In this study we want to compare how well two different drugs work to treat kids and young adults that have a narrow or stiff esophagus because of a health problem called eosinophilic esophagitis.
This study will look at whether getting a second dose of RSVpreF (Abrysvo®) vaccine during another pregnancy is safe and can help your body make antibodies that may protect your baby from Respiratory Syncytial Virus (RSV). We will also check to see if you still have antibodies from the dose you got during your previous pregnancy.
This study wants to learn if a short, high-intensity exercise program can be done safely at home and if this exercise may affect sleep in people with Parkinson's Disease.
In this study we are testing how two drugs, Thymoglobulin ® and verapamil, work together to treat children and young adults with newly diagnosed type 1 diabetes.
This study wants to learn how well the investigational drug IFx-Hu2.0 works as an added treatment before giving pembrolizumab to people with advanced Merkel cell carcinoma.
This study wants to learn how cannabidiol (CBD) affects drinking in people who drink alcohol often. This study will look to see if CBD can help people drink less and if CBD can help reduce problems linked to alcohol use.
This study wants to learn if a new drug called atacicept can help protect the kidneys and reduce kidney damage in people with multiple autoimmune kidney diseases.
This study wants to find a dose of ziftomenib that people with advanced gastrointestinal stromal tumors (CIST) can handle safely when taken with imatinib. We also want to learn how well these two drugs work together.
This study wants to learn how equol, a supplement made from soy, affects blood vessel health in postmenopausal women with chronic kidney disease (CKD). This study wants to see if taking equol for 12 weeks can help blood vessels work better.
In this study we want to learn how a device that automates insulin delivery (called the iLet Bionic Pancreas) helps people with Cystic Fibrosis Related Diabetes manage their insulin levels. We want to learn how well this device works compared to a normal insulin delivery method.
In this study we want to learn if a drug called ravulizumab is a safe and effective treatment for children and teens that have both Immunoglobulin A Vasculitis Nephritis (IgAVN) and Immunoglobulin A Nephritis (IgAN).
This study is being done to test new treatments for people with newly diagnosed glioblastoma (GBM), a type of brain cancer. The goal is to see if any of these new treatments help people live longer compared to the usual treatments. This study will compare the usual medicine (Temozolomide) used to treat newly diagnosed GBM to new drugs such as VT102, ADI-PEG20, Troriluzole, or AZD1390.
Researchers are trying to find new ways to help improve the mood of teenagers who have Type 2 diabetes (T2D).
This study wants to learn more about heart and brain health of people with and without endometriosis.
This study wants to find out if using a new cancer drug called lurbinectedin together with doxorubicin as the first treatment for people with metastatic leiomyosarcoma helps them live longer without the cancer getting worse, compared to using doxorubicin alone.
This study wants to learn how late menopause affects women. This study wants to see whether diet education, lifestyle changes, and medication can help women feel healthier. We are looking for women ages 45 to 55 who are in late menopause to join.
In this study we are testing a new drug called teplizumab to see if it can help protect the cells that make insulin in people with type 1 diabetes. We want to know if it can improve blood sugar levels, reduce the need for extra insulin, and lower the risk of low blood sugar.
In this study we want to learn how well a cream called Ruxolitinib works to treat vitiligo on the face and body of children between 2 and 12 years old.
This study wants to see if a case management program helps people with lung, head-and-neck, thyroid, breast, cervical, colon or rectum, or bladder cancers start and finish treatment sooner compared to usual care. We also want to find out if this program improves care and outcomes for people with these types of cancers.
This study wants to learn more about how a drug called L-citrulline affects lung function and asthma control in people with deployment-related asthma.
This study wants to see if a new drug called SAB-142 in addition to regular insulin therapy can help slow down Type 1 Diabetes (T1D) in people who were diagnosed in the last 100 days.
This study will look at two ways to prevent heart and blood vessel problems. It will test which treatment works better for people who may have hidden artery disease because of conditions like diabetes or metabolic syndrome. One way uses your risk factors, and the other way uses pictures of your heart arteries to guide care.
In this study, we want to learn how teens handle stress, deal with feelings of depression, and manage habits like eating, exercise, and sleep. We will use what we learn to make a Digital App that helps teens struggling with these challenges.
In this study we want to learn more about how common health problems like high blood pressure, vision problems, and kidney disease are in people with cystic fibrosis-related diabetes (CFRD).
In this study we want to learn if a new drug called vosoritide is safe and effective in helping kids with short stature and have been diagnosed with Turner syndrome, SHOX deficiency, or Noonan syndrome grow.
In this study we want to see if improving the amount and quality of sleep will help improve the overall health of adolescents that have type 1 diabetes (TID).
In this study we want to gather information about Stargardt Disease Type 1 (STGD1) and learn how it develops over time. We hope to use this information to help scientists come up with treatments or a cure for STGD1 in the future.
This study will test a new medicine called DMX-200 to see if it can lower protein in the urine and slow kidney damage in people with focal segmental glomerulosclerosis (FSGS) who are already taking an ARB medicine. Researchers will also look at how safe DMX-200 is, how well people can handle it, how it affects kidney health and quality of life, and how the body uses the medicine.
In this study we want to learn more about how safe and how well a new vaccine works against invasive pneumococcal disease (IPD) in babies.
