Study Looking at How Gut Bacteria Affect the Gut Lining in Men who have Sex with Men with and without Metabolic Syndrome
This study wants to see if gut problems are worse in men with and without HIV that have sex with men who have metabolic syndrome compared to those without metabolic syndrome. We are looking for men that do not have HIV.
Why this Research Matters
This study plans to learn more about metabolic syndrome in people living with HIV, especially men who have sex with men. Metabolic syndrome is common in people living with HIV and linked to gut health. Metabolic syndrome is a group of problems that happen when your body is not working right. It includes high blood sugar, high blood pressure, overweight or obesity, and unhealthy cholesterol. We want to find out what causes metabolic syndrome in men who have sex with men and people living with HIV.
If you join this study, you will have three visits. The first visit will check to see if you qualify to join. We will take your blood through an IV in your arm. We will test your blood for metabolic syndrome and HIV. This visit will take 1 hour. At the second visit, you will fill out surveys, do a physical exam, and talk about your medical history. We will give you a kit to collect your poop at home before your next visit. This visit will take 1.5 hours. At the last visit, we will take your blood through an IV in your arm. You also will be asked to have 30 small samples of tissues removed from your colon. This is done with a flexible tube with a light that goes in your rectum and moves up to the lower part of your large bowel. This will take 15 minutes and may cause some belly discomfort. This visit will take 1.5 hours.
You will have three visits. You will be in the study for 2 months.
Adults 18 to 70 years old
You may be able to join this study if you:
- Are a man who has sex with other men
- Are 18-70 years old
- Do not have gut disease (like IBD or celiac)
- Have not had bowel surgery
- Have not used high-dose blood thinners in the past year
- Do not have HIV
Protocol Number: 22-1180x
You will get up to $375 if you complete all study visits.
Catherine Lozupone, Ph.D
Principal Investigator
