Find a Research Study

This study looks at whether a digital mindfulness program can help people diagnosed with breast cancer by age 50 who are feeling depressed. We will compare different digital programs to see which one helps the most.

The purpose of this study is to keep collecting information from people with and without Parkinson's disease (PD). This study will also measure biomarkers that may be linked to how PD develops and changes over time.

This study wants to find out if a new medicine called zenagamtide can help people with obesity lose weight compared to a placebo. We are looking for adults aged 18 to 69 years old who want to lose at least 25% of their body weight to join!

This study wants to learn effects of montelukast (an asthma/allergy medication) on kidney and eye function in people with type 2 diabetes.

PRIMARY OBJECTIVES: I. To establish the recommended phase 2 dose of pidnarulex (CX-5461) with anti-programmed cell death protein 1 (PD-1) in phase 1, and to determine safety and tolerability of pidnarulex (CX-5461) alone, and in combination with anti-PD-1 in phases 1 and 2. II. To determine the progression-free survival (PFS) of pidnarulex (CX-5461) alone and in combination with anti-PD-1 in...

To compare progression-free survival (PFS) of amivantamab monotherapy versus cetuximab monotherapy in patients with locoregionally incurable or metastatic cutaneous squamous cell carcinoma and an active immunosuppressed condition

PRIMARY OBJECTIVES: I. To compare the overall survival (OS) of patients with metastatic castration-resistant prostate carcinoma (mCRPC) receiving prostate-specific antigen (PSA) adaptive dosing of lutetium 177 Lu prostate specific membrane antigen radioligand therapy (177Lu PSMA RLT) to that of patients receiving standard dose 177Lu PSMA RLT every 6 weeks. II. To compare quality of life, as ...

Phase II study in participants with moderately-to-severely active rheumatoid Arthritis (RA) to evaluate efficacy and safety of AZD1163

This is a Phase 2, open-label, multicenter, multi-cohort trial to evaluate the safety, efficacy, pharmacokinetics (PK), and pharmacodynamics of Rina-S as monotherapy in participants with GI cancers who have progressed on or after prior standard of care (SoC) therapies.

Researchers are looking for new ways to treat high-risk, localized non-small cell lung cancer (NSCLC) that has been removed with surgery. People with high-risk, localized NSCLC are often treated with surgery. Researchers want to learn if participants can receive 1 or 2 trial treatments to help prevent NSCLC from coming back after surgery. One trial medicine is intismeran (also called V940/mRNA-...

This research study plans to examine an online stress-resilience (mindfulness-based) program for women in perimenopause who have experienced stress earlier in life. It is also designed to learn about the feasibility, acceptability, and effects of the program on stress, mood, thinking abilities, and health markers.

PRIMARY OBJECTIVE: I. To demonstrate that bevacizumab, an anti-VEGF antibody therapy, (or an anti-VEGF antibody biosimilar) in combination with carboplatin, paclitaxel, and pembrolizumab is superior to carboplatin, paclitaxel, and pembrolizumab (the control arm) or carboplatin, paclitaxel, and bevacizumab in prolonging progression-free survival (PFS) in patients with pMMR, TP53 mutated advanced...

Gocatamig and I-DXd (short for ifinatamab deruxtecan) are study medicines. Researchers want to know if giving gocatamig and I-DXd together can treat ES-SCLC. Researchers will also look at giving the study medicines with standard treatment. Gocatamig is a T-cell engager therapy. I-DXd is an antibody drug conjugate. T-cell engager therapy is a certain type of immunotherapy that uses T-cells to fi...

The goal of this study is to identify a safe and tolerated dose of the orally administered KIF18A inhibitor ATX-295. In addition, this study will evaluate the pharmacokinetics, pharmacodynamics and preliminary antitumor activity of ATX-295 in patients with advanced solid tumors and ovarian cancer.

To evaluate the efficacy of ALK-001 compared with placebo in slowing the progression of retinal atrophic lesion growth in participants with STGD

Global, Phase 3, randomized, multicenter, open-label study evaluating the efficacy and safety of firmonertinib at a dose level of 240 mg QD compared to investigator's choice of osimertinib (80 mg QD) or afatinib (40 mg QD) in participants who have locally advanced or metastatic NSCLC with EGFR PACC mutations, and who have not received any prior therapy for advanced disease.

This study looks at how GLP-1 RA medicines like Ozempic and Mounjaro affect the liver in people with type 1 diabetes (T1D) compared to people without T1D. We are focusing on a liver condition called metabolic dysfunction-associated steatotic liver disease (MASLD), which happens when too much fat builds up in the liver and can lead to other health problems. The goal is to find out if these drugs ca...

This study wants to learn more about muvalaplin (LY3473329). Muvalaplin is being studied to treat high lipoprotein, which is a type of unhealthy fat in your blood. The goal of this study is to see if muvalaplin can lower the risk of serious health problems, such as heart attack or stroke, and see what side effects people may have.

In this study, we want to learn more about what helps and what makes it harder for teens with type 2 diabetes to be physically active. To do this, we are talking to teens and their parents/caregivers in small group discussions.

The purpose of this study is to evaluate the effects of the investigational use of a GLP-1 medication called tirzepatide (Zepbound) on cigarette smoking, cigarette craving, and related outcomes.

This study wants to find out if a mobile app that suggests daily insulin doses is safe and works well for adults with type 2 diabetes.

The main goal of this study is to see how well two drugs, tirzepatide and retatrutide, work for treating metabolic dysfunction associated steatotic liver disease compared to placebo.

This study, the first clinical trial of AVZO-103, aims to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose, and antitumor activity of AVZO-103 when administered intravenously as a monotherapy and in combination therapy to patients with locally advanced or metastatic urothelial cancer or other solid tumors.

The purpose of this study is to measure the efficacy and safety of rilvegostomig with gemcitabine plus cisplatin vs. durvalumab with gemcitabine plus cisplatin as first line treatment for patients with advanced BTC.

This study is testing a new drug called baricitinib in children and young adults who have recently been diagnosed with type 1 diabetes (T1D). We want to learn whether it can help preserve beta cells and slow the progression of T1D.

This study plans to learn more about whether exercise can help protect the body from health problems that happen when a person’s sleep and daily schedule are out of sync with their natural body clock.

We are looking for women who are within six weeks of giving birth to help us learn how doula support and spending time in nature can lower stress, improve sleep, and support overall wellbeing. This study looks at ways to help mothers recover and thrive during the early weeks after giving birth.

This clinical study is testing whether a new combination of medicines (DSP107 and atezolizumab) is more effective and safer than an existing treatment (fruquintinib) for people with advanced colorectal cancer that is microsatellite stable (MSS). Participants will be randomly assigned to receive one of the two treatments, and researchers will monitor how well the cancer responds, how safe the treat...

The objective of this study is to evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of BL-M14D1 in Subjects with locally Advanced or Metastatic Small Cell Lung Cancer and Other Neuroendocrine Neoplasms

Primary Objective To assess efficacy of intravenous (IV) brincidofovir (BCV), compared with IV cidofovir (CDV), in subjects after allo-HCT with adenovirus (AdV) viremia. Secondary Objectives To assess the safety of IV BCV, compared with IV CDV, in subjects after allo-HCT with AdV viremia. To assess IV BCV pharmacokinetics (PK).

The researchers want to find out if Sofe-M works better than the standard treatments that doctors use now and to better understand how safe it is. Each participant's time in the study will depend on how they respond to the treatment.

PRIMARY OBJECTIVE: To determine whether the combination of cabozantinib plus cemiplimab (REGN2810) (Cabo-Cemiplimab REGN2810) improves progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors (RECIST) version (v.) 1.1 relative to cabozantinib alone in patients with locally advanced unresectable or recurrent/metastatic advanced adrenocortical cancer.

The study will test whether GSK5460025 alone or in combination (potential combinations may be included in future amendments to the protocol) with other anti-cancer agents can decrease tumor size, is safe, well-tolerated, and how the drug is processed in the body over time.

The goal of this clinical trial is to learn about the safety and recommended dose of TRI-611 when administered to adults with ALK-positive non-small cell lung cancer (NSCLC). The trial will also evaluate the antitumor activity of TRI-611 in adults with ALK-positive NSCLC. The study will be conducted in two parts. The first part will examine different doses of TRI-611. The second part will look ...

PRIMARY OBJECTIVE: I. Demonstrate non-inferiority of ultra-hypofractionated (stereotactic body radiation therapy SBRT) compared to hypofractionated radiation therapy (RT) with a 10% non-inferiority margin (from 50% to 40%) in the rate of bladder-intact event-free survival (BI-EFS) at 3 years (corresponding to a hazard ratio < 1.32)

A clinical study for the treatment of agitation in adults with Alzheimer's disease

Progression-free survival (PFS), Overall Survival (OS) in the mCRC population, Efficacy measures such as overall response rate (ORR), incidence and severity of adverse events (AEs) and clinically significant abnormal laboratory test results, Efficacy measures such as duration of response (DoR)

This study is for adults age 21 or older who have alcohol use disorder (AUD). It tests whether a medicine called Apremilast can help reduce alcohol cravings compared to a placebo, a pill that looks the same but has no medicine.

