This phase 3 study will evaluate the superiority of the fixed dose combination (FDC) of fianlimab + cemiplimab versus the FDC of relatlimab + nivolumab (referred to as Opdualag™) in participants with unresectable locally advanced or metastatic melanoma.
Our study is seeking individuals aged 55-85, who have been diagnosed with Mild Cognitive Impairment (MCI) and are at risk for Alzheimer's Disease. The goal of the study is to see whether cannabidiol (CBD) can improve MCI symptoms.
After taking an investigational medication (Retatrutide) for weight loss for 80 weeks, to look at the effect on weight when comparing continued Retatrutide to placebo.
We are looking for couples, 21 or older, to join a study about how alcohol and media affect relationships.
This study wants to learn more about the heart and brain health of people with and without endometriosis.
We want to see how well over-the-counter (OTC) hearing aids work when fitted in different ways like self-fit, online self-fit, or fit by a hearing healthcare provider, compared to prescription hearing aids.
This study is using MRI to learn how skeletal muscles and blood vessels respond to exercise in people with and without Type 2 Diabetes. We are currently looking for healthy volunteers to join our study!
The purpose of this study is to compare how long the participants are disease-free (progression-free survival) and and the length of time until a participant dies (overall survival), when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, and irinotecan hydrochloride (FOLFIRI) versus either cetuximab or bevacizumab and FOLFIRI given ...
This study wants to learn if breathing tests (called spirometry) performed in an outpatient clinic give results that are as reliable and accurate as spirometry that is done in a specialized lung function lab.
The primary objective of the CDK Study is to compare time to treatment discontinuation (TTD) on the approved dosing for palbociclib (125 mg orally daily on days 1-21 of 28-day cycle) or ribociclib (600 mg orally daily on days 1-21 of 28-day cycle) vs. TTD using titrated dosing approach with the same schedule but starting at a lower dose of palbociclib (100 mg or 75 mg) or ribociclib (400 mg or 200...
To assess the efficacy and safety of opevesostat plus hormone replacement therapy (HRT) compared to alternative abiraterone acetate or enzalutamide in participants with Metastatic Castration-resistant Prostate Cancer (mCRPC)
This study plans to learn more about how providing interventions in the home during family meals affects the health of children. We want to learn how we can best educate families about things that affect the health of children.
Phase 1/2, dose escalation and expansion study designed to evaluate the safety and tolerability of NVL-520, determine the recommended phase 2 dose (RP2D), and evaluate the antitumor activity in patients with advanced ROS1-positive (ROS1+) NSCLC and other advanced ROS1-positive solid tumors
This study wants to learn more about how blood sugar levels in healthy children without chronic disease compare to the blood sugar levels of children with Cystic Fibrosis (CF). We are only recruiting children without chronic disease to join the study.
PRIMARY OBJECTIVE: I. To compare progression-free survival (PFS) in patients with BRAF V600Em differentiated thyroid cancer who progressed on frontline multikinase inhibitor treated with dabrafenib/trametinib or cabozantinib. SECONDARY OBJECTIVES: I. To compare the objective response rate in patients with BRAF V600Em differentiated thyroid cancer that progressed on frontline multikinase i...
This is a phase 3, randomized, controlled study of IMC-F106C plus nivolumab compared to standard nivolumab regimens in HLA-A*02:01-positive participants with previously untreated advanced melanoma.
The aim of this Expanded Access Program (EAP) is to enable the use of 18F-Floretyrosine with positron emission tomography/computed tomography (PET/CT) or positron emission tomography/magnetic resonance (PET/MR) imaging to non-invasively detect tumor burden or treatment related change to assist in optimal management of patients with glioma. Within the EAP, additional data will be collected to supp...
This study wants to learn more about how estrogen affects women's reproductive hormones and system.
To assess the proper amount of dose to give participants and to evaluate the safety of [177Lu]Lu-NeoB (called Lutetium-NeoB) in participants who have just been diagnosed with glioblastoma (our site won't enroll anyone with recurrent glioblastoma). This research study will also assess if an investigational imaging agent, [68Ga]Ga-NeoB (called Gallium-NeoB), is well tolerated and has the ability...
This study wants to look at how endocannabinoids are different in children with and without autism. We are only looking for children who do not have autism to join our study.
The primary objective of the study is to compare the efficacy of zanidatamab plus chemotherapy versus trastuzumab plus chemotherapy. The secondary objectives of the study will include further comparing the efficacy, safety and tolerability, patient-reported tolerability, and patient-reported physical functioning of zanidatamab plus chemotherapy versus trastuzumab plus chemotherapy. The pharmacokin...
This study wants to learn more about how the food we eat affects the reproductive hormones of adult women with obesity.
Do you currently smoke? Would you like to know if you are one of the 4 in 10 people who may develop COPD someday?
The purpose of this research study is to learn more about how cannabidiol (CBD) may affect cannabis use, effects, and craving.
We are looking for people who are overweight and want to cut back or stop drinking. This is for a study to see how a medicine called semaglutide (Rybelsus®) might help with Alcohol Use Disorder (AUD) and the behaviors associated with it.
The proposed project presents an opportunity to expand use cases for a social engagement virtual reality (VR) program. The purpose is to assess the feasibility, usability, and acceptability of VR for anxiety symptoms associated with social interactions in public places, using a technology developed by Rey (previously Oxford VR or OVR). This project is a first step toward understanding new populati...
The WeCanWork research study at the University of Colorado Cancer Center wants to learn how a cancer diagnosis impacts work, finances, and general well-being for employed people undergoing treatment. The research team hopes to find ways to lessen the negative impact of cancer on employment by focusing on working patients.
This study wants to learn how a type of fat in the blood, called triglycerides, affects how the fetus grows.
1. Determine if L-citrulline supplementation improves asthma control and increases FeNO (co-primary outcomes). Secondary outcomes will include changes in plasma L-arginine/ADMA, lung function (FEV1) and bronchial hyperreactivity. Asthmatic subjects will receive either 15 g L-citrulline/day or matched placebo for 7 weeks followed by a 4 week washout and then 7 weeks of the opposite treatment. A pa...
1. Determine if L-citrulline supplementation improves deployment related asthma control and increases FeNO (co-primary outcomes). Subjects will receive either 15 g L-citrulline/day or matched placebo for 7 weeks followed by a 4-6 week washout and then 7 weeks of the opposite treatment.
We hope to learn how safe and effective the Neuroport array plus stimulation is in controlling computer generated images and real-world objects, such as a robotic arm, using imagined movements of the arms and hands.
This study wants to learn about the best way to take pictures of unborn babies' hearts to better identify certain heart health problems.
To assess the real-world use and effectiveness of belimumab in routine practice for the treatment of adults with active lupus nephritis. Aims to provide the first long-term assessment of renal function preservation in patients treated with belimumab.
An Open-Label multinational, multicenter study to evaluate the long-term safety, tolerability, and efficacy of subcutaneous amlitelimab in participants aged 12 years and older with moderate to severe atopic dermatitis
The purpose of this study is to evaluate the efficacy and safety of treatment with subcutaneous anifrolumab versus placebo in adult participants with systemic sclerosis. The target population for this study includes patients who meet the 2013 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification for systemic sclerosis, either limited or diffuse cutaneous su...
We are looking for couples that have had two or more pregnancy losses with no known cause. We want to find out if genetics might be a reason for recurrent pregnancy loss (RPL).
To study a new anti-obesity medication
The goal of this study is to learn if a new combination treatment is effective for patients with microsatellite stable, advanced colorectal cancer. The study treatment combines 3 drugs: atezolizumab, bevacizumab, and tiragolumab. The main questions the study aims to answer are: Does the study treatment effectively treat colorectal cancer? Is the study treatment safe for patients with colorecta...
The purpose of this study is to gather ideas and opinions about content that is part of a sexual assault workshop for women.
To compare pramipexole to escitalopram in the treatment of major depressive disorder in people living with HIV.
We need your help! College women needed for an online survey to share their experiences with alcohol, cannabis, and sexual assault.
The purpose of this research study is to understand how alcohol and gender influence behavior in social settings.
The purpose of this study is to determine the putative recommended phase 2 dose(s) (RP2Ds) of JNJ-89402638 and to determine the safety of JNJ-89402638 at the RP2D(s) in participants with metastatic colorectal cancer.
