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A retrospective and prospective-cohort study to compare the immune response to Respiratory Syncytial Virus and clinical outcomes in patients who received nirsevimab versus those who did not receive nirsevimab in the prior respiratory season.

To evaluate the Season 2 (2024/ 2025) immune response of children who received nirsevimab in the 2023-2024 season (Season 1) compared to the immune response of children who did not receive nirsevimab in Season 1 and To compare the frequency and severity of illness in Season 2 between children who received nirsevimab in Season 1 to children who did not receive nirsevimab in Season 1 as assessed by Medically attended LRTI (MA LRTI) and RSV associated MA LRTI (RSV MA LRTI).


Why this Research Matters

This research study wants to find out whether receiving the RSV vaccine (Beyfortus/nirsevimab) compared to not receiving it affects the body's immune response to RSV in the following respiratory season. If your child was diagnosed with RSV from November 2024-May 2025 and you are interested in participating in a 1 visit research study, please reach out for more information.


Who can Participate

Child and Teen

7 - 37 months of age with + RSV infection (nirsevimab recipients and non-nirsevimab recipients from the prior year)


Study ID

Protocol Number: 24-1696

Meet the Team

Image of Principal Investigator

Eric Simoes, MD

Principal Investigator