A Phase 2 Study of Genicular Artery Embolization for Knee Osteoarthritis to See How It Relates to Pain Relief and Knee Inflammation
This study looks at changes in the fluid in your knee, your knee MRI scans, and your physical abilities before and after Genicular Artery Embolization (GAE). GAE is a treatment that can give long-lasting pain relief to adults with osteoarthritis.
Why this Research Matters
Up to 46 people from across the country, including your area, may take part in this study. The study wants to learn more about what changes in the fluid inside your knee, what shows up on scans, and how your knee works before and after a procedure called Genicular Artery Embolization (GAE), which is used to help reduce knee pain. You are being asked to join because you have knee pain and want to have the GAE procedure. The results may help researchers better understand how GAE works and who it helps the most.
What to Expect
If you join this study, you will first have a visit to review your medical history and do a physical exam. You will also complete questionnaires, a knee MRI, and simple movement tests to see if you qualify. If you qualify, you will have five more visits over the next 12 months. During these visits, we will do a knee fluid test called arthrocentesis. For this, we will numb your knee and use a small needle to take a little bit of fluid so we can check for swelling. You will also have MRI scans with contrast to look for inflammation in the knee. You will do simple tests like standing up and sitting down for 30 seconds and walking 50 feet. Finally, you will answer short questions about your pain and how your knee feels during everyday activities. The study will pay for tests that are not part of your regular care. This includes the knee fluid tests (arthrocentesis), the contrast part of the knee MRI, and the physical movement tests.
Study Duration
Patients will finish all study activities 12 months after their treatment visit. The first screening will happen within 3 months before treatment. The whole study will last about 15 months.
Who can Participate
You may be able to join this study if:
- You are 18 years or older
- You have been diagnosed with knee osteoarthritis
- You are planning to have GAE (genicular artery embolization) to help treat your knee pain
- You have had moderate to severe knee pain for at least six months
- Your body mass index (BMI) is less than 35
Study ID
Protocol Number: 24-1048
Compensation Information
Meet the Team
Leigh Casadaban, MD, MS
Principal Investigator