This study wants to find out how the body responds when the birth control implant, Nexplanon, is placed over the shoulder bone instead of in the arm.
Gocatamig and I-DXd (short for ifinatamab deruxtecan) are study medicines. Researchers want to know if giving gocatamig and I-DXd together can treat ES-SCLC. Researchers will also look at giving the study medicines with standard treatment. Gocatamig is a T-cell engager therapy. I-DXd is an antibody drug conjugate. T-cell engager therapy is a certain type of immunotherapy that uses T-cells to find...
A clinical study for the treatment of agitation in adults with Alzheimer's disease
The goal of this study is to learn whether veverimer is safe and helpful in preventing or treating the problems of metabolic acidosis in adults with chronic kidney disease (CKD).
The purpose of this study is to learn about the safety and side effects of a treatment called yttrium-90 (Y90) radioembolization for a type of kidney cancer called renal cell carcinoma (RCC).
This study intends to evaluate the safety and efficacy of ficerafusp alfa in combination with pembrolizumab versus placebo with pembrolizumab in 1L PD-L1-positive, recurrent or metastatic Head and Neck Squamous Cell Carcinoma (HNSCC).
The goal of this research study is to learn more about how pain is related to alcohol use and mental health across different stages of adulthood.
The objective of the proposed trial is to show that the association - carboplatin with the SonoCloud-9 - will increase efficacy of the drug in patients with recurrent glioblastoma.
In this study, we want to learn whether adding anifrolumab to standard treatment for people with polymyositis (PM) and dermatomyositis (DM) works better than standard treatment alone. We also want to learn more about how PM and DM affect the body.
The purpose of this study is to learn how well relacorilant works and how safe it is when used with other treatments for gynecological cancers, such as ovarian and endometrial cancer.
This study will look at whether a medication called alendronate can reduce the amount of hidden HIV (called the HIV reservoir) in people living with HIV. Alendronate is a medication used to strengthen bones.
Researchers are studying whether a treatment called ALLO329 CAR T cells is safe and works well for adults with autoimmune disease such as systemic lupus erythematosus (SLE), idiopathic inflammatory myopathy (IIM), and systemic sclerosis (SSc).
This study looks at the short and long term effects of psilocybin use and explores whether these effects are different for males and females.
The main goals of this study are to see how tiny blood vessels called capillaries in the brain communicate with small arteries to increase blood flow where the brain needs it, and to learn how this process may not work the right way in certain diseases.
PRIMARY OBJECTIVE: I. To demonstrate that bevacizumab, an anti-VEGF antibody therapy, (or an anti-VEGF antibody biosimilar) in combination with carboplatin, paclitaxel, and pembrolizumab is superior to carboplatin, paclitaxel, and pembrolizumab (the control arm) or carboplatin, paclitaxel, and bevacizumab in prolonging progression-free survival (PFS) in patients with pMMR, TP53 mutated advanced s...
This research study is testing whether the investigational drug OPT101 is safe and helpful for people with Type 1 Diabetes (T1D).
This study plans to learn more about two commonly used minimally invasive techniques (US-guided percutaneous needle tenotomy vs percutaneous ultrasonic tenotomy) for the treatment of gluteal tendinosis. The goal of the study is to see which works better at reducing pain and improving movement in people with gluteal tendinosis (a condition that causes pain in the hip area).
To determine the MTD and/or RP2D(s) of RLY- 8161. To evaluate the safety and tolerability of RLY- 8161
This study aims to investigate the combination of BNT324, a B7-H3 antibody-drug conjugate (ADC) with BNT327, a programmed death-ligand 1 (PD-L1) and vascular endothelial growth factor (VEGF) bispecific antibody, in participants with advanced/metastatic or relapsed/progressive small cell lung cancer (SCLC) and non small cell lung cancer (NSCLC).
This study, the first clinical trial of AVZO-103, aims to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose, and antitumor activity of AVZO-103 when administered intravenously as a monotherapy and in combination therapy to patients with locally advanced or metastatic urothelial cancer or other solid tumors.
This study is comparing how well remibrutinib (Rhapsido) and dupilumab (Dupixent) work in adults with Chronic Spontaneous Urticaria (CSU).
This study aims to learn more about activity behavior in people with Functional Neurologic Disorder (FND). You will wear a device called an accelerometer and talk with the study team to help researchers learn how FND may affect your daily activities and experiences.
This is a first-in-human study to learn about the study drug called BG-C9074 alone and in combination with tislelizumab in participants with advanced solid tumors.
To investigate a blood-flow restriction exercise-based intervention for people with Multiple Sclerosis (MS).
The purpose of this study is to evaluate the effects of the investigational use of a GLP-1 medication called tirzepatide (Zepbound) on cigarette smoking, cigarette craving, and related outcomes.
This project will test whether cyclic versus continuous estradiol administration differentially influences brain, metabolic, immune, and stress systems, as well as behavioral (mood, sleep, activity, perceived stress) and cognitive (memory, attention, decision-making, processing speed) outcomes in healthy early postmenopausal women.
To compare the efficacy of IDRX-42 (GSK6042981) to that of sunitinib in participants with metastatic and/or unresectable GIST after failure of imatinib therapy, as evidenced by PFS. To compare the efficacy of IDRX-42 (GSK6042981) to that of sunitinib.
This study wants to learn more about how the anesthesia care you had at University of Colorado Health Hospital (UCHealth) may affect your health and quality of life in the future.
This phase II/III trial tests whether adding trastuzumab and hyaluronidase-oysk (Herceptin Hylecta [TM]) or pertuzumab, trastuzumab and hyaluronidase-zzxf (Phesgo [TM]) to the usual chemotherapy (paclitaxel and carboplatin) works to shrink tumors in patients with HER2 positive endometrial cancer. Trastuzumab and pertuzumab are monoclonal antibodies and forms of targeted therapy that attach to spec...
The main goal of this study is to see how well two drugs, tirzepatide and retatrutide, work for treating metabolic dysfunction associated steatotic liver disease compared to placebo.
The purpose of this study is to measure the efficacy and safety of rilvegostomig with gemcitabine plus cisplatin vs. durvalumab with gemcitabine plus cisplatin as first line treatment for patients with advanced BTC.
This is a multi-center, open-label Phase 1/2 trial evaluating the safety and efficacy of AB-3028 in subjects with metastatic castration resistant prostate cancer (mCRPC).
The study will test whether GSK5460025 alone or in combination (potential combinations may be included in future amendments to the protocol) with other anti-cancer agents can decrease tumor size, is safe, well-tolerated, and how the drug is processed in the body over time.
This study is looking for adults age 18 and older who are using or will be using the Okami Medical LOBO Vascular Occluder Device to treat their condition.
This study tests how safe Mocertatug-Rezetecan (Mo-Rez) is, how well people can handle it, how the body uses it, and how well it works when taken with other cancer medicines. We are looking for people with advanced solid tumors whose cancer has not improved with standard treatments, who cannot handle those treatments, or who do not have other good treatment options.
This is an international, multicenter, randomized, double-blind, active-controlled, phase 3 clinical trial. The purpose of this trial is to compare the efficacy and safety of palazestrant in combination with ribociclib +letrozole -matching placebo (Arm A: investigational arm) with letrozole in combination with ribociclib + palazestrant-matching placebo (Arm B: control arm). This trial is seeking a...