The goal of this study is to learn whether veverimer is safe and helpful in preventing or treating the problems of metabolic acidosis in adults with chronic kidney disease (CKD).

This is an international, multicenter, randomized, double-blind, active-controlled, phase 3 clinical trial. The purpose of this trial is to compare the efficacy and safety of palazestrant in combination with ribociclib +letrozole -matching placebo (Arm A: investigational arm) with letrozole in combination with ribociclib + palazestrant-matching placebo (Arm B: control arm). This trial is seek...

The goal of this study is to learn more about how different types of snacks may affect brain activity, hunger, and eating behaviors during a diet program.

PRIMARY OBJECTIVE: I. To determine whether induction immunotherapy (IO) and chemotherapy prior to concurrent chemoradiation therapy (CCRT) + IO improves progression-free survival (PFS) compared to CCRT+IO alone. SECONDARY OBJECTIVES: I. To assess whether induction IO and chemotherapy prior to CCRT+IO improves the overall survival (OS) compared to CCRT+IO alone. II. To determine the nat...

This is an open-label, multi-center, phase I/II study to evaluate the safety, efficacy, and pharmacokinetics of MRG007 in patients with unresectable locally advanced and metastatic solid tumors.

This study wants to better understand how people respond to nutrient stimulated hormone receptor agonist (NuSH RA) medications like semaglutide (Wegovy) and tirzepaide (Zepbound).

Cohort 1: To demonstrate that the proportion of subjects with vision loss is lower for subjects in the Treatment Arm vs the Control Arm. Cohort 2: To demonstrate the ability to salvage the eye and prevent enucleation in the Treatment Arm

This is a first-in-human, open-label, multicenter phase 1 study to evaluate safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of OP-3136, a lysine acetyltransferases 6A and 6B (KAT6A/B) inhibitor, as monotherapy and in combination with other anticancer agents in participants with advanced solid tumors. This study consists of 2 parts: a dose escalation ...

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of BG-C477 alone and in combination with anticancer agents in participants with selected advanced solid tumors.

This is a first-in human clinical study of DPTX3186 in subjects with Wnt-pathway activated solid tumors where no other treatments exist. The study will evaluate safety, pharmacokinetics, and initial activity of DPTX3186, as well as explore pharmacodynamic parameters to identify potential biomarkers of efficacy

This study wants to find out how physical activity affects bone strength in teens with and without cerebral palsy (CP).

An open-label, multicenter study of ZL-1310 as a single agent and in combination with Atezolizumab (with and without Carboplatin) to evaluate the safety, efficacy, and pharmacokinetics in subjects with small cell lung cancer

This study wants to learn how safe psilocybin is for healthy older adults and how their bodies and minds react to it. We also want to see how psilocybin affects mood, thinking, and well-being.

In this study, we are comparing two growth hormone treatments, lonapegsomatropin and somatropin, for children with short stature due to Turner syndrome, SHOX deficiency, being born small for gestational age, or idiopathic short stature. We want to learn how safe these treatments are and how well they help children grow.

This is a two-stage Phase 2 trial evaluating the efficacy and safety of ONC206 in participants with Pheochromocytoma and Paraganglioma (PCPG).

This study wants to see how well three medicines, atogepant (Qulipta), propranolol (Inderal), and topiramate (Topamax), work at reducing the number of migraines people have and how bad the migraines are. The results will help people and their doctors choose which medicine might be best to try first to prevent their migraines.

The main purpose of this study is to evaluate the safety and preliminary efficacy of CHS-114 in combination with toripalimab and/or other standard of care (SOC) compound(s) in participants with advanced or metastatic solid tumors.

This study wants to learn how cannabidiol (CBD) affects drinking in people who drink alcohol often. This study will look to see if CBD can help people drink less and if CBD can help reduce problems linked to alcohol use.

The purpose of this study is to assess adverse events and change in disease activity when telisotuzumab adizutecan is given in combination with a fixed dose of osimertinib (Osi), Osi alone, or standard of care (SOC) alone.

The purpose of this study is to evaluate the overall survival (length of time from the start of study to date of death from any cause) for pasritamig (JNJ-78278343) in combination with best supportive care (BSC) as compared to placebo with BSC in participants with metastatic castration-resistant prostate cancer (mCRPC; a stage of cancer that has spread beyond the prostate gland and is no longer re...

Researchers are looking for adults with Alcohol Use Disorder (AUD) to learn how a type of brain stimulation called low-intensity focused ultrasound (LIFU) affects the brain and behavior.

This study will check how well a new medicine, GSK5764227, works, how safe it is and how the body handles it in participants all around the world with advanced inoperable or metastatic gastrointestinal cancer who have previously received treatment.

This study is comparing two commonly used minimally invasive treatments for gluteal tendinosis (GT) to learn how well they reduce pain and improve movement.

In this study we want to learn how babies are affected when their mothers have a viral infection during pregnancy. To do this, we will collect blood samples from pregnant women who have viral infections (like COVID-19) and those who do not.

This study aims to investigate the combination of BNT324, a B7-H3 antibody-drug conjugate (ADC) with BNT327, a programmed death-ligand 1 (PD-L1) and vascular endothelial growth factor (VEGF) bispecific antibody, in participants with advanced/metastatic or relapsed/progressive small cell lung cancer (SCLC) and non small cell lung cancer (NSCLC).

This study wants to learn how treating Hepatitis C during pregnancy affects the health of pregnant women and their babies.

PRIMARY OBJECTIVE: I. To compare metastasis-free survival, determined using conventional imaging, between men with high-risk prostate cancer randomized to ultrahypofractionation (stereotactic body radiation therapy SBRT) to those randomized to moderate hypofractionation and conventional fractionation.

A first in human study to evaluate the safety and preliminary antitumor activity of BBO-8520, a KRAS G12C (ON and OFF) inhibitor, as a single agent and in combination with pembrolizumab in subjects with locally advanced and unresectable or metastatic non-small cell lung cancer with a KRAS (Kirsten rat sarcoma) G12C mutation.

This is a 3-part study. The purpose of Part 1 of the study is to evaluate the efficacy, safety, and pharmacokinetic (PK) characteristics of safusidenib in participants with recurrent/progressive IDH1-mutant World Health Organization (WHO) Grade 2 or Grade 3 glioma. The purpose of Part 2 will be to evaluate the efficacy of maintenance safusidenib treatment versus placebo in IDH1-mutant Grade 2 o...

This research study wants to learn how well and safe the Cryosa system works in people with obstructive sleep apnea (OSA). The Cryosa system is a device used to freeze the base of the tongue and soft palate which reduces the amount of fat in those areas and may improve OSA symptoms.

To compare bone health near the knee, muscle quality, movement patterns, and physical function between adults with knee osteoarthritis and adults without knee osteoarthritis, and to examine whether an exercise program improves these outcomes in adults with knee osteoarthritis.

This study aims to evaluate the safety and tolerability of RO7673396 in participants with advanced solid tumors harboring RAS mutation(s). This study consists of two stages: Stage 1 (Dose Escalation) and Stage 2 (Dose Expansion). Stage 1 will define the recommended dose(s) for expansion (RDEs) of RO7673396. Stage 2 will evaluate preliminary anti-tumor activity of the RDE(s) defined in Stage 1 and ...

PRIMARY OBJECTIVE: To compare disease free survival (DFS) as assessed by the investigator for high-risk renal cell carcinoma patients treated with adjuvant pembrolizumab and tivozanib versus those receiving pembrolizumab alone.

To evaluate the efficacy of 2 dose levels of HBV-8000 compared to placebo by delaying the time to the first qualifying worsening event on the Movement Disorder Society-Unified Parkinson's Disease Rating Scale Part II, through week 48 of the double blinded treatment phase of the trial.

To evaluate the efficacy of IMA203 compared with control (investigator's choice)

The goals of this study are to learn: - If gocatamig alone, I-DXd alone, and gocatamig with I-DXd or durvalumab are safe and well tolerated - If people who receive gocatamig alone, I-DXd alone, and gocatamig with I-DXd or durvalumab have their SCLC get smaller or go away

This study wants to learn how changing the stiffness of a prosthetic foot affects how people with below-the-knee amputations move and do everyday tasks. We are looking for people who use either a bone-anchored prosthetic leg or a standard socket prosthetic leg to join!

This study wants to learn how difficult childhood experiences during might impact when certain people get multiple sclerosis (MS), how severe the disease is, and how much it impacts brain health. We hope that this study will help us better understand MS and find ways to improve care and support.