We are looking for people who drink alcohol and are 18 or older to take part in a study. This study is about how alcohol affects sexual behavior in romantic couples.
The purpose of this research study is to examine alcohol use among couples.
Determine whether patients undergoing prophylactic nail placement return to at least their preoperative pain interference (PI) and physical function (PF) scores by 6 weeks post operatively.
This study will look at how well an injectable treatment works for people with detectable levels of HIV who are taking oral antiretroviral therapy (ART). This study will also check if the treatment is safe, how long it lasts, and ask about people’s experience.
The purpose of this study is to see if an experimental vaccine called CH505 TF chTrimer is safe and well tolerated in people living with human immunodeficiency virus (HIV) and to see if it will help the body's immune system respond to HIV.
Compare the change in 24-h EE in response to acute fasting in pre- and postmenopausal women. Compare the change in 24-h EE in pre- and postmenopausal women in response to acute low-protein overfeeding (200% of energy balance).
Determine the safety and toxicity of losartan in combination with SBRT and subsequently pembrolizumab in patients with locally recurrent, refractory, or oligometastatic head and neck squamous cell carcinoma (HNSCC).
The primary objective of the study is to evaluate the efficacy of switching to oral weekly ISL/LEN tablet regimen versus continuing standard of care in virologically suppressed PWH at Week 48.
A Phase 2, Randomized, Human Growth Hormone-Controlled, Multicenter, Basket Study of Vosoritide in Children with Turner Syndrome, Short Stature Homeobox-Containing Gene Deficiency, and Noonan Syndrome with an Inadequate Response to Human Growth Hormone
This study is intended to evaluate the optimal alisertib dose administered in combination with the selected endocrine therapy. The study is also planned to evaluate the efficacy, safety, and pharmacokinetics of alisertib in combination with endocrine and to identify the biomarker-defined subgroup(s) that may benefit most from combined alisertib and endocrine therapy.
Part 1 of the study will evaluate the safety and tolerability of ZW171. Part 2 of the study will evaluate the anti-tumor activity of ZW171 while continuing to evaluate the safety and tolerability.
The goal of the study is to learn if people who receive sacituzumab govitecan live longer overall and without the cancer getting worse compared to people who receive chemotherapy.
This phase II trial tests how well tailoring therapy in post-surgery works in patients with low-risk endometrial cancer. The usual approach for patients with low-risk endometrial cancer is treatment with surgery. In this study, tissue that is removed as part of the surgical procedure is analyzed in the pathology laboratory to help guide the doctor to decide whether or not additional treatment such...
This study is being done to learn more about sweat electrolytes in people who do not have Cystic Fibrosis to inform goals for CF treatment.
The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON) inhibitors combined with Standard(s) of Care (SOC) or with novel agents. The first three subprotocols include the following: Subprotocol A: RMC-6236 + 5-fluorouracil-based regimens Subprotocol B: RMC-6236 + cetuximab with or without mFOLFOX...
We are looking for adults to join a national study to help us learn more about how rheumatoid arthritis (RA) develops.
The purpose of this protocol is to enable the creation of a Perioperative Informatics of Colorado (PICO) database that allows the evaluation of various aspects of care provided by members of the Department of Anesthesiology at the University of Colorado School (CU-DOA) and their association with perioperative outcomes or hospital resource utilization. Perioperative data for the PICO database will ...
This study will test whether a single dose of antibodies can help prevent COVID-19 from getting worse in high-risk adult patients recently diagnosed with COVID-19.
A global study to assess the efficacy and tolerability of rilvegostomig compared to placebo in combination with investigator's choice of chemotherapy in participants with BTC after surgical resection with curative intent.
This study looks at how choline supplements and exposure to cannabis-based products affect pregnancy and child health.
I. Establish a prospective cohort of individuals with Lynch syndrome II. Collect standardized longitudinal clinical and biosample data to elucidate Lynch Syndrome epidemiology and gene-host interactions III. Promote intervention trials to improve cancer prevention and early detection in Lynch Syndrome
In this study, we aim to characterize the stress response to a visual field exam performed as part of a standard ophthalmology visit with the use of biometric devices, a standardized anxiety inventory, and measurement of salivary cortisol before and after the test. We further aim to assess how stress responses vary depending on the length of time required to complete testing as well as variability...
To determine the sensitivity and specificity of the mt-sDNA 2.0 test, for colorectal neoplasia in patients with Lynch Syndrome
The primary objective of the study is to investigate the safety and efficacy of KPI-012 compared to vehicle in participants who have a documented clinical diagnosis of PCED
This phase II/III trial examines whether patients who have undergone surgical removal of bladder, but require an additional treatment called immunotherapy to help prevent their bladder cancer from coming back, can be identified by a blood test. Many types of tumors tend to lose cells or release different types of cellular products including their DNA which is referred to as circulating tumor DNA (...
This is a Phase 1b, open-label, multicenter, safety, tolerability and efficacy study of HC-7366 in combination with belzutifan (WELIREG™). This is a multipart study that consists of a HC-7366 monotherapy cohort, a combination dose escalation, and a combination dose expansion. Approximately 80 patients will be enrolled in this study (up to 20 patients will be enrolled into the HC-7366 monotherapy c...
This study is testing if a single dose of the psychedelic drug RE104 can help reduce symptoms of moderate-to-severe postpartum depression compared to a placebo in pregnant women aged 18 to 45.
Aim 1: Test the effectiveness of Rehabbing with Peloton on physical activity as measured by daily steps. Aim 2. Examine the effectiveness of Rehabbing with Peloton on secondary health outcomes. Aim 3. Assess the implementation of the Rehabbing with Peloton using the Reach, Effectiveness, Adoption, Implementation, and Maintenance Framework (RE-AIM).
To evaluate the safety and effectiveness of the GPX® Embolic Device when used as indicated for embolization requiring distal vessel penetration.
Research has shown a link between tinnitus and differences in brain responses. However, there is limited research investigating how the severity of tinnitus is reflected in brain responses and cognitive abilities in the same individuals. Additionally, although research studies have demonstrated Internet based cognitive behavioral therapy (ICBT) is effective for tinnitus, objective measures have n...
To evaluate the safety and tolerability of benralizumab
Are you a woman taking non-hormonal therapy for hot flashes or night sweats? We want to learn how this affects your sleep, daily life, and work.
The purpose of this study is to determine safety and preliminary efficacy of amivantamab monotherapy, amivantamab in addition to pembrolizumab, and amivantamab in addition to paclitaxel in participants with recurrent/metastatic head and neck cancer. The study will also confirm the recommended Phase 2 combination dose (RP2CD) for amivantamab in addition to paclitaxel
This is a first-in-human study to learn more about the study drugs called RMS-6291 and RMC-6236.
This phase II trial tests how well giving durvalumab with standard chemotherapy, gemcitabine and cisplatin, before surgery works in treating patients with high risk liver cancer (cholangiocarcinoma) that can be removed by surgery (resectable). Durvalumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as gemcitabine and cispl...
To compare the response rate (confirmed or unconfirmed, complete or impartial) between participants with MET exon 14 skipping positive non-small cell lung cancer (NSCLC) randomized to tepotinib with or without ramucirumab.
Evaluate the safety and efficacy of the Cleaner™ Pro Thrombectomy System for aspiration thrombectomy in patients with acute pulmonary embolism (PE).
Measure the preliminary effect of psilocybin assisted psychotherapy on fear of recurrence.
This phase III trial compares the addition of an immunotherapy drug (durvalumab) to usual chemotherapy versus usual chemotherapy alone in treating patients with MammaPrint Ultrahigh (MP2) stage II-III hormone receptor positive, HER2 negative breast cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the a...
This is a phase III, randomized, open-label, multicenter, global study to determine the efficacy and safety of Volrustomig (MEDI5752) + Carboplatin + Pemetrexed vs the investigator's choice of platinum + Pemetrexed or Nivolumab + Ipilimumab in participants with unresectable pleural mesothelioma.
This study wants to collect health and growth information about children with hypochondroplasia. This information will help us understand their basic health and see if they can join future studies about hypochondroplasia.