This study wants to learn more about muvalaplin (LY3473329). Muvalaplin is being studied to treat high lipoprotein, which is a type of unhealthy fat in your blood. The goal of this study is to see if muvalaplin can lower the risk of serious health problems, such as heart attack or stroke, and see what side effects people may have.
This study plans to learn more about whether exercise can help protect the body from health problems that happen when a person’s sleep and daily schedule are out of sync with their natural body clock.
To see how safe and tolerable the study drug is when given alone and together with other anticancer drugs at different dose levels in patients; To determine the optimal dose of the study drug when given alone and together with other anticancer drugs that is effective but does not result in severe side effects; To evaluate the preliminary anti-tumor activity of the study drug when given alone and t...
This study wants to find out if a mobile app that suggests daily insulin doses is safe and works well for adults with type 2 diabetes.
This study will look at how easy and well accepted it is to add a nutrition program called BfedBwell to a cancer exercise program called BfitBwell. We will see how both programs (BfedBwell and BfitBwell) together improve physical and mental health.
We are looking for women who are within six weeks of giving birth to help us learn how doula support and spending time in nature can lower stress, improve sleep, and support overall wellbeing. This study looks at ways to help mothers recover and thrive during the early weeks after giving birth.
This clinical study is testing whether a new combination of medicines (DSP107 and atezolizumab) is more effective and safer than an existing treatment (fruquintinib) for people with advanced colorectal cancer that is microsatellite stable (MSS). Participants will be randomly assigned to receive one of the two treatments, and researchers will monitor how well the cancer responds, how safe the treat...
The objective of this study is to evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of BL-M14D1 in Subjects with locally Advanced or Metastatic Small Cell Lung Cancer and Other Neuroendocrine Neoplasms
PRIMARY OBJECTIVE: To determine whether the combination of cabozantinib plus cemiplimab (REGN2810) (Cabo-Cemiplimab [REGN2810]) improves progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors (RECIST) version (v.) 1.1 relative to cabozantinib alone in patients with locally advanced unresectable or recurrent/metastatic advanced adrenocortical cancer.
The goal of this clinical trial is to learn about the safety and recommended dose of TRI-611 when administered to adults with ALK-positive non-small cell lung cancer (NSCLC). The trial will also evaluate the antitumor activity of TRI-611 in adults with ALK-positive NSCLC. The study will be conducted in two parts. The first part will examine different doses of TRI-611. The second part will look at...
PRIMARY OBJECTIVE: I. Demonstrate non-inferiority of ultra-hypofractionated (stereotactic body radiation therapy [SBRT]) compared to hypofractionated radiation therapy (RT) with a 10% non-inferiority margin (from 50% to 40%) in the rate of bladder-intact event-free survival (BI-EFS) at 3 years (corresponding to a hazard ratio < 1.32)
This study looks at whether a digital mindfulness program can help people diagnosed with breast cancer by age 50 who are feeling depressed. We will compare different digital programs to see which one helps the most.
This study is for adults age 21 or older who have alcohol use disorder (AUD). It tests whether a medicine called Apremilast can help reduce alcohol cravings compared to a placebo, a pill that looks the same but has no medicine.
The goal of this study is to learn more about how different types of snacks may affect brain activity, hunger, and eating behaviors during a diet program.
PRIMARY OBJECTIVE: I. To determine whether induction immunotherapy (IO) and chemotherapy prior to concurrent chemoradiation therapy (CCRT) + IO improves progression-free survival (PFS) compared to CCRT+IO alone. SECONDARY OBJECTIVES: I. To assess whether induction IO and chemotherapy prior to CCRT+IO improves the overall survival (OS) compared to CCRT+IO alone. II. To determine the nature and ...
This is an open-label, multi-center, phase I/II study to evaluate the safety, efficacy, and pharmacokinetics of MRG007 in patients with unresectable locally advanced and metastatic solid tumors.
This study wants to better understand how people respond to nutrient stimulated hormone receptor agonist (NuSH RA) medications like semaglutide (Wegovy) and tirzepaide (Zepbound).
Cohort 1: To demonstrate that the proportion of subjects with vision loss is lower for subjects in the Treatment Arm vs the Control Arm. Cohort 2: To demonstrate the ability to salvage the eye and prevent enucleation in the Treatment Arm
This is a first-in-human, open-label, multicenter phase 1 study to evaluate safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of OP-3136, a lysine acetyltransferases 6A and 6B (KAT6A/B) inhibitor, as monotherapy and in combination with other anticancer agents in participants with advanced solid tumors. This study consists of 2 parts: a dose escalation pa...
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of BG-C477 alone and in combination with anticancer agents in participants with selected advanced solid tumors.
This is a first-in human clinical study of DPTX3186 in subjects with Wnt-pathway activated solid tumors where no other treatments exist. The study will evaluate safety, pharmacokinetics, and initial activity of DPTX3186, as well as explore pharmacodynamic parameters to identify potential biomarkers of efficacy
An open-label, multicenter study of ZL-1310 as a single agent and in combination with Atezolizumab (with and without Carboplatin) to evaluate the safety, efficacy, and pharmacokinetics in subjects with small cell lung cancer
This study wants to learn how safe psilocybin is for healthy older adults and how their bodies and minds react to it. We also want to see how psilocybin affects mood, thinking, and well-being.
This study wants to see how safe and how well two different ways to treat asthma (adding an inhaled corticosteroid or using an antibiotic) work when compared to usual care. By figuring out which treatment decreases the number of asthma attacks and reduces the need for emergency care, we hope to improve people’s symptoms and quality of life.
The objective of this study is to evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of BL-M05D1 in Subjects with Advanced or Metastatic Solid Tumors.
This is a two-stage Phase 2 trial evaluating the efficacy and safety of ONC206 in participants with Pheochromocytoma and Paraganglioma (PCPG).
This study wants to see how well three medicines, atogepant (Qulipta), propranolol (Inderal), and topiramate (Topamax), work at reducing the number of migraines people have and how bad the migraines are. The results will help people and their doctors choose which medicine might be best to try first to prevent their migraines.
A Phase 2 study to evaluate the safety and efficacy of TORL-1-23 in patients with advanced ovarian cancer.
The main purpose of this study is to evaluate the safety and preliminary efficacy of CHS-114 in combination with toripalimab and/or other standard of care (SOC) compound(s) in participants with advanced or metastatic solid tumors.
This study wants to learn how cannabidiol (CBD) affects drinking in people who drink alcohol often. This study will look to see if CBD can help people drink less and if CBD can help reduce problems linked to alcohol use.
The purpose of this study is to assess adverse events and change in disease activity when telisotuzumab adizutecan is given in combination with a fixed dose of osimertinib (Osi), Osi alone, or standard of care (SOC) alone.
The purpose of this study is to evaluate the overall survival (length of time from the start of study to date of death from any cause) for pasritamig (JNJ-78278343) in combination with best supportive care (BSC) as compared to placebo with BSC in participants with metastatic castration-resistant prostate cancer (mCRPC; a stage of cancer that has spread beyond the prostate gland and is no longer re...
