Restoring Endothelial Function After Traumatic Injury to Reduce ARDS and Multi-Organ Dysfunction
We will investigate the association between transfusion of fibrinogen-containing blood products and multi-organ dysfunction resulting from endotheliopathy of trauma (EOT). Fibrinogen is frequently acutely decreased in critically ill trauma patients. Early fibrinogen replacement may be the key to restoring the endothelial glycocalyx and preventing end-organ injury. However, few human data exist to guide treatment.
Why this Research Matters
Blood draws will be completed at baseline, 6-24 hours after arrival, and then daily through study day 7 to evaluate fibrinogen levels and response to trauma.
Who can Participate
Adult
Acute traumatic injury Acute traumatic injury, over 18, admitted to STICU at UCH within 24 hours of hospital admission
Study ID
Protocol Number: 23-0581
Meet the Team
Principal Investigator