Study

Human Trisome Project

This study wants to better understand Down syndrome and related health problems by comparing blood and saliva samples from people with and without Down syndrome. Right now, we are mainly looking for people who do not have Down syndrome but do have chronic constipation to join our study.

Why this Research Matters

Down syndrome happens when a person has an extra copy of chromosome 21. This can increase the risk of certain health problems, like Alzheimer’s, heart issues, and immune system issues. Our study is creating a central source of health data and biological samples to help scientists and doctors learn more about Down syndrome and other health issues. One part of our study wants to learn more about chronic constipation, which affects people both with and without Down syndrome. By comparing samples from these two groups, we can learn more about the many ways that constipation presents and find better ways to treat it.

What to Expect

If you join this study, we will collect a blood sample using a needle in your arm. We will gently rub a sponge in your mouth to collect a few of the cells there. You will also be asked to fill out a short survey about your health. We may also ask you to give other biological samples, but you do not have to give these. For example, if you join the part of the study focusing on constipation, we may ask you to give a stool sample.

Study Duration

If you decide to join this study, you will come to one visit at the Anschutz Medical Campus. You may be asked to come back for future visits once a year, for up to four more years. You do not have to come for future visits even if you complete the first visit.

Who can Participate

People aged 6 months to 89 years old.

You or your child can join this study if you are between 6 months and 89 years old. We welcome people with and without Down syndrome. We are always enrolling people with Down syndrome!

Right now, we are especially looking for people without Down syndrome who have a diagnosis of chronic constipation.