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Paclitaxel is a chemotherapy drug used to treat gastric cancer. It can help stop cancer cells from growing or spreading. Chemotherapy drugs given through a vein also kill cancer cells or stops them from spreading. When paclitaxel is given directly into the abdomen along with standard chemotherapy, it may help control cancer in that area. If you join this study, you will first have a procedure called a diagnostic laparoscopy. This is a short surgery done while you are asleep. The doctor will make small cuts on your belly and use a camera to look inside. This will take about 1 hour to complete. Your study group will be assigned during the surgery. You will not choose which group you are in and will depend on what the doctor sees during surgery. If you are placed in group 1, you will get standard chemotherapy. This treatment is given through a vein. If you are placed into group 2, you will get standard chemotherapy plus paclitaxel directly in your abdomen through a small tube placed during surgery. After you recover from surgery, you will start treatment. You will get treatment for 3 months. After 3 months, your doctor will check how your cancer responds. If your cancer is stable or getting better, you may continue treatment. If your cancer grows, side effects are too strong, or surgery becomes an option; your doctor will talk to you about the next steps. During treatment, you will have regular visits with the study team and doctor. At these visits, you may receive treatment, have exams, give blood samples, and have scans to check your cancer. After study treatment ends, your doctor or study team will watch you for side effects. You will have follow up visits. They will continue to follow your condition every 3 months during the first 2 years, then every 6 months until year 5. You will not be paid for being in this study. You and your insurance may need to pay for your routine medical care. Some study-related costs may be covered.

Who can Participate

You may be able to join this study if you have gastric cancer that has spread to the abdominal cavity. The study team will review your medical history, test results, and overall health to decide if this study is right for you. More eligibility information is listed on ClinicalTrials.gov. Your doctor or a study team member will review these requirements with you. You can click on the NCT number link below to learn more about this study on ClinicalTrials.gov.

Study ID

More information available at ClinicalTrials.gov: NCT07001748