Find a Research Study

This study will assess the safety and efficacy of VS-7375 alone and in combination with cetuximab in patients with metastatic KRAS G12D - mutated Non-Small Cell Lung Cancer

To better understand how health, aging-related factors, and social circumstances affect breast cancer treatment and outcomes among older adults, particularly those from racial and ethnic groups that have historically been underrepresented in cancer research.

Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. The purpose of this study is to assess safety and tolerability of IMGN151 when given as monotherapy and in combination with other anti-cancer therapies in adult participants with gynecologic cancers.

We want to find out if using RP2 with nivolumab works better than using ipilimumab with nivolumab to help adults with eye cancer that has spread and cannot be removed by surgery live longer.

Colorectal cancer (CRC) is the third most common type of cancer diagnosed worldwide. The purpose of this study is to assess change in disease activity when telisotuzumab adizutecan is given alone compared to standard of care (SOC) given alone.

This study wants to find out if using two drugs, belimumab and rituximab, works better than using rituximab alone to treat people with primary membranous nephropathy (primary NM). The study will see how people react to belimumab compared to a placebo which looks like the study drug but does not have active medicine

This study is testing whether a new drug called BHV-8000 is safe and can slow the progression of early Parkinson's Disease for adults aged 40 to 80 years old. Researchers believe BHV-8000 may reduce inflammation and help protect nerve cells in the brain and spinal cord.

The purpose of this study is to test the effectiveness of a sexual assault education program for college women.

The researchers want to find out if Sofe-M works better than the standard treatments that doctors use now and to better understand how safe it is. Each participant's time in the study will depend on how they respond to the treatment.

The study is divided into two cohorts (Cohort 1 and Cohort 2), to which participants will be enrolled based on the amount of human epidermal growth factor receptor 2 (HER2) in their tumor sample. In Cohort 1, the main goal is to assess how well BNT323 (also known as DB-1303) or chemotherapy (doxorubicin or paclitaxel or docetaxel, if participants cannot take paclitaxel) works by determining the...

This study wants to learn if semaglutide is safe and helpful for those with Type 1 Diabetes (T1D) compared to a placebo. Researchers also want to understand whether semaglutide can protect the kidneys in adults aged 18 and older with T1D.

To determine ORR by RECIST v1.1 of nab-sirolimus in patients with EHE who require systemic treatment

This study is comparing rectal artery embolization to surgical removal of hemorrhoids to see which treatment works best for bleeding hemorrhoids. We also want to understand how people feel and how their quality of life changes after treatment.

This study looks at whether a digital mindfulness program can help people diagnosed with breast cancer by age 50 who are feeling depressed. We will compare different digital programs to see which one helps the most.

The purpose of this study is to keep collecting information from people with and without Parkinson's disease (PD). This study will also measure biomarkers that may be linked to how PD develops and changes over time.

This study wants to find out if a new medicine called zenagamtide can help people with obesity lose weight compared to a placebo. We are looking for adults aged 18 to 69 years old who want to lose at least 25% of their body weight to join!

This study wants to learn effects of montelukast (an asthma/allergy medication) on kidney and eye function in people with type 2 diabetes.

To evaluate and compare 2-year recurrence-free survival (RFS) rates in both study arms.

PRIMARY OBJECTIVES: I. To establish the recommended phase 2 dose of pidnarulex (CX-5461) with anti-programmed cell death protein 1 (PD-1) in phase 1, and to determine safety and tolerability of pidnarulex (CX-5461) alone, and in combination with anti-PD-1 in phases 1 and 2. II. To determine the progression-free survival (PFS) of pidnarulex (CX-5461) alone and in combination with anti-PD-1 in...

To compare progression-free survival (PFS) of amivantamab monotherapy versus cetuximab monotherapy in patients with locoregionally incurable or metastatic cutaneous squamous cell carcinoma and an active immunosuppressed condition

PRIMARY OBJECTIVES: I. To compare the overall survival (OS) of patients with metastatic castration-resistant prostate carcinoma (mCRPC) receiving prostate-specific antigen (PSA) adaptive dosing of lutetium 177 Lu prostate specific membrane antigen radioligand therapy (177Lu PSMA RLT) to that of patients receiving standard dose 177Lu PSMA RLT every 6 weeks. II. To compare quality of life, as ...

Phase II study in participants with moderately-to-severely active rheumatoid Arthritis (RA) to evaluate efficacy and safety of AZD1163

This is a Phase 2, open-label, multicenter, multi-cohort trial to evaluate the safety, efficacy, pharmacokinetics (PK), and pharmacodynamics of Rina-S as monotherapy in participants with GI cancers who have progressed on or after prior standard of care (SoC) therapies.

Researchers are looking for new ways to treat high-risk, localized non-small cell lung cancer (NSCLC) that has been removed with surgery. People with high-risk, localized NSCLC are often treated with surgery. Researchers want to learn if participants can receive 1 or 2 trial treatments to help prevent NSCLC from coming back after surgery. One trial medicine is intismeran (also called V940/mRNA-...

This research study plans to examine an online stress-resilience (mindfulness-based) program for women in perimenopause who have experienced stress earlier in life. It is also designed to learn about the feasibility, acceptability, and effects of the program on stress, mood, thinking abilities, and health markers.

PRIMARY OBJECTIVE: I. To demonstrate that bevacizumab, an anti-VEGF antibody therapy, (or an anti-VEGF antibody biosimilar) in combination with carboplatin, paclitaxel, and pembrolizumab is superior to carboplatin, paclitaxel, and pembrolizumab (the control arm) or carboplatin, paclitaxel, and bevacizumab in prolonging progression-free survival (PFS) in patients with pMMR, TP53 mutated advanced...

Gocatamig and I-DXd (short for ifinatamab deruxtecan) are study medicines. Researchers want to know if giving gocatamig and I-DXd together can treat ES-SCLC. Researchers will also look at giving the study medicines with standard treatment. Gocatamig is a T-cell engager therapy. I-DXd is an antibody drug conjugate. T-cell engager therapy is a certain type of immunotherapy that uses T-cells to fi...

The goal of this study is to identify a safe and tolerated dose of the orally administered KIF18A inhibitor ATX-295. In addition, this study will evaluate the pharmacokinetics, pharmacodynamics and preliminary antitumor activity of ATX-295 in patients with advanced solid tumors and ovarian cancer.

Global, Phase 3, randomized, multicenter, open-label study evaluating the efficacy and safety of firmonertinib at a dose level of 240 mg QD compared to investigator's choice of osimertinib (80 mg QD) or afatinib (40 mg QD) in participants who have locally advanced or metastatic NSCLC with EGFR PACC mutations, and who have not received any prior therapy for advanced disease.

This study looks at how GLP-1 RA medicines like Ozempic and Mounjaro affect the liver in people with type 1 diabetes (T1D) compared to people without T1D. We are focusing on a liver condition called metabolic dysfunction-associated steatotic liver disease (MASLD), which happens when too much fat builds up in the liver and can lead to other health problems. The goal is to find out if these drugs ca...