This research study plans to learn more about how a form of brain stimulation called low-intensity focused ultrasound (LIFU) affects the brain and behaviors related to Alcohol Use Disorder (AUD). LIFU is a non-invasive (meaning it does not require surgery or electrodes) form of brain stimulation that uses ultrasonic energy (sound waves that you cannot hear) to affect the function of brain tissue. ...
This study will check how well a new medicine, GSK5764227, works, how safe it is and how the body handles it in participants all around the world with advanced inoperable or metastatic gastrointestinal cancer who have previously received treatment.
PRIMARY OBJECTIVE: I. To compare metastasis-free survival, determined using conventional imaging, between men with high-risk prostate cancer randomized to ultrahypofractionation (stereotactic body radiation therapy [SBRT]) to those randomized to moderate hypofractionation and conventional fractionation.
A first in human study to evaluate the safety and preliminary antitumor activity of BBO-8520, a KRAS G12C (ON and OFF) inhibitor, as a single agent and in combination with pembrolizumab in subjects with locally advanced and unresectable or metastatic non-small cell lung cancer with a KRAS (Kirsten rat sarcoma) G12C mutation.
This is a 3-part study. The purpose of Part 1 of the study is to evaluate the efficacy, safety, and pharmacokinetic (PK) characteristics of safusidenib in participants with recurrent/progressive IDH1-mutant World Health Organization (WHO) Grade 2 or Grade 3 glioma. The purpose of Part 2 will be to evaluate the efficacy of maintenance safusidenib treatment versus placebo in IDH1-mutant Grade 2 or ...
The purpose of this study is to evaluate the safety and effectiveness of the Cryosa System applied to the tongue and soft palate in patients with clinically diagnosed obstructive sleep apnea (OSA).
This study aims to evaluate the safety and tolerability of RO7673396 in participants with advanced solid tumors harboring RAS mutation(s). This study consists of two stages: Stage 1 (Dose Escalation) and Stage 2 (Dose Expansion). Stage 1 will define the recommended dose(s) for expansion (RDEs) of RO7673396. Stage 2 will evaluate preliminary anti-tumor activity of the RDE(s) defined in Stage 1 and ...
PRIMARY OBJECTIVE: To compare disease free survival (DFS) as assessed by the investigator for high-risk renal cell carcinoma patients treated with adjuvant pembrolizumab and tivozanib versus those receiving pembrolizumab alone.
Determine if bone density, bone microarchitecture, and estimates of bone strength change in response to 12 months of glucagon-like peptide-1 receptor agonist (GLP-1 RA)-induced weight loss in pre- and post-menopausal women.
To evaluate the efficacy of IMA203 compared with control (investigator's choice)
The goals of this study are to learn: - If gocatamig alone, I-DXd alone, and gocatamig with I-DXd or durvalumab are safe and well tolerated - If people who receive gocatamig alone, I-DXd alone, and gocatamig with I-DXd or durvalumab have their SCLC get smaller or go away
This study wants to learn how changing the stiffness of a prosthetic foot affects how people with below-the-knee amputations move and do everyday tasks. We are looking for people who use either a bone-anchored prosthetic leg or a standard socket prosthetic leg to join!
The objectives both in stage I and stage II are to evaluate the intracranial and systemic efficacy and safety of utidelone plus capecitabine for the treatment of HER2-negative breast cancer patients with brain metastases.
This is a Phase III, randomized, open-label, Sponsor-blinded, 3-arm, global, multicenter study assessing the efficacy and safety of rilvegostomig in combination with fluoropyrimidine and T-DXd (Arm A) compared to trastuzumab, chemotherapy, and pembrolizumab (Arm B) in HER2-positive locally advanced or metastatic gastric or GEJ adenocarcinoma participants whose tumors express PD L1 CPS>=1. Rilvegos...
Overall Survival (OS) [Time Frame: Up to approximately 36 months] Progression free survival (PFS) [Time Frame: Up to approximately 36 months]
This study will test a new investigational drug called NBI-1065845 to see if it helps improve symptoms of depression when taken with your current antidepressants. The study team will compare this drug with a placebo, a treatment with no medicine.
This phase III trial compares the effect of olaparib for one year versus two years, with or without bevacizumab, for the treatment of BRCA 1/2 mutated or homologous recombination deficient stage III or IV ovarian cancer. Olaparib is a polyadenosine 5'-diphosphoribose polymerase (PARP) enzyme inhibitor and may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Be...
The primary objective of this 3-arm clinical trial is to compare progression-free survival (PFS) of LNS8801 + pembrolizumab arm vs Physicians’ Choice (PC) treatment using RECIST 1.1.
This is a Phase 1/1b open-label, multi-center dose escalation and dose optimization study designed to evaluate the safety and preliminary efficacy of IAM1363 in participants with advanced cancers that harbor HER2 alterations.
This study is looking at whether hormone therapy can help reduce hot flashes and night sweats in women living with HIV who are going through menopause or who recently finished menopause.
This study wants to learn more about heart and brain health of people with and without endometriosis.
Dose Escalation: To evaluate the safety and tolerability of peposertib in combination with low-dose liposomal doxorubicin as evaluated by the dose-limiting toxicity (DLT) rate at each tested dose level. Dose Escalation: To determine the recommended phase 2 dose (RP2D) of liposomal doxorubicin and peposertib combination and determine the maximal tolerated dose (MTD) if identified. Dose Expansion:...
Non small cell lung carcinoma (NSCLC) is the most frequently occurring histologic subtype of lung cancer and is the leading cause of cancer-related deaths worldwide. The purpose of this study is to assess adverse events and change in disease activity when Telisotuzumab Adizutecan (ABBV-400) is given in combination with a programmed cell death receptor 1 (PD1) inhibitor (budigalimab) to adult parti...
Determine the efficacy of treatment with weekly doxorubicin chemotherapy in anthracycline-naïve elderly patients with advanced or metastatic LMS of soft tissue.
Primary Objective: 1) To assess the relationship of polymorphisms in IL-6 and/or IL-6R genes to the development of irAEs in ICI-treated cancer patients. Secondary Objective: 1) To determine whether polymorphisms in IL-6 and/or IL-6R genes affect the production of IL-6 and sIL-6R by CD4 cells before and after ICI treatment. Exploratory Objectives: 1) To evaluate whether polymorphisms in IL-6 and/or...
-To determine the MTD/maximum administered dose and RP2DS of ADCE-D01. -To assess the safety and tolerability of ADCE-D01.
The objective of this study is to see if executive functioning can be effected by non-invasive vagus nerve stimulation.
The purpose of this study is to evaluate the efficacy and safety of rapcabtagene autoleucel versus comparator in participants with severe active Granulomatosis with Polyangiitis (GPA) or Microscopic Polyangiitis (MPA) This is a Phase 2, randomized, assessor-blinded active controlled study.
This study plans to learn more about how a telehealth exercise program designed for rural survivors of cancer can help improve cancer related fatigue.
Researchers are testing a drug called IMVT-1402 to see if it is safe and if it helps people with skin lupus (a type called subacute or chronic cutaneous lupus) with or without lupus that affects the whole body.
The purpose of this study is to compare how long the participants are disease-free (progression-free survival) and and the length of time until a participant dies (overall survival), when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, and irinotecan hydrochloride (FOLFIRI) versus either cetuximab or bevacizumab and FOLFIRI given ...