This is a Phase III, randomized, open-label, Sponsor-blinded, 3-arm, global, multicenter study assessing the efficacy and safety of rilvegostomig in combination with fluoropyrimidine and T-DXd (Arm A) compared to trastuzumab, chemotherapy, and pembrolizumab (Arm B) in HER2-positive locally advanced or metastatic gastric or GEJ adenocarcinoma participants whose tumors express PD L1 CPS>=1. Rilvegos...

In this study we are testing a new drug called teplizumab to see if it can help protect the cells that make insulin in people with type 1 diabetes. We want to know if it can improve blood sugar levels, reduce the need for extra insulin, and lower the risk of low blood sugar.

To assess the pharmacodynamic and clinical efficacy of CNP-103

Overall Survival (OS) Time Frame: Up to approximately 36 months Progression free survival (PFS) Time Frame: Up to approximately 36 months

This study will test a new investigational drug called NBI-1065845 to see if it helps improve symptoms of depression when taken with your current antidepressants. The study team will compare this drug with a placebo, a treatment with no medicine.

This study will look at whether getting a second dose of RSVpreF (Abrysvo®) vaccine during another pregnancy is safe and can help your body make antibodies that may protect your baby from Respiratory Syncytial Virus (RSV). We will also check to see if you still have antibodies from the dose you got during your previous pregnancy.

This phase III trial compares the effect of olaparib for one year versus two years, with or without bevacizumab, for the treatment of BRCA 1/2 mutated or homologous recombination deficient stage III or IV ovarian cancer. Olaparib is a polyadenosine 5'-diphosphoribose polymerase (PARP) enzyme inhibitor and may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Be...

The primary objective of this 3-arm clinical trial is to compare progression-free survival (PFS) of LNS8801 + pembrolizumab arm vs Physicians’ Choice (PC) treatment using RECIST 1.1.

This is a Phase 1/1b open-label, multi-center dose escalation and dose optimization study designed to evaluate the safety and preliminary efficacy of IAM1363 in participants with advanced cancers that harbor HER2 alterations.

This phase I trial tests the safety, best dose, and effectiveness of ZEN003694 in combination with cetuximab and encorafenib in treating patients with colorectal cancer that has not responded to previous treatment (refractory), that has come back after a period of improvement (relapsed), and that has spread from where it first started (primary site) to other places in the body (metastatic). ZEN003...

This study is looking at whether hormone therapy can help reduce hot flashes and night sweats in women living with HIV who are going through menopause or who recently finished menopause.

This is a Phase 1/2, open-label study designed to evaluate the safety and efficacy of CABA-201 in patients with active IIM or JIIM and to identify an appropriate dose for future studies.

This study wants to learn more about heart and brain health of people with and without endometriosis.

Dose Escalation: To evaluate the safety and tolerability of peposertib in combination with low-dose liposomal doxorubicin as evaluated by the dose-limiting toxicity (DLT) rate at each tested dose level. Dose Escalation: To determine the recommended phase 2 dose (RP2D) of liposomal doxorubicin and peposertib combination and determine the maximal tolerated dose (MTD) if identified. Dose Ex...

This study intends to evaluate the safety and efficacy of ficerafusp alfa in combination with pembrolizumab versus placebo with pembrolizumab in 1L PD-L1-positive, recurrent or metastatic Head and Neck Squamous Cell Carcinoma (HNSCC).

Non small cell lung carcinoma (NSCLC) is the most frequently occurring histologic subtype of lung cancer and is the leading cause of cancer-related deaths worldwide. The purpose of this study is to assess adverse events and change in disease activity when Telisotuzumab Adizutecan (ABBV-400) is given in combination with a programmed cell death receptor 1 (PD1) inhibitor (budigalimab) to adult parti...

In this study, we aim to learn how oral health may differ in children who require long-term breathing support compared to those who do not.

The goal of this research study is to learn more about how pain is related to alcohol use and mental health across different stages of adulthood.

Determine the efficacy of treatment with weekly doxorubicin chemotherapy in anthracycline-naïve elderly patients with advanced or metastatic LMS of soft tissue.

In this study we want to learn how well a cream called Ruxolitinib works to treat vitiligo on the face and body of children between 2 and 12 years old.

Primary Objective: 1) To assess the relationship of polymorphisms in IL-6 and/or IL-6R genes to the development of irAEs in ICI-treated cancer patients. Secondary Objective: 1) To determine whether polymorphisms in IL-6 and/or IL-6R genes affect the production of IL-6 and sIL-6R by CD4 cells before and after ICI treatment. Exploratory Objectives: 1) To evaluate whether polymorphisms in IL-...

Are you a charming, aggressive, carefree person who makes up their own rules and is good at handling people while looking out for number one? If so, you could be selected to participant in a brain research study.

-To determine the MTD/maximum administered dose and RP2DS of ADCE-D01. -To assess the safety and tolerability of ADCE-D01.

We are looking for healthy people to help us learn how gently stimulating the vagus nerve through the ear affects thinking skills like decision-making and problem-solving.

This study plans to learn more about how a telehealth exercise program designed for rural survivors of cancer can help improve cancer related fatigue.

Researchers are testing a drug called IMVT-1402 to see if it is safe and if it helps people with skin lupus (a type called subacute or chronic cutaneous lupus) with or without lupus that affects the whole body.

The purpose of this study is to compare how long the participants are disease-free (progression-free survival) and and the length of time until a participant dies (overall survival), when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, and irinotecan hydrochloride (FOLFIRI) versus either cetuximab or bevacizumab and FOLFIRI given ...

This study wants to see if avacopan is safe and works well for people with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. We also want to find out if it helps prevent the disease from coming back.

• To evaluate the safety and tolerability of DCC-3009 as monotherapy in participants with advanced GIST. • To determine the recommended dose(s) for expansion in Module A, and if reached, the maximum tolerated dose (MTD) of DCC-3009 as monotherapy.

We are doing this study to see if a medicine called anifrolumab is safe to use in adults with systemic sclerosis. We also want to find out if the medicine helps with disease symptoms and if it stops the disease from getting worse.

This study will compare how well pramipexole and escitalopram help treat depression in people living with HIV.

We want to learn how nightmares from trauma or posttraumatic stress disorder (PTSD) affect heart and artery health in women. We also want to see if a treatment called NightWare, which is used on a smartwatch, can help women with these nightmares sleep better and improve their heart and artery health.

The purpose of this study is to determine the putative recommended phase 2 dose(s) (RP2Ds) of JNJ-89402638 and to determine the safety of JNJ-89402638 at the RP2D(s) in participants with metastatic colorectal cancer.

Researchers want to learn if patritumab deruxtecan (MK-1022) can treat certain gastrointestinal (GI) cancers. The GI cancers being studied are advanced (the cancer has spread to other parts of the body). The goals of this study are to learn: About the safety and how well people tolerate of patritumab deruxtecan How many people have the cancer respond (get smaller or go away) to treatment

This study wants to learn more about how the food we eat affects the reproductive hormones of adult women with obesity.

We are looking for couples who drink and are 18 years or older to join a study looking at alcohol use among romantic couples.

We are looking for couples, 21 or older, to join a study about how alcohol and media affect relationships.

Determine the safety and toxicity of losartan in combination with SBRT and subsequently pembrolizumab in patients with locally recurrent, refractory, or oligometastatic head and neck squamous cell carcinoma (HNSCC).

This registry wants to learn whether taking Vumerity (Diroximel Fumarate) during pregnancy impacts the health of pregnant women with MS or their babies. We will compare the health of women who took Vumerity during pregnancy with the health of women who took other MS medicines or no MS medicine during pregnancy.

This study wants to find out if people with certain types of early-stage endometrial cancers need less treatment than usual, like less radiation and chemotherapy. We also want to see if less treatment works well and keeps your cancer from coming back.

In this study, we want to learn more about inflammation and the immune system in people with Down syndrome. We are testing whether a study drug called tofacitinib can help lower inflammation and improve health and development in children and young adults with Down syndrome.

This study wants to learn how age and sex affect how our blood vessels age and how exercise (both short-term and long-term) changes the body.

The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON) inhibitors combined with Standard(s) of Care (SOC) or with novel agents. The first three subprotocols include the following: Subprotocol A: RMC-6236 + 5-fluorouracil-based regimens Subprotocol B: RMC-6236 + cetuximab with or without mFOLFOX...

Researchers want to learn if sacituzumab tirumotecan (MK-2870) alone or with chemotherapy can treat certain gastrointestinal (GI) cancers. The GI cancers being studied are either advanced (the cancer has spread to other parts of the body), or unresectable (the cancer cannot be removed with surgery). The goals of this study are to learn: About the safety and how well people tolerate sacituzumab ...

We are looking for adults to join a national study to help us learn more about how rheumatoid arthritis (RA) develops.

