| Study Protocol Number | Study Title and Description |
|---|---|
| 25-0619 |
Do Belimumab and Rituximab Work Better to Treat Primary Membranous Nephropathy than Rituximab Alone?
This study wants to find out if using two drugs, belimumab and rituximab, works better than using rituximab alone to treat people with primary membranous nephropathy (primary NM). The study will see how people react to belimumab compared to a placebo which looks like the study drug but does not have active medicine |
| 25-0838 |
Early Parkinson's Disease: Testing BHV-8000 as a Treatment Option
This study is testing whether a new drug called BHV-8000 is safe and can slow the progression of early Parkinson's Disease for adults aged 40 to 80 years old. Researchers believe BHV-8000 may reduce inflammation and help protect nerve cells in the brain and spinal cord. |
| 25-0689 |
Testing the Effects of CNP-103 in People with Recently Diagnosed Type 1 Diabetes
The main goal of this study is to learn whether CNP-103 is safe and well tolerated in teenagers and young adults with recently diagnosed type 1 diabetes. We will look at how people react to CNP-103 compared to a placebo which looks like the study drug but has no active medicine. |
| 26-0260 |
Comparing the Safety and Immune Response of Two Pneumococcal Vaccines in Young Children
In this study, we want to learn whether a new vaccine (PG4) is safe and helps protect kids against pneumococcal disease. We will compare a single dose of PG4 with a single dose of the currently available pneumococcal vaccine to see the level of protection provided and how the body responds to each vaccine. |
| 23-1107 |
Can Semaglutide Help Protect Kidney Health in Type 1 Diabetes?
This study wants to learn if semaglutide is safe and helpful for those with Type 1 Diabetes (T1D) compared to a placebo. Researchers also want to understand whether semaglutide can protect the kidneys in adults aged 18 and older with T1D. |
| 26-1319 |
Is Zenagamtide Safe and Well Tolerated in People with Obesity Who Want to Lose Weight?
This study wants to find out if a new medicine called zenagamtide can help people with obesity lose weight compared to a placebo. We are looking for adults aged 18 to 69 years old who want to lose at least 25% of their body weight to join! |
| 26-1228 |
MENO-RISE: Pilot Trial of a Stress Resilience Intervention for Perimenopausal Depression and Cognitive Concerns in Women with Histories of Childhood Adversity
This research study plans to examine an online stress-resilience (mindfulness-based) program for women in perimenopause who have experienced stress earlier in life. It is also designed to learn about the feasibility, acceptability, and effects of the program on stress, mood, thinking abilities, and health markers. |
| 26-0203 |
Smart Basal Insulin Dosing Study for Adults with Type 2 Diabetes
This study wants to find out if a mobile app that suggests daily insulin doses is safe and works well for adults with type 2 diabetes. |
| 26-0239 |
Using GLP-1 Drugs to Treat Metabolic Dysfunction Associated Steatotic Liver Disease
The main goal of this study is to see how well two drugs, tirzepatide and retatrutide, work for treating metabolic dysfunction associated steatotic liver disease compared to placebo. |
| 26-0145 |
New Treatment for Children and Young Adults with Newly Diagnosed Type 1 Diabetes (BARICADE-PRESERVE)
This study is testing a new drug called baricitinib in children and young adults who have recently been diagnosed with type 1 diabetes (T1D). We want to learn whether it can help preserve beta cells and slow the progression of T1D. |
| 25-2638 |
Testing Apremilast to Help Treat Alcohol Use Disorder
This study is for adults age 21 or older who have alcohol use disorder (AUD). It tests whether a medicine called Apremilast can help reduce alcohol cravings compared to a placebo, a pill that looks the same but has no medicine. |
| 25-2612 |
Learning About Veverimer for People with CKD and Metabolic Acidosis
The goal of this study is to learn whether veverimer is safe and helpful in preventing or treating the problems of metabolic acidosis in adults with chronic kidney disease (CKD). |
| 25-2220 |
Comparing Growth Hormone Treatments for Children with Short Stature
In this study, we are comparing two growth hormone treatments, lonapegsomatropin and somatropin, for children with short stature due to Turner syndrome, SHOX deficiency, being born small for gestational age, or idiopathic short stature. We want to learn how safe these treatments are and how well they help children grow. |
| 25-0695 |
Evaluating a New Treatment Option for Alcohol Use Disorder
Researchers are looking for adults with Alcohol Use Disorder (AUD) to learn how a type of brain stimulation called low-intensity focused ultrasound (LIFU) affects the brain and behavior. |
| 25-1102 |
How Safe is Hepatitis C Treatment for Pregnant Women and their Babies?