This study wants to learn more about muvalaplin (LY3473329). Muvalaplin is being studied to treat high lipoprotein, which is a type of unhealthy fat in your blood. The goal of this study is to see if muvalaplin can lower the risk of serious health problems, such as heart attack or stroke, and see what side effects people may have.

The purpose of this study is to evaluate the effects of the investigational use of a GLP-1 medication called tirzepatide (Zepbound) on cigarette smoking, cigarette craving, and related outcomes.

This study wants to find out if a mobile app that suggests daily insulin doses is safe and works well for adults with type 2 diabetes.

The main goal of this study is to see how well two drugs, tirzepatide and retatrutide, work for treating metabolic dysfunction associated steatotic liver disease compared to placebo.

This study, the first clinical trial of AVZO-103, aims to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose, and antitumor activity of AVZO-103 when administered intravenously as a monotherapy and in combination therapy to patients with locally advanced or metastatic urothelial cancer or other solid tumors.

The purpose of this study is to measure the efficacy and safety of rilvegostomig with gemcitabine plus cisplatin vs. durvalumab with gemcitabine plus cisplatin as first line treatment for patients with advanced BTC.

This study plans to learn more about whether exercise can help protect the body from health problems that happen when a person’s sleep and daily schedule are out of sync with their natural body clock.

We are looking for women who are within six weeks of giving birth to help us learn how doula support and spending time in nature can lower stress, improve sleep, and support overall wellbeing. This study looks at ways to help mothers recover and thrive during the early weeks after giving birth.

This clinical study is testing whether a new combination of medicines (DSP107 and atezolizumab) is more effective and safer than an existing treatment (fruquintinib) for people with advanced colorectal cancer that is microsatellite stable (MSS). Participants will be randomly assigned to receive one of the two treatments, and researchers will monitor how well the cancer responds, how safe the treat...

The objective of this study is to evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of BL-M14D1 in Subjects with locally Advanced or Metastatic Small Cell Lung Cancer and Other Neuroendocrine Neoplasms

PRIMARY OBJECTIVE: To determine whether the combination of cabozantinib plus cemiplimab (REGN2810) (Cabo-Cemiplimab REGN2810) improves progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors (RECIST) version (v.) 1.1 relative to cabozantinib alone in patients with locally advanced unresectable or recurrent/metastatic advanced adrenocortical cancer.

The study will test whether GSK5460025 alone or in combination (potential combinations may be included in future amendments to the protocol) with other anti-cancer agents can decrease tumor size, is safe, well-tolerated, and how the drug is processed in the body over time.

The goal of this clinical trial is to learn about the safety and recommended dose of TRI-611 when administered to adults with ALK-positive non-small cell lung cancer (NSCLC). The trial will also evaluate the antitumor activity of TRI-611 in adults with ALK-positive NSCLC. The study will be conducted in two parts. The first part will examine different doses of TRI-611. The second part will look ...

PRIMARY OBJECTIVE: I. Demonstrate non-inferiority of ultra-hypofractionated (stereotactic body radiation therapy SBRT) compared to hypofractionated radiation therapy (RT) with a 10% non-inferiority margin (from 50% to 40%) in the rate of bladder-intact event-free survival (BI-EFS) at 3 years (corresponding to a hazard ratio < 1.32)

A clinical study for the treatment of agitation in adults with Alzheimer's disease

Progression-free survival (PFS), Overall Survival (OS) in the mCRC population, Efficacy measures such as overall response rate (ORR), incidence and severity of adverse events (AEs) and clinically significant abnormal laboratory test results, Efficacy measures such as duration of response (DoR)

This study is for adults age 21 or older who have alcohol use disorder (AUD). It tests whether a medicine called Apremilast can help reduce alcohol cravings compared to a placebo, a pill that looks the same but has no medicine.

The goal of this study is to learn whether veverimer is safe and helpful in preventing or treating the problems of metabolic acidosis in adults with chronic kidney disease (CKD).

This is an international, multicenter, randomized, double-blind, active-controlled, phase 3 clinical trial. The purpose of this trial is to compare the efficacy and safety of palazestrant in combination with ribociclib +letrozole -matching placebo (Arm A: investigational arm) with letrozole in combination with ribociclib + palazestrant-matching placebo (Arm B: control arm). This trial is seek...

The goal of this study is to learn more about how different types of snacks may affect brain activity, hunger, and eating behaviors during a diet program.

PRIMARY OBJECTIVE: I. To determine whether induction immunotherapy (IO) and chemotherapy prior to concurrent chemoradiation therapy (CCRT) + IO improves progression-free survival (PFS) compared to CCRT+IO alone. SECONDARY OBJECTIVES: I. To assess whether induction IO and chemotherapy prior to CCRT+IO improves the overall survival (OS) compared to CCRT+IO alone. II. To determine the nat...

This is an open-label, multi-center, phase I/II study to evaluate the safety, efficacy, and pharmacokinetics of MRG007 in patients with unresectable locally advanced and metastatic solid tumors.

This study wants to better understand how people respond to nutrient stimulated hormone receptor agonist (NuSH RA) medications like semaglutide (Wegovy) and tirzepaide (Zepbound).

Cohort 1: To demonstrate that the proportion of subjects with vision loss is lower for subjects in the Treatment Arm vs the Control Arm. Cohort 2: To demonstrate the ability to salvage the eye and prevent enucleation in the Treatment Arm

This is a first-in-human, open-label, multicenter phase 1 study to evaluate safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of OP-3136, a lysine acetyltransferases 6A and 6B (KAT6A/B) inhibitor, as monotherapy and in combination with other anticancer agents in participants with advanced solid tumors. This study consists of 2 parts: a dose escalation ...

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of BG-C477 alone and in combination with anticancer agents in participants with selected advanced solid tumors.

This is a first-in human clinical study of DPTX3186 in subjects with Wnt-pathway activated solid tumors where no other treatments exist. The study will evaluate safety, pharmacokinetics, and initial activity of DPTX3186, as well as explore pharmacodynamic parameters to identify potential biomarkers of efficacy

An open-label, multicenter study of ZL-1310 as a single agent and in combination with Atezolizumab (with and without Carboplatin) to evaluate the safety, efficacy, and pharmacokinetics in subjects with small cell lung cancer

This study wants to learn how safe psilocybin is for healthy older adults and how their bodies and minds react to it. We also want to see how psilocybin affects mood, thinking, and well-being.

This is a two-stage Phase 2 trial evaluating the efficacy and safety of ONC206 in participants with Pheochromocytoma and Paraganglioma (PCPG).

This study wants to see how well three medicines, atogepant (Qulipta), propranolol (Inderal), and topiramate (Topamax), work at reducing the number of migraines people have and how bad the migraines are. The results will help people and their doctors choose which medicine might be best to try first to prevent their migraines.

The main purpose of this study is to evaluate the safety and preliminary efficacy of CHS-114 in combination with toripalimab and/or other standard of care (SOC) compound(s) in participants with advanced or metastatic solid tumors.

This study wants to learn how cannabidiol (CBD) affects drinking in people who drink alcohol often. This study will look to see if CBD can help people drink less and if CBD can help reduce problems linked to alcohol use.

