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Detection of Colorectal Cancer or Advanced Neoplasia by Stool DNA in Lynch Syndrome: CORAL Study

To determine the sensitivity and specificity of the mt-sDNA 2.0 test, for colorectal neoplasia in patients with Lynch Syndrome


Why this Research Matters

The purpose of this research is to determine a new approach for non-invasive screening and early detection of Colorectal Cancer or Advanced Neoplasia in patients with Lynch syndrome. Participation in this study includes one time stool collection and an optional blood colletion.


Who can Participate

Adult

Patients at least 18 years of age Individuals diagnosed with Lynch syndrome (mutation in MLH1, MSH2, MSH6, PMS2, EPCAM) or CRC with suspected Lynch syndrome or individuals diagnosed with early onset CRC (<55 yo) Colonoscopy/Flex Sig scheduled +/- 90 days from sample collection Patient has agreed to participate and has signed the study consent form


Study ID

Protocol Number: 24-0824
More information available at ClinicalTrials.gov: NCT00000000

Meet the Team

Image of Principal Investigator

Swati Patel, MD

Principal Investigator