This study wants to see if avacopan is safe and works well for people with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. We also want to find out if it helps prevent the disease from coming back.
• To evaluate the safety and tolerability of DCC-3009 as monotherapy in participants with advanced GIST. • To determine the recommended dose(s) for expansion in Module A, and if reached, the maximum tolerated dose (MTD) of DCC-3009 as monotherapy.
We are doing this study to see if a medicine called anifrolumab is safe to use in adults with systemic sclerosis. We also want to find out if the medicine helps with disease symptoms and if it stops the disease from getting worse.
This study will compare how well pramipexole and escitalopram help treat depression in people living with HIV.
We want to learn how nightmares from trauma or posttraumatic stress disorder (PTSD) affect heart and artery health in women. We also want to see if a treatment called NightWare, which is used on a smartwatch, can help women with these nightmares sleep better and improve their heart and artery health.
The purpose of this study is to determine the putative recommended phase 2 dose(s) (RP2Ds) of JNJ-89402638 and to determine the safety of JNJ-89402638 at the RP2D(s) in participants with metastatic colorectal cancer.
The main purpose of this study is to find out whether the study drug, LY4050784, is safe, tolerable and effective in participants with locally advanced or metastatic solid tumors with a BRG1 (Brahma-related gene 1, also known as SMARCA4) alteration who have previously received, do not qualify for, or are refusing standard of care treatments, or there is no standard therapy available for the diseas...
Researchers want to learn if patritumab deruxtecan (MK-1022) can treat certain gastrointestinal (GI) cancers. The GI cancers being studied are advanced (the cancer has spread to other parts of the body). The goals of this study are to learn: About the safety and how well people tolerate of patritumab deruxtecan How many people have the cancer respond (get smaller or go away) to treatment
This study wants to learn more about how the food we eat affects the reproductive hormones of adult women with obesity.
We are looking for couples who drink and are 18 years or older to join a study looking at alcohol use among romantic couples.
We are looking for couples, 21 or older, to join a study about how alcohol and media affect relationships.
This is a Phase Ib/II, open-label, multicenter, randomized umbrella study in participants with advanced liver cancers. The study is designed with the flexibility to open new treatment arms as new treatments become available, close existing treatment arms that demonstrate minimal clinical activity or unacceptable toxicity, modify the participant population, or introduce additional cohorts of partic...
Determine the safety and toxicity of losartan in combination with SBRT and subsequently pembrolizumab in patients with locally recurrent, refractory, or oligometastatic head and neck squamous cell carcinoma (HNSCC).
This study looks at how people with type 1 diabetes take care of their diabetes during pregnancy. Your experience and health data can help us make it easier for people in the future.
This study wants to find out if a glucose monitor can help detect type 1 diabetes early in people getting immune therapy for cancer treatment. It also wants to learn if certain genes or antibodies can help identify people at higher risk.
This study wants to find out if people with certain types of early-stage endometrial cancers need less treatment than usual, like less radiation and chemotherapy. We also want to see if less treatment works well and keeps your cancer from coming back.
This study wants to learn how age and sex affect how our blood vessels age and how exercise (both short-term and long-term) changes the body.
The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON) inhibitors combined with Standard(s) of Care (SOC) or with novel agents. The first three subprotocols include the following: Subprotocol A: RMC-6236 + 5-fluorouracil-based regimens Subprotocol B: RMC-6236 + cetuximab with or without mFOLFOX6 Sub...
We are looking for adults to join a national study to help us learn more about how rheumatoid arthritis (RA) develops.
This study wants to learn more about people who get a treatment called Genicular Artery Embolization (GAE). GAE is a procedure to help adults with long-term knee pain feel better. This study will look at changes in the fluid in your knee, pictures of your knee (MRI), and how well you move before and after the treatment.
I. Establish a prospective cohort of individuals with Lynch syndrome II. Collect standardized longitudinal clinical and biosample data to elucidate Lynch Syndrome epidemiology and gene-host interactions III. Promote intervention trials to improve cancer prevention and early detection in Lynch Syndrome
To determine the sensitivity and specificity of the mt-sDNA 2.0 test, for colorectal neoplasia in patients with Lynch Syndrome
This phase II/III trial examines whether patients who have undergone surgical removal of bladder, but require an additional treatment called immunotherapy to help prevent their bladder cancer from coming back, can be identified by a blood test. Many types of tumors tend to lose cells or release different types of cellular products including their DNA which is referred to as circulating tumor DNA (...
To evaluate the long-term safety through 15 years post infusion of patients who received IP in a Caribou-sponsored study, special access program or ITT
The main goal of this study is to find out if one dose of psilocybin (a drug from certain mushrooms) and talk therapy can help people feel less scared about their cancer returning. We also want to make sure this treatment is safe.
This phase III trial compares the addition of an immunotherapy drug (durvalumab) to usual chemotherapy versus usual chemotherapy alone in treating patients with MammaPrint Ultrahigh (MP2) stage II-III hormone receptor positive, HER2 negative breast cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the a...
This study wants to learn more about whether a drug called sotagliflozin (SOTA) can slow down the loss of kidney function in people with type 1 diabetes and diabetic kidney disease.
This Phase III Trial will determine whether adjuvant chemotherapy (ACT) added to ovarian function suppression (OFS) plus endocrine therapy (ET) is superior to OFS plus ET in improving invasive breast cancer-free survival (IBCFS) among premenopausal, early- stage breast cancer (EBC) patients with estrogen receptor (ER)-positive, HER2-negative tumors and 21-gene recurrence score (RS) between 16-25 (...
This study wants to learn how early changes in airway cells may help predict who is at risk for developing Chronic Obstructive Pulmonary Disease (COPD). We are looking for people who are current smokers with or without COPD.
This phase III trial compares hepatic arterial infusion (HAI) (pump chemotherapy) in addition to standard of care chemotherapy versus standard of care chemotherapy alone in treating patients with colorectal cancer that has spread to the liver (liver metastases) and cannot be removed by surgery (unresectable). HAI uses a catheter to carry a tumor-killing chemotherapy drug called floxuridine directl...
This phase II trial tests how well carboplatin before surgery works in treating patients with high-risk prostate cancer and an inherited BRCA1 or BRCA2 gene mutation. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping, or slowi...
This study is open to adults with different types of advanced cancer (solid tumors) that are accessible for injection and/or biopsy. This is a study for people with a life expectancy of at least 3 months after starting study treatment. The purpose of this study is to find the highest dose of a medicine called BI 1831169 that people with advanced cancer can tolerate when taken with or without a typ...
This clinical trial is studying advanced solid tumors. Solid tumors are cancers that start in a part of your body like your lungs or liver instead of your blood. Once tumors have grown bigger in one place but haven't spread, they're called locally advanced. If your cancer has spread to other parts of your body, it's called metastatic. When a cancer has gotten so big it can't easily be removed or h...
We want to see how well over-the-counter (OTC) hearing aids work when fitted in different ways like self-fit, online self-fit, or fit by a hearing healthcare provider, compared to prescription hearing aids.