This study wants to learn how treating Hepatitis C during pregnancy affects the health of pregnant women and their babies. |
| 25-0971 |
Exploring the Cryosa System Device as a Treatment Option for Obstructive Sleep Apnea
This research study wants to learn how well and safe the Cryosa system works in people with obstructive sleep apnea (OSA). The Cryosa system is a device used to freeze the base of the tongue and soft palate which reduces the amount of fat in those areas and may improve OSA symptoms. |
| 25-0870 |
How Childhood Experiences May Affect Multiple Sclerosis
This study wants to learn how difficult childhood experiences during might impact when certain people get multiple sclerosis (MS), how severe the disease is, and how much it impacts brain health. We hope that this study will help us better understand MS and find ways to improve care and support. |
| 25-0693 |
New Drug Treatment to Protect Insulin-Making Cells in Kids and Adolescents with Type 1 Diabetes
In this study we are testing a new drug called teplizumab to see if it can help protect the cells that make insulin in people with type 1 diabetes. We want to know if it can improve blood sugar levels, reduce the need for extra insulin, and lower the risk of low blood sugar. |
| 25-0323 |
Evaluating the Safety and Antibody Protection of a Second RSV Vaccine in Pregnancy
This study will look at whether getting a second dose of RSVpreF (Abrysvo®) vaccine during another pregnancy is safe and can help your body make antibodies that may protect your baby from Respiratory Syncytial Virus (RSV). We will also check to see if you still have antibodies from the dose you got during your previous pregnancy. |
| 25-0262 |
Study to See if Hormone Therapy Helps Reduce Hot Flashes and Night Sweats in Women Living with HIV
This study is looking at whether hormone therapy can help reduce hot flashes and night sweats in women living with HIV who are going through menopause or who recently finished menopause. |
| 25-0286 |
Study on Brain and Vascular Health in People with Endometriosis
This study wants to learn more about heart and brain health of people with and without endometriosis. |
| 25-0128 |
Exploring the Relationship Between Alcohol Use, Pain, and Mental Health
The goal of this research study is to learn more about how pain is related to alcohol use and mental health across different stages of adulthood. |
| 25-0010 |
Effectiveness of Ruxoltinib Cream to Treat Non-Segmental Vitiligo in Kids
In this study we want to learn how well a cream called Ruxolitinib works to treat vitiligo on the face and body of children between 2 and 12 years old. |
| 24-1398 |
Telehealth Exercise Program evaluating fatigue and physical function in rural cancer survivors
This study plans to learn more about how a telehealth exercise program designed for rural survivors of cancer can help improve cancer related fatigue. |
| 24-2207 |
Studying the Long-term Safety & Effectiveness of Avacopan in People with ANCA-associated Vasculitis
This study wants to see if avacopan is safe and works well for people with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. We also want to find out if it helps prevent the disease from coming back. |
| 24-2084 |
A Study Comparing Pramipexole and Escitalopram for Treating Depression in People with HIV (A5402)
This study will compare how well pramipexole and escitalopram help treat depression in people living with HIV. |
| 24-1345 |
Registry Study for Pregnant Women with Multiple Sclerosis
This registry wants to learn whether taking Vumerity (Diroximel Fumarate) during pregnancy impacts the health of pregnant women with MS or their babies. We will compare the health of women who took Vumerity during pregnancy with the health of women who took other MS medicines or no MS medicine during pregnancy. |
| 24-0240 |
Studying Sotagliflozin to Help Slow Kidney Damage in People with Type 1 Diabetes: SugarNSalt Trial
This study wants to learn more about whether a drug called sotagliflozin (SOTA) can slow down the loss of kidney function in people with type 1 diabetes and diabetic kidney disease. |
| 23-1852 |
A Study Comparing Care Based on Heart Scan Results to Care Based on Risk Factor
This study will look at two ways to prevent heart and blood vessel problems. It will test which treatment works better for people who may have hidden artery disease because of conditions like diabetes or metabolic syndrome. One way uses your risk factors, and the other way uses pictures of your heart arteries to guide care. |
| 23-0022 |
Better Understanding of Joint Destruction in People with Rheumatoid Arthritis
This study wants to find better treatments for people with autoimmune diseases like rheumatoid arthritis (RA). By studying the different types of cells found in people with RA, researchers can learn more about how RA damages joints. |
| 23-1727 |
How Well Does Sogroya Work for Adults with Growth Hormone Deficiency