The purpose of this study is to assess adverse events and change in disease activity when telisotuzumab adizutecan is given in combination with a fixed dose of osimertinib (Osi), Osi alone, or standard of care (SOC) alone.

The purpose of this study is to evaluate the overall survival (length of time from the start of study to date of death from any cause) for pasritamig (JNJ-78278343) in combination with best supportive care (BSC) as compared to placebo with BSC in participants with metastatic castration-resistant prostate cancer (mCRPC; a stage of cancer that has spread beyond the prostate gland and is no longer re...

Researchers are looking for adults with Alcohol Use Disorder (AUD) to learn how a type of brain stimulation called low-intensity focused ultrasound (LIFU) affects the brain and behavior.

This study is comparing two commonly used minimally invasive treatments for gluteal tendinosis (GT) to learn how well they reduce pain and improve movement.

This study aims to investigate the combination of BNT324, a B7-H3 antibody-drug conjugate (ADC) with BNT327, a programmed death-ligand 1 (PD-L1) and vascular endothelial growth factor (VEGF) bispecific antibody, in participants with advanced/metastatic or relapsed/progressive small cell lung cancer (SCLC) and non small cell lung cancer (NSCLC).

PRIMARY OBJECTIVE: I. To compare metastasis-free survival, determined using conventional imaging, between men with high-risk prostate cancer randomized to ultrahypofractionation (stereotactic body radiation therapy SBRT) to those randomized to moderate hypofractionation and conventional fractionation.

A first in human study to evaluate the safety and preliminary antitumor activity of BBO-8520, a KRAS G12C (ON and OFF) inhibitor, as a single agent and in combination with pembrolizumab in subjects with locally advanced and unresectable or metastatic non-small cell lung cancer with a KRAS (Kirsten rat sarcoma) G12C mutation.

This is a 3-part study. The purpose of Part 1 of the study is to evaluate the efficacy, safety, and pharmacokinetic (PK) characteristics of safusidenib in participants with recurrent/progressive IDH1-mutant World Health Organization (WHO) Grade 2 or Grade 3 glioma. The purpose of Part 2 will be to evaluate the efficacy of maintenance safusidenib treatment versus placebo in IDH1-mutant Grade 2 o...

This research study wants to learn how well and safe the Cryosa system works in people with obstructive sleep apnea (OSA). The Cryosa system is a device used to freeze the base of the tongue and soft palate which reduces the amount of fat in those areas and may improve OSA symptoms.

To compare bone health near the knee, muscle quality, movement patterns, and physical function between adults with knee osteoarthritis and adults without knee osteoarthritis, and to examine whether an exercise program improves these outcomes in adults with knee osteoarthritis.

This study aims to evaluate the safety and tolerability of RO7673396 in participants with advanced solid tumors harboring RAS mutation(s). This study consists of two stages: Stage 1 (Dose Escalation) and Stage 2 (Dose Expansion). Stage 1 will define the recommended dose(s) for expansion (RDEs) of RO7673396. Stage 2 will evaluate preliminary anti-tumor activity of the RDE(s) defined in Stage 1 and ...

PRIMARY OBJECTIVE: To compare disease free survival (DFS) as assessed by the investigator for high-risk renal cell carcinoma patients treated with adjuvant pembrolizumab and tivozanib versus those receiving pembrolizumab alone.

To evaluate the efficacy of IMA203 compared with control (investigator's choice)

The goals of this study are to learn: - If gocatamig alone, I-DXd alone, and gocatamig with I-DXd or durvalumab are safe and well tolerated - If people who receive gocatamig alone, I-DXd alone, and gocatamig with I-DXd or durvalumab have their SCLC get smaller or go away

This study wants to learn how changing the stiffness of a prosthetic foot affects how people with below-the-knee amputations move and do everyday tasks. We are looking for people who use either a bone-anchored prosthetic leg or a standard socket prosthetic leg to join!

This study wants to learn how difficult childhood experiences during might impact when certain people get multiple sclerosis (MS), how severe the disease is, and how much it impacts brain health. We hope that this study will help us better understand MS and find ways to improve care and support.

This is a Phase III, randomized, open-label, Sponsor-blinded, 3-arm, global, multicenter study assessing the efficacy and safety of rilvegostomig in combination with fluoropyrimidine and T-DXd (Arm A) compared to trastuzumab, chemotherapy, and pembrolizumab (Arm B) in HER2-positive locally advanced or metastatic gastric or GEJ adenocarcinoma participants whose tumors express PD L1 CPS>=1. Rilvegos...

Overall Survival (OS) Time Frame: Up to approximately 36 months Progression free survival (PFS) Time Frame: Up to approximately 36 months

This phase III trial compares the effect of olaparib for one year versus two years, with or without bevacizumab, for the treatment of BRCA 1/2 mutated or homologous recombination deficient stage III or IV ovarian cancer. Olaparib is a polyadenosine 5'-diphosphoribose polymerase (PARP) enzyme inhibitor and may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Be...

The primary objective of this 3-arm clinical trial is to compare progression-free survival (PFS) of LNS8801 + pembrolizumab arm vs Physicians’ Choice (PC) treatment using RECIST 1.1.

This is a Phase 1/1b open-label, multi-center dose escalation and dose optimization study designed to evaluate the safety and preliminary efficacy of IAM1363 in participants with advanced cancers that harbor HER2 alterations.

This phase I trial tests the safety, best dose, and effectiveness of ZEN003694 in combination with cetuximab and encorafenib in treating patients with colorectal cancer that has not responded to previous treatment (refractory), that has come back after a period of improvement (relapsed), and that has spread from where it first started (primary site) to other places in the body (metastatic). ZEN003...

This study is looking at whether hormone therapy can help reduce hot flashes and night sweats in women living with HIV who are going through menopause or who recently finished menopause.

This study wants to learn more about heart and brain health of people with and without endometriosis.

Dose Escalation: To evaluate the safety and tolerability of peposertib in combination with low-dose liposomal doxorubicin as evaluated by the dose-limiting toxicity (DLT) rate at each tested dose level. Dose Escalation: To determine the recommended phase 2 dose (RP2D) of liposomal doxorubicin and peposertib combination and determine the maximal tolerated dose (MTD) if identified. Dose Ex...

This study intends to evaluate the safety and efficacy of ficerafusp alfa in combination with pembrolizumab versus placebo with pembrolizumab in 1L PD-L1-positive, recurrent or metastatic Head and Neck Squamous Cell Carcinoma (HNSCC).

Non small cell lung carcinoma (NSCLC) is the most frequently occurring histologic subtype of lung cancer and is the leading cause of cancer-related deaths worldwide. The purpose of this study is to assess adverse events and change in disease activity when Telisotuzumab Adizutecan (ABBV-400) is given in combination with a programmed cell death receptor 1 (PD1) inhibitor (budigalimab) to adult parti...

The goal of this research study is to learn more about how pain is related to alcohol use and mental health across different stages of adulthood.

Determine the efficacy of treatment with weekly doxorubicin chemotherapy in anthracycline-naïve elderly patients with advanced or metastatic LMS of soft tissue.

