During the late menopause transition, changes in hormones can affect a woman’s heart health, weight, sleep, mood, and daily activity. These changes can raise the risk of heart disease, and other health problems. Many of these changes start years before menopause is complete, but treatment often starts later. This study is being done to learn more about these health changes during late menopause and to see if diet education, lifestyle changes, and medication can help improve health and quality of life. About 200 women from three locations in the United States will take part in this study. If you want to join this study, you will first have a screening visit. At this visit you will have a physical exam, fill out surveys, and have blood drawn to check hormone levels and other health tests. You will also have a test to see how well your blood vessels work. If you are able to join the study, the study doctor may suggest diet education or life changes. The study doctor may also suggest medications such as metformin or Ozempic based on your test results and health needs. You may be asked to take monthly blood pressure measurements using a device that will be provided to you by the study team. You will be asked to wear an activity tracker for a short time to look at sleep and activity. You will not choose the treatments; they are based on your screening results and health needs. You will be in the study for about 2 years. You will have at least 3 in person visits and monthly phone check-ins with the study team. If you complete the study, you will earn $100. You will also get a Fitbit that you can keep after the study ends.

Who can Participate

You may be able to join this study if you are a woman between 45 and 55 years old and are in the late stage of menopause, meaning you have missed your period for at least 60 days but less than 1 year. You must not be using hormone therapy or hormonal birth control. You must have a uterus and at least one ovary. You also need a smartphone and reliable internet to fill out surveys and telehealth visits. You cannot join if you do not have reliable internet access, if you had irregular periods between ages 25 to 38, if you are pregnant or actively trying to get pregnant, or if you have untreated alcohol or substance use problems. At your first visit, the study team will check to make sure you meet all the requirements to join the study.

Study ID