The goal of this clinical trial is to assess the efficacy of DB-1303/BNT323 compared with investigator's choice chemotherapy in terms of progression-free survival (PFS) by blinded independent central review (BICR) in the HR+, HER2-low (immunohistochemistry [IHC]2+/in situ hybridization [ISH]- and IHC 1+) population.
The objective of this study is to evaluate disease progression, using multiple modalities, in subjects with genetically-confirmed STGD1.
To evaluate the ability of ravulizumab to reduce proteinuria in adults with IgAN
To understand variations in the health of people with achondroplasia
To screen and assign patients to ComboMATCH treatment trials.
The primary objectives of DISCOVERY are to: 1. Identify the physiologic drivers and other determinants of progression to youth-onset T2D by charting the course of changes in glycemia, β-cell function, insulin sensitivity, psychosocial, behavioral, and social determinants of health during this critical period of maturation 2. Inform approaches for precise prediction of which youth are at highes...
This is a study wants to find out if the birth control pill Slynd affects bone health in adolescent girls ages 14 to 17.
This is a Phase 1/2, multi-center, open-label basket study designed to evaluate the safety and anti-tumor activity of IDE196 in patients with solid tumors harboring GNAQ or GNA11 (GNAQ/11) mutations or PRKC fusions, including metastatic uveal melanoma (MUM), cutaneous melanoma, colorectal cancer, and other solid tumors. Phase 1 (dose escalation - monotherapy) will assess safety, tolerability an...
This Phase III Trial will determine whether adjuvant chemotherapy (ACT) added to ovarian function suppression (OFS) plus endocrine therapy (ET) is superior to OFS plus ET in improving invasive breast cancer-free survival (IBCFS) among premenopausal, early- stage breast cancer (EBC) patients with estrogen receptor (ER)-positive, HER2-negative tumors and 21-gene recurrence score (RS) between 16-25 (...
The main objective of the study is to evaluate the effect of pegloticase 16 mg administered Q4W with MTX versus pegloticase 8 mg administered Q2W with MTX, on the response rate during Month 6, as measured by the sustained normalization of sUA to < 6 mg/dL for at least 80% of the time.
This phase III trial compares the effect of stero-ablative radiotherapy (SAbR) followed by standard of care systemic therapy, to standard of care systemic therapy alone, in patients with kidney cancer that has spread from where it first started (primary site) to a limited (2-5) number of places in the body (metastatic). Study doctors want to find out if this approach is better or worse than the us...
This phase I/II trial studies the best dose and side effects of peposertib and to see how well it works with avelumab and hypofractionated radiation therapy in treating patients with solid tumors and hepatobiliary malignancies that have spread to other places in the body (advanced/metastatic). Peposertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Imm...
The objective of the proposed trial is to show that the association - carboplatin with the SonoCloud-9 - will increase efficacy of the drug in patients with recurrent glioblastoma.
This study wants to learn if retatrutide works better than a placebo at lowering the risk of serious heart problems and slowing kidney damage in people with body mass index of 27 or higher.
Vorasidenib in combination with pembrolizumab in participants with recurrent or progressive enhancing isocitrate dehydrogenase-1 (IDH-1) mutant Glioma
To follow changes in bone mineral density (BMD) over time when Myfembree is used for up to 4 years. Also to follow BMD for 1 year after treatment is stopped.
This phase III trial compares hepatic arterial infusion (HAI) (pump chemotherapy) in addition to standard of care chemotherapy versus standard of care chemotherapy alone in treating patients with colorectal cancer that has spread to the liver (liver metastases) and cannot be removed by surgery (unresectable). HAI uses a catheter to carry a tumor-killing chemotherapy drug called floxuridine directl...
Can ADAP assay accurately detect GADA, IA2A, IAA and ZnT8A in self-collected capillary dried blood spot specimens.
The purpose of this study is to determine if the frequency of patients' use of incentive spirometry after surgery increases with visual and auditory electronic reminders, as compared to the no signal cohort. The short-term hypothesis is that patient performance of incentive spirometer (IS) (defined as frequency of adequate volume breaths) will be greater with the electronic reminders than without ...
Evaluate safety and tolerability of SC291; and, to evaluate clinical response to SC291.
To determine the recommended phase 2 dose (RP2D) of SNDX-5613 administered in combination with chemotherapy in patients with relapsed or refractory (R/R) KMT2A-rearranged (KMT2A-R) acute lymphoblastic leukemia (ALL).
This phase II trial tests how well carboplatin before surgery works in treating patients with high-risk prostate cancer and an inherited BRCA1 or BRCA2 gene mutation. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping, or slowi...
This study will evaluate the effectiveness and safety of risdiplam (Evrysdi®) administered to patients under 2 years of age genetically diagnosed with spinal muscular atrophy (SMA) and 2 SMN2 copies who have previously received onasemnogene abeparvovec.
This study will evaluate the effectiveness and safety of risdiplam (Evrysdi®) administered to patients under 2 years of age genetically diagnosed with spinal muscular atrophy (SMA) and 2 SMN2 copies who have previously received onasemnogene abeparvovec and experience a plateau or decline in function.
Establish the long-term safety and efficacy of pegcetacoplan in participants with C3 glomerulopathy (C3G) or immune complex membranoproliferative glomerulonephritis (IC-MPGN)
study on the efficacy, safety and pharmacokinetics of Debio 4326 in pediatric participants who are receiving gonadotropin-releasing hormone agonist therapy for central precocious puberty
Examine the acute effects of an acute bout of exercise on Cancer Related Fatigue (CRF)
The main purpose of this study is to assess the efficacy and safety of volrustomig compared to observation in participants with unresected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) who have not progressed after receiving definitive concurrent chemoradiotherapy (cCRT)
Join a weight loss study for men and women aged 18-65 with breast cancer. Get a free 6-month diet and exercise program and monetary compensation.
This study is open to adults with different types of advanced cancer (solid tumors) that are accessible for injection and/or biopsy. This is a study for people with a life expectancy of at least 3 months after starting study treatment. The purpose of this study is to find the highest dose of a medicine called BI 1831169 that people with advanced cancer can tolerate when taken with or without a typ...
This clinical trial is studying advanced solid tumors. Solid tumors are cancers that start in a part of your body like your lungs or liver instead of your blood. Once tumors have grown bigger in one place but haven't spread, they're called locally advanced. If your cancer has spread to other parts of your body, it's called metastatic. When a cancer has gotten so big it can't easily be removed or h...
This is a first-in-human study to learn about the study drug GS-9716.
BL-B01D1-LUNG-101 is a global, multi-center, Phase 1 study to evaluate the safety, tolerability, pharmacokinetics , and initial efficacy of BL-B01D1 in participants with metastatic or unresectable NSCLC and Other Solid Tumors. This study will be conducted in two different dosing schedules (Cohort A and Cohort B) and three parts (dose escalation, dose finding and dose expansion). Cohort A will b...
We want to see how easy and acceptable it is for people who have had any adult cancer within the past 10 years to join both a nutrition program and an exercise program.
This research study is designed to learn more about racial inequities in Obstetric and Gynecologic care.
This phase II trial compares the effect of retreatment with 177Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) to the usual approach of treatment with everolimus in patients who have previously received 177Lu-DOTATATE for midgut neuroendocrine tumor (NET) that has spread from where it first started (primary site) to other places in the body (metastatic) and that cannot be removed by surge...
This research is designed to determine if experimental treatment with Antibody-drug conjugate, AZD5335, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced tumors
Patients will be registered prior to, during or at the completion of neoadjuvant chemotherapy (Paclitaxel 175 mg/m2 IV over 3 hours and Carboplatin AUC 6 IV on Day 1 every 21 days for 3-4 cycles). Registered patients who progress during neoadjuvant chemotherapy will not be eligible for iCRS and will be removed from the study. Following completion of neoadjuvant chemotherapy, interval cytoreduct...
Treatment of Duchenne Muscular Dystrophy (DMD) with dystrophin deletion amenable to exon 50 skipping
To compare whether de novo use of belatacept and sirolimus versus tacrolimus and MMF maintenance therapy will prevent the development of DSA or maintain optimal graft function (eGFR).
This study wants to see how blood sugar changes with sex hormones during regular menstrual cycles or when using hormonal birth control. We also want to learn how exercise and hormonal birth control affect blood sugar.
