This study wants to see if gut problems are worse in HIV+ men that have sex with men that have metabolic syndrome compared those without metabolic syndrome.
This study plans to learn more about metabolic syndrome in people living with HIV, especially men who have sex with men. Metabolic syndrome is common in people living with HIV and linked to gut health. We want to find out what causes metabolic syndrome in men who have sex with men and people living with HIV. If you join this study, you will have three visits. The first visit will check to see if you qualify to join. We will take your blood through an IV in your arm. We will test your blood for metabolic syndrome and HIV. This visit will take 1 hour. At the second visit, you will fill out surveys, do a physical exam, and talk about your medical history. We will give you a kit to collect your poop at home before your next visit. This visit will take 1.5 hours. At the last visit, we will take your blood through an IV in your arm. You also will be asked to have 30 small samples of tissues removed from your colon. This is done with a flexible tube with a light that goes in your rectum and moves up to the lower part of your large bowel. This will take 15 minutes and may cause some belly discomfort. This visit will take 1.5 hours. You will be in the study for 2 months.
You may be able to join this study if you are: a man who has sex with other men, 18-70 years old, have HIV, and have been on ART for 12 months with detectable virus in the last 6 months. You can't join this study if you have gut disease (like IBD or celiac), had bowel surgery, used high-dose blood thinners in the past year, took antibiotics in the past 2 months, or have an infection other than HIV.
Principal Investigator