Primary Objective: 1) To assess the relationship of polymorphisms in IL-6 and/or IL-6R genes to the development of irAEs in ICI-treated cancer patients. Secondary Objective: 1) To determine whether polymorphisms in IL-6 and/or IL-6R genes affect the production of IL-6 and sIL-6R by CD4 cells before and after ICI treatment. Exploratory Objectives: 1) To evaluate whether polymorphisms in IL-...

Are you a charming, aggressive, carefree person who makes up their own rules and is good at handling people while looking out for number one? If so, you could be selected to participant in a brain research study.

-To determine the MTD/maximum administered dose and RP2DS of ADCE-D01. -To assess the safety and tolerability of ADCE-D01.

We are looking for healthy people to help us learn how gently stimulating the vagus nerve through the ear affects thinking skills like decision-making and problem-solving.

This study plans to learn more about how a telehealth exercise program designed for rural survivors of cancer can help improve cancer related fatigue.

Researchers are testing a drug called IMVT-1402 to see if it is safe and if it helps people with skin lupus (a type called subacute or chronic cutaneous lupus) with or without lupus that affects the whole body.

The purpose of this study is to compare how long the participants are disease-free (progression-free survival) and and the length of time until a participant dies (overall survival), when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, and irinotecan hydrochloride (FOLFIRI) versus either cetuximab or bevacizumab and FOLFIRI given ...

This study wants to see if avacopan is safe and works well for people with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. We also want to find out if it helps prevent the disease from coming back.

• To evaluate the safety and tolerability of DCC-3009 as monotherapy in participants with advanced GIST. • To determine the recommended dose(s) for expansion in Module A, and if reached, the maximum tolerated dose (MTD) of DCC-3009 as monotherapy.

We are doing this study to see if a medicine called anifrolumab is safe to use in adults with systemic sclerosis. We also want to find out if the medicine helps with disease symptoms and if it stops the disease from getting worse.

This study will compare how well pramipexole and escitalopram help treat depression in people living with HIV.

We want to learn how nightmares from trauma or posttraumatic stress disorder (PTSD) affect heart and artery health in women. We also want to see if a treatment called NightWare, which is used on a smartwatch, can help women with these nightmares sleep better and improve their heart and artery health.

The purpose of this study is to determine the putative recommended phase 2 dose(s) (RP2Ds) of JNJ-89402638 and to determine the safety of JNJ-89402638 at the RP2D(s) in participants with metastatic colorectal cancer.

This study wants to learn more about how the food we eat affects the reproductive hormones of adult women with obesity.

We are looking for couples who drink and are 18 years or older to join a study looking at alcohol use among romantic couples.

We are looking for couples, 21 or older, to join a study about how alcohol and media affect relationships.

Determine the safety and toxicity of losartan in combination with SBRT and subsequently pembrolizumab in patients with locally recurrent, refractory, or oligometastatic head and neck squamous cell carcinoma (HNSCC).

This study wants to find out if people with certain types of early-stage endometrial cancers need less treatment than usual, like less radiation and chemotherapy. We also want to see if less treatment works well and keeps your cancer from coming back.

This study wants to learn how age and sex affect how our blood vessels age and how exercise (both short-term and long-term) changes the body.

The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON) inhibitors combined with Standard(s) of Care (SOC) or with novel agents. The first three subprotocols include the following: Subprotocol A: RMC-6236 + 5-fluorouracil-based regimens Subprotocol B: RMC-6236 + cetuximab with or without mFOLFOX...

Researchers want to learn if sacituzumab tirumotecan (MK-2870) alone or with chemotherapy can treat certain gastrointestinal (GI) cancers. The GI cancers being studied are either advanced (the cancer has spread to other parts of the body), or unresectable (the cancer cannot be removed with surgery). The goals of this study are to learn: About the safety and how well people tolerate sacituzumab ...

We are looking for adults to join a national study to help us learn more about how rheumatoid arthritis (RA) develops.

This study wants to learn more about people who get a treatment called Genicular Artery Embolization (GAE). GAE is a procedure to help adults with long-term knee pain feel better. This study will look at changes in the fluid in your knee, pictures of your knee (MRI), and how well you move before and after the treatment.

I. Establish a prospective cohort of individuals with Lynch syndrome II. Collect standardized longitudinal clinical and biosample data to elucidate Lynch Syndrome epidemiology and gene-host interactions III. Promote intervention trials to improve cancer prevention and early detection in Lynch Syndrome

To determine the sensitivity and specificity of the mt-sDNA 2.0 test, for colorectal neoplasia in patients with Lynch Syndrome

This phase II/III trial examines whether patients who have undergone surgical removal of bladder, but require an additional treatment called immunotherapy to help prevent their bladder cancer from coming back, can be identified by a blood test. Many types of tumors tend to lose cells or release different types of cellular products including their DNA which is referred to as circulating tumor DNA (...

To evaluate the long-term safety through 15 years post infusion of patients who received IP in a Caribou-sponsored study, special access program or ITT

The main goal of this study is to find out if one dose of psilocybin (a drug from certain mushrooms) and talk therapy can help people feel less scared about their cancer returning. We also want to make sure this treatment is safe.

This phase III trial compares the addition of an immunotherapy drug (durvalumab) to usual chemotherapy versus usual chemotherapy alone in treating patients with MammaPrint Ultrahigh (MP2) stage II-III hormone receptor positive, HER2 negative breast cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the a...

This study wants to learn more about whether a drug called sotagliflozin (SOTA) can slow down the loss of kidney function in people with type 1 diabetes and diabetic kidney disease.

This Phase III Trial will determine whether adjuvant chemotherapy (ACT) added to ovarian function suppression (OFS) plus endocrine therapy (ET) is superior to OFS plus ET in improving invasive breast cancer-free survival (IBCFS) among premenopausal, early- stage breast cancer (EBC) patients with estrogen receptor (ER)-positive, HER2-negative tumors and 21-gene recurrence score (RS) between 16-25 (...

This study wants to learn how early changes in airway cells may help predict who is at risk for developing Chronic Obstructive Pulmonary Disease (COPD). We are looking for people who are current smokers with or without COPD.

This phase III trial compares hepatic arterial infusion (HAI) (pump chemotherapy) in addition to standard of care chemotherapy versus standard of care chemotherapy alone in treating patients with colorectal cancer that has spread to the liver (liver metastases) and cannot be removed by surgery (unresectable). HAI uses a catheter to carry a tumor-killing chemotherapy drug called floxuridine directl...

This phase II trial tests how well carboplatin before surgery works in treating patients with high-risk prostate cancer and an inherited BRCA1 or BRCA2 gene mutation. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping, or slowi...

This study is open to adults with different types of advanced cancer (solid tumors) that are accessible for injection and/or biopsy. This is a study for people with a life expectancy of at least 3 months after starting study treatment. The purpose of this study is to find the highest dose of a medicine called BI 1831169 that people with advanced cancer can tolerate when taken with or without a typ...

This clinical trial is studying advanced solid tumors. Solid tumors are cancers that start in a part of your body like your lungs or liver instead of your blood. Once tumors have grown bigger in one place but haven't spread, they're called locally advanced. If your cancer has spread to other parts of your body, it's called metastatic. When a cancer has gotten so big it can't easily be removed or h...