Primary objective: To assess the persistence rate of patients undergoing pulmonary arteriovenous malformation (PAVM) embolization at multiple hereditary hemorrhagic telangiectasias (HHT) centers of excellence in the United States using standardized reports. Second objective: To assess the impact of technical factors like the type of embolic device and embolization technique (feeding artery vs. ve...
This study will test the Home Health Box in real homes by having people measure and track the air quality in their home, see how easy it is to use based on their feedback, and make improvements before bringing the device to market.
The goals of this study are to refine the implementation and pilot test the feasibility of an adapted cognitive behavioral therapy (CBT), the Balanced and Empowered EaTing in Diabetes (or the BEET Diabetes Program), compared with the original CBT program, delivered by behavioral health providers to treat disordered eating behaviors (DEBs) in patients with type 2 diabetes in real-world clinical set...
ECHO is a national research initiative sponsored by the National Institutes of Health (NIH) to determine what factors give children the highest likelihood of achieving the best health outcomes over their lifetimes.
Specific Aims. 1. Determine whether hemp-derived CBD alters cannabis cue-related neural response. A subsample of 52 participants will be recruited from the larger Project 1 (“emerging adult”) randomized controlled trial comparing 400mg/day hemp-derived CBD to placebo. We will conduct a functional MRI scan at enrollment and after 8 weeks in the trial. During the scan, we will conduct a cue-reacti...
The purpose of this research study is to examine and understand the various mechanisms that contribute to CFRD and gain a better understanding of possible ways to treat CFRD.
This is a first-in-human phase I/II study to examine the safety, tolerability and preliminary efficacy of VLS-1488 in subjects with advanced cancers.
The purpose of the study is to determine the recommended regimen for Phase 2 (RP2Rs) of combination of JNJ-87189401 with JNJ-78278343 (Part 1: dose escalation) and further evaluate the safety at RP2Rs (Part 2: dose expansion) in participants with advanced prostate cancer.
To demonstrate the efficacy of different doses of frexalimab in comparison with placebo and in addition to standard of care (SOC) on endogenous insulin secretion in participants (12-21 y.o.) with newly diagnosed T1D over a 52-week period
A prospective, multicenter, observational study to evaluate the correlation of Molecular Residual Disease (MRD) detection using circulating tumor DNA guided test to pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in stage I-III triple negative breast cancer (TNBC). Results from this study aim to improve MRD detection and disease outcomes for future patients.
This is a multicenter, open-label, Phase II, randomized, controlled study to determine the efficacy, safety, and other indicators of clinical and biological activity of the combination of danvatirsen and pembrolizumab as first-line treatment for R/M HNSCC
The purpose of this study is to measure the efficacy and safety of durvalumab intravenous (IV) solution plus bevacizumab IV solution after transarterial radioembolization (Yttrium 90 glass microspheres TARE) in participants with unresectable hepatocellular carcinoma (HCC) amenable to embolization.
The goal of the Accelerating Medicines Partnership (AMP) research study is to better understand the molecular and cellular characteristics of Rheumatoid Arthritis (RA) to help develop better therapies for people with RA.
Evaluate the Efficacy and Safety of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)
To investigate long-term safety of Sogroya (somapacitan) therapy in patients with AGHD in the setting of routine clinical practice with special focus on neoplasms and diabetes mellitus type 2.
To compare the efficacy and safety in subjects with advanced or metastatic LMS previously treated with an anthracycline.
The goal of this study is to find out if the experimental product, sacituzumab govitecan-hziy (SG) in combination with pembrolizumab given after surgery, is effective and safe compared to the treatment of physician's choice (TPC) which includes either pembrolizumab or pembrolizumab plus capecitabine in participants with triple negative breast cancer that still remains after surgery and pre-surgica...
We want to learn how estrogen levels during menopause might affect artery health, body fat, and risk of heart disease in women with regular periods.
To determine prospectively if SCLC tumor tissue transcriptional subtypes can be detected by Tempus|xT RNAseq
To evaluate the efficacy of GS-5718 versus placebo-to-match (PTM) in reducing skin disease activity for participants with CLE with or without systemic lupus erythematosus. To evaluate the efficacy of GS-5718 versus PTM in reducing skin disease activity for participants with CLE with or without SLE. To evaluate the safety and tolerability of GS-5178 in participants with CLE with or without SLE.
This ComboMATCH patient screening trial. The study will identify patients with certain gene changes or mutations for treatment using a combination of targeted therapy.
The primary outcome variables will be the change in hemoglobin A1c, and diabetes medications recorded at 4.5 month and 13.5 month follow-up assessments.
The phase III trial compares the effect of pembrolizumab to observation for the treatment of patients with early-stage triple-negative breast cancer who achieved a pathologic complete response after preoperative chemotherapy in combination with pembrolizumab. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with...
This study wants to learn how working at night or outside normal daytime hours affects women’s heart and reproductive health in women. We are looking for women who work night shifts, both day and night shifts, or only daytime shifts to see how different work hours may affect heart and reproductive health.
For Period 1, the primary objective is to evaluate the efficacy and safety of upadacitinib and adalimumab, in adult subjects on background MTX, following an inadequate response or intolerance to a single TNFi. For Period 2, the objective is to evaluate the long-term safety, tolerability, and efficacy of upadacitinib and adalimumab in subjects who have completed Period 1.
This is a first-in-human study to learn about the study drug DCSZ11, given alone and in combination in patients with advanced or metastatic solid tumors.
This research study is being conducted to examine the effects of dapagliflozin on kidney function, blood vessel function and heart function. We are studying the effects/impact of dapagliflozin (a SGLT2 inhibitor) on: - Kidney function - Protein in the urine - Blood vessel function - Heart function
To compare investigator-assessed progression-free survival (IA-PFS) between participants with EGFR mutated, MET amplified non-small cell lung cancer (NSCLC) randomized to INC280 (capmatinib) and osimertinib with or without ramucirumab.
This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection. Collecting and storing samples of blood and tissue from patients with and without cancer to study in the laboratory may help researchers develop tests for the early detection of cancers.
This is a multicenter, randomized (2:1), open-label, controlled Phase 3 trial of XL092 in combination with nivolumab versus sunitinib in subjects with unresectable, locally advanced or metastatic nccRCC who have not received prior systemic anticancer therapy.
This study is testing whether taking an essential amino acid (EAA) supplement for 8 weeks will lower fat in the liver compared to a placebo.
This Phase III trial compares the recurrence-free interval (RFI) among patients with early-stage, low risk HER2+ breast cancer who undergo breast conserving surgery and receive HER2-directed therapy, and are randomized to not receive adjuvant breast radiotherapy versus those who are randomized to receive adjuvant radiotherapy per the standard of care.
To evaluate the effect of three doses of Diamyd compared to placebo in terms of (1) beta cell function; and (2) glycemic control in adolescents and adults recently diagnosed with type 1 diabetes (T1D), who carry the human leukocyte antigen (HLA) DR3-DQ2 haplotype and have antibodies against GAD65.
Given the negative symptoms associated with cancer, palliative care, a broad term for the prevention and treatment of adverse effects that arise from a disease or its treatment, continues to be a focus of cancer related research. In recent years one of the most popular options for this has become cannabis. There has been in increase of cancer patients using cannabis for relief; specifically, to im...
The goal of this study is to prioritize caregiver perspectives regarding the quality and satisfaction of dementia care their loved one is receiving. Sharing the lived experiences of caregivers gives health care providers an opportunity to better meet the needs of the patient and the caregiver in the future.
To demonstrate the superiority of iptacopan compared to placebo in reducing proteinuria at 6 months of treatment
Investigators at the University of Colorado are conducting research on the ability to exercise under high altitude (low oxygen) conditions. The study is looking at the safety and effects on exercise of a high dose of an inhaled asthma medication (salmeterol/fluticasone, or Advair®) on exercise performance while breathing low-oxygen air.
To compare the 1-year cumulative incidence of severe GVHD (from day of HCT) defined as Grade III-IV acute GVHD (aGVHD) and/or chronic GVHD (cGVHD) that requires systemic immunosuppression and to compare the disease free survival (DFS) (from time of randomization) in children and young adults (AYA) with acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), and Myelodysplastic Syndrome (MDS) ...