This study wants to learn more about people who get a treatment called Genicular Artery Embolization (GAE). GAE is a procedure to help adults with long-term knee pain feel better. This study will look at changes in the fluid in your knee, pictures of your knee (MRI), and how well you move before and after the treatment.

We are studying how a type of chemotherapy called doxorubicin affects the heart and arteries. We are looking for lymphoma survivors and healthy adults to join this study.

This study looks at how choline supplements and exposure to cannabis-based products affect pregnancy and child health.

I. Establish a prospective cohort of individuals with Lynch syndrome II. Collect standardized longitudinal clinical and biosample data to elucidate Lynch Syndrome epidemiology and gene-host interactions III. Promote intervention trials to improve cancer prevention and early detection in Lynch Syndrome

To determine the sensitivity and specificity of the mt-sDNA 2.0 test, for colorectal neoplasia in patients with Lynch Syndrome

This phase II/III trial examines whether patients who have undergone surgical removal of bladder, but require an additional treatment called immunotherapy to help prevent their bladder cancer from coming back, can be identified by a blood test. Many types of tumors tend to lose cells or release different types of cellular products including their DNA which is referred to as circulating tumor DNA (...

To evaluate the long-term safety through 15 years post infusion of patients who received IP in a Caribou-sponsored study, special access program or ITT

In this study, we want to learn if eating meals together as a family can help improve your child’s health, and the health of other family members too!

We are looking for children and teens aged 10 to 18 who have bothersome tinnitus, such as ringing or other sounds in their ears. This study will test a virtual reality program that can be used at home. This program teaches skills that may help you or your child manage tinnitus, stress, and emotions.

The main goal of this study is to find out if one dose of psilocybin (a drug from certain mushrooms) and talk therapy can help people feel less scared about their cancer returning. We also want to make sure this treatment is safe.

This phase III trial compares the addition of an immunotherapy drug (durvalumab) to usual chemotherapy versus usual chemotherapy alone in treating patients with MammaPrint Ultrahigh (MP2) stage II-III hormone receptor positive, HER2 negative breast cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the a...

This study wants to collect health and growth information about children with hypochondroplasia. This information will help us understand their basic health and see if they can join future studies about hypochondroplasia.

This study wants to learn more about whether a drug called sotagliflozin (SOTA) can slow down the loss of kidney function in people with type 1 diabetes and diabetic kidney disease.

We are studying adolescents who may be at higher risk of getting type 2 diabetes, as they go through puberty. Our goal is to identify early signs that might help predict who will develop the disease.

This Phase III Trial will determine whether adjuvant chemotherapy (ACT) added to ovarian function suppression (OFS) plus endocrine therapy (ET) is superior to OFS plus ET in improving invasive breast cancer-free survival (IBCFS) among premenopausal, early- stage breast cancer (EBC) patients with estrogen receptor (ER)-positive, HER2-negative tumors and 21-gene recurrence score (RS) between 16-25 (...

The objective of the proposed trial is to show that the association - carboplatin with the SonoCloud-9 - will increase efficacy of the drug in patients with recurrent glioblastoma.

This study wants to learn how early changes in airway cells may help predict who is at risk for developing Chronic Obstructive Pulmonary Disease (COPD). We are looking for people who are current smokers with or without COPD.

This phase III trial compares hepatic arterial infusion (HAI) (pump chemotherapy) in addition to standard of care chemotherapy versus standard of care chemotherapy alone in treating patients with colorectal cancer that has spread to the liver (liver metastases) and cannot be removed by surgery (unresectable). HAI uses a catheter to carry a tumor-killing chemotherapy drug called floxuridine directl...

This phase II trial tests how well carboplatin before surgery works in treating patients with high-risk prostate cancer and an inherited BRCA1 or BRCA2 gene mutation. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping, or slowi...

This study is open to adults with different types of advanced cancer (solid tumors) that are accessible for injection and/or biopsy. This is a study for people with a life expectancy of at least 3 months after starting study treatment. The purpose of this study is to find the highest dose of a medicine called BI 1831169 that people with advanced cancer can tolerate when taken with or without a typ...

This clinical trial is studying advanced solid tumors. Solid tumors are cancers that start in a part of your body like your lungs or liver instead of your blood. Once tumors have grown bigger in one place but haven't spread, they're called locally advanced. If your cancer has spread to other parts of your body, it's called metastatic. When a cancer has gotten so big it can't easily be removed or h...

We want to see how well over-the-counter (OTC) hearing aids work when fitted in different ways like self-fit, online self-fit, or fit by a hearing healthcare provider, compared to prescription hearing aids.

BL-B01D1-LUNG-101 is a global, multi-center, Phase 1 study to evaluate the safety, tolerability, pharmacokinetics , and initial efficacy of BL-B01D1 in participants with metastatic or unresectable NSCLC and Other Solid Tumors. This study will be conducted in two different dosing schedules (Cohort A and Cohort B) and three parts (dose escalation, dose finding and dose expansion). Cohort A will b...

This phase II trial compares the effect of retreatment with 177Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) to the usual approach of treatment with everolimus in patients who have previously received 177Lu-DOTATATE for midgut neuroendocrine tumor (NET) that has spread from where it first started (primary site) to other places in the body (metastatic) and that cannot be removed by surge...

Patients will be registered prior to, during or at the completion of neoadjuvant chemotherapy (Paclitaxel 175 mg/m2 IV over 3 hours and Carboplatin AUC 6 IV on Day 1 every 21 days for 3-4 cycles). Registered patients who progress during neoadjuvant chemotherapy will not be eligible for iCRS and will be removed from the study. Following completion of neoadjuvant chemotherapy, interval cytoreduct...

This study wants to see how blood sugar changes with sex hormones during regular menstrual cycles or when using hormonal birth control. We also want to learn how exercise and hormonal birth control affect blood sugar.

The goals of this study are to refine the implementation and pilot test the feasibility of an adapted cognitive behavioral therapy (CBT), the Balanced and Empowered EaTing in Diabetes (or the BEET Diabetes Program), compared with the original CBT program, delivered by behavioral health providers to treat disordered eating behaviors (DEBs) in patients with type 2 diabetes in real-world clinical set...

In this study, we want to better understand how the environment and things that happen early in children’s lives—even before they are born—affect their development, health, and well-being.

Specific Aims. 1. Determine whether hemp-derived CBD alters cannabis cue-related neural response. A subsample of 52 participants will be recruited from the larger Project 1 (“emerging adult”) randomized controlled trial comparing 400mg/day hemp-derived CBD to placebo. We will conduct a functional MRI scan at enrollment and after 8 weeks in the trial. During the scan, we will conduct a cue-reacti...

This is a first-in-human phase I/II study to examine the safety, tolerability and preliminary efficacy of VLS-1488 in subjects with advanced cancers.

The purpose of the study is to determine the recommended regimen for Phase 2 (RP2Rs) of combination of JNJ-87189401 with JNJ-78278343 (Part 1: dose escalation) and further evaluate the safety at RP2Rs (Part 2: dose expansion) in participants with advanced prostate cancer.

This study will look at two ways to prevent heart and blood vessel problems. It will test which treatment works better for people who may have hidden artery disease because of conditions like diabetes or metabolic syndrome. One way uses your risk factors, and the other way uses pictures of your heart arteries to guide care.

This study wants to find better treatments for people with autoimmune diseases like rheumatoid arthritis (RA). By studying the different types of cells found in people with RA, researchers can learn more about how RA damages joints.

We want to learn more about how safe Sogroya (somapacitan) is and how well it works for people with growth hormone deficiency. To join, you must already be taking or be planning to take Sogroya.

We want to learn how estrogen levels during menopause might affect artery health, body fat, and risk of heart disease in women with regular periods.

The phase III trial compares the effect of pembrolizumab to observation for the treatment of patients with early-stage triple-negative breast cancer who achieved a pathologic complete response after preoperative chemotherapy in combination with pembrolizumab. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with...

This study wants to learn how well and safe dapagliflozin works in people who had a kidney transplant and have Type 2 or post-transplant diabetes. We will look at how dapagliflozin affects the function of your kidney, heart, and blood vessels. We are studying the effects/impact of dapagliflozin (a SGLT2 inhibitor) on: - Kidney function - Protein in the urine - Blood vessel function - Heart f...

This phase 3 study will evaluate the superiority of the fixed dose combination (FDC) of fianlimab + cemiplimab versus the FDC of relatlimab + nivolumab (referred to as Opdualag™) in participants with unresectable locally advanced or metastatic melanoma.

This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection. Collecting and storing samples of blood and tissue from patients with and without cancer to study in the laboratory may help researchers develop tests for the early detection of cancers.

The purpose of this research study is to learn more about how cannabidiol (CBD) may affect cannabis use, effects, and craving.

This study wants to learn more about how the right side of the heart works in people with chronic obstructive pulmonary disease (COPD). We want to see how the heart responds to high blood pressure in the lungs, both while resting and during exercise. The goal is to find patterns that could lead to better treatments for people with COPD.

