Cancer treatments do not work the same for everyone. This study is testing different drug combinations to learn about the safest dose, how well they work and what side effects they cause. The goal is to find better ways to match people with the right treatment. If you join, you will be placed in a treatment group called an arm. Each arm will test a different drug or drug combination. Each arm will focus on finding the safest dose and then enroll more patients to test that dose even more. Which arm you join will depend on your cancer type, such as solid tumors or breast cancer, and test results. During the study you may have blood draws, CT scans, bone scans, and sometimes biopsies. The way study drug is given to you will depend on the study arm. How long you stay in the study depends on your health and how your cancer responds. Some people may be in the study for about one year, while others may stay on as long as the treatment is helping, and side effects are not too serious. After your treatment ends, the study team may reach out to you to review your health records and check your health.

Who can Participate

You may be able to join this study if you are at least 18 years old, can give written consent and agree to give tumor tissue samples. People of any gender may join. Participants need to be well enough to take part (ECOG performance status Grade 0-2) and should have a life expectancy of at least 12 weeks. You may not be able to join if you have recently had other cancer treatment within a certain time, if you are allergic to similar drugs, if you have uncontrolled illness, such as active infections, diabetes, recent blood clots, or some psychiatric conditions. Your doctor or a member of the study team will review the requirements with you and discuss if this trial is a good choice. You can visit ClinicalTrials.gov to learn more about this study.

Study ID

More information available at ClinicalTrials.gov: NCT05868226