If you join this study, you will first have a health check to make sure it’s safe for you to join. You will answer questions about your health, RA symptoms, and medications. A doctor will do a physical exam and check your vitals like blood pressure, heart rate, and temperature. You may also have an ultrasound, an MRI, and possibly a small sample (biopsy) taken from your joints. You will give blood and urine samples to check your overall health. You can choose to have two joint tissue samples taken. This tissue, called synovial tissue, helps keep your joints moving smoothly. The first sample will be taken before you get CAR T cell therapy. Next, you will have a procedure called apheresis, which collects special cells from your blood. Your blood goes through a machine that separates out the white blood cells, and the rest of the blood goes back into your body. The takes about 2-3 hours. The collected cells are sent to a lab to make the treatment called, SBT777101, which takes about 6 weeks. Before getting the treatment, you will have another health check. Then, you will get the CAR T cell therapy through an IV in your arm. You will stay overnight at the clinic so doctors can monitor you. After that, you will come back for 15 follow-up visits over 11 months. These visits will include more health checks, blood and urine tests, and another joint biopsy. You can earn up to $2,000 if you complete all study visits.

Who can Participate

To join this study, you must be between 18 and 70 years old, have a BMI under 35, have moderate to severe rheumatoid arthritis (RA) that is not well controlled with your current medications, have tried RA treatments before but they did not work well , have at least one swollen joint (knee, wrist, or ankle) that can be used for a sample (biopsy), have tried at least three RA medications like Humira, Enbrel, Simponi, Remicade, Actemra, Kevzara, Orencia, Rituxan, Xeljanz, and Rinvoq, but they didn’t help enough.

Study ID