We want to learn more about how safe Sogroya (somapacitan) is and how well it works for people with growth hormone deficiency. To join, you must already be taking or be planning to take Sogroya. |
| 23-0516 |
Studying Heart Problems During Rest & Exercise in People with Chronic Obstructive Pulmonary Disease
This study wants to learn more about how the right side of the heart works in people with chronic obstructive pulmonary disease (COPD). We want to see how the heart responds to high blood pressure in the lungs, both while resting and during exercise. The goal is to find patterns that could lead to better treatments for people with COPD. |
| 22-0853 |
Child Bipolar Disorder Network (CBN) Study: Treating Youth with or at Risk for Bipolar
We want to find better ways to treat bipolar disorders. We are looking for children, teens, and young adults, aged 9 to 21 years old, to join our study. |
| 22-0895 |
The Nephrotic Syndrome Study Network (NEPTUNE)
We want to learn more about the diseases that cause nephrotic syndrome. This is a group of symptoms that happen when the kidneys don't work the right way. We will collect health information and lab samples to help us discover new things. We hope this will help doctors, researchers, and the public. |
| 21-3959 |
Investigating CXA-10 for Managing Asthma in Adults with Obesity and Asthma
This study wants to learn more about CXA-10, a naturally occurring compound in the body. Researchers will test whether CXA-10 is safe and if it helps people who have asthma and are also living with obesity. |
| 21-2804 |
Study to Improve Deployment-related Asthma by Using L-citrulline Supplementation
This study wants to learn more about how a drug called L-citrulline affects lung function and asthma control in people with deployment-related asthma. |
| 23-0954 |
How CBD Influences Cannabis Habits and Mental Function in Young Adult Cannabis Users
This study wants to find out how cannabidiol (CBD) may affect cannabis use, the effects of cannabis, mood, and thinking in people that use cannabis regularly. |
| 25-0503 |
Dysautonomia in Down Syndrome
This study wants to learn how adults with Down syndrome (DS) respond to everyday stress compared with adults without DS of the same sex and age. This study will look at changes in heart rate, blood pressure, and other body responses during stress. |
| 25-2431 |
Study to See if Alendronate Wakes Up Hidden HIV in People Living with HIV
This study will look at whether a medication called alendronate can reduce the amount of hidden HIV (called the HIV reservoir) in people living with HIV. Alendronate is a medication used to strengthen bones. |
| 22-1490 |
Testing a New Cancer Treatment Alone or With Pembrolizumab in Adults with Advanced Solid Tumors
This study is testing a new drug called mRNA-4359, given alone or with pembrolizumab. We want to learn how safe these drugs are and find the best dose for people with cancer that has spread, returned, or is hard to treat. |
| 26-0057 |
A Study of Relacorilant Combined with Different Treatments for Gynecological Cancers
The purpose of this study is to learn how well relacorilant works and how safe it is when used with other treatments for gynecological cancers, such as ovarian and endometrial cancer. |
| 22-0657 |
Investigating Strength Training in Veterans with Multiple Sclerosis and Mobility Limitations
This study wants to learn more about a strength training program in veterans with Multiple Sclerosis (MS) who use a mobility aid. |
| 26-0161 |
A Study to Learn How a New Pneumococcal Vaccine Works in Healthy Infants
In this study, we want to learn how safe a new pneumococcal vaccine is and how well it works to protect infants against pneumococcal disease. We will compare the new vaccine with the pneumococcal vaccine currently used in children, Prevnar 20® (20vPnC). |
| 25-2690 |
A Study of Montelukast for Kidney and Heart Health in Young Adults with Type 2 Diabetes
The goal of this study is to learn more about inflammation and how well the kidneys and blood vessels work in young adults with type 2 diabetes (T2D). |
| 25-0875 |
Exploring Anifrolumab as a Treatment Option for People with Polymyositis and Dermatomyositis
In this study, we want to learn whether adding anifrolumab to standard treatment for people with polymyositis (PM) and dermatomyositis (DM) works better than standard treatment alone. We also want to learn more about how PM and DM affect the body. |
| 25-1323 |
Exploring Cell Therapy for People Living with Autoimmune Diseases
Researchers are studying whether a treatment called ALLO329 CAR T cells is safe and works well for adults with autoimmune disease such as systemic lupus erythematosus (SLE), idiopathic inflammatory myopathy (IIM), and systemic sclerosis (SSc). |
| 25-0291 |
Understanding the Effects of Psilocybin Use in Adults