We want to see how well over-the-counter (OTC) hearing aids work when fitted in different ways like self-fit, online self-fit, or fit by a hearing healthcare provider, compared to prescription hearing aids.

BL-B01D1-LUNG-101 is a global, multi-center, Phase 1 study to evaluate the safety, tolerability, pharmacokinetics , and initial efficacy of BL-B01D1 in participants with metastatic or unresectable NSCLC and Other Solid Tumors. This study will be conducted in two different dosing schedules (Cohort A and Cohort B) and three parts (dose escalation, dose finding and dose expansion). Cohort A will b...

This phase II trial compares the effect of retreatment with 177Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) to the usual approach of treatment with everolimus in patients who have previously received 177Lu-DOTATATE for midgut neuroendocrine tumor (NET) that has spread from where it first started (primary site) to other places in the body (metastatic) and that cannot be removed by surge...

Patients will be registered prior to, during or at the completion of neoadjuvant chemotherapy (Paclitaxel 175 mg/m2 IV over 3 hours and Carboplatin AUC 6 IV on Day 1 every 21 days for 3-4 cycles). Registered patients who progress during neoadjuvant chemotherapy will not be eligible for iCRS and will be removed from the study. Following completion of neoadjuvant chemotherapy, interval cytoreduct...

This study wants to see how blood sugar changes with sex hormones during regular menstrual cycles or when using hormonal birth control. We also want to learn how exercise and hormonal birth control affect blood sugar.

The goals of this study are to refine the implementation and pilot test the feasibility of an adapted cognitive behavioral therapy (CBT), the Balanced and Empowered EaTing in Diabetes (or the BEET Diabetes Program), compared with the original CBT program, delivered by behavioral health providers to treat disordered eating behaviors (DEBs) in patients with type 2 diabetes in real-world clinical set...

Specific Aims. 1. Determine whether hemp-derived CBD alters cannabis cue-related neural response. A subsample of 52 participants will be recruited from the larger Project 1 (“emerging adult”) randomized controlled trial comparing 400mg/day hemp-derived CBD to placebo. We will conduct a functional MRI scan at enrollment and after 8 weeks in the trial. During the scan, we will conduct a cue-reacti...

This is a first-in-human phase I/II study to examine the safety, tolerability and preliminary efficacy of VLS-1488 in subjects with advanced cancers.

The purpose of the study is to determine the recommended regimen for Phase 2 (RP2Rs) of combination of JNJ-87189401 with JNJ-78278343 (Part 1: dose escalation) and further evaluate the safety at RP2Rs (Part 2: dose expansion) in participants with advanced prostate cancer.

This study will look at two ways to prevent heart and blood vessel problems. It will test which treatment works better for people who may have hidden artery disease because of conditions like diabetes or metabolic syndrome. One way uses your risk factors, and the other way uses pictures of your heart arteries to guide care.

This study wants to find better treatments for people with autoimmune diseases like rheumatoid arthritis (RA). By studying the different types of cells found in people with RA, researchers can learn more about how RA damages joints.

We want to learn more about how safe Sogroya (somapacitan) is and how well it works for people with growth hormone deficiency. To join, you must already be taking or be planning to take Sogroya.

We want to learn how estrogen levels during menopause might affect artery health, body fat, and risk of heart disease in women with regular periods.

The phase III trial compares the effect of pembrolizumab to observation for the treatment of patients with early-stage triple-negative breast cancer who achieved a pathologic complete response after preoperative chemotherapy in combination with pembrolizumab. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with...

This study wants to learn how well and safe dapagliflozin works in people who had a kidney transplant and have Type 2 or post-transplant diabetes. We will look at how dapagliflozin affects the function of your kidney, heart, and blood vessels. We are studying the effects/impact of dapagliflozin (a SGLT2 inhibitor) on: - Kidney function - Protein in the urine - Blood vessel function - Heart f...

This phase 3 study will evaluate the superiority of the fixed dose combination (FDC) of fianlimab + cemiplimab versus the FDC of relatlimab + nivolumab (referred to as Opdualag™) in participants with unresectable locally advanced or metastatic melanoma.

This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection. Collecting and storing samples of blood and tissue from patients with and without cancer to study in the laboratory may help researchers develop tests for the early detection of cancers.

The purpose of this research study is to learn more about how cannabidiol (CBD) may affect cannabis use, effects, and craving.

This is a first-in-human study to learn more about the investigational drug EBC-129. This study will assess the safety and tolerability of EBC-129 when given alone and in combination with pembrolizumab in patients with advanced solid tumors.

This study wants to learn more about how the right side of the heart works in people with chronic obstructive pulmonary disease (COPD). We want to see how the heart responds to high blood pressure in the lungs, both while resting and during exercise. The goal is to find patterns that could lead to better treatments for people with COPD.

This study wants to learn how losing weight affects cell communication in muscle fat tissue among people with obesity. We also want to see how this impacts insulin resistance, inflammation, and muscle strength.

Evaluate the efficacy of the neoadjuvant Pembrolizumab and Axitinib in reducing the inferior vena cava tumor thrombus (IVC TT) among patients with renal cell carcinoma

This is a first-in-human study to learn more about the investigational drug STX-478. The study will have 3 parts.

This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine in participants with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma, and urothelial carcinoma based on Acrivon's OncoSignature® test status.

To develop a program that will help reduce distress in patients with metastatic colorectal cancer and their partners/spouses.

The primary study objective is to compare the clinical outcomes of patients treated with an interventional strategy using the ClotTriever System to achieve and maintain vessel patency (ClotTriever Intervention Arm) versus conservative medical management using anticoagulation therapy alone (Conservative Medical Management Arm) in the treatment of symptomatic unilateral iliofemoral DVT

This study plans to learn more about the safety and effectiveness of TTI-101 when given either alone or in combination treatment using continuous or intermittent TTI-101 dosing, and to see if it will help in the treatment of liver cancer. Continuous dosing of TTI-101 means you will take your TTI-101 dose(s) every day. Intermittent dosing of TTI-101 means you will take a TTI-101 dose on a schedule....

1. Evaluate the effects of consumption of an oral high (20 mg) vs. placebo (0 mg) THC (dronabinol) on brain activation associated with alcohol salience. 2. Test the effects of high THC vs placebo consumption on alcohol self-administration. 3. Test whether neural response under high THC vs placebo predicts differences in alcohol self-administration in the laboratory or alcohol and cannabis...

This study will test if one dose of psilocybin, given with talk therapy, can safely help people with advanced cancer feel less anxious, less depressed, and improve quality of life. We will compare it to a placebo (inactive medicine) called niacin given with the same kind of talk therapy.

This study wants to see if gut problems are worse in HIV+ men that have sex with men that have metabolic syndrome compared those without metabolic syndrome.

We want to learn more about the diseases that cause nephrotic syndrome. This is a group of symptoms that happen when the kidneys don't work the right way. We will collect health information and lab samples to help us discover new things. We hope this will help doctors, researchers, and the public.