BL-B01D1-LUNG-101 is a global, multi-center, Phase 1 study to evaluate the safety, tolerability, pharmacokinetics , and initial efficacy of BL-B01D1 in participants with metastatic or unresectable NSCLC and Other Solid Tumors. This study will be conducted in two different dosing schedules (Cohort A and Cohort B) and three parts (dose escalation, dose finding and dose expansion). Cohort A will be ...
This phase II trial compares the effect of retreatment with 177Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) to the usual approach of treatment with everolimus in patients who have previously received 177Lu-DOTATATE for midgut neuroendocrine tumor (NET) that has spread from where it first started (primary site) to other places in the body (metastatic) and that cannot be removed by surge...
Patients will be registered prior to, during or at the completion of neoadjuvant chemotherapy (Paclitaxel 175 mg/m2 IV over 3 hours and Carboplatin AUC 6 IV on Day 1 every 21 days for 3-4 cycles). Registered patients who progress during neoadjuvant chemotherapy will not be eligible for iCRS and will be removed from the study. Following completion of neoadjuvant chemotherapy, interval cytoreductiv...
This study wants to see how blood sugar changes with sex hormones during regular menstrual cycles or when using hormonal birth control. We also want to learn how exercise and hormonal birth control affect blood sugar.
The goals of this study are to refine the implementation and pilot test the feasibility of an adapted cognitive behavioral therapy (CBT), the Balanced and Empowered EaTing in Diabetes (or the BEET Diabetes Program), compared with the original CBT program, delivered by behavioral health providers to treat disordered eating behaviors (DEBs) in patients with type 2 diabetes in real-world clinical set...
Specific Aims. 1. Determine whether hemp-derived CBD alters cannabis cue-related neural response. A subsample of 52 participants will be recruited from the larger Project 1 (“emerging adult”) randomized controlled trial comparing 400mg/day hemp-derived CBD to placebo. We will conduct a functional MRI scan at enrollment and after 8 weeks in the trial. During the scan, we will conduct a cue-reactiv...
This phase 3 clinical trial compares the safety and efficacy of palazestrant (OP-1250) to the standard-of-care options of fulvestrant or an aromatase inhibitor in women and men with breast cancer whose disease has advanced on one endocrine therapy in combination with a CDK4/6 inhibitor.
This is a first-in-human phase I/II study to examine the safety, tolerability and preliminary efficacy of VLS-1488 in subjects with advanced cancers.
The purpose of the study is to determine the recommended regimen for Phase 2 (RP2Rs) of combination of JNJ-87189401 with JNJ-78278343 (Part 1: dose escalation) and further evaluate the safety at RP2Rs (Part 2: dose expansion) in participants with advanced prostate cancer.
This study will look at two ways to prevent heart and blood vessel problems. It will test which treatment works better for people who may have hidden artery disease because of conditions like diabetes or metabolic syndrome. One way uses your risk factors, and the other way uses pictures of your heart arteries to guide care.
This study wants to find better treatments for people with autoimmune diseases like rheumatoid arthritis (RA). By studying the different types of cells found in people with RA, researchers can learn more about how RA damages joints.
To investigate long-term safety of Sogroya (somapacitan) therapy in patients with AGHD in the setting of routine clinical practice with special focus on neoplasms and diabetes mellitus type 2.
We want to learn how estrogen levels during menopause might affect artery health, body fat, and risk of heart disease in women with regular periods.
The phase III trial compares the effect of pembrolizumab to observation for the treatment of patients with early-stage triple-negative breast cancer who achieved a pathologic complete response after preoperative chemotherapy in combination with pembrolizumab. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with...
This study wants to learn how working at night or outside normal daytime hours affects women’s heart and reproductive health in women. We are looking for women who work night shifts, both day and night shifts, or only daytime shifts to see how different work hours may affect heart and reproductive health.
This research study is being conducted to examine the effects of dapagliflozin on kidney function, blood vessel function and heart function. We are studying the effects/impact of dapagliflozin (a SGLT2 inhibitor) on: - Kidney function - Protein in the urine - Blood vessel function - Heart function
This phase 3 study will evaluate the superiority of the fixed dose combination (FDC) of fianlimab + cemiplimab versus the FDC of relatlimab + nivolumab (referred to as Opdualag™) in participants with unresectable locally advanced or metastatic melanoma.
This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection. Collecting and storing samples of blood and tissue from patients with and without cancer to study in the laboratory may help researchers develop tests for the early detection of cancers.
The purpose of this research study is to learn more about how cannabidiol (CBD) may affect cannabis use, effects, and craving.
This is a first-in-human study to learn more about the investigational drug EBC-129. This study will assess the safety and tolerability of EBC-129 when given alone and in combination with pembrolizumab in patients with advanced solid tumors.
This study wants to learn more about how the right side of the heart works in people with chronic obstructive pulmonary disease (COPD). We want to see how the heart responds to high blood pressure in the lungs, both while resting and during exercise. The goal is to find patterns that could lead to better treatments for people with COPD.
We will investigate the association between transfusion of fibrinogen-containing blood products and multi-organ dysfunction resulting from endotheliopathy of trauma (EOT). Fibrinogen is frequently acutely decreased in critically ill trauma patients. Early fibrinogen replacement may be the key to restoring the endothelial glycocalyx and preventing end-organ injury. However, few human data exist to ...
This study wants to learn how losing weight affects cell communication in muscle fat tissue among people with obesity. We also want to see how this impacts insulin resistance, inflammation, and muscle strength.
Evaluate the efficacy of the neoadjuvant Pembrolizumab and Axitinib in reducing the inferior vena cava tumor thrombus (IVC TT) among patients with renal cell carcinoma
This is a first-in-human study to learn more about the investigational drug STX-478. The study will have 3 parts.
This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine in participants with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma, and urothelial carcinoma based on Acrivon's OncoSignature® test status.
To develop a program that will help reduce distress in patients with metastatic colorectal cancer and their partners/spouses.
The primary study objective is to compare the clinical outcomes of patients treated with an interventional strategy using the ClotTriever System to achieve and maintain vessel patency (ClotTriever Intervention Arm) versus conservative medical management using anticoagulation therapy alone (Conservative Medical Management Arm) in the treatment of symptomatic unilateral iliofemoral DVT
Study ML41591, is an umbrella trial that will evaluate the efficacy and safety of various therapies in patients with Stage IB, IIA, IIB, IIIA, selected IIIB (only T3N2) (8th edition AJCC TNM staging) resectable and untreated NSCLC tumors that meet protocol specified biomarker criteria determined in a Clinical Laboratory Improvement Amendments (CLIA) certified laboratory.
This study plans to learn more about the safety and effectiveness of TTI-101 when given either alone or in combination treatment using continuous or intermittent TTI-101 dosing, and to see if it will help in the treatment of liver cancer. Continuous dosing of TTI-101 means you will take your TTI-101 dose(s) every day. Intermittent dosing of TTI-101 means you will take a TTI-101 dose on a schedule....
1. Evaluate the effects of consumption of an oral high (20 mg) vs. placebo (0 mg) THC (dronabinol) on brain activation associated with alcohol salience. 2. Test the effects of high THC vs placebo consumption on alcohol self-administration. 3. Test whether neural response under high THC vs placebo predicts differences in alcohol self-administration in the laboratory or alcohol and cannabis co-...