This study looks at the short and long term effects of psilocybin use and explores whether these effects are different for males and females. |
| 25-1730 |
Studying the Effects of OPT101 in People with Type 1 Diabetes
This research study is testing whether the investigational drug OPT101 is safe and helpful for people with Type 1 Diabetes (T1D). |
| 25-0964 |
Exploring Remibrutinib as a Treatment Option for Chronic Spontaneous Urticaria in Adults
This study is comparing how well remibrutinib (Rhapsido) and dupilumab (Dupixent) work in adults with Chronic Spontaneous Urticaria (CSU). |
| 25-2380 |
Understanding How Functional Neurologic Disorder Affects Movement
This study aims to learn more about activity behavior in people with Functional Neurologic Disorder (FND). You will wear a device called an accelerometer and talk with the study team to help researchers learn how FND may affect your daily activities and experiences. |
| 23-2367 |
Comparing Medications to Treat Eosinophilic Esophagitis in Children and Young Adults
In this study we want to compare how well two different drugs work to treat kids and young adults that have a narrow or stiff esophagus because of a health problem called eosinophilic esophagitis. |
| 25-1184 |
A Study to Test Treatment for Age-Related Hearing Loss
This study wants to see if an FDA-approved drug called Clemastine Fumarate and sound therapy can help improve hearing problems in noisy places that some people get as they age called age-related auditory processing disorder. |
| 24-2469 |
Role of Stress and Environment in Pregnant and Postpartum Women (MOM-EV)
In this study we want to learn more about how life experiences and everyday stress impact the physical and mental health of mothers during pregnancy and postpartum. |
| 19-1658 |
Exploring Brexpiprazole as a New Medication Option for Alcohol Use Disorder
We want to learn how a new drug called brexpiprazole (BREX) affects alcohol use and brain function in adults who are not currently getting treatment for Alcohol Use Disorder. |
| 25-2345 |
Exercise and Sleep Tracking at Home for People with Parkinson's Disease
This study wants to learn if a short, high-intensity exercise program can be done safely at home and if this exercise may affect sleep in people with Parkinson's Disease. |
| 25-1919 |
Study of Targeted Drug Treatment for Kids and Young Adults with Newly Diagnosed Type 1 Diabetes
In this study we are testing how two drugs, Thymoglobulin ® and verapamil, work together to treat children and young adults with newly diagnosed type 1 diabetes. |
| 25-0580 |
Study Testing IFx-Hu2.0 Plus Pembrolizumab for Advanced Merkel Cell Carcinoma
This study wants to learn how well the investigational drug IFx-Hu2.0 works as an added treatment before giving pembrolizumab to people with advanced Merkel cell carcinoma. |
| 24-2480 |
Combining Precision Radiation Therapy with Immunotherapy for Metastatic Kidney Cancer
This study wants to find out if adding radiation therapy to your tumor, along with your regular immune therapy, can help keep your cancer from growing or even make it shrink, compared to using immune therapy alone in people with metastatic kidney cancer who cannot have surgery. |
| 25-0466 |
Combining Ziftomenib and Imatinib to Treat Advanced Gastrointestinal Stromal Tumors
This study wants to find a dose of ziftomenib that people with advanced gastrointestinal stromal tumors (CIST) can handle safely when taken with imatinib. We also want to learn how well these two drugs work together. |
| 25-0095 |
Equol for Better Blood Vessel Health in Postmenopausal Women with Kidney Disease
This study wants to learn how equol, a supplement made from soy, affects blood vessel health in postmenopausal women with chronic kidney disease (CKD). This study wants to see if taking equol for 12 weeks can help blood vessels work better. |
| 24-0061 |
New Device to Manage Insulin Delivery for Kids and Adults with Cystic Fibrosis Related Diabetes
In this study we want to learn how a device that automates insulin delivery (called the iLet Bionic Pancreas) helps people with Cystic Fibrosis Related Diabetes manage their insulin levels. We want to learn how well this device works compared to a normal insulin delivery method. |
| 25-0559 |
Study on New Drug to Treat Immunoglobulin A Vasculitis Nephritis in Children and Teens
In this study we want to learn if a drug called ravulizumab is a safe and effective treatment for children and teens that have both Immunoglobulin A Vasculitis Nephritis (IgAVN) and Immunoglobulin A Nephritis (IgAN). |
| 19-0744 |
Study Comparing Standard Glioblastoma Treatments to New Treatment Options
This study is being done to test new treatments for people with newly diagnosed glioblastoma (GBM), a type of brain cancer. The goal is to see if any of these new treatments help people live longer compared to the usual treatments. This study will compare the usual medicine (Temozolomide) used to treat newly diagnosed GBM to new drugs such as VT102, ADI-PEG20, Troriluzole, or AZD1390. |
