In this study we are testing a new drug called teplizumab to see if it can help protect the cells that make insulin in people with type 1 diabetes. We want to know if it can improve blood sugar levels, reduce the need for extra insulin, and lower the risk of low blood sugar.
In this study we want to learn how well a cream called Ruxolitinib works to treat vitiligo on the face and body of children between 2 and 12 years old.
This study wants to see if a case management program helps people with lung, head-and-neck, thyroid, breast, cervical, colon or rectum, or bladder cancers start and finish treatment sooner compared to usual care. We also want to find out if this program improves care and outcomes for people with these types of cancers.
This study wants to learn more about how a drug called L-citrulline affects lung function and asthma control in people with deployment-related asthma.
This study wants to see if a new drug called SAB-142 in addition to regular insulin therapy can help slow down Type 1 Diabetes (T1D) in people who were diagnosed in the last 100 days.
We want to find out if using RP2 with nivolumab works better than using ipilimumab with nivolumab to help adults with eye cancer that has spread and cannot be removed by surgery live longer.
This study will look at two ways to prevent heart and blood vessel problems. It will test which treatment works better for people who may have hidden artery disease because of conditions like diabetes or metabolic syndrome. One way uses your risk factors, and the other way uses pictures of your heart arteries to guide care.
In this study, we want to learn how teens handle stress, deal with feelings of depression, and manage habits like eating, exercise, and sleep. We will use what we learn to make a Digital App that helps teens struggling with these challenges.
In this study we want to learn more about how common health problems like high blood pressure, vision problems, and kidney disease are in people with cystic fibrosis-related diabetes (CFRD).
In this study we want to learn if a new drug called vosoritide is safe and effective in helping kids with short stature and have been diagnosed with Turner syndrome, SHOX deficiency, or Noonan syndrome grow.
In this study we want to see if improving the amount and quality of sleep will help improve the overall health of adolescents that have type 1 diabetes (TID).
In this study we want to gather information about Stargardt Disease Type 1 (STGD1) and learn how it develops over time. We hope to use this information to help scientists come up with treatments or a cure for STGD1 in the future.
This study will test a new medicine called DMX-200 to see if it can lower protein in the urine and slow kidney damage in people with focal segmental glomerulosclerosis (FSGS) who are already taking an ARB medicine. Researchers will also look at how safe DMX-200 is, how well people can handle it, how it affects kidney health and quality of life, and how the body uses the medicine.
In this study we want to learn more about how safe and how well a new vaccine works against invasive pneumococcal disease (IPD) in babies.
In this study we want to learn more about the safety and effectiveness of a drug called Xyosted ® (testosterone) to treat adolescent males that have a health problem called hypogonadism (low testosterone).
In this study we want to determine the best intervention for improving sleep quality in people recovering from a concussion. To do this we are comparing two sleep interventions and seeing how the impact the recovery time for a concussion.
In this study we want to understand more about the causes of cystic fibrosis related diabetes (CFRD) and find better ways to treat it.
In this study we want to learn more about the safety and effectiveness of a drug called frexalimab to treat people with newly diagnosed type 1 diabetes.
This study wants to learn more about spondyloarthritis, a type of arthritis that causes a lot of inflammation. We are looking for adults who have a parent, sibling, or child who has spondyloarthritis or a similar health problem to join our study.
This study is looking at how well a new drug called GS-5718 works for people with Cutaneous Lupus Erythematosus (CLE), with or without systemic lupus. We want to see if it helps reduce rashes and sores and if people can take it without a lot of side effects.
This study is testing a new treatment called CAR T cell therapy to see if it’s safe and works well for people with rheumatoid arthritis (RA). It uses a person’s own immune cells to help fight disease. In this study, a type of cell called regulatory T cells (Tregs) will be genetically modified into CAR Tregs (called SBT777101) to see if they are better at reducing inflammation in people with RA.
This study wants to see if three different wearable devices can track how long a person's heart beats in an irregular way over four months. This kind of irregular heartbeat is called Atrial Fibrillation, or AF. The time someone spends in AF is different for each person and can change. If doctors can measure how often it happens, they might be able to find better ways to treat it.
This study wants to find out if people with certain types of early-stage endometrial cancers need less treatment than usual, like less radiation and chemotherapy. We also want to see if less treatment works well and keeps your cancer from coming back.
This study wants to learn more about how blood sugar levels in healthy children without chronic disease compare to the blood sugar levels of children with Cystic Fibrosis (CF). We are only recruiting children without chronic disease to join the study.