This is a first-in-human study to learn more about the investigational drug EBC-129. This study will assess the safety and tolerability of EBC-129 when given alone and in combination with pembrolizumab in patients with advanced solid tumors.
The purpose of this study is to evaluate the efficacy and safety of elacestrant over the course of 6 months in patients with estrogen receptor positive (ER+)/human epidermal growth factor receptor-2 negative (HER2-) advanced/metastatic breast cancer who received no prior cyclin-dependent kinase targeting enzymes CDK4 and CDK6 inhibitor (CDK4/6i) in the metastatic setting.
This study plans to learn more about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response to pulmonary hypertension (high pressure in the lungs) during rest and exercise. By identifying patterns of right ventricular dysfunction, this study will help identify bette...
In this study, we plan to learn about the causes of rheumatoid arthritis (RA) and about lung disease in RA. RA is an autoimmune disease that can cause arthritis, and in some people, RA can also be related to lung disease called ‘interstitial lung disease’ (or ILD).
To test a new medication (BION-1301) for the treatment of IgAN.
This phase Ib trial evaluates the best dose, potential benefits, and/or side effects of erdafitinib in combination with enfortumab vedotin in treating patients with bladder cancer that has spread from where it first started (primary site) to other places in the body (metastatic) and possesses genetic alterations in FGFR2/3 genes. Erdafitinib is in a class of medications called kinase inhibitors. I...
We will investigate the association between transfusion of fibrinogen-containing blood products and multi-organ dysfunction resulting from endotheliopathy of trauma (EOT). Fibrinogen is frequently acutely decreased in critically ill trauma patients. Early fibrinogen replacement may be the key to restoring the endothelial glycocalyx and preventing end-organ injury. However, few human data exist to ...
The purpose of our research study is to assess satisfaction with genetic testing for hereditary cancer risk in a high-risk population in Colorado and New Mexico.
Primary objective of this study is to assess the efficacy of DZD9008 versus platinum-based doublet chemotherapy using by BICR-assessed PFS per RECIST 1.1 as primary endpoint. Approximately 320 participants are estimated to be randomized into the study. Participants enrolled will be randomized to DZD9008 or platinum-based doublet chemotherapy in a 1:1 manner, stratified by baseline brain metastasis...
This study wants to learn how losing weight affects cell communication in muscle fat tissue among people with obesity. We also want to see how this impacts insulin resistance, inflammation, and muscle strength.
Evaluate the efficacy of the neoadjuvant Pembrolizumab and Axitinib in reducing the inferior vena cava tumor thrombus (IVC TT) among patients with renal cell carcinoma
• Examine the clinical efficacy of 1000 mg/m2 /day of oral DFMO to stabilize or improve loss of β cell function in persons with recent onset T1D. Our primary endpoint defining clinical efficacy will be based on mixed-meal stimulated C-peptide AUC in the treatment group compared to placebo after 6 months of DFMO treatment. • Examine the safety and tolerability of 1000 mg/m2 /day of oral DFMO i...
This study is being done to assess the accuracy of an at-home urine test for the management of Pregnancy of Unknown Location (PUL).
This is a first-in-human study to learn more about the investigational drug STX-478. The study will have 3 parts.
This study is being done to answer the following question: Can we lower the growth or spread of your advanced cancer by treating you with the combination of the drugs ZEN003694 (ZEN-3694) and talazoparib? We are doing this study because we want to find out if this approach is tolerable and active for your advanced solid tumor.
The study hypothesis is that BCG naïve non-muscle invasive bladder cancer (NMIBC) patients treated with intravesical Gemcitabine + Docetaxel (GEMDOCE) will result in a non-inferior event-free survival (EFS) compared to standard treatment with intravesical BCG. The purpose of this study is to test whether Gemcitabine + Docetaxel is a better or worse treatment than the usual BCG therapy approach. Th...
This study is looking at the short-term effect of equol supplementation (1, 2, and 3 hours after ingestion) on blood vessel function in women with and without chronic kidney disease. Equol is a dietary supplement. Equol is a metabolite of soy that is produced by the gut microbiome.
To assess the safety and tolerability of ferric citrate in pediatric subjects with hyperphosphatemia related to chronic kidney disease (CKD).
To evaluate the safety and performance of sacral nerve stimulation (SNS) in subjects diagnosed with Crohn’s disease (CD) or ulcerative colitis (UC) who meet all eligibility criteria, and To provide guidance for future clinical study designs
This study wants to learn more about how exposures during pregnancy like infections, diet and growth, can affect a baby’s chances of developing type 1 diabetes later in life.
Although non-small cell lung cancer (NSCLC) patients with anaplastic lymphoma kinase (ALK), c-ros oncogene 1(ROS1), and ret proto-oncogene (RET) gene fusions initially respond well to tyrosine kinase inhibitor (TKI) therapies, acquired resistance is inevitable. In many of these cases, increased activation of the erythroblastic leukemia viral oncogene homologue (ERBB) or cMet pathways appears to be...
The purpose of this study is to determine the ways in which androgen deprivation therapy for prostate cancer increases the risk of hypertension and cardiovascular diseases.
To develop a program that will help reduce distress in patients with metastatic colorectal cancer and their partners/spouses.
To assess the safety and tolerability of EDG-5506 in children with DMD
The primary study objective is to compare the clinical outcomes of patients treated with an interventional strategy using the ClotTriever System to achieve and maintain vessel patency (ClotTriever Intervention Arm) versus conservative medical management using anticoagulation therapy alone (Conservative Medical Management Arm) in the treatment of symptomatic unilateral iliofemoral DVT
To determine the effect of abnormal menstruation on markers of cardiovascular disease in adolescent athletes.
This study is looking at how psilocybin with therapy affects adults aged 21 years old with anhedonia in depression that hasn’t improved with other treatments compared to a placebo.
The main purpose of this study is to measure how well imlunestrant works compared to standard hormone therapy in participants with early breast cancer that is estrogen receptor positive (ER+) and human epidermal receptor 2 negative (HER2-). Participants must have already taken endocrine therapy for two to five years and must have a higher-than-average risk for their cancer to return. Study partici...
Study ML41591, is an umbrella trial that will evaluate the efficacy and safety of various therapies in patients with Stage IB, IIA, IIB, IIIA, selected IIIB (only T3N2) (8th edition AJCC TNM staging) resectable and untreated NSCLC tumors that meet protocol specified biomarker criteria determined in a Clinical Laboratory Improvement Amendments (CLIA) certified laboratory.
This study plans to learn more about the safety and effectiveness of TTI-101 when given either alone or in combination treatment using continuous or intermittent TTI-101 dosing, and to see if it will help in the treatment of liver cancer. Continuous dosing of TTI-101 means you will take your TTI-101 dose(s) every day. Intermittent dosing of TTI-101 means you will take a TTI-101 dose on a schedule....
This is a first-in-human study. The main goal of this study is to assess the safety and tolerability of mRNA-4359 given alone and in combination with pembrolizumab.
Brenetafusp (IMC-F106C) is an immune-mobilizing monoclonal T cell receptor against cancer (ImmTAC ®) designed for the treatment of cancers positive for the tumor-associated antigen PRAME. This is a first-in-human trial designed to evaluate the safety and efficacy of brenetafusp in adult patients who have the appropriate HLA-A2 tissue marker and whose cancer is positive for PRAME.
This is a first-in-human study to learn about the investigational drug called RO7502175.
To evaluate the safety and effectiveness of the Spinal Kinetics M6-C™ artificial cervical disc in patients with contiguous twolevel symptomatic cervical radiculopathy with or without cord compression.
This is a Phase 1b open-label, 2-part study in 3 treatment groups. The 3 treatment groups are as follows: Treatment Group 1: OP-1250 in combination with ribociclib (KISQALI®, Novartis Pharmaceuticals Corporation). Treatment Group 2: OP-1250 in combination with alpelisib (PIQRAY®, Novartis Pharmaceuticals Corporation). Treatment Group 3: OP-1250 in combination with everolimus.
We want to test the effects of THC on brain activation and alcohol consumption.
This study will test if one dose of psilocybin, given with talk therapy, can safely help people with advanced cancer feel less anxious, less depressed, and improve quality of life. We will compare it to a placebo (inactive medicine) called niacin given with the same kind of talk therapy.
