This study plans to learn more about the brain's role in alcohol use problems and recovery. Prominent theories about alcohol use disorder suggest that it is a disorder of the brain. However, it remains unclear what parts of the brain work differently in alcohol use disorder. This study intends to add to the understanding of how brain function differs in individuals with alcohol use disorder relative to individuals without alcohol use disorder. We also plan to increase understanding of how treatment for alcohol use disorder changes brain function.

Who can Participate

i. Inclusion criteria for all participants: A) Between 21 and 65 years of age, and B) can understand the nature of study and can sign an informed consent document. iii. Inclusion criteria for healthy comparison group: We will recruit adults without a history of alcohol use disorder. iv. Exclusion criteria for all participants: A) positive result on urine drug screen or breathalyzer at the start of any study visit, B) inability to complete MRI (e.g. presence of ferromagnetic objects in body), C) current use of medications that alter the hemodynamic response, D) history of trauma resulting in loss of consciousness longer than 15 minutes, E) history of certain mental health conditions G) past 48-hour use of drugs to treat alcohol withdrawal (e.g. benzodiazepines), G) for females, pregnancy. v. Exclusion criteria for healthy group: A) History of a substance use disorder (lifetime or current).

Study ID