This study wants to compare the immune response in children who received the RSV vaccine during the 2024-2025 respiratory season to those who didn’t. It will also look at how often children in both groups get sick and how severe their sickness is during the 2025-2026 respiratory season.
In this study we want to learn more about how puberty and puberty hormones impact heart health, fitness, and the risk of diabetes in teenagers.
This study wants to see if avacopan is safe and works well for people with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. We also want to find out if it helps prevent the disease from coming back.
This study is testing a new injectable medication called anifrolumab to see how safe and effective it is for adults with chronic cutaneous lupus erythematosus (CLE). Our goal is to find better treatments for people living with CLE.
This study is looking at a medicine called Upadacitinib to see if it is safe and helps adults with moderate to severe lupus (SLE). We want to compare it to a placebo (a pill with no medicine) to see how well it works. We also want to find out how much of the medicine is needed to keep symptoms from getting worse.
In this study, we want to compare two methods for treating teens who have substance use disorder (SUD) and symptoms of post-traumatic stress disorder (PTSD). We want to see if Risk Reduction Through Family Therapy (RRFT) or Encompass Treatment is more helpful for treating teens with these mental health problems.
This study wants to learn more about CXA-10, a naturally occurring compound in the body. Researchers will test whether CXA-10 is safe and if it helps people who have asthma and are also living with obesity.
In this study we want to learn more about the effects of the study drug, benralizumab, for treating children with eosinophilic granulomatosis with polyangiitis (EGPA).
The main goal of this study is to see if using a Fitbit and getting helpful text messages can support people with type 2 diabetes in taking better care of their health. The study will check if the 12-week program is easy to use and useful for patients.
This study plans to learn more about how a telehealth exercise program designed for rural survivors of cancer can help improve cancer related fatigue.
This study wants to learn if taking a protein supplement drink twice a day for 8 weeks can help lower the amount of fat that is stored in the liver.
We want to learn more about the diseases that cause nephrotic syndrome. This is a group of symptoms that happen when the kidneys don't work the right way. We will collect health information and lab samples to help us discover new things. We hope this will help doctors, researchers, and the public.
This study wants to learn more about the heart and brain health of people with and without endometriosis.
We want to find out how well the medicine Belimumab works in real life for adults who have active lupus nephritis. This study also wants to see if belimumab helps keep the kidneys healthy for a long time.
This study wants to learn more about how estrogen affects women's reproductive hormones and system.
We want to learn if ravulizumab can help slow down or stop kidney problems and lower protein in the urine. We will also compare ravulizumab to a placebo (a substance with no medicine) to see how well it works.
This study wants to find better treatments for people with autoimmune diseases like rheumatoid arthritis (RA). By studying the different types of cells found in people with RA, researchers can learn more about how RA damages joints.
This research study is being conducted to examine the effects of dapagliflozin on kidney function, blood vessel function and heart function. We are studying the effects/impact of dapagliflozin (a SGLT2 inhibitor) on: - Kidney function - Protein in the urine - Blood vessel function - Heart function
This study wants to know if a new drug called Diamyd®, can safely and effectively treat type 1 diabetes.
In this study, we want to learn more about a new drug called iptacopan to see if it can help treat a rare kidney disease called IC-MPGN (immune complex mediated membranoproliferative glomerulonephritis).
This study wants to learn more about how the right side of the heart works in people with chronic obstructive pulmonary disease (COPD). We want to see how the heart responds to high blood pressure in the lungs, both while resting and during exercise. The goal is to find patterns that could lead to better treatments for people with COPD.
In this study we want to gather more information about the safety and tolerability of a drug called ferric citrate for treating children with chronic kidney disease who have hyperphosphatemia.
We want to find better ways to treat bipolar disorders. We are looking for children, teens, and young adults, aged 9 to 21 years old, to join our study.
This study is for women who are about to start IVF. It will test if the medicine, Orilissa, which helps with endometriosis symptoms, will affect fertility.
This study wants to learn more about hearing loss using samples from a child, both of their biological parents, and/or other family members. We will use the samples to study heritable risk factors for hearing loss and changes in gene expression that lead to hearing loss and/or ear abnormalities.
In this study we want to learn if a medicine approved for diabetes and weight loss called Ozempic® and Wegovy® (semaglutide) can help improve the frequency of periods and the way the body uses sugar in women with polycystic ovary syndrome (PCOS).