In this study we want to learn more about the safety and effectiveness of a drug called Xyosted ® (testosterone) to treat adolescent males that have a health problem called hypogonadism (low testosterone).
In this study we want to determine the best intervention for improving sleep quality in people recovering from a concussion. To do this we are comparing two sleep interventions and seeing how the impact the recovery time for a concussion.
In this study we want to understand more about the causes of cystic fibrosis related diabetes (CFRD) and find better ways to treat it.
In this study we want to learn more about the safety and effectiveness of a drug called frexalimab to treat people with newly diagnosed type 1 diabetes.
This study wants to learn more about spondyloarthritis, a type of arthritis that causes a lot of inflammation. We are looking for adults who have a parent, sibling, or child who has spondyloarthritis or a similar health problem to join our study.
This study is looking at how well a new drug called GS-5718 works for people with Cutaneous Lupus Erythematosus (CLE), with or without systemic lupus. We want to see if it helps reduce rashes and sores and if people can take it without a lot of side effects.
This study is testing a new treatment called CAR T cell therapy to see if it’s safe and works well for people with rheumatoid arthritis (RA). It uses a person’s own immune cells to help fight disease. In this study, a type of cell called regulatory T cells (Tregs) will be genetically modified into CAR Tregs (called SBT777101) to see if they are better at reducing inflammation in people with RA.
This study wants to see if three different wearable devices can track how long a person's heart beats in an irregular way over four months. This kind of irregular heartbeat is called Atrial Fibrillation, or AF. The time someone spends in AF is different for each person and can change. If doctors can measure how often it happens, they might be able to find better ways to treat it.
This study wants to learn more about how blood sugar levels in healthy children without chronic disease compare to the blood sugar levels of children with Cystic Fibrosis (CF). We are only recruiting children without chronic disease to join the study.
This study wants to compare the immune response in children who received the RSV vaccine during the 2024-2025 respiratory season to those who didn’t. It will also look at how often children in both groups get sick and how severe their sickness is during the 2025-2026 respiratory season.
In this study we want to learn more about how puberty and puberty hormones impact heart health, fitness, and the risk of diabetes in teenagers.
This study wants to see if avacopan is safe and works well for people with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. We also want to find out if it helps prevent the disease from coming back.
This study is testing a new injectable medication called anifrolumab to see how safe and effective it is for adults with chronic cutaneous lupus erythematosus (CLE). Our goal is to find better treatments for people living with CLE.
This study wants to learn more about CXA-10, a naturally occurring compound in the body. Researchers will test whether CXA-10 is safe and if it helps people who have asthma and are also living with obesity.
In this study we want to learn more about the effects of the study drug, benralizumab, for treating children with eosinophilic granulomatosis with polyangiitis (EGPA).
This study plans to learn more about how a telehealth exercise program designed for rural survivors of cancer can help improve cancer related fatigue.
This study wants to learn if taking a protein supplement drink twice a day for 8 weeks can help lower the amount of fat that is stored in the liver.
We want to learn more about the diseases that cause nephrotic syndrome. This is a group of symptoms that happen when the kidneys don't work the right way. We will collect health information and lab samples to help us discover new things. We hope this will help doctors, researchers, and the public.
We want to find out how well the medicine Belimumab works in real life for adults who have active lupus nephritis. This study also wants to see if belimumab helps keep the kidneys healthy for a long time.
This study wants to learn more about how estrogen affects women's reproductive hormones and system.
We want to learn if ravulizumab can help slow down or stop kidney problems and lower protein in the urine. We will also compare ravulizumab to a placebo (a substance with no medicine) to see how well it works.
This study wants to find better treatments for people with autoimmune diseases like rheumatoid arthritis (RA). By studying the different types of cells found in people with RA, researchers can learn more about how RA damages joints.
This research study is being conducted to examine the effects of dapagliflozin on kidney function, blood vessel function and heart function. We are studying the effects/impact of dapagliflozin (a SGLT2 inhibitor) on: - Kidney function - Protein in the urine - Blood vessel function - Heart function
This study wants to know if a new drug called Diamyd®, can safely and effectively treat type 1 diabetes.
In this study, we want to learn more about a new drug called iptacopan to see if it can help treat a rare kidney disease called IC-MPGN (immune complex mediated membranoproliferative glomerulonephritis).
This study wants to learn more about how the right side of the heart works in people with chronic obstructive pulmonary disease (COPD). We want to see how the heart responds to high blood pressure in the lungs, both while resting and during exercise. The goal is to find patterns that could lead to better treatments for people with COPD.
In this study we want to gather more information about the safety and tolerability of a drug called ferric citrate for treating children with chronic kidney disease who have hyperphosphatemia.
We want to find better ways to treat bipolar disorders. We are looking for children, teens, and young adults, aged 9 to 21 years old, to join our study.
This study is for women who are about to start IVF. It will test if the medicine, Orilissa, which helps with endometriosis symptoms, will affect fertility.
This study wants to learn more about hearing loss using samples from a child, both of their biological parents, and/or other family members. We will use the samples to study heritable risk factors for hearing loss and changes in gene expression that lead to hearing loss and/or ear abnormalities.
In this study we want to learn if a medicine approved for diabetes and weight loss called Ozempic® and Wegovy® (semaglutide) can help improve the frequency of periods and the way the body uses sugar in women with polycystic ovary syndrome (PCOS).