This study wants to see if gut problems are worse in HIV+ men that have sex with men that have metabolic syndrome compared those without metabolic syndrome.
We want to find better ways to treat bipolar disorders. We are looking for children, teens, and young adults, aged 9 to 21 years old, to join our study.
This is a first-in-human study. The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07799933) administered as a single agent and in combination with other study medicines (called binimetinib) in people with solid tumors.
Assess effectiveness of post-op ACL physical therapy modification to increase quad strength during recovery.
This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon cancer. ctDNA-ve Cohort (Arms 1 + 2): Phase II: To compare time to ctDNA (+ve) status in ctDNA (-ve) cohort following resection of stage III colon cancer treated with immediate vs delayed (based on serial ctDNA...
This phase III trial compares the usual chemotherapy treatment to eribulin plus gemcitabine in treating patients with urothelial cancer that has spread to other places in the body (metastatic). Chemotherapy drugs, such as eribulin, gemcitabine, docetaxel, paclitaxel, and sacituzumab govitecan work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them fr...
The primary objective of this Phase I open-label study is to assess the safety and tolerability of CD19x22 CAR T cells in pediatric patients with R/R B-ALL.
This is a Phase 1b open-label, multicenter study, evaluating the safety, tolerability, preliminary clinical activity, pharmacokinetics (PK), and pharmacodynamics of ZN-c3 in combination with other drugs.
To learn more about the diseases that cause nephrotic syndrome so that improved treatments can be developed.
This study seeks to better understand the effects of cannabis use during adolescence on decision making and reward responsivity and may identify biomarkers that help distinguish youth who experience impairments in decision making and are at higher risk of the negative effects of cannabis use.
To evaluate the efficacy of VIB4920 antoagonism of CD40L in achieving a complete renal response in active lupus nephritis
This study is designed as a real-world evaluation of two integrated treatments for substance use and trauma, Risk Reduction Through Family Therapy (RRFT) or Encompass Treatment for adolescents with co-occurring Substance Use Disorder (SUD) and symptoms of Post-Traumatic Stress Disorder (PTSD).
Study ICT-GCC19CART-US-001 (CARAPIA-1) is a Phase 1 study evaluating the safety, tolerability, clinical activity, pharmacokinetics and pharmacodynamics of GCC19CART in subjects with relapsed or refractory metastatic colorectal cancer. Primary 1. To evaluate the safety of GCC19CART in adult subjects with relapsed or refractory metastatic colorectal cancer 2. To obtain maximum tolerable dose (M...
This study plans to test whether oral acetate supplementation is effective at improving artery function and stiffness in healthy adults over 50 years of age.
This phase III trial uses the Decipher risk score to guide intensification (for higher Decipher gene risk) or de-intensification (for low Decipher gene risk) of treatment to better match therapies to an individual patient's cancer aggressiveness. The Decipher risk score evaluates a prostate cancer tumor for its potential for spreading. In patients with low risk scores, this trial compares radiatio...
This study will collect data from health records about people that have variations in their X & Y chromosomes to learn about their health. We also ask if people are willing to join future studies about X & Y variations.
The purpose of this research study is to learn more about how CBD may reduce chronic pain and pain medication use.
This Phase III Trial evaluates whether breast conservation surgery and endocrine therapy results in a non-inferior rate of invasive or non-invasive ipsilateral breast tumor recurrence (IBTR) compared to breast conservation with breast radiation and endocrine therapy.
This study will evaluate the efficacy, safety, and pharmacokinetics of tirabrutinib monotherapy in patients with relapsed or refractory PCNSL (Part A), and tirabrutinib in combination with one of two different high dose methotrexate based regimens (methotrexate/ temozolomide/rituximab or rituximab/methotrexate/procarbazine/ vincristine) as first line therapy in patients with newly diagnosed, treat...
This study is an open-label, phase II study with a safety lead-in to assess the response rate of induction olaparib and stereotactic beam radiotherapy (SBRT) followed by combination olaparib/pembrolizumab in patients with metastatic gastric and GEJ cancers after at least one of therapy.
This phase II trial studies how well green tea catechins work in preventing progression of prostate cancer from a low risk stage to higher risk stages in men who are on active surveillance. Green tea catechins may stabilize prostate cancer and lower the chance of prostate growing.
This is a Phase 3, open-label, single arm trial designed to evaluate Cretostimogene patients with NMIBC who have failed prior BCG therapy. Up to approximately 115 CIS bladder cancer patients with or without HG Ta or HG T1 papillary disease will be enrolled under the original protocol through Amendment 4, which will comprise Cohort C. Cohort C is closed to enrollment. Under Amendment 5-1, Cohort...
We want to see how breathing in air pollution, cigarette or marijuana smoke, and job dangers affect lung health in young adults.
Use of blood flow restriction cuffs in post surgical hip patients.
To learn more about lung disease and risk of lung disease in early RA.
Primary outcome: The primary aim is to determine the efficacy of CXA-10 in improving pre bronchodilator FEV1 from baseline, relative to placebo. Secondary outcomes: A) Methacholine testing is the key standard for determining bronchial hyperresponsivess. Our protocol uses a quadrupling dose, according to the standards proposed by the American Thoracic Society (ATS) (61), which meets all safety r...
Finerenone vs. Placebo in addition to Standard of Care on the Progression of Kidney Disease in non-Diabetic Patients
The purpose of the current study is to collect data on gaps in care in adults with congenital heart disease
AIM 1: Determine the safety profile of direct peritoneal resuscitation on liver transplant recipients at risk of return to the operating room and ICU admission. Hypothesis: Liver transplant recipients that receive DPR will have comparable complication rates to historic controls of liver transplant recipients with similar demographics. AIM 2: Identify if direct peritoneal resuscitation demonstra...
We are studying teens who feel angry a little, sometimes, or a lot to see if they think about social situations in different ways. Teens who often feel very angry might have more problems when they grow up, so we want to learn more about how their brains work.
Why should I join this research study? We want to help prepare for future pandemics by learning more about infections that can cause people to become sick, like Enterovirus D68, and how a person may respond and fight off a potential infection
To evaluate the health and wellbeing of women living with HIV of reproductive age utilizing innovative epidemiologic study designs and cost-effective methods for enrollment, follow-up and data collection
This study will provide pilot data examining suction as a mechanism of IUD displacement with menstrual cup use. We hypothesize that manufacturer-recommended menstrual cup insertion and removal by breaking the seal will result in 15% rate of IUD displacement/expulsion. We will also use this data to explore variables associated with IUD displacement and menstrual cup use. By examining the role of su...
The objective of this study is to follow, characterize and evaluate the natural history of the disease course, burden of illness, risk factors, quality of life (QoL), and biomarkers associated with disease progression and treatments in pediatric patients with cardiomyopathy (CM) due to MYBPC3 pathogenic or likely pathogenic mutations.
Randomized, blinded, placebo-controlled, Phase 2 study of INBRX-109 in unresectable or metastatic conventional chondrosarcoma patients.
This study plans to learn more about what factors are most important in making decisions about cancer care. Patients have either recently been diagnosed with a new Central Nervous System (CNS) Tumor or have recently had a relapse of a CNS tumor and further therapy is indicated by the treating physician.
This phase II/III trial compares the effect of adding durvalumab to chemotherapy versus chemotherapy alone before surgery in treating patients with upper urinary tract cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as methotrexat...
Aim 1: Examine the efficacy of a group cognitive behavioral treatment (CBT), Facing Your Fears: Autism Spectrum disorder/Intellectual Disability (FYF: ASD/ID) on anxiety in a randomized controlled trial (RCT). Participants will be randomized to FYF: ASD/ID or a treatment as usual (TAU) group. Aim 2: Examine secondary outcomes such as how emotion regulation, problem behavior, parenting self...
This study is for women who are about to start IVF. It will test if the medicine, Orilissa, which helps with endometriosis symptoms, will affect fertility.
This phase II trial studies whether adding pembrolizumab to olaparib (standard of care) works better than olaparib alone in treating patients with pancreatic cancer with germline BRCA1 or BRCA2 mutations that has spread to other places in the body (metastatic). BRCA1 and BRCA2 are human genes that produce tumor suppressor proteins. These proteins help repair damaged deoxyribonucleic acid (DNA) and...