| 23-1600 |
Managing Type 2 Diabetes in Teens with Depression
Researchers are trying to find new ways to help improve the mood of teenagers who have Type 2 diabetes (T2D). |
| 25-0943 |
Enhancing Health in Women During the Menopause Transition
This study wants to learn how late menopause affects women. This study wants to see whether diet education, lifestyle changes, and medication can help women feel healthier. We are looking for women ages 45 to 55 who are in late menopause to join. |
| 21-2666 |
Improving Cancer Treatment Timeliness with Case Management Support for People Living in Rural Areas
This study wants to see if a case management program helps people with lung, head-and-neck, thyroid, breast, cervical, colon or rectum, or bladder cancers start and finish treatment sooner compared to usual care. We also want to find out if this program improves care and outcomes for people with these types of cancers. |
| 25-1807 |
A Study Testing if SAB-142 Can Slow the Progression of Type 1 Diabetes in People Recently Diagnosed
This study wants to see if a new drug called SAB-142 in addition to regular insulin therapy can help slow down Type 1 Diabetes (T1D) in people who were diagnosed in the last 100 days. |
| 25-0997 |
Creating a Digital Tool to Support Teen Mental Health
In this study, we want to learn how teens handle stress, deal with feelings of depression, and manage habits like eating, exercise, and sleep. We will use what we learn to make a Digital App that helps teens struggling with these challenges. |
| 24-2267 |
Understanding Health Problems Connected to Cystic Fibrosis Related Diabetes (SPeCTRuM)
In this study we want to learn more about how common health problems like high blood pressure, vision problems, and kidney disease are in people with cystic fibrosis-related diabetes (CFRD). |
| 24-1490 |
Impact of Sleep Health in Adolescents with Type 1 Diabetes
In this study we want to see if improving the amount and quality of sleep will help improve the overall health of adolescents that have type 1 diabetes (TID). |
| 24-2571 |
Methods for Improving Sleep for Concussion Recovery
In this study we want to determine the best intervention for improving sleep quality in people recovering from a concussion. To do this we are comparing two sleep interventions and seeing how the impact the recovery time for a concussion. |
| 23-1267 |
Role of Dulaglutide in Improving Insulin Levels in Adults with Cystic Fibrosis Related Diabetes
In this study we want to understand more about the causes of cystic fibrosis related diabetes (CFRD) and find better ways to treat it. |
| 17-0977 |
Study Exploring How Spondyloarthritis Develops Among First Degree Relatives
This study wants to learn more about spondyloarthritis, a type of arthritis that causes a lot of inflammation. We are looking for adults who have a parent, sibling, or child who has spondyloarthritis or a similar health problem to join our study. |
| 23-2296 |
Blood Sugar Levels in Healthy Children
This study wants to learn more about how blood sugar levels in healthy children without chronic disease compare to the blood sugar levels of children with Cystic Fibrosis (CF). We are only recruiting children without chronic disease to join the study. |
| 24-1932 |
Study to Test the Efficacy and Safety of Anifrolumab in Adults with Chronic CLE
This study is testing a new injectable medication called anifrolumab to see how safe and effective it is for adults with chronic cutaneous lupus erythematosus (CLE). Our goal is to find better treatments for people living with CLE. |
| 24-0657 |
Safety and Efficacy of Benralizumab in Children with EGPA
In this study we want to learn more about the effects of the study drug, benralizumab, for treating children with eosinophilic granulomatosis with polyangiitis (EGPA). |
| 23-0690 |
Effect of Protein Supplement on Liver Fat in Adolescents
This study wants to learn if taking a protein supplement drink twice a day for 8 weeks can help lower the amount of fat that is stored in the liver. |
| 24-1269 |
The Impact of Estrogen on Women's Reproductive Hormones and System
This study wants to learn more about how estrogen affects women's reproductive hormones and system. |
| 23-0839 |
Safety and Effectiveness of a New Drug Treatment for IC-MPGN
In this study, we want to learn more about a new drug called iptacopan to see if it can help treat a rare kidney disease called IC-MPGN (immune complex mediated membranoproliferative glomerulonephritis). |
| 21-4941 |
Semaglutide as a Treatment for Adolescents and Adults with Polycystic Ovary Syndrome (PCOS)
In this study we want to learn if a medicine approved for diabetes and weight loss called Ozempic® and Wegovy® (semaglutide) can help improve the frequency of periods and the way the body uses sugar in women with polycystic ovary syndrome (PCOS). |