Study ICT-GCC19CART-US-001 (CARAPIA-1) is a Phase 1 study evaluating the safety, tolerability, clinical activity, pharmacokinetics and pharmacodynamics of GCC19CART in subjects with relapsed or refractory metastatic colorectal cancer. Primary 1. To evaluate the safety of GCC19CART in adult subjects with relapsed or refractory metastatic colorectal cancer 2. To obtain maximum tolerable dose (M...

This study wants to learn more about CXA-10, a naturally occurring compound in the body. Researchers will test whether CXA-10 is safe and if it helps people who have asthma and are also living with obesity.

This phase II/III trial compares the effect of adding durvalumab to chemotherapy versus chemotherapy alone before surgery in treating patients with upper urinary tract cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as methotrexat...

The purpose of this study is to assess the safety and efficacy of pembrolizumab (MK-3475) combination therapy in participants with metastatic castration resistant prostate cancer (mCRPC). There will be ten cohorts in this study: Cohort A will receive pembrolizumab + olaparib, Cohort B will receive pembrolizumab + docetaxel + prednisone, Cohort C will receive pembrolizumab + enzalutamide, Cohort D ...

This study wants to learn how having too much acid in the blood after a kidney transplant affects your body. Researchers will look at how acid levels may impact the health of your blood vessels and your new kidney.

We are looking for healthy adults who can safely have an MRI scan. This study looks at how drinking and not drinking alcohol affects how the brain works.

We are recruiting individuals with type 2 diabetes (T2D) in need of an exercise program, aged 30 to 55, to help us test how exercise affects heart health, blood vessels, and blood sugar.

Preserving endothelial function with pulsatility during CPB will be associated with less AKI after cardiac surgery.

This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study m...

A study to investigate the efficacy and safety of the lifileucel (LN-144, autologous tumor-infiltrating lymphocytes TIL) regimen plus pembrolizumab infusions compared with pembrolizumab infusions alone in participants with untreated, unresectable or metastatic melanoma

This study wants to find out if taking oral cannabis (marijuana) with THC or THC and CBD can help adults lower long-term back or neck pain.

We are looking for healthy people that are not currently taking drugs that slow down the clotting process (anticoagulants like Warfarin) or stop platelets from sticking together (antiplatelets like aspirin) to join our study. We want to learn more about how your blood composition affects the formation of blood clots and how individuals respond to common drugs.

The FLEX Registry will be implemented to operate as a large-scale, population based, prospective registry. All patients with stage I to III breast cancer who receive MammaPrint® and BluePrint testing on a primary breast tumor are eligible for entry into the FLEX Registry, which is intended to enable additional study arms at low incremental effort and cost. FLEX Registry will utilize an adaptive de...

If your doctor has told you that you have diabetes, but it doesn’t seem like type 1 or type 2, you might be able to join our study. The goal of this study is to better understand different kinds of diabetes that are not common.

To determine if trastuzumab emtansine (ado-trastuzumab emtansine T-DM1) shows better progression-free survival (PFS) when compared to docetaxel plus trastuzumab (TH) in recurrent and/or metastatic (R/M) HER2-positive salivary gland cancer (SGC) patients who have not previously received HER2 therapy for unresectable or recurrent and/or metastatic disease, as determined by local assessment.

Our study is seeking individuals aged 55-85, who have been diagnosed with Mild Cognitive Impairment (MCI) and are at risk for Alzheimer's Disease. The goal of the study is to see whether cannabidiol (CBD) can improve MCI symptoms.

This study wants to learn about the best way to take pictures of unborn babies' hearts to better identify certain heart health problems.

This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Addition of prostate removal surgery or radiation therapy to standard systemic therapy for prostate cancer may lower the chance of the cancer growing or s...

This study plans to learn more about how different adipose tissues are related to diabetes and muscle mass and strength, as well as how to non-invasively track liver disease in those undergoing elective abdominal surgeries.

This study is looking at whether a type of special antibody called broadly neutralizing antibodies (bNAbs) is safe to use along with antiretroviral therapy (ART) in people who have been recently diagnosed with HIV. We also want to find out if these antibodies help control HIV better after people stop their regular medicine (ART), compared to those who didn’t get the antibodies.

This study wants to learn more about how a drug called L-citrulline affects lung function and asthma control in people with deployment-related asthma.

We are looking for people aged 25 to 55 who smoke and/or vape cannabis, and people aged 25 to 55 who do not smoke cannabis, to see how cannabis use affects lung health over time.

We are looking for people aged 30 to 50 who are daily users of e-cigarettes (e-cigs) as well as healthy controls to see how vaping nicotine affects lung or general health.

We are looking for asthmatics and non-asthmatics between 18-65 years old to participate in a study that will look at how cells in the lungs are different between populations.

This study will create a list of patients with inflamed kidneys to help with future research. It will also collect and safely store data and samples like blood, urine, stool, cells, and kidney tissue for later studies.

A comparison of baseline tumor characteristics in oncogene-driven cancers to tumor characteristics after early response to TKI targeted treatment will allow identification of early adaptive mechanisms of cell survival. This will facilitate targeting and termination of these survival/ resistance pathways before they develop with rational combinations of therapeutic agents to improve outcomes.

The overall objective of this study is to ultimately develop an improved standard of cancer care by facilitating new clinical trials, new technology, new informatics solutions and "personalized medicine".

The purpose of this research is to identify strategies that minimize bone loss that occurs when older adults lose weight

To measure distant recurrence free interval from end of treatment stratified by landmark (4-12 weeks post-treatment) and serial post-treatment ctDNA detection status (detected vs. not detected). The purpose of ORACLE is to demonstrate the ability of a novel ctDNA assay developed by Guardant Health to detect recurrence in individuals treated for early-stage solid tumors. It is necessary that ctD...

This study wants to find out how differences in our DNA might affect how birth control works in our bodies and which side effects they may experience.

The main purpose of the study is to assess whether the study drug, ERAS-0015, is safe and tolerable when administered to patients with advanced or metastatic solid tumors with certain RAS mutations. ERAS-0015 will be given alone or in combination with other treatments.

This study plans to learn more about pulmonary fibrosis, a disease that causes scarring in the lungs. We want to see if some forms of this disease are passed down through families by looking at genes that may play a role in pulmonary fibrosis. What we learn may help people with pulmonary fibrosis and their family members in the future.

This study wants to find out how cannabidiol (CBD) may affect cannabis use, the effects of cannabis, mood, and thinking in people that use cannabis regularly.

This research study wants to learn more about how estradiol patch treatment affects brain function, health and wellbeing in healthy women who have experienced menopause.

This observational study is to learn more about the safety, effectiveness, and treatment experience of patients prescribed BRIUMVI® (ublituximab-xiiy).

This study wants to learn how adults with Down syndrome (DS) respond to everyday stress compared with adults without DS of the same sex and age. This study will look at changes in heart rate, blood pressure, and other body responses during stress.

This study will look at whether a medication called alendronate can reduce the amount of hidden HIV (called the HIV reservoir) in people living with HIV. Alendronate is a medication used to strengthen bones.

This study is testing a new drug called mRNA-4359, given alone or with pembrolizumab. We want to learn how safe these drugs are and find the best dose for people with cancer that has spread, returned, or is hard to treat.

