrent glioblastoma as determined by progression-free survival (PFS). (Phase 2)
In this study we want to learn more about how life experiences and everyday stress impact the physical and mental health of mothers during pregnancy and postpartum.
This study wants to find out how cannabis affects driving in older adults. This study also wants to learn whether how older adults think and how often they use cannabis may affect driving after using cannabis.
In this study we want to learn if a new drug called vosoritide is safe and effective in helping kids with short stature and have been diagnosed with Turner syndrome, SHOX deficiency, or Noonan syndrome grow.
In this study we want to understand more about the causes of cystic fibrosis related diabetes (CFRD) and find better ways to treat it.
This study wants to learn more about how blood sugar levels in healthy children without chronic disease compare to the blood sugar levels of children with Cystic Fibrosis (CF). We are only recruiting children without chronic disease to join the study.
This study will test a new drug called IMVT-1402 to see if it works and is safe compared to a placebo (a treatment with no medicine) in adults with Graves' Disease. Graves' Disease makes the thyroid gland overactive. We want to see if IMVT-1402 can help people reach normal thyroid hormone levels and possibly stop taking their regular thyroid medicine. The study will compare how well IMVT-1402 work...
This study is using MRI to learn how skeletal muscles and blood vessels respond to exercise in people with and without Type 2 Diabetes. We are currently looking for healthy volunteers to join our study!
To prospectively collect data regarding the diagnosis and treatment of orthopedic infections including upper and lower limb as well as pelvic and spinal infection in order to improve quality of care. The database will be used for subsequent future research.
Our team is here to find out if taking part in a cognitive-behavioral therapy group, exercise training group, or combination of therapy and exercise training lowers stress, improves mood, raises physical activity and fitness, and lowers diabetes risk among teen girls at risk for diabetes.
To collect data on the recurrence rate and outcomes of benign and primary/metastatic malignant tumors seen in Orthopaedic patients at the University of Colorado Hospital.
To collect prospectively (after informed consent) fresh, excess surgical tissues, blood and other bodily fluids, and saliva from patients with HNC slated to undergo biopsy or surgical resection, and to collect prospectively optional samples from patients with HNC slated to undergo other therapies
This study is testing a virtual exercise program to help older adults who take care of family members. We hope to help them feel better both physically and mentally, so they can feel more confident and capable in their caregiving.
In this study we want to learn how infants hear speech sounds and how that affects their language development.
We are studying how sleep affects memory in people with traumatic brain injuries. We need healthy people that do not have any neurological conditions to join our study!
With our community partner, the Gyedi Project, we want to see how different levels of goal-setting exercises can encourage physical activity in the Black community. We also want to see how this program affects sticking to exercise and attitudes toward exercise.
This study wants to see if gut problems are worse in men with and without HIV that have sex with men who have metabolic syndrome compared to those without metabolic syndrome. We are looking for men that do not have HIV.
We are recruiting healthy individuals in need of an exercise program, aged 30 to 55, to help us test how exercise affects heart health, blood vessels, and blood sugar.
We’re doing this study to better understand if healthcare students feel safe speaking up and working together in team-based care. Your input can help us learn how to build stronger, safer healthcare teams for better patient care.
Our goal is to find out if a mental health program that uses a smartphone app, along with support from a care team and therapy, works well and is helpful. We are looking for adults who have signs of anxiety or depression and are willing to join the program from home for 8 weeks.
This study is testing a digital sleep treatment, called NightWare, to see if it can improve sleep and heart health in veterans by reducing nightmares related to post-traumatic stress disorder (PTSD).
This study wants to compare the immune response in children who received the RSV vaccine during the 2024-2025 respiratory season to those who didn’t. It will also look at how often children in both groups get sick and how severe their sickness is during the 2025-2026 respiratory season.
In this study, we want to learn more about how a child’s swimming ability relates to certain things such as playing sports, as well as traits like age, gender, and ethnicity.
This study is looking at airway cells in people who have never smoked to better understand normal airway cell function and early changes that may be linked to lung disease.
This study wants to learn how a Baby Bonds program could work in Colorado. Baby Bonds are savings accounts started at birth to help families with children build money for the future. The study looks at how much the program may cost, whether people support it, and whether it could be run and kept going over time in a fair and useful way.
We are looking for couples who have had a baby in the past 6 months. We want to learn about their experiences as new parents.
This study wants to find out more about nonfatal gun violence in past romantic relationships. The goal is to learn how gun-related harm or threats happen between partners.
Este estudio quiere descubrir que tan útil es un programa de 8 semanas para padres hispanohablantes y sus hijos de entre 8 y 11 años que tengan dificultades para planificar, concentrarse y autocontrol.