The purpose of this study is to assess the safety and efficacy of pembrolizumab (MK-3475) combination therapy in participants with metastatic castration resistant prostate cancer (mCRPC). There will be ten cohorts in this study: Cohort A will receive pembrolizumab + olaparib, Cohort B will receive pembrolizumab + docetaxel + prednisone, Cohort C will receive pembrolizumab + enzalutamide, Cohort D ...
This study plans to learn more about hearing loss using samples from a family trio (participant and both biological parents) and/or additional relatives. The goal of the study is to better understand the genetic variants that may underlie hearing loss.
Our research team wants to learn how birth control pills affect the brain and emotional wellbeing.
This study plans to learn more about the effects of having too much acid in the blood as a result of having a kidney transplant. This study will look at how acid levels in the blood affect the function of blood vessels and the transplanted kidney.
This phase III trial compares less intense hormone therapy and radiation therapy to usual hormone therapy and radiation therapy in treating patients with high risk prostate cancer and low gene risk score. This trial also compares more intense hormone therapy and radiation therapy to usual hormone therapy and radiation therapy in patients with high risk prostate cancer and high gene risk score. Apa...
We are looking for healthy men & women to study the effects of sleep disruption on bone. Please click on the "Let's Get Started!" button below to determine your eligibility.
A Phase Ib/III Open-label, Randomised Study of Capivasertib plus CDK4/6 Inhibitors and Fulvestrant versus CDK4/6 Inhibitors and Fulvestrant in Hormone Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative Locally Advanced, Unresectable or Metastatic Breast Cancer (CAPItello-292)
This study will investigate the maximum tolerated dose, the recommended dose for expansion (RDE), safety, efficacy, and pharmacokinetics of MK-6070 alone, MK-6070 with Atezolizumab and MK-6070 with I-DXd in participants with advanced cancers associated with expression of Delta-like Canonical Notch Ligand 3 (DLL3)
This phase III trial studies how well trastuzumab emtansine (T-DM1) and tucatinib work in preventing breast cancer from coming back (relapsing) in patients with high risk, HER2 positive breast cancer. T-DM1 is a monoclonal antibody, called trastuzumab, linked to a chemotherapy drug, called DM1. Trastuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the s...
The objective for this study is to evaluate the effect of crovalimab on treatment-naive patients based on complete response to treatment based on lab measurements
The primary objective of this study is to demonstrate the efficacy of alpelisib as measured by the proportion of participants randomized to alpelisib with a response at Week 24 in at least one of the following groups: - Group 1 (greater than or equal to 18 yr-old) - Group 2 (6 - 17 yr-old) The primary scientific question of interest is, for children/adolescents and adults with PROS, to assess ...
This study will measure emotion regulation on several levels (self-report, behavioral, neuroimaging) in healthy adults and adults beginning AUD treatment. The adults being treated will be followed for 6 months after treatment to assess relapse.
The purpose of this research study is to learn more about the safety and effectiveness of a drug called sargramostim for improving cognitive function and memory in people with Alzheimer’s disease.
We are recruiting individuals with type 2 diabetes (T2D) in need of an exercise program, aged 30 to 55, to help us test how exercise affects heart health, blood vessels, and blood sugar.
A randomized, Phase II trial of circulating tumor DNA-guided second line Adjuvant therapy for high Residual risk, stage II-III, Estrogen Receptor positive, HER-2 negative breast cancer (DARE)
This study wants to learn more about people’s food perception and how this impacts what they eat.
Preserving endothelial function with pulsatility during CPB will be associated with less AKI after cardiac surgery.
This study looks at whether men with prostate cancer improve their metabolism more with lifestyle changes alone or with lifestyle changes plus metformin.
This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study m...
TRC-DS is a community of clinical trial volunteers who could help find a cure for Alzheimer's disease for people with Down syndrome.
This study involves chimeric antigen receptor (CAR) T cell therapy, which is a relatively new therapeutic approach that uses a patient's own immune cells to treat their disease. In autoimmune diseases such as rheumatoid arthritis (RA), certain parts of the immune system are overactive, leading to inflammation. A subtype of immune cells, called regulatory T cells (Tregs), normally help to reduce ...
To evaluate the safety and tolerability of multiple-ascending dose (MAD) levels, 40 mg/kg, 60 mg/kg, and 80 mg/kg, of NS-089/NCNP-02 in ambulant boys with DMD after 4 weeks of once weekly intravenous (IV) treatment; and o evaluate the pharmacokinetics (PK) of MAD levels of NS-089/NCNP-02.
This phase I/II trial studies the safety, side effects and best dose of M3814 and to see how well it works when given together with radiation therapy in treating patients with pancreatic cancer that has spread to nearby tissue or lymph nodes (locally advanced). M3814 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hypofractionated radiation therapy delive...
To measure the compensatory reserve volume of pregnant women undergoing cesarean section.
This study is looking for male and female participants with prediabetes that are aged 18 to 45 years old to learn how how short, frequent periods of physical activity impact your health.
This study wants to learn how aerobic exercise affects people with Parkinson’s disease who have not started medication for their Parkinson’s symptoms. It will compare two types of treadmill exercise – moderate-intensity and high-intensity – to see how they impact Parkinson’s symptoms.
We will recruit 50 adult patients with stage IIIb-IV Chronic Kidney Disease (eGFR 15-45 mL/min/1.73 m2) with clonal hematopoiesis (CH) and 50 adult patients with stage IIIb-IV CKD without CH. All patients will undergo MRI scanning of the upper leg and lower back for assessment of fat in the bone marrow and we will compare the results between the two groups to see if CH is associated with greater b...
Join a CU Anschutz study about the impact of cannabis on driving.
This phase II trial tests whether relugolix and radiation therapy works to shrink tumors in patients with prostate cancer that has spread in a limited way to 1 to 5 other parts of the body (oligometastatic). Testosterone can cause the growth of prostate cancer cells. Relugolix lowers the amount of testosterone made by the body. This may help stop the growth of tumor cells that need testosterone to...
The purpose of this study is to learn more about the effects of how many hours a day we eat in adults with autosomal dominant polycystic kidney disease (ADPKD) who are overweight or obese and how feasible it is to restrict eating to 8 hours a day.
The aim of the INSIGHTS Registry is to establish a national, multicenter database with clinical data for individuals with Turner syndrome. Specifically: 1. Measure various chronic illnesses in individuals with Turner syndrome including premature birth, heart disease, sleep problems, infertility, and others. 2. Determine if there is an association between these chronic illnesses and other varia...
This is a first-in-human study to learn about the study drug called BG-C9074 alone and in combination with tislelizumab in participants with advanced solid tumors.
To compare the effectiveness of two approaches for the management of Barrett’s esophagus (BE) and low-grade dysplasia (LGD), endoscopic surveillance and endoscopic eradication therapy (EET), using an accepted clinical endpoint of neoplastic progression [high-grade dysplasia (HGD)/mucosal esophageal adenocarcinoma (EAC)/invasive EAC].
This phase III trial studies magnetic resonance imaging (MRI) surveillance and prophylactic cranial irradiation (PCI) to see how well they work compared to MRI surveillance alone in treating patients with small cell lung cancer. MRI scans are used to monitor the possible spread of the cancer with an MRI machine over time. PCI is radiation therapy that is delivered to the brain in hopes of preventi...
The primary objective of the current study is to validate the performance of the current ASAS classification criteria in a prospective, combined cohort of patients presenting with undiagnosed current back pain.
This Phase 1B/2 study is a multicenter, open-label, study of RP1 to investigate the (a) objective response rate, in addition to (b) safety and tolerability of RP1 for the treatment of advanced cutaneous malignancies in up to 65 evaluable organ transplant recipients. This will include patients with either previous renal, hepatic, heart, lung, or other solid organ transplantation or hematopoietic ce...
This phase III trial studies how well letrozole with or without paclitaxel and carboplatin works in treating patients with stage II-IV low-grade serous carcinoma of the ovary, fallopian tube, or peritoneum. Letrozole is an enzyme inhibitor that lowers the amount of estrogen made by the body which in turn may stop the growth of tumor cells that need estrogen to grow. Drugs used in chemotherapy, suc...