This study wants to see if a new treatment called rapcabtagene autoleucel (YTB323) is safe and works well for people with severe Granulomatosis with Polyangiitis (GPA) or Microscopic Polyangiitis (MPA) vasculitis compared to Rituximab.

The main goal of this study is to see how a new treatment (brentuximab vedotin and nivolumab, called Bv-NIVO) compares to the usual treatment for people who were just diagnosed with early-stage (Stage I or II) Hodgkin lymphoma (HL). We want to find out which treatment works better.

The purpose of this study is to learn about the safety of FOG-001, find the best dose, and see how it affects the body. Researchers will also study how well it works in treating advanced or metastatic cancer when used alone or with other cancer treatments.

The purpose of this study is to find out whether the study drug IDRX-42 can help your gastrointestinal stromal tumor (GIST) compared with another drug called sunitinib.

The purpose of this study is to learn how well relacorilant works and how safe it is when used with other treatments for gynecological cancers, such as ovarian and endometrial cancer.

The purpose of the study is to evaluate the progression-free survival (PFS) of casdatifan versus placebo when each is given in combination with cabozantinib in adult patients with confirmed advanced or metastatic clear cell Renal Cell Carcinoma who have experienced progression on or after prior anti-PD-1 or anti-PD-L1 immunotherapy.

This study wants to learn more about a strength training program in veterans with Multiple Sclerosis (MS) who use a mobility aid.

This study wants to find out how the body responds when the birth control implant, Nexplanon, is placed over the shoulder bone instead of in the arm.

In this study, we want to learn whether adding anifrolumab to standard treatment for people with polymyositis (PM) and dermatomyositis (DM) works better than standard treatment alone. We also want to learn more about how PM and DM affect the body.

Researchers are studying whether a treatment called ALLO329 CAR T cells is safe and works well for adults with autoimmune disease such as systemic lupus erythematosus (SLE), idiopathic inflammatory myopathy (IIM), and systemic sclerosis (SSc).

This study looks at the short and long term effects of psilocybin use and explores whether these effects are different for males and females.

The main goals of this study are to see how tiny blood vessels called capillaries in the brain communicate with small arteries to increase blood flow where the brain needs it, and to learn how this process may not work the right way in certain diseases.

This research study is testing whether the investigational drug OPT101 is safe and helpful for people with Type 1 Diabetes (T1D).

This study is comparing how well remibrutinib (Rhapsido) and dupilumab (Dupixent) work in adults with Chronic Spontaneous Urticaria (CSU).

This study aims to learn more about activity behavior in people with Functional Neurologic Disorder (FND). You will wear a device called an accelerometer and talk with the study team to help researchers learn how FND may affect your daily activities and experiences.

This is a first-in-human study to learn about the study drug called BG-C9074 alone and in combination with tislelizumab in participants with advanced solid tumors.

This study wants to learn more about how the anesthesia care you had at University of Colorado Health Hospital (UCHealth) may affect your health and quality of life in the future.

This study is looking for adults age 18 and older who are using or will be using the Okami Medical LOBO Vascular Occluder Device to treat their condition.

We will investigate the association between transfusion of fibrinogen-containing blood products and multi-organ dysfunction resulting from endotheliopathy of trauma (EOT). Fibrinogen is frequently acutely decreased in critically ill trauma patients. Early fibrinogen replacement may be the key to restoring the endothelial glycocalyx and preventing end-organ injury. However, few human data exist to ...

This study wants to learn more about factors in the body (called biomarkers) that are linked to preventable vision loss and changes in the retina. We will use artificial intelligence (AI) to help find signs of health problems in the body, such as high blood pressure, diabetes, Parkinson’s disease, and Alzheimer’s disease.

This study wants to see if an FDA-approved drug called Clemastine Fumarate and sound therapy can help improve hearing problems in noisy places that some people get as they age called age-related auditory processing disorder.

This study looks at whether a new product called Onyx LES is safe and works well when doctors use it to stop bleeding in blood vessels outside the brain and heart in adults that have arterial hemorrhage in the peripheral blood vessels.

To determine the maximum tolerated dose of temozolomide followed by selinexor in recurrent glioblastoma patients as determined by dose-limiting toxicities (DLTs) and the total toxicity profile. (Phase I) II. To evaluate the efficacy of sequentially administering temozolomide and selinexor in recurrent glioblastoma as determined by progression-free survival (PFS). (Phase 2)

Researchers are studying whether using pembrolizumab with radiation therapy can help people with muscle invasive bladder cancer avoid bladder removal surgery and have better quality of life.

This study wants to learn if 6 months of HER2-targeted treatment works as well as 12 months of HER2-targeted treatment for people with early stage HER2-positive breast cancer who had no cancer found at surgery after chemotherapy and trastuzumab. This study also wants to learn how the 2 treatment lengths affect quality of life.

In this study we want to learn more about how life experiences and everyday stress impact the physical and mental health of mothers during pregnancy and postpartum.

We want to learn how a new drug called brexpiprazole (BREX) affects alcohol use and brain function in adults who are not currently getting treatment for Alcohol Use Disorder.

This study wants to find out if adding a chemotherapy drug called paclitaxel directly into the abdomen, along with chemotherapy given through a vein, can help slow or stop gastric cancer. This study also wants to learn if this treatment can help people live longer. This study will compare this approach to the usual treatment people get for gastric cancer.

This study wants to find out how cannabis affects driving in older adults. This study also wants to learn whether how older adults think and how often they use cannabis may affect driving after using cannabis.

This study wants to find out how well the drug tebentafusp works for people with metastatic uveal melanoma who have a genetic marker called HLA-A*0201. The study will also measure tumor DNA in the blood, called W10 ctDNA, to see how the cancer responds to treatment.

This study wants to learn how safe the study drug V940 is when given with pembrolizumab and how well this treatment works in people with non-small cell lung cancer after surgery.

This study wants to learn if a short, high-intensity exercise program can be done safely at home and if this exercise may affect sleep in people with Parkinson's Disease.

This study wants to learn how well the investigational drug IFx-Hu2.0 works as an added treatment before giving pembrolizumab to people with advanced Merkel cell carcinoma.

This phase II trial tests how well biomarker tests on patients tumor tissue works in selecting personalized treatments for patients with extensive stage small cell lung cancer (ES-SCLC). Biomarker tests look for certain features in cancer cells that may give doctors more information about what is driving cancer and how to treat it. Based on the biomarker test results, study doctors can determine t...

This study wants to find out if adding radiation therapy to your tumor, along with your regular immune therapy, can help keep your cancer from growing or even make it shrink, compared to using immune therapy alone in people with metastatic kidney cancer who cannot have surgery.

This study wants to learn how genes in your lymphoma are linked to your symptoms and how you respond to treatment. We hope that by understanding these genetic differences, we can learn how to choose better treatments for lymphoma in the future.

This study wants to find a dose of ziftomenib that people with advanced gastrointestinal stromal tumors (CIST) can handle safely when taken with imatinib. We also want to learn how well these two drugs work together.

This study wants to learn how equol, a supplement made from soy, affects blood vessel health in postmenopausal women with chronic kidney disease (CKD). This study wants to see if taking equol for 12 weeks can help blood vessels work better.

