Genicular Artery Embolization for Knee Osteoarthritis: Pain Relief and Knee Inflammation
This study wants to learn more about people who get a treatment called Genicular Artery Embolization (GAE). GAE is a procedure to help adults with long-term knee pain feel better. This study will look at changes in the fluid in your knee, pictures of your knee (MRI), and how well you move before and after the treatment.
Why this Research Matters
This study will include up to 46 people from across the country, including your area, who may take part in this study. The study wants to learn more about what changes in the fluid inside your knee, what shows up on scans, and how your knee works before and after a procedure called Genicular Artery Embolization (GAE), which is used to help reduce knee pain. You are being asked to join because you have knee pain and want to have the GAE procedure. The results may help researchers better understand how GAE works and who it helps the most.
What to Expect
If you join this study, your first visit will include a review of your medical history and a physical exam. You will also answer questions, have an MRI of your knee, and do simple movement tests to see if you can be in the study. If you qualify, you will have five more visits over the next 12 months after your procedure. At these visits, we will take a small amount of fluid from your knee using a test called arthrocentesis. To do this, we will numb the area and use a small needle. This test helps us check for inflammation. You will also answer questions about your pain and how your knee feels when you do daily activities. You will have MRI scans with contrast dye before and after the procedure to check for inflammation. You will also do short movement tests like standing up and sitting down for 30 seconds and walking 50 feet before and after the procedure.
Study Duration
You will finish all study activities 12 months after the treatment visit. The first screening will happen within 3 months before treatment. The whole study will last for about 15 months.
Who can Participate
You may be able to join this study if:
- You are 18 years or older
- You have been diagnosed with knee osteoarthritis
- You are planning to have GAE (genicular artery embolization) to help treat your knee pain
- You have had moderate to severe knee pain for at least six months
- Your body mass index (BMI) is less than 35
Study ID
Protocol Number: 24-1048
Compensation Information
Meet the Team
Principal Investigator