This study wants to learn how losing weight affects cell communication in muscle fat tissue among people with obesity. We also want to see how this impacts insulin resistance, inflammation, and muscle strength.

Evaluate the efficacy of the neoadjuvant Pembrolizumab and Axitinib in reducing the inferior vena cava tumor thrombus (IVC TT) among patients with renal cell carcinoma

This is a first-in-human study to learn more about the investigational drug STX-478. The study will have 3 parts.

This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine in participants with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma, and urothelial carcinoma based on Acrivon's OncoSignature® test status.

This study wants to learn more about how exposures during pregnancy like infections, diet and growth, can affect a baby’s chances of developing type 1 diabetes later in life.

To develop a program that will help reduce distress in patients with metastatic colorectal cancer and their partners/spouses.

The primary study objective is to compare the clinical outcomes of patients treated with an interventional strategy using the ClotTriever System to achieve and maintain vessel patency (ClotTriever Intervention Arm) versus conservative medical management using anticoagulation therapy alone (Conservative Medical Management Arm) in the treatment of symptomatic unilateral iliofemoral DVT

This study plans to learn more about the safety and effectiveness of TTI-101 when given either alone or in combination treatment using continuous or intermittent TTI-101 dosing, and to see if it will help in the treatment of liver cancer. Continuous dosing of TTI-101 means you will take your TTI-101 dose(s) every day. Intermittent dosing of TTI-101 means you will take a TTI-101 dose on a schedule....

1. Evaluate the effects of consumption of an oral high (20 mg) vs. placebo (0 mg) THC (dronabinol) on brain activation associated with alcohol salience. 2. Test the effects of high THC vs placebo consumption on alcohol self-administration. 3. Test whether neural response under high THC vs placebo predicts differences in alcohol self-administration in the laboratory or alcohol and cannabis...

This study will test if one dose of psilocybin, given with talk therapy, can safely help people with advanced cancer feel less anxious, less depressed, and improve quality of life. We will compare it to a placebo (inactive medicine) called niacin given with the same kind of talk therapy.

This study wants to see if gut problems are worse in HIV+ men that have sex with men that have metabolic syndrome compared those without metabolic syndrome.

We want to find better ways to treat bipolar disorders. We are looking for children, teens, and young adults, aged 9 to 21 years old, to join our study.

We want to learn more about the diseases that cause nephrotic syndrome. This is a group of symptoms that happen when the kidneys don't work the right way. We will collect health information and lab samples to help us discover new things. We hope this will help doctors, researchers, and the public.

Study ICT-GCC19CART-US-001 (CARAPIA-1) is a Phase 1 study evaluating the safety, tolerability, clinical activity, pharmacokinetics and pharmacodynamics of GCC19CART in subjects with relapsed or refractory metastatic colorectal cancer. Primary 1. To evaluate the safety of GCC19CART in adult subjects with relapsed or refractory metastatic colorectal cancer 2. To obtain maximum tolerable dose (M...

This study will collect data from health records about people that have variations in their X & Y chromosomes to learn about their health. We also ask if people are willing to join future studies about X & Y variations.

This study wants to learn more about CXA-10, a naturally occurring compound in the body. Researchers will test whether CXA-10 is safe and if it helps people who have asthma and are also living with obesity.

We are looking for couples that have had two or more pregnancy losses with no known cause. We want to find out if genetics might be a reason for recurrent pregnancy loss (RPL).

This phase II/III trial compares the effect of adding durvalumab to chemotherapy versus chemotherapy alone before surgery in treating patients with upper urinary tract cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as methotrexat...

The purpose of this study is to assess the safety and efficacy of pembrolizumab (MK-3475) combination therapy in participants with metastatic castration resistant prostate cancer (mCRPC). There will be ten cohorts in this study: Cohort A will receive pembrolizumab + olaparib, Cohort B will receive pembrolizumab + docetaxel + prednisone, Cohort C will receive pembrolizumab + enzalutamide, Cohort D ...

This study wants to learn how having too much acid in the blood after a kidney transplant affects your body. Researchers will look at how acid levels may impact the health of your blood vessels and your new kidney.

This study wants to learn more about how COVID-19 and diabetes are connected.

We are looking for healthy adults who can safely have an MRI scan. This study looks at how drinking and not drinking alcohol affects how the brain works.

We are recruiting individuals with type 2 diabetes (T2D) in need of an exercise program, aged 30 to 55, to help us test how exercise affects heart health, blood vessels, and blood sugar.

Preserving endothelial function with pulsatility during CPB will be associated with less AKI after cardiac surgery.

This study looks at whether men with prostate cancer improve their metabolism more with lifestyle changes alone or with lifestyle changes plus metformin.

This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study m...

This phase I/II trial studies the safety, side effects and best dose of M3814 and to see how well it works when given together with radiation therapy in treating patients with pancreatic cancer that has spread to nearby tissue or lymph nodes (locally advanced). M3814 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hypofractionated radiation therapy delive...

A study to investigate the efficacy and safety of the lifileucel (LN-144, autologous tumor-infiltrating lymphocytes TIL) regimen plus pembrolizumab infusions compared with pembrolizumab infusions alone in participants with untreated, unresectable or metastatic melanoma

This study wants to collect medical information from people with Turner Syndrome at clinics across the country to learn more about the condition. We are gathering this data in a national registry to help improve the health and care for people with Turner Syndrome in the future.

This study wants to learn how a type of fat in the blood, called triglycerides, affects how the fetus grows.

This study wants to find out if taking oral cannabis (marijuana) with THC or THC and CBD can help adults lower long-term back or neck pain.

We are looking for healthy people that are not currently taking drugs that slow down the clotting process (anticoagulants like Warfarin) or stop platelets from sticking together (antiplatelets like aspirin) to join our study. We want to learn more about how your blood composition affects the formation of blood clots and how individuals respond to common drugs.

The FLEX Registry will be implemented to operate as a large-scale, population based, prospective registry. All patients with stage I to III breast cancer who receive MammaPrint® and BluePrint testing on a primary breast tumor are eligible for entry into the FLEX Registry, which is intended to enable additional study arms at low incremental effort and cost. FLEX Registry will utilize an adaptive de...

If your doctor has told you that you have diabetes, but it doesn’t seem like type 1 or type 2, you might be able to join our study. The goal of this study is to better understand different kinds of diabetes that are not common.

To determine if trastuzumab emtansine (ado-trastuzumab emtansine T-DM1) shows better progression-free survival (PFS) when compared to docetaxel plus trastuzumab (TH) in recurrent and/or metastatic (R/M) HER2-positive salivary gland cancer (SGC) patients who have not previously received HER2 therapy for unresectable or recurrent and/or metastatic disease, as determined by local assessment.

Our study is seeking individuals aged 55-85, who have been diagnosed with Mild Cognitive Impairment (MCI) and are at risk for Alzheimer's Disease. The goal of the study is to see whether cannabidiol (CBD) can improve MCI symptoms.

This study wants to find a new combination of drugs that is safe and effective to treat people who have bone cancer that has come back or not responded to other treatments.

This study wants to learn about the best way to take pictures of unborn babies' hearts to better identify certain heart health problems.

This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Addition of prostate removal surgery or radiation therapy to standard systemic therapy for prostate cancer may lower the chance of the cancer growing or s...

This study plans to learn more about how different adipose tissues are related to diabetes and muscle mass and strength, as well as how to non-invasively track liver disease in those undergoing elective abdominal surgeries.

This study is looking at whether a type of special antibody called broadly neutralizing antibodies (bNAbs) is safe to use along with antiretroviral therapy (ART) in people who have been recently diagnosed with HIV. We also want to find out if these antibodies help control HIV better after people stop their regular medicine (ART), compared to those who didn’t get the antibodies.

In this study, we want to learn about the effects of physical activity on the health of teenagers. We will compare the physical, mental, and emotional health of teens who take part in physical activities with those who do not during a fall semester (10–14 weeks).

This study wants to learn more about how a drug called L-citrulline affects lung function and asthma control in people with deployment-related asthma.

We are looking for people aged 25 to 55 who smoke and/or vape cannabis, and people aged 25 to 55 who do not smoke cannabis, to see how cannabis use affects lung health over time.

This study wants to better understand Down syndrome and related health problems by comparing blood and saliva samples from people with and without Down syndrome. Right now, we are mainly looking for people who do not have Down syndrome but do have chronic constipation to join our study.

We are looking for people aged 30 to 50 who are daily users of e-cigarettes (e-cigs) as well as healthy controls to see how vaping nicotine affects lung or general health.

In this study we want to find out how the body’s immune system reacts to nuts and other foods and causes allergies. We also want to check how well a new test works that may help predict allergic reactions to peanuts

We are looking for asthmatics and non-asthmatics between 18-65 years old to participate in a study that will look at how cells in the lungs are different between populations.

