This study wants to learn more about how the food we eat affects the reproductive hormones of adult women with obesity.
The goal of the study is to learn if people who receive sacituzumab govitecan live longer overall and without the cancer getting worse compared to people who receive chemotherapy.
To understand variations in the health of people with achondroplasia
Specific Aims. 1. Determine whether hemp-derived CBD alters cannabis cue-related neural response. A subsample of 52 participants will be recruited from the larger Project 1 (“emerging adult”) randomized controlled trial comparing 400mg/day hemp-derived CBD to placebo. We will conduct a functional MRI scan at enrollment and after 8 weeks in the trial. During the scan, we will conduct a cue-reacti...
This research study is being conducted to examine the effects of dapagliflozin on kidney function, blood vessel function and heart function. We are studying the effects/impact of dapagliflozin (a SGLT2 inhibitor) on: - Kidney function - Protein in the urine - Blood vessel function - Heart function
We will investigate the association between transfusion of fibrinogen-containing blood products and multi-organ dysfunction resulting from endotheliopathy of trauma (EOT). Fibrinogen is frequently acutely decreased in critically ill trauma patients. Early fibrinogen replacement may be the key to restoring the endothelial glycocalyx and preventing end-organ injury. However, few human data exist to ...
This study seeks to better understand the effects of cannabis use during adolescence on decision making and reward responsivity and may identify biomarkers that help distinguish youth who experience impairments in decision making and are at higher risk of the negative effects of cannabis use.
Primary outcome: The primary aim is to determine the efficacy of CXA-10 in improving pre bronchodilator FEV1 from baseline, relative to placebo. Secondary outcomes: A) Methacholine testing is the key standard for determining bronchial hyperresponsivess. Our protocol uses a quadrupling dose, according to the standards proposed by the American Thoracic Society (ATS) (61), which meets all safety r...
Join a CU Anschutz study about the impact of cannabis on driving.
To compare the effectiveness of two approaches for the management of Barrett’s esophagus (BE) and low-grade dysplasia (LGD), endoscopic surveillance and endoscopic eradication therapy (EET), using an accepted clinical endpoint of neoplastic progression [high-grade dysplasia (HGD)/mucosal esophageal adenocarcinoma (EAC)/invasive EAC].
To prospectively collect data regarding the diagnosis and treatment of orthopedic infections including upper and lower limb as well as pelvic and spinal infection in order to improve quality of care. The database will be used for subsequent future research.
This study plans to learn more about the inherited genetic factors that cause Birdshot chorioretinitis and the risk factors associated with this disease. We also aim to include your family members (parents and siblings) to determine if there are any genetic differences between individuals who do not have this disease.
This study is looking for ways to prevent type 2 diabetes in adolescent girls who may be at risk for developing type 2 diabetes. We want to see if teaching girls coping skills and/or increasing their physical activity and fitness helps them feel less stressed and decreases their chance of getting diabetes.
We are looking for people aged 25 to 55 who smoke and/or vape cannabis, and people aged 25 to 55 who do not smoke cannabis, to see how cannabis use affects lung health over time.
This study plans to learn more about cannabidiol (CBD) as a potential treatment in patients that have Traumatic Brain Injury (TBI)-related symptoms. CBD is a chemical found in the cannabis (or hemp) plant that can be used as a medication.
This study is designed to assess whether broad spectrum CBD and full spectrum CBD, compared to placebo, is effective in reducing alcohol drinking in participants with an alcohol use disorder. If eligible for the study, participants will be randomly chosen to receive one of the study conditions for 12 weeks.
We are recruiting adult women with regular periods to learn more about how reproductive hormones are impacted by two different diets. We also will look at how women's hormones influence weight and metabolism.
To collect data on the recurrence rate and outcomes of benign and primary/metastatic malignant tumors seen in Orthopaedic patients at the University of Colorado Hospital.
To collect prospectively (after informed consent) fresh, excess surgical tissues, blood and other bodily fluids, and saliva from patients with HNC slated to undergo biopsy or surgical resection, and to collect prospectively optional samples from patients with HNC slated to undergo other therapies