In this study we want to learn if a drug called ravulizumab is a safe and effective treatment for children and teens that have both Immunoglobulin A Vasculitis Nephritis (IgAVN) and Immunoglobulin A Nephritis (IgAN).

This study is being done to test new treatments for people with newly diagnosed glioblastoma (GBM), a type of brain cancer. The goal is to see if any of these new treatments help people live longer compared to the usual treatments. This study will compare the usual medicine (Temozolomide) used to treat newly diagnosed GBM to new drugs such as VT102, ADI-PEG20, Troriluzole, or AZD1390.

This study wants to learn how late menopause affects women. This study wants to see whether diet education, lifestyle changes, and medication can help women feel healthier. We are looking for women ages 45 to 55 who are in late menopause to join.

This study wants to see if a case management program helps people with lung, head-and-neck, thyroid, breast, cervical, colon or rectum, or bladder cancers start and finish treatment sooner compared to usual care. We also want to find out if this program improves care and outcomes for people with these types of cancers.

This study wants to find out if adding a chemotherapy drug to the usual hormone treatment for metastatic prostate cancer can help slow down or stop the cancer from growing or spreading. We also want to see if this new treatment works better or worse than the standard treatment doctor's use.

This study wants to learn more about what causes diabetic neuropathy. Diabetic neuropathy happens when nerves are damaged. We look for certain molecules in the blood and skin that may harm nerves. We compare these molecules in people with Type 2 Diabetes who have neuropathy, people with Type 2 Diabetes who do not have neuropathy, and people who do not have diabetes.

The purpose of this research is to test the safety of an investigational NRTX-1001 cell therapy in participants with drug resistant bilateral mesial temporal lobe epilepsy (MTLE). Another purpose is to see if NRTX-1001 can reduce the number of seizures you have.

In this study we want to understand more about the causes of cystic fibrosis related diabetes (CFRD) and find better ways to treat it.

This study wants to learn more about spondyloarthritis, a type of arthritis that causes a lot of inflammation. We are looking for adults who have a parent, sibling, or child who has spondyloarthritis or a similar health problem to join our study.

The goal of this study is to find out if a combination of chemotherapy drugs is safe and works in adults with pancreatic cancer that has spread inside the abdomen. This study will test whether giving one drug, called paclitaxel, directly into the abdomen through a small tube (catheter) and giving another set of drugs, called NALIRIFOX, into a vein can help control the cancer. 

This is a Phase 1b, open-label, multicenter, safety, tolerability and efficacy study of HC-7366 in combination with belzutifan (WELIREG™). This is a multipart study that consists of a HC-7366 monotherapy cohort, a combination dose escalation, and a combination dose expansion. Approximately 80 patients will be enrolled in this study (up to 20 patients will be enrolled into the HC-7366 monotherapy c...

This study will test if one shot of a medicine called RE104, given in different amounts, can safely help with cancer or other illnesses who are having trouble coping and adjusting.

To learn more about patients who use artificial intelligence (AI) to understand more about their brain tumor diagnosis and their brain tumor doctor.

This study will test a new drug called IMVT-1402 to see if it works and is safe compared to a placebo (a treatment with no medicine) in adults with Graves' Disease. Graves' Disease makes the thyroid gland overactive. We want to see if IMVT-1402 can help people reach normal thyroid hormone levels and possibly stop taking their regular thyroid medicine. The study will compare how well IMVT-1402 work...

In this study we want to learn more about how the body responds to giving birth for cesarean deliveries.

The purpose of this study is to determine safety and preliminary efficacy of amivantamab monotherapy, amivantamab in addition to pembrolizumab, and amivantamab in addition to paclitaxel in participants with recurrent/metastatic head and neck cancer. The study will also confirm the recommended Phase 2 combination dose (RP2CD) for amivantamab in addition to paclitaxel

This study is testing a new injectable medication called anifrolumab to see how safe and effective it is for adults with chronic cutaneous lupus erythematosus (CLE). Our goal is to find better treatments for people living with CLE.

The main purpose of this study is to assess the efficacy and safety of volrustomig compared to observation in participants with unresected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) who have not progressed after receiving definitive concurrent chemoradiotherapy (cCRT)

This study wants to learn more about how estrogen affects women's reproductive hormones and system.

To assess the efficacy and safety of opevesostat plus hormone replacement therapy (HRT) compared to alternative abiraterone acetate or enzalutamide in participants with Metastatic Castration-resistant Prostate Cancer (mCRPC)

To compare the response rate (confirmed or unconfirmed, complete or impartial) between participants with MET exon 14 skipping positive non-small cell lung cancer (NSCLC) randomized to tepotinib with or without ramucirumab.

To determine prospectively if SCLC tumor tissue transcriptional subtypes can be detected by Tempus|xT RNAseq

To compare investigator-assessed progression-free survival (IA-PFS) between participants with EGFR mutated, MET amplified non-small cell lung cancer (NSCLC) randomized to INC280 (capmatinib) and osimertinib with or without ramucirumab.

The purpose of our research study is to assess satisfaction with genetic testing for hereditary cancer risk in a high-risk population in Colorado and New Mexico.

This study is using MRI to learn how skeletal muscles and blood vessels respond to exercise in people with and without Type 2 Diabetes. We are currently looking for healthy volunteers to join our study!

To prospectively collect data regarding the diagnosis and treatment of orthopedic infections including upper and lower limb as well as pelvic and spinal infection in order to improve quality of care. The database will be used for subsequent future research.

The primary objective of this screening study is to test patient specimens to determine eligibility for participation in the biomarker-driven and non-matched sub-studies included within the Lung-MAP umbrella protocol.

Evaluate the Arctic Sun Cooling device for fever prevention to standard of care measures for controlling fever in the ICU

We hope to learn how safe and effective the Neuroport array plus stimulation is in controlling computer generated images and real-world objects, such as a robotic arm, using imagined movements of the arms and hands.

The primary objective of the BISON-PRO Database is to establish a prospective repository of real-world, longitudinally-collected patient-reported outcomes (PRO) and quality-of-life data for patients with both malignant and non-neoplastic blood disorders to support patient-centered research.

We want to learn how stimulating the vagus nerve while moving the hand can help improve fine motor control in people with relapsing-remitting multiple sclerosis (MS), who have trouble moving their hands and arms.

To collect data on the recurrence rate and outcomes of benign and primary/metastatic malignant tumors seen in Orthopaedic patients at the University of Colorado Hospital.

To collect prospectively (after informed consent) fresh, excess surgical tissues, blood and other bodily fluids, and saliva from patients with HNC slated to undergo biopsy or surgical resection, and to collect prospectively optional samples from patients with HNC slated to undergo other therapies

Use of blood flow restriction cuffs in post surgical hip patients.

The purpose of this study is to learn if a drug called sargramostim is safe and if it can help improve thinking and memory in people with Alzheimer’s disease.

This study plans to learn more about genes that are expressed in blood vessels in the brain and in the blood of patients without brain aneurysms. This will help us understand diseases that affect those blood vessels such as aneurysms.