This study will create a list of patients with inflamed kidneys to help with future research. It will also collect and safely store data and samples like blood, urine, stool, cells, and kidney tissue for later studies.

A comparison of baseline tumor characteristics in oncogene-driven cancers to tumor characteristics after early response to TKI targeted treatment will allow identification of early adaptive mechanisms of cell survival. This will facilitate targeting and termination of these survival/ resistance pathways before they develop with rational combinations of therapeutic agents to improve outcomes.

The overall objective of this study is to ultimately develop an improved standard of cancer care by facilitating new clinical trials, new technology, new informatics solutions and "personalized medicine".

The purpose of this research is to identify strategies that minimize bone loss that occurs when older adults lose weight

This study wants to look at how endocannabinoids are different in children with and without autism. We are only looking for children who do not have autism to join our study.

To measure distant recurrence free interval from end of treatment stratified by landmark (4-12 weeks post-treatment) and serial post-treatment ctDNA detection status (detected vs. not detected). The purpose of ORACLE is to demonstrate the ability of a novel ctDNA assay developed by Guardant Health to detect recurrence in individuals treated for early-stage solid tumors. It is necessary that ctD...

This study wants to find out how differences in our DNA might affect how birth control works in our bodies and which side effects they may experience.

The main purpose of the study is to assess whether the study drug, ERAS-0015, is safe and tolerable when administered to patients with advanced or metastatic solid tumors with certain RAS mutations. ERAS-0015 will be given alone or in combination with other treatments.

This study plans to learn more about pulmonary fibrosis, a disease that causes scarring in the lungs. We want to see if some forms of this disease are passed down through families by looking at genes that may play a role in pulmonary fibrosis. What we learn may help people with pulmonary fibrosis and their family members in the future.

This study wants to find out how cannabidiol (CBD) may affect cannabis use, the effects of cannabis, mood, and thinking in people that use cannabis regularly.

This research study wants to learn more about how estradiol patch treatment affects brain function, health and wellbeing in healthy women who have experienced menopause.

This study wants to know how well the study drug, remibrutinib, works and how safe it is compared to placebo in people with secondary progressive multiple sclerosis (SPMS).

This observational study is to learn more about the safety, effectiveness, and treatment experience of patients prescribed BRIUMVI® (ublituximab-xiiy).

The purpose of this study is to learn if improving sleep habits and sleep timing can help improve blood sugar and heart health in teens who do not get enough sleep.

This study wants to learn how adults with Down syndrome (DS) respond to everyday stress compared with adults without DS of the same sex and age. This study will look at changes in heart rate, blood pressure, and other body responses during stress.

This study will look at whether a medication called alendronate can reduce the amount of hidden HIV (called the HIV reservoir) in people living with HIV. Alendronate is a medication used to strengthen bones.

This study is testing a new drug called mRNA-4359, given alone or with pembrolizumab. We want to learn how safe these drugs are and find the best dose for people with cancer that has spread, returned, or is hard to treat.

This study wants to see if a new treatment called rapcabtagene autoleucel (YTB323) is safe and works well for people with severe Granulomatosis with Polyangiitis (GPA) or Microscopic Polyangiitis (MPA) vasculitis compared to Rituximab.

The main goal of this study is to see how a new treatment (brentuximab vedotin and nivolumab, called Bv-NIVO) compares to the usual treatment for people who were just diagnosed with early-stage (Stage I or II) Hodgkin lymphoma (HL). We want to find out which treatment works better.

The purpose of this study is to learn about the safety of FOG-001, find the best dose, and see how it affects the body. Researchers will also study how well it works in treating advanced or metastatic cancer when used alone or with other cancer treatments.

The purpose of this study is to find out whether the study drug IDRX-42 can help your gastrointestinal stromal tumor (GIST) compared with another drug called sunitinib.

The purpose of this study is to learn how well relacorilant works and how safe it is when used with other treatments for gynecological cancers, such as ovarian and endometrial cancer.

In this study, we want to learn whether a new vaccine (PG4) is safe and helps protect kids against pneumococcal disease. We will compare a single dose of PG4 with a single dose of the currently available pneumococcal vaccine to see the level of protection provided and how the body responds to each vaccine.

The purpose of the study is to evaluate the progression-free survival (PFS) of casdatifan versus placebo when each is given in combination with cabozantinib in adult patients with confirmed advanced or metastatic clear cell Renal Cell Carcinoma who have experienced progression on or after prior anti-PD-1 or anti-PD-L1 immunotherapy.

This study wants to learn more about a strength training program in veterans with Multiple Sclerosis (MS) who use a mobility aid.

This study will look at whether a one-time session can help you prepare for delivery, reduce concerns about giving birth, and improve perinatal mood, anxiety, and trauma symptoms (PMATS).

This study wants to find out how the body responds when the birth control implant, Nexplanon, is placed over the shoulder bone instead of in the arm.

In this study, we want to learn how safe a new pneumococcal vaccine is and how well it works to protect infants against pneumococcal disease. We will compare the new vaccine with the pneumococcal vaccine currently used in children, Prevnar 20® (20vPnC).

The goal of this study is to learn more about inflammation and how well the kidneys and blood vessels work in young adults with type 2 diabetes (T2D).

In this study, we want to learn whether adding anifrolumab to standard treatment for people with polymyositis (PM) and dermatomyositis (DM) works better than standard treatment alone. We also want to learn more about how PM and DM affect the body.

Researchers are studying whether a treatment called ALLO329 CAR T cells is safe and works well for adults with autoimmune disease such as systemic lupus erythematosus (SLE), idiopathic inflammatory myopathy (IIM), and systemic sclerosis (SSc).

This study looks at the short and long term effects of psilocybin use and explores whether these effects are different for males and females.

The main goals of this study are to see how tiny blood vessels called capillaries in the brain communicate with small arteries to increase blood flow where the brain needs it, and to learn how this process may not work the right way in certain diseases.

This research study is testing whether the investigational drug OPT101 is safe and helpful for people with Type 1 Diabetes (T1D).

This study is comparing how well remibrutinib (Rhapsido) and dupilumab (Dupixent) work in adults with Chronic Spontaneous Urticaria (CSU).

This study aims to learn more about activity behavior in people with Functional Neurologic Disorder (FND). You will wear a device called an accelerometer and talk with the study team to help researchers learn how FND may affect your daily activities and experiences.

This is a first-in-human study to learn about the study drug called BG-C9074 alone and in combination with tislelizumab in participants with advanced solid tumors.

This study wants to learn more about how the anesthesia care you had at University of Colorado Health Hospital (UCHealth) may affect your health and quality of life in the future.

This study is looking for adults age 18 and older who are using or will be using the Okami Medical LOBO Vascular Occluder Device to treat their condition.

This intervention development and proof-of-concept study addresses the need for a developmentally tailored, flexible intervention that targets risk factors and features of children with SITBs. We will systematically and iteratively adapt and combine existing EBIs for children targeting emotion dysregulation and executive functioning for SITBs and evaluate feasibility and safety of SURE-Kids, as we...

In this study we want to compare how well two different drugs work to treat kids and young adults that have a narrow or stiff esophagus because of a health problem called eosinophilic esophagitis.

We will investigate the association between transfusion of fibrinogen-containing blood products and multi-organ dysfunction resulting from endotheliopathy of trauma (EOT). Fibrinogen is frequently acutely decreased in critically ill trauma patients. Early fibrinogen replacement may be the key to restoring the endothelial glycocalyx and preventing end-organ injury. However, few human data exist to ...

In this study, we want to learn more about how doctors use a special type of dialysis machine called CARPEDIEM to treat babies that have kidney problems. We want to collect medical information from babies who were treated with this machine to help improve care in the future.

The research is studying how easy it is to provide CAR-T cells to children who may have treatment at different hospitals. We are using CAR-T cells in this study because there is some evidence to believe it may work against cancers like yours.

This study wants to learn more about factors in the body (called biomarkers) that are linked to preventable vision loss and changes in the retina. We will use artificial intelligence (AI) to help find signs of health problems in the body, such as high blood pressure, diabetes, Parkinson’s disease, and Alzheimer’s disease.

This study wants to find out if a new treatment called Nexsphere-F can safely reduce knee pain in people with arthritis. It will also compare how well this treatment works compared to a standard steroid injection.

This study wants to see if an FDA-approved drug called Clemastine Fumarate and sound therapy can help improve hearing problems in noisy places that some people get as they age called age-related auditory processing disorder.

This study looks at whether a new product called Onyx LES is safe and works well when doctors use it to stop bleeding in blood vessels outside the brain and heart in adults that have arterial hemorrhage in the peripheral blood vessels.

To determine the maximum tolerated dose of temozolomide followed by selinexor in recurrent glioblastoma patients as determined by dose-limiting toxicities (DLTs) and the total toxicity profile. (Phase I) II. To evaluate the efficacy of sequentially administering temozolomide and selinexor in recurrent glioblastoma as determined by progression-free survival (PFS). (Phase 2)

Researchers are studying whether using pembrolizumab with radiation therapy can help people with muscle invasive bladder cancer avoid bladder removal surgery and have better quality of life.