This study will test if one dose of psilocybin, given with talk therapy, can safely help people with advanced cancer feel less anxious, less depressed, and improve quality of life. We will compare it to a placebo (inactive medicine) called niacin given with the same kind of talk therapy.
This study wants to see if gut problems are worse in HIV+ men that have sex with men that have metabolic syndrome compared those without metabolic syndrome.
This is a first-in-human study. The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07799933) administered as a single agent and in combination with other study medicines (called binimetinib) in people with solid tumors.
This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon cancer. ctDNA-ve Cohort (Arms 1 + 2): Phase II: To compare time to ctDNA (+ve) status in ctDNA (-ve) cohort following resection of stage III colon cancer treated with immediate vs delayed (based on serial ctDNA sur...
We want to learn more about the diseases that cause nephrotic syndrome. This is a group of symptoms that happen when the kidneys don't work the right way. We will collect health information and lab samples to help us discover new things. We hope this will help doctors, researchers, and the public.
Study ICT-GCC19CART-US-001 (CARAPIA-1) is a Phase 1 study evaluating the safety, tolerability, clinical activity, pharmacokinetics and pharmacodynamics of GCC19CART in subjects with relapsed or refractory metastatic colorectal cancer. Primary 1. To evaluate the safety of GCC19CART in adult subjects with relapsed or refractory metastatic colorectal cancer 2. To obtain maximum tolerable dose (MTD) ...
This study wants to learn more about CXA-10, a naturally occurring compound in the body. Researchers will test whether CXA-10 is safe and if it helps people who have asthma and are also living with obesity.
This study will provide pilot data examining suction as a mechanism of IUD displacement with menstrual cup use. We hypothesize that manufacturer-recommended menstrual cup insertion and removal by breaking the seal will result in 15% rate of IUD displacement/expulsion. We will also use this data to explore variables associated with IUD displacement and menstrual cup use. By examining the role of su...
This phase II/III trial compares the effect of adding durvalumab to chemotherapy versus chemotherapy alone before surgery in treating patients with upper urinary tract cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as methotrexat...
The purpose of this study is to assess the safety and efficacy of pembrolizumab (MK-3475) combination therapy in participants with metastatic castration resistant prostate cancer (mCRPC). There will be ten cohorts in this study: Cohort A will receive pembrolizumab + olaparib, Cohort B will receive pembrolizumab + docetaxel + prednisone, Cohort C will receive pembrolizumab + enzalutamide, Cohort D ...
This study wants to learn how having too much acid in the blood after a kidney transplant affects your body. Researchers will look at how acid levels may impact the health of your blood vessels and your new kidney.
We are looking for healthy adults who can safely have an MRI scan. This study looks at how drinking and not drinking alcohol affects how the brain works.
We are recruiting individuals with type 2 diabetes (T2D) in need of an exercise program, aged 30 to 55, to help us test how exercise affects heart health, blood vessels, and blood sugar.
Preserving endothelial function with pulsatility during CPB will be associated with less AKI after cardiac surgery.
This study looks at whether men with prostate cancer improve their metabolism more with lifestyle changes alone or with lifestyle changes plus metformin.
This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study m...
This phase I/II trial studies the safety, side effects and best dose of M3814 and to see how well it works when given together with radiation therapy in treating patients with pancreatic cancer that has spread to nearby tissue or lymph nodes (locally advanced). M3814 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hypofractionated radiation therapy delive...
This study wants to find out if taking oral cannabis (marijuana) with THC or THC and CBD can help adults lower long-term back or neck pain.
We are looking for healthy people that are not currently taking drugs that slow down the clotting process (anticoagulants like Warfarin) or stop platelets from sticking together (antiplatelets like aspirin) to join our study. We want to learn more about how your blood composition affects the formation of blood clots and how individuals respond to common drugs.
The FLEX Registry will be implemented to operate as a large-scale, population based, prospective registry. All patients with stage I to III breast cancer who receive MammaPrint® and BluePrint testing on a primary breast tumor are eligible for entry into the FLEX Registry, which is intended to enable additional study arms at low incremental effort and cost. FLEX Registry will utilize an adaptive de...
If your doctor has told you that you have diabetes, but it doesn’t seem like type 1 or type 2, you might be able to join our study. The goal of this study is to better understand different kinds of diabetes that are not common.
Our study is seeking individuals aged 55-85, who have been diagnosed with Mild Cognitive Impairment (MCI) and are at risk for Alzheimer's Disease. The goal of the study is to see whether cannabidiol (CBD) can improve MCI symptoms.
This study wants to learn about the best way to take pictures of unborn babies' hearts to better identify certain heart health problems.
This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Addition of prostate removal surgery or radiation therapy to standard systemic therapy for prostate cancer may lower the chance of the cancer growing or s...
This study plans to learn more about how different adipose tissues are related to diabetes and muscle mass and strength, as well as how to non-invasively track liver disease in those undergoing elective abdominal surgeries.
This study is looking at whether a type of special antibody called broadly neutralizing antibodies (bNAbs) is safe to use along with antiretroviral therapy (ART) in people who have been recently diagnosed with HIV. We also want to find out if these antibodies help control HIV better after people stop their regular medicine (ART), compared to those who didn’t get the antibodies.
This study wants to learn more about how a drug called L-citrulline affects lung function and asthma control in people with deployment-related asthma.
Aim 1: To compare pain and function in patients undergoing operative versus non-operative treatment of atraumatic rotator cuff tears at 12 months of follow-up. Aim 2: To assess effects of rotator cuff tear size and age on comparative outcomes (measured by SPADI) in operative versus non-operative treatments for atraumatic rotator cuff tears.
We are looking for people aged 25 to 55 who smoke and/or vape cannabis, and people aged 25 to 55 who do not smoke cannabis, to see how cannabis use affects lung health over time.
We are looking for people aged 30 to 50 who are daily users of e-cigarettes (e-cigs) as well as healthy controls to see how vaping nicotine affects lung or general health.
We are looking for asthmatics and non-asthmatics between 18-65 years old to participate in a study that will look at how cells in the lungs are different between populations.
This study will create a list of patients with inflamed kidneys to help with future research. It will also collect and safely store data and samples like blood, urine, stool, cells, and kidney tissue for later studies.
A comparison of baseline tumor characteristics in oncogene-driven cancers to tumor characteristics after early response to TKI targeted treatment will allow identification of early adaptive mechanisms of cell survival. This will facilitate targeting and termination of these survival/ resistance pathways before they develop with rational combinations of therapeutic agents to improve outcomes.
The overall objective of this study is to ultimately develop an improved standard of cancer care by facilitating new clinical trials, new technology, new informatics solutions and "personalized medicine".
The purpose of this research is to identify strategies that minimize bone loss that occurs when older adults lose weight
To measure distant recurrence free interval from end of treatment stratified by landmark (4-12 weeks post-treatment) and serial post-treatment ctDNA detection status (detected vs. not detected). The purpose of ORACLE is to demonstrate the ability of a novel ctDNA assay developed by Guardant Health to detect recurrence in individuals treated for early-stage solid tumors. It is necessary that ctDNA...
This study wants to find out how differences in our DNA might affect how birth control works in our bodies and which side effects they may experience.
