We want to know if a drug called dulaglutide will help your body release insulin, which lowers your blood sugar after you eat a meal. To do this, we are comparing the impact of six rounds of dulaglutide on blood sugar after a meal vs. blood sugar after a meal when not on dulaglutide. If you join this study, you will come to 4 study visits at Children's Hospital Colorado. These visits will take place across 4-6 months. At these visits we will ask about your health and do physical exams. We will measure your height, weight, and vital signs. We will ask you to eat a prepared breakfast and then use a needle in your arm to take blood samples. We will also ask you to use a machine called a glucometer to measure your blood sugar at home. You will be paid up to $1300 if you complete all the visits in this study.

Who can Participate

You may be able to join this study if you are male or female, and over the age of 18. You must be diagnosed with cystic fibrosis, pancreatic insufficiency, and have had an abnormal oral glucose tolerance test. If you are a female with reproductive potential, you must be willing to use a highly effective contraception method while taking part in this study. Stated willingness to comply with all study procedures and availability for the duration of the study; ability to take subcutaneous medication and be willing to adhere to the weekly administration regimen and complete study specific procedures (MMTT-mixed meal tolerance test); for females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation and for an additional 6 weeks after the end of dulaglutide or observation.

Study ID