Study | Research Studies | School of Medicine

Relationship between Cardiac Health and Exercise Capacity in Men and Women with and without Type 2 Diabetes

We are recruiting people with and without type 2 diabetes (T2D), aged 30 to 55, to help us test how exercise affects heart health, blood vessels, and blood sugar.

Why this Research Matters

This study will test how exercise impacts heart health, blood vessel function, and how the body uses sugar, among adults with and without T2D.

What to Expect

If you join this study, we will complete testing to see how your heart, blood vessel, and muscles are currently functioning. These tests, called baseline tests, show how well you can exercise. They include riding a stationary bicycle while we measure your oxygen use, doing a scan of your heart and muscles using an ultrasound, checking to see how your body uses sugar, a small muscle sample (biopsy), and an MRI scan. Then, you will do 15 weeks of exercise training after which we will repeat all the tests.

Study Duration

About 7-8 months

Who can Participate

30 to 55 years

You may join the study if you:

Are aged 30-55 years old
Have a BMI between 25-40 kg/m²
Don't use tobacco
Have no heart disease or any physical issues that prevents you from using a stationary bike

If you do not have T2D, you will be in the control group, and you A1c must be under 5.7%. If you have T2D, your A1c must be under 9%. Females must be pre-menopausal.