The purpose of this study is to see how safe and well tolerated an investigational drug called Alintegimod is when taken alone or given with Ipilimumab and Nivolumab in people with advanced or metastatic cancers who had other treatments before.
The goal of this study is to learn how certain medicines, like Ozempic and Mounjaro, affect the liver in people with type 1 diabetes. We are especially looking at a liver disease called MASLD (MASLD (metabolic dysfunction-associated steatotic liver disease), which happens when the liver builds up too much fat.
This study wants to learn more about factors in the body (called biomarkers) that are linked to preventable vision loss and changes in the retina. We will use artificial intelligence (AI) to help find signs of health problems in the body, such as high blood pressure, diabetes, Parkinson’s disease, and Alzheimer’s disease.
This study is testing new cancer treatments, either alone or in combination, in people with breast cancer or other solid tumors. The goal is to see which treatments are safe and show promise, so patients can move to other cancer studies more quickly.
This study wants to find out if a new treatment called Nexsphere-F can safely reduce knee pain in people with arthritis. It will also compare how well this treatment works compared to a standard steroid injection.
This study wants to see if an FDA-approved drug called Clemastine Fumarate and sound therapy can help improve hearing problems in noisy places that some people get as they age called age-related auditory processing disorder.
This study looks at whether a new product called Onyx LES is safe and works well when doctors use it to stop bleeding in blood vessels outside the brain and heart in adults that have arterial hemorrhage in the peripheral blood vessels.
To determine the maximum tolerated dose of temozolomide followed by selinexor in recurrent glioblastoma patients as determined by dose-limiting toxicities (DLTs) and the total toxicity profile. (Phase I) II. To evaluate the efficacy of sequentially administering temozolomide and selinexor in recurrent glioblastoma as determined by progression-free survival (PFS). (Phase 2)
Researchers are studying whether using pembrolizumab with radiation therapy can help people with muscle invasive bladder cancer avoid bladder removal surgery and have better quality of life.
This study wants to learn if 6 months of HER2-targeted treatment works as well as 12 months of HER2-targeted treatment for people with early stage HER2-positive breast cancer who had no cancer found at surgery after chemotherapy and trastuzumab. This study also wants to learn how the 2 treatment lengths affect quality of life.
This study wants to learn how adults with Down syndrome (DS) respond to everyday stress compared with adults without DS of the same sex and age. This study will look at changes in heart rate, blood pressure, and other body responses during stress.
In this study we want to learn more about how life experiences and everyday stress impact the physical and mental health of mothers during pregnancy and postpartum.
We want to learn how a new drug called brexpiprazole (BREX) affects alcohol use and brain function in adults who are not currently getting treatment for Alcohol Use Disorder.
This study wants to find out if adding a chemotherapy drug called paclitaxel directly into the abdomen, along with chemotherapy given through a vein, can help slow or stop gastric cancer. This study also wants to learn if this treatment can help people live longer. This study will compare this approach to the usual treatment people get for gastric cancer.
This study wants to find out how cannabis affects driving in older adults. This study also wants to learn whether how older adults think and how often they use cannabis may affect driving after using cannabis.
This study wants to find out how well the drug tebentafusp works for people with metastatic uveal melanoma who have a genetic marker called HLA-A*0201. The study will also measure tumor DNA in the blood, called W10 ctDNA, to see how the cancer responds to treatment.
This study wants to find out how well people with high-risk liver cancer tolerate taking durvalumab along with standard chemotherapy drugs gemcitabine and cisplatin before and after surgery. We also want to learn whether this combination of treatments helps people with liver cancer that can be removed by surgery live longer.
This study wants to find out if cannabidiol (CBD) may help adults with alcohol use disorder lower their alcohol use.
This study wants to learn how safe the study drug V940 is when given with pembrolizumab and how well this treatment works in people with non-small cell lung cancer after surgery.
This study wants to learn if a short, high-intensity exercise program can be done safely at home and if this exercise may affect sleep in people with Parkinson's Disease.
This study wants to learn how well the investigational drug IFx-Hu2.0 works as an added treatment before giving pembrolizumab to people with advanced Merkel cell carcinoma.
This phase II trial tests how well biomarker tests on patients tumor tissue works in selecting personalized treatments for patients with extensive stage small cell lung cancer (ES-SCLC). Biomarker tests look for certain features in cancer cells that may give doctors more information about what is driving cancer and how to treat it. Based on the biomarker test results, study doctors can determine t...
This study wants to find out if adding radiation therapy to your tumor, along with your regular immune therapy, can help keep your cancer from growing or even make it shrink, compared to using immune therapy alone in people with metastatic kidney cancer who cannot have surgery.
This study wants to learn how genes in your lymphoma are linked to your symptoms and how you respond to treatment. We hope that by understanding these genetic differences, we can learn how to choose better treatments for lymphoma in the future.
This study wants to learn if a new drug called atacicept can help protect the kidneys and reduce kidney damage in people with multiple autoimmune kidney diseases.
This study wants to find a dose of ziftomenib that people with advanced gastrointestinal stromal tumors (CIST) can handle safely when taken with imatinib. We also want to learn how well these two drugs work together.
This study wants to learn how equol, a supplement made from soy, affects blood vessel health in postmenopausal women with chronic kidney disease (CKD). This study wants to see if taking equol for 12 weeks can help blood vessels work better.
In this study we want to learn if a drug called ravulizumab is a safe and effective treatment for children and teens that have both Immunoglobulin A Vasculitis Nephritis (IgAVN) and Immunoglobulin A Nephritis (IgAN).
This study is being done to test new treatments for people with newly diagnosed glioblastoma (GBM), a type of brain cancer. The goal is to see if any of these new treatments help people live longer compared to the usual treatments. This study will compare the usual medicine (Temozolomide) used to treat newly diagnosed GBM to new drugs such as VT102, ADI-PEG20, Troriluzole, or AZD1390.
This study wants to learn how late menopause affects women. This study wants to see whether diet education, lifestyle changes, and medication can help women feel healthier. We are looking for women ages 45 to 55 who are in late menopause to join.
This study wants to see if a case management program helps people with lung, head-and-neck, thyroid, breast, cervical, colon or rectum, or bladder cancers start and finish treatment sooner compared to usual care. We also want to find out if this program improves care and outcomes for people with these types of cancers.
We want to find out if using RP2 with nivolumab works better than using ipilimumab with nivolumab to help adults with eye cancer that has spread and cannot be removed by surgery live longer.
The main goal of this study is to see how a new treatment (brentuximab vedotin and nivolumab, called Bv-NIVO) compares to the usual treatment for people who were just diagnosed with early-stage (Stage I or II) Hodgkin lymphoma (HL). We want to find out which treatment works better.
This study wants to find out if adding a chemotherapy drug to the usual hormone treatment for metastatic prostate cancer can help slow down or stop the cancer from growing or spreading. We also want to see if this new treatment works better or worse than the standard treatment doctor's use.
This study wants to learn more about what causes diabetic neuropathy. Diabetic neuropathy happens when nerves are damaged. We look for certain molecules in the blood and skin that may harm nerves. We compare these molecules in people with Type 2 Diabetes who have neuropathy, people with Type 2 Diabetes who do not have neuropathy, and people who do not have diabetes.
