Studying How Airway Cells May Predict COPD Risk in People Who Smoke
This study wants to learn how early changes in airway cells may help predict who is at risk for developing Chronic Obstructive Pulmonary Disease (COPD). We are looking for people who are current smokers with or without COPD.
Why this Research Matters
COPD is a long-term lung disease that happens slowly over many years. Many people do not know they are at risk until lung damage has occurred. This study looks at special airway cells found in the nose and lungs. We want to see whether changes in these cells happen early and whether they are linked to faster lung disease progression in people who smoke. By learning more about early airway cell changes, we hope to find people at higher risk for COPD earlier. We also hope to improve early detection of lung disease and help create better prevention and treatment options in the future.
What to Expect
If you are interested, your participation starts with a visit at the University of Colorado Hospital. This visit may last 6 to 8 hours. If you decide to join the study, you will complete health questionnaires, breathing tests, and a lung CT scan. You may be asked to provide blood, urine, or breath samples to help researchers learn more about airway health. Some people may be asked to complete a bronchoscopy. This is a procedure where doctors look inside your lungs and collect small samples from your airways and nose. The study team will explain all procedures, and you will be able to ask questions before anything takes place.
Study Duration
After the first visit, you will be invited to return for short yearly visits once a year for up to 3 years. A final visit may occur about 2 to 4 years after enrollment and may last 3 to 8 hours. The study team will review all visits, time commitments, and answer any questions before you decide to take part.
Who can Participate
You may be able to join if:
- You are 30 to 50 years old
- You are a current smoker
- You have never been diagnosed with asthma
Study ID
Protocol Number: 23-1215
Compensation Information
Meet the Team
Principal Investigator