This study wants to learn if 6 months of HER2-targeted treatment works as well as 12 months of HER2-targeted treatment for people with early stage HER2-positive breast cancer who had no cancer found at surgery after chemotherapy and trastuzumab. This study also wants to learn how the 2 treatment lengths affect quality of life.

In this study we want to learn more about how life experiences and everyday stress impact the physical and mental health of mothers during pregnancy and postpartum.

We want to learn how a new drug called brexpiprazole (BREX) affects alcohol use and brain function in adults who are not currently getting treatment for Alcohol Use Disorder.

This study wants to find out if adding a chemotherapy drug called paclitaxel directly into the abdomen, along with chemotherapy given through a vein, can help slow or stop gastric cancer. This study also wants to learn if this treatment can help people live longer. This study will compare this approach to the usual treatment people get for gastric cancer.

This study wants to find out how cannabis affects driving in older adults. This study also wants to learn whether how older adults think and how often they use cannabis may affect driving after using cannabis.

This study wants to find out how well the drug tebentafusp works for people with metastatic uveal melanoma who have a genetic marker called HLA-A*0201. The study will also measure tumor DNA in the blood, called W10 ctDNA, to see how the cancer responds to treatment.

In this study we want to learn about how safe and how well a treatment called Fetoscopic Endoluminal Tracheal Occlusion works to treat babies that have a condition called right and left Congenital Diaphragmatic Hernia.

This study wants to learn how safe the study drug V940 is when given with pembrolizumab and how well this treatment works in people with non-small cell lung cancer after surgery.

This study wants to learn if a short, high-intensity exercise program can be done safely at home and if this exercise may affect sleep in people with Parkinson's Disease.

In this study we are testing how two drugs, Thymoglobulin ® and verapamil, work together to treat children and young adults with newly diagnosed type 1 diabetes.

This study wants to learn how well the investigational drug IFx-Hu2.0 works as an added treatment before giving pembrolizumab to people with advanced Merkel cell carcinoma.

This phase II trial tests how well biomarker tests on patients tumor tissue works in selecting personalized treatments for patients with extensive stage small cell lung cancer (ES-SCLC). Biomarker tests look for certain features in cancer cells that may give doctors more information about what is driving cancer and how to treat it. Based on the biomarker test results, study doctors can determine t...

This study wants to find out if adding radiation therapy to your tumor, along with your regular immune therapy, can help keep your cancer from growing or even make it shrink, compared to using immune therapy alone in people with metastatic kidney cancer who cannot have surgery.

This study wants to learn how genes in your lymphoma are linked to your symptoms and how you respond to treatment. We hope that by understanding these genetic differences, we can learn how to choose better treatments for lymphoma in the future.

In this study we want to collect baseline data on how well treatment works for kids and adults with pulmonary arteriovenous malformations.

This study wants to learn if a new drug called atacicept can help protect the kidneys and reduce kidney damage in people with multiple autoimmune kidney diseases.

This study wants to find a dose of ziftomenib that people with advanced gastrointestinal stromal tumors (CIST) can handle safely when taken with imatinib. We also want to learn how well these two drugs work together.

This study wants to learn how equol, a supplement made from soy, affects blood vessel health in postmenopausal women with chronic kidney disease (CKD). This study wants to see if taking equol for 12 weeks can help blood vessels work better.

In this study we want to learn how a device that automates insulin delivery (called the iLet Bionic Pancreas) helps people with Cystic Fibrosis Related Diabetes manage their insulin levels. We want to learn how well this device works compared to a normal insulin delivery method.

In this study we want to learn if a drug called ravulizumab is a safe and effective treatment for children and teens that have both Immunoglobulin A Vasculitis Nephritis (IgAVN) and Immunoglobulin A Nephritis (IgAN).

This study is being done to test new treatments for people with newly diagnosed glioblastoma (GBM), a type of brain cancer. The goal is to see if any of these new treatments help people live longer compared to the usual treatments. This study will compare the usual medicine (Temozolomide) used to treat newly diagnosed GBM to new drugs such as VT102, ADI-PEG20, Troriluzole, or AZD1390.

Researchers are trying to find new ways to help improve the mood of teenagers who have Type 2 diabetes (T2D).

In this study, we want to learn whether adding a new oral drug called Venetoclax to standard chemotherapy affects how long children and young adults with acute myeloid leukemia (AML) stay in remission and what side effects they experience.

This study wants to learn how late menopause affects women. This study wants to see whether diet education, lifestyle changes, and medication can help women feel healthier. We are looking for women ages 45 to 55 who are in late menopause to join.

This study wants to see if a case management program helps people with lung, head-and-neck, thyroid, breast, cervical, colon or rectum, or bladder cancers start and finish treatment sooner compared to usual care. We also want to find out if this program improves care and outcomes for people with these types of cancers.

This study wants to see if a new drug called SAB-142 in addition to regular insulin therapy can help slow down Type 1 Diabetes (T1D) in people who were diagnosed in the last 100 days.

We want to find out if using RP2 with nivolumab works better than using ipilimumab with nivolumab to help adults with eye cancer that has spread and cannot be removed by surgery live longer.

In this study, we want to learn how teens handle stress, deal with feelings of depression, and manage habits like eating, exercise, and sleep. We will use what we learn to make a Digital App that helps teens struggling with these challenges.

In this study we want to learn more about how common health problems like high blood pressure, vision problems, and kidney disease are in people with cystic fibrosis-related diabetes (CFRD).

In this study we want to learn if a new drug called vosoritide is safe and effective in helping kids with short stature and have been diagnosed with Turner syndrome, SHOX deficiency, or Noonan syndrome grow.

In this study we want to see if improving the amount and quality of sleep will help improve the overall health of adolescents that have type 1 diabetes (TID).

This study wants to find out if adding a chemotherapy drug to the usual hormone treatment for metastatic prostate cancer can help slow down or stop the cancer from growing or spreading. We also want to see if this new treatment works better or worse than the standard treatment doctor's use.

This study wants to learn more about what causes diabetic neuropathy. Diabetic neuropathy happens when nerves are damaged. We look for certain molecules in the blood and skin that may harm nerves. We compare these molecules in people with Type 2 Diabetes who have neuropathy, people with Type 2 Diabetes who do not have neuropathy, and people who do not have diabetes.

In this study we want to determine the best intervention for improving sleep quality in people recovering from a concussion. To do this we are comparing two sleep interventions and seeing how the impact the recovery time for a concussion.

The purpose of this research is to test the safety of an investigational NRTX-1001 cell therapy in participants with drug resistant bilateral mesial temporal lobe epilepsy (MTLE). Another purpose is to see if NRTX-1001 can reduce the number of seizures you have.

In this study we want to understand more about the causes of cystic fibrosis related diabetes (CFRD) and find better ways to treat it.

This study wants to learn more about spondyloarthritis, a type of arthritis that causes a lot of inflammation. We are looking for adults who have a parent, sibling, or child who has spondyloarthritis or a similar health problem to join our study.

The goal of this study is to find out if a combination of chemotherapy drugs is safe and works in adults with pancreatic cancer that has spread inside the abdomen. This study will test whether giving one drug, called paclitaxel, directly into the abdomen through a small tube (catheter) and giving another set of drugs, called NALIRIFOX, into a vein can help control the cancer. 

This is a Phase 1b, open-label, multicenter, safety, tolerability and efficacy study of HC-7366 in combination with belzutifan (WELIREG™). This is a multipart study that consists of a HC-7366 monotherapy cohort, a combination dose escalation, and a combination dose expansion. Approximately 80 patients will be enrolled in this study (up to 20 patients will be enrolled into the HC-7366 monotherapy c...

This study wants to learn more about how blood sugar levels in healthy children without chronic disease compare to the blood sugar levels of children with Cystic Fibrosis (CF). We are only recruiting children without chronic disease to join the study.

This study will test if one shot of a medicine called RE104, given in different amounts, can safely help with cancer or other illnesses who are having trouble coping and adjusting.

To learn more about patients who use artificial intelligence (AI) to understand more about their brain tumor diagnosis and their brain tumor doctor.

This study will test a new drug called IMVT-1402 to see if it works and is safe compared to a placebo (a treatment with no medicine) in adults with Graves' Disease. Graves' Disease makes the thyroid gland overactive. We want to see if IMVT-1402 can help people reach normal thyroid hormone levels and possibly stop taking their regular thyroid medicine. The study will compare how well IMVT-1402 work...

In this study we want to learn more about how the body responds to giving birth for cesarean deliveries.