The purpose of this research is to test the safety of an investigational NRTX-1001 cell therapy in participants with drug resistant bilateral mesial temporal lobe epilepsy (MTLE). Another purpose is to see if NRTX-1001 can reduce the number of seizures you have.
In this study we want to understand more about the causes of cystic fibrosis related diabetes (CFRD) and find better ways to treat it.
This study wants to learn more about spondyloarthritis, a type of arthritis that causes a lot of inflammation. We are looking for adults who have a parent, sibling, or child who has spondyloarthritis or a similar health problem to join our study.
This study is looking at how well a new drug called GS-5718 works for people with Cutaneous Lupus Erythematosus (CLE), with or without systemic lupus. We want to see if it helps reduce rashes and sores and if people can take it without a lot of side effects.
The goal of this study is to find out if a combination of chemotherapy drugs is safe and works in adults with pancreatic cancer that has spread inside the abdomen. This study will test whether giving one drug, called paclitaxel, directly into the abdomen through a small tube (catheter) and giving another set of drugs, called NALIRIFOX, into a vein can help control the cancer.
This is a Phase 1b, open-label, multicenter, safety, tolerability and efficacy study of HC-7366 in combination with belzutifan (WELIREG™). This is a multipart study that consists of a HC-7366 monotherapy cohort, a combination dose escalation, and a combination dose expansion. Approximately 80 patients will be enrolled in this study (up to 20 patients will be enrolled into the HC-7366 monotherapy c...
This study will test if one shot of a medicine called RE104, given in different amounts, can safely help with cancer or other illnesses who are having trouble coping and adjusting.
To learn more about patients who use artificial intelligence (AI) to understand more about their brain tumor diagnosis and their brain tumor doctor.
This study will test a new drug called IMVT-1402 to see if it works and is safe compared to a placebo (a treatment with no medicine) in adults with Graves' Disease. Graves' Disease makes the thyroid gland overactive. We want to see if IMVT-1402 can help people reach normal thyroid hormone levels and possibly stop taking their regular thyroid medicine. The study will compare how well IMVT-1402 work...
In this study we want to learn more about how the body responds to giving birth for cesarean deliveries.
The purpose of this study is to determine safety and preliminary efficacy of amivantamab monotherapy, amivantamab in addition to pembrolizumab, and amivantamab in addition to paclitaxel in participants with recurrent/metastatic head and neck cancer. The study will also confirm the recommended Phase 2 combination dose (RP2CD) for amivantamab in addition to paclitaxel
This study is testing a new injectable medication called anifrolumab to see how safe and effective it is for adults with chronic cutaneous lupus erythematosus (CLE). Our goal is to find better treatments for people living with CLE.
To assess the preliminary anti-tumor activity of erdafitinib in patients with recurrent or progressive IDH-WT glioma with FGFR-TACC gene fusion as measured by the best response at any time during treatment in terms of objective response rate (ORR)
To determine the effectiveness of belimumab and rituximab in treating primary membranous nephropathy
The main purpose of this study is to assess the efficacy and safety of volrustomig compared to observation in participants with unresected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) who have not progressed after receiving definitive concurrent chemoradiotherapy (cCRT)
To investigate the efficacy of extended TARPEYO treatment in adults with IgAN.
This study wants to learn more about how estrogen affects women's reproductive hormones and system.
To assess the efficacy and safety of opevesostat plus hormone replacement therapy (HRT) compared to alternative abiraterone acetate or enzalutamide in participants with Metastatic Castration-resistant Prostate Cancer (mCRPC)
To compare the response rate (confirmed or unconfirmed, complete or impartial) between participants with MET exon 14 skipping positive non-small cell lung cancer (NSCLC) randomized to tepotinib with or without ramucirumab.
To determine prospectively if SCLC tumor tissue transcriptional subtypes can be detected by Tempus|xT RNAseq
To compare investigator-assessed progression-free survival (IA-PFS) between participants with EGFR mutated, MET amplified non-small cell lung cancer (NSCLC) randomized to INC280 (capmatinib) and osimertinib with or without ramucirumab.
Given the negative symptoms associated with cancer, palliative care, a broad term for the prevention and treatment of adverse effects that arise from a disease or its treatment, continues to be a focus of cancer related research. In recent years one of the most popular options for this has become cannabis. There has been in increase of cancer patients using cannabis for relief; specifically, to im...
The purpose of our research study is to assess satisfaction with genetic testing for hereditary cancer risk in a high-risk population in Colorado and New Mexico.
This study is using MRI to learn how skeletal muscles and blood vessels respond to exercise in people with and without Type 2 Diabetes. We are currently looking for healthy volunteers to join our study!
A study to investigate the efficacy and safety of the lifileucel (LN-144, autologous tumor-infiltrating lymphocytes [TIL]) regimen plus pembrolizumab infusions compared with pembrolizumab infusions alone in participants with untreated, unresectable or metastatic melanoma
To determine if trastuzumab emtansine (ado-trastuzumab emtansine [T-DM1]) shows better progression-free survival (PFS) when compared to docetaxel plus trastuzumab (TH) in recurrent and/or metastatic (R/M) HER2-positive salivary gland cancer (SGC) patients who have not previously received HER2 therapy for unresectable or recurrent and/or metastatic disease, as determined by local assessment.
To prospectively collect data regarding the diagnosis and treatment of orthopedic infections including upper and lower limb as well as pelvic and spinal infection in order to improve quality of care. The database will be used for subsequent future research.
The primary objective of this screening study is to test patient specimens to determine eligibility for participation in the biomarker-driven and non-matched sub-studies included within the Lung-MAP umbrella protocol.
This study plans to learn more about pulmonary fibrosis and determine if some diseases that cause scarring in the lung might be inherited diseases. We are especially interested in the genetics of pulmonary fibrosis and cases where it might run in families. What we learn may be helpful in the future to people with pulmonary fibrosis and their family members.
Evaluate the Arctic Sun Cooling device for fever prevention to standard of care measures for controlling fever in the ICU
We hope to learn how safe and effective the Neuroport array plus stimulation is in controlling computer generated images and real-world objects, such as a robotic arm, using imagined movements of the arms and hands.
The primary objective of the BISON-PRO Database is to establish a prospective repository of real-world, longitudinally-collected patient-reported outcomes (PRO) and quality-of-life data for patients with both malignant and non-neoplastic blood disorders to support patient-centered research.
We want to learn how stimulating the vagus nerve while moving the hand can help improve fine motor control in people with relapsing-remitting multiple sclerosis (MS), who have trouble moving their hands and arms.
To collect data on the recurrence rate and outcomes of benign and primary/metastatic malignant tumors seen in Orthopaedic patients at the University of Colorado Hospital.
To collect prospectively (after informed consent) fresh, excess surgical tissues, blood and other bodily fluids, and saliva from patients with HNC slated to undergo biopsy or surgical resection, and to collect prospectively optional samples from patients with HNC slated to undergo other therapies
Use of blood flow restriction cuffs in post surgical hip patients.
The purpose of this study is to learn if a drug called sargramostim is safe and if it can help improve thinking and memory in people with Alzheimer’s disease.
This study plans to learn more about genes that are expressed in blood vessels in the brain and in the blood of patients without brain aneurysms. This will help us understand diseases that affect those blood vessels such as aneurysms.