The purpose of this study is to determine safety and preliminary efficacy of amivantamab monotherapy, amivantamab in addition to pembrolizumab, and amivantamab in addition to paclitaxel in participants with recurrent/metastatic head and neck cancer. The study will also confirm the recommended Phase 2 combination dose (RP2CD) for amivantamab in addition to paclitaxel

This study is testing a new injectable medication called anifrolumab to see how safe and effective it is for adults with chronic cutaneous lupus erythematosus (CLE). Our goal is to find better treatments for people living with CLE.

In this study we want to learn more about a new treatment called CD19x22 CAR T cells. We want to see how well it works as a treatment for B-cell Acute Lymphoblastic Leukemia (B-ALL) when the cancer has come back after treatment or hasn’t responded to previous treatments.

In this study we want to learn more about the effects of the study drug, benralizumab, for treating children with eosinophilic granulomatosis with polyangiitis (EGPA).

To determine the effectiveness of belimumab and rituximab in treating primary membranous nephropathy

The main purpose of this study is to assess the efficacy and safety of volrustomig compared to observation in participants with unresected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) who have not progressed after receiving definitive concurrent chemoradiotherapy (cCRT)

In this study we want to learn more about achondroplasia and the genetic factors and health outcomes linked to it. To do this, we are collecting DNA (from saliva samples) from people who have achondroplasia and their family members.

This study wants to learn if taking a protein supplement drink twice a day for 8 weeks can help lower the amount of fat that is stored in the liver.

To investigate the efficacy of extended TARPEYO treatment in adults with IgAN.

We are looking for young people with bipolar disorder to join a study. The study will test if a special 16-week keto diet, along with regular mental health care, is safe and helpful. We want to see if it can improve mood and health. We are especially looking for young people who have been feeling very sad or depressed lately.

This study wants to learn more about how estrogen affects women's reproductive hormones and system.

To assess the efficacy and safety of opevesostat plus hormone replacement therapy (HRT) compared to alternative abiraterone acetate or enzalutamide in participants with Metastatic Castration-resistant Prostate Cancer (mCRPC)

To compare the response rate (confirmed or unconfirmed, complete or impartial) between participants with MET exon 14 skipping positive non-small cell lung cancer (NSCLC) randomized to tepotinib with or without ramucirumab.

This study wants to learn if breathing tests (called spirometry) performed in an outpatient clinic give results that are as reliable and accurate as spirometry that is done in a specialized lung function lab.

In this study, we want to see if two anti-rejection drugs (belatacept and sirolimus) can better protect your new kidney after kidney transplant, compared to the currently used drugs (tacrolimus and MMF).

To determine prospectively if SCLC tumor tissue transcriptional subtypes can be detected by Tempus|xT RNAseq

To compare investigator-assessed progression-free survival (IA-PFS) between participants with EGFR mutated, MET amplified non-small cell lung cancer (NSCLC) randomized to INC280 (capmatinib) and osimertinib with or without ramucirumab.

Given the negative symptoms associated with cancer, palliative care, a broad term for the prevention and treatment of adverse effects that arise from a disease or its treatment, continues to be a focus of cancer related research. In recent years one of the most popular options for this has become cannabis. There has been in increase of cancer patients using cannabis for relief; specifically, to im...

In this study, we want to learn more about a new drug called iptacopan to see if it can help treat a rare kidney disease called IC-MPGN (immune complex mediated membranoproliferative glomerulonephritis).

The purpose of our research study is to assess satisfaction with genetic testing for hereditary cancer risk in a high-risk population in Colorado and New Mexico.

This study is using MRI to learn how skeletal muscles and blood vessels respond to exercise in people with and without Type 2 Diabetes. We are currently looking for healthy volunteers to join our study!

To prospectively collect data regarding the diagnosis and treatment of orthopedic infections including upper and lower limb as well as pelvic and spinal infection in order to improve quality of care. The database will be used for subsequent future research.

In this study we want to learn if a medicine approved for diabetes and weight loss called Ozempic® and Wegovy® (semaglutide) can help improve the frequency of periods and the way the body uses sugar in women with polycystic ovary syndrome (PCOS).

Our team is here to find out if taking part in a cognitive-behavioral therapy group, exercise training group, or combination of therapy and exercise training lowers stress, improves mood, raises physical activity and fitness, and lowers diabetes risk among teen girls at risk for diabetes.

The primary objective of this screening study is to test patient specimens to determine eligibility for participation in the biomarker-driven and non-matched sub-studies included within the Lung-MAP umbrella protocol.

Evaluate the Arctic Sun Cooling device for fever prevention to standard of care measures for controlling fever in the ICU

Our goal is to determine if 12 sessions of Parent Management Training can reduce anger outbursts and irritable moods in children aged 10 to 14 years old. We are also looking at body responses, like heart rate, that might be used to develop better treatments for irritability.

We hope to learn how safe and effective the Neuroport array plus stimulation is in controlling computer generated images and real-world objects, such as a robotic arm, using imagined movements of the arms and hands.

The primary objective of the BISON-PRO Database is to establish a prospective repository of real-world, longitudinally-collected patient-reported outcomes (PRO) and quality-of-life data for patients with both malignant and non-neoplastic blood disorders to support patient-centered research.

We want to learn how stimulating the vagus nerve while moving the hand can help improve fine motor control in people with relapsing-remitting multiple sclerosis (MS), who have trouble moving their hands and arms.

To collect data on the recurrence rate and outcomes of benign and primary/metastatic malignant tumors seen in Orthopaedic patients at the University of Colorado Hospital.

To collect prospectively (after informed consent) fresh, excess surgical tissues, blood and other bodily fluids, and saliva from patients with HNC slated to undergo biopsy or surgical resection, and to collect prospectively optional samples from patients with HNC slated to undergo other therapies

Use of blood flow restriction cuffs in post surgical hip patients.

The purpose of this study is to learn if a drug called sargramostim is safe and if it can help improve thinking and memory in people with Alzheimer’s disease.

This study plans to learn more about genes that are expressed in blood vessels in the brain and in the blood of patients without brain aneurysms. This will help us understand diseases that affect those blood vessels such as aneurysms.

This study is testing a virtual exercise program to help older adults who take care of family members. We hope to help them feel better both physically and mentally, so they can feel more confident and capable in their caregiving.

In this study we want to learn how infants hear speech sounds and how that affects their language development.

With our community partner, the Gyedi Project, we want to see how different levels of goal-setting exercises can encourage physical activity in the Black community. We also want to see how this program affects sticking to exercise and attitudes toward exercise.

This study wants to see if gut problems are worse in men with and without HIV that have sex with men who have metabolic syndrome compared to those without metabolic syndrome. We are looking for men that do not have HIV.

We’re doing this study to better understand if healthcare students feel safe speaking up and working together in team-based care. Your input can help us learn how to build stronger, safer healthcare teams for better patient care.

Our goal is to find out if a mental health program that uses a smartphone app, along with support from a care team and therapy, works well and is helpful. We are looking for adults who have signs of anxiety or depression and are willing to join the program from home for 8 weeks.

This study is testing a digital sleep treatment, called NightWare, to see if it can improve sleep and heart health in veterans by reducing nightmares related to post-traumatic stress disorder (PTSD).

This study wants to compare the immune response in children who received the RSV vaccine during the 2024-2025 respiratory season to those who didn’t. It will also look at how often children in both groups get sick and how severe their sickness is during the 2025-2026 respiratory season.

In this study, we want to learn more about how a child’s swimming ability relates to certain things such as playing sports, as well as traits like age, gender, and ethnicity.

This study is looking at airway cells in people who have never smoked to better understand normal airway cell function and early changes that may be linked to lung disease.

We are looking for people who have Opioid Use Disorder to see if whether getting methadone treatment or getting buprenorphine treatment in an office helps them stick to their treatment plan.

This study wants to learn how well a new meditation, called Essence Breathing (EB), works for adults who have pain. It also wants to find out if difficult life experiences impact how well this meditation helps to improve symptoms.

We are looking for couples who are currently pregnant or have had a baby in the past 12 months. We want to learn about their experiences as new parents.

This study wants to find out more about nonfatal gun violence in past romantic relationships. The goal is to learn how gun-related harm or threats happen between partners.

We are looking for students, staff, and faculty at the University of Colorado Anschutz to help us learn how spending time in nature can support wellbeing, lower stress, and help people feel more connected. We also want to learn how easy and helpful it is to take part in a program that teaches people to use their senses (sight, smell, touch) while outdoors.

This study wants to learn more about unfair differences in health and health care for people with chronic pain.

This study wants to find out how helpful an 8-week program is for Spanish-speaking parents and their children ages 8 to 11 who have difficulties with planning, focus, and self-control.

Este estudio quiere descubrir que tan útil es un programa de 8 semanas para padres hispanohablantes y sus hijos de entre 8 y 11 años que tengan dificultades para planificar, concentrarse y autocontrol.

This study wants to know how helpful a virtual physical therapy program is for older Veterans having physical difficulties in their day-to-day life.