In this research we will learn more about blood clotting and drugs that modify blood clotting.
We will evaluate the effects of deep brain stimulation (DBS) of bilateral nucleus accumbens (NAc) added to background treatment for treatment refractory Methamphetamine Use Disorder (MUD). This is a small randomized cross-over study to demonstrate feasibility and safety, test treatment outcomes (use, craving), and identify novel biological targets (NAc local field potentials (LFP) and functional M...
The FLEX Registry will be implemented to operate as a large-scale, population based, prospective registry. All patients with stage I to III breast cancer who receive MammaPrint® and BluePrint testing on a primary breast tumor are eligible for entry into the FLEX Registry, which is intended to enable additional study arms at low incremental effort and cost. FLEX Registry will utilize an adaptive de...
Evaluate the effects of a medication, tolcapone (TOLC), on non-treatment-seeking individuals with Alcohol Use Disorder and Attention-Deficit/Hyperactivity Disorder (ADHD).
If your doctor has told you that you have diabetes, but it doesn’t seem like type 1 or type 2, you might be able to join our study. The goal of this study is to better understand different kinds of diabetes that are not common.
To understand the effects of puberty blockers and puberty on insulin sensitivity, metabolism and vascular health
To determine if trastuzumab emtansine (ado-trastuzumab emtansine [T-DM1]) shows better progression-free survival (PFS) when compared to docetaxel plus trastuzumab (TH) in recurrent and/or metastatic (R/M) HER2-positive salivary gland cancer (SGC) patients who have not previously received HER2 therapy for unresectable or recurrent and/or metastatic disease, as determined by local assessment.
To prospectively collect data regarding the diagnosis and treatment of orthopedic infections including upper and lower limb as well as pelvic and spinal infection in order to improve quality of care. The database will be used for subsequent future research.
This study plans to learn more about the inherited genetic factors that cause Birdshot chorioretinitis and the risk factors associated with this disease. We also aim to include your family members (parents and siblings) to determine if there are any genetic differences between individuals who do not have this disease.
Evaluate the effects of a medication, brexpiprazole (BREX), on non-treatment-seeking individuals with Alcohol Use Disorder.
Glioblastoma (GBM) adaptive, global, innovative learning environment (GBM AGILE) is an international, seamless Phase II/III response adaptive randomization platform trial designed to evaluate multiple therapies in newly diagnosed (ND) and recurrent GBM
The purpose of this study is to understand the role of semaglutide, with or without metformin, in restoring ovulation in youth and adults (12-35 years old) with polycystic ovary syndrome.
This is an open-label, non-randomized, single-institution, single arm Phase II study conducted using a Simon two-stage design with an additional safety lead-in. The overall objective is to determine the efficacy of combination doxorubicin with dual checkpoint blockade with anti-CTLA-4 antibody AGEN1884 and anti-PD-1 antibody AGEN2034. The investigators will estimate the progression-free survival r...
The purpose of this study is to assess whether postoperative adjuvant therapy with mRNA-4157 and pembrolizumab improves recurrence free survival (RFS) compared to pembrolizumab alone in participants with complete resection of cutaneous melanoma and a high risk of recurrence.
Our team is here to find out if taking part in a cognitive-behavioral therapy group, exercise training group, or combination of therapy and exercise training lowers stress, improves mood, raises physical activity and fitness, and lowers diabetes risk among teen girls at risk for diabetes.
We are purposing this retrospective and prospective, multicenter observational study in order to facilitate quality improvement and description of treatment with this novel dialysis device dedicated to the treatment of infants with AKI or fluid overload.
This study evaluates a novel regimen of induction chemotherapy using a combination of docetaxel, oxaliplatin, and leucovorin, with short term infusional 5-FU (FLOT), given prior to chemoradiotherapy with concurrent carboplatin and paclitaxel, as neoadjuvant therapy prior to definitive surgical resection for patients with adenocarcinoma of the esophagus or gastroesophageal junction
The Lung PCA BU goals include enrollment of informative retrospective and prospective patients from which informative biospecimens can be collected and processed for advanced analyses of PMLs. Central to this process will be the development of techniques to optimize data production from limited tissues. The generation of a deep and interactive database will be critical to help direct the studies...
The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming back.
To evaluate the maximum tolerated combination and safety profile of multi-fraction radiosurgery with concurrent nivolumab plus or minus ipilimumab for recurrent radiation-relapsed high-grade meningioma. (Phase I) II. To evaluate the objective response rate (ORR) of multi-fraction radiosurgery with concurrent nivolumab plus or minus ipilimumab for recurrent radiation-relapsed high-grade meningioma....
The primary objective of this study is to demonstrate efficacy of BIIB059 compared with placebo in participants with active systemic lupus erythematosus (SLE), who are receiving background lupus standard of care (SOC) therapy in reducing disease activity.
This study wants to learn about how total joint replacements affect the lives and physical abilities of children and young adults as they grow older.
The primary objective of this screening study is to test patient specimens to determine eligibility for participation in the biomarker-driven and non-matched sub-studies included within the Lung-MAP umbrella protocol.
The specific aims of the project are to: 1) Discover biomarkers associated with marijuana use. 2) Discover biological pathways associated with marijuana use. 3) Exploratory Aim: Test whether peripheral endocannabinoid levels vary with marijuana use and predict marijuana craving.
This study wants to find a new combination of drugs that is safe and effective to treat people who have bone cancer that has come back or not responded to other treatments.
This study plans to learn more about genes that are expressed in blood vessels in the brain and in the blood of patients without brain aneurysms. This will help us understand diseases that affect those blood vessels such as aneurysms.
To establish whether or not nicotinamide riboside will improve large artery stiffness in patients with stage III and IV chronic kidney disease.
To evaluate the efficacy of batoclimab 680 mg subcutaneously (SC) once a week (QW) for 12 weeks followed by 340 mg SC QW for 12 weeks versus placebo on proptosis responder rate at Week 24
This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Addition of prostate removal surgery or radiation therapy to standard systemic therapy for prostate cancer may lower the chance of the cancer growing or s...
This phase II trial studies how well olaparib works in treating patients with bladder cancer and other genitourinary tumors with deoxyribonucleic acid (DNA)-repair defects that has spread to other places in the body (advanced or metastatic) and usually cannot be cured or controlled with treatment. PARPs are proteins that help repair DNA mutations. PARP inhibitors, such as olaparib, can keep PARP f...
To fully characterize safety and efficacy when the coflex® device is used in the intended subject population under the actual conditions of use”
This phase II trial compares the effect of irinotecan versus oxaliplatin after long-course chemoradiation in patients with stage II-III rectal cancer. Combination chemotherapy drugs, such as FOLFIRINOX (fluorouracil, irinotecan, leucovorin, and oxaliplatin), FOLFOX (leucovorin, fluorouracil, oxaliplatin, and irinotecan ), and CAPOX (capecitabin and oxaliplatin) work in different ways to stop the g...
The purpose of this study is to investigate high frequency ultrasound as a future modality for the diagnosis of chronic exertional compartment syndrome (CECS).
This study plans to learn more about pulmonary fibrosis and determine if some diseases that cause scarring in the lung might be inherited diseases. We are especially interested in the genetics of pulmonary fibrosis and cases where it might run in families. What we learn may be helpful in the future to people with pulmonary fibrosis and their family members.
To determine if the chronic administration of riociguat improves exercise hemodynamic profiles measured by tight heart catheterization (RHC) - in patients with subjective exercise limitation at least 6 months post-PTE surgery.
This study plans to learn more about how different adipose tissues are related to diabetes and muscle mass and strength, as well as how to non-invasively track liver disease in those undergoing elective abdominal surgeries.
Evaluate the Arctic Sun Cooling device for fever prevention to standard of care measures for controlling fever in the ICU
To find out if bNAbs, VRC07-523LS and PGT121.414.LS, are safe for administration with ART. To evaluate if the bNAbs are effective at keeping HIV from reproducing. It is necessary to stop taking ART after receiving the bNAbs or placebos for bNAbs. This is referred to as an ATI (analytical treatment interruption).
Our goal is to determine if 12 sessions of Parent Management Training can reduce anger outbursts and irritable moods in children aged 10-14.
To compare the physical, mental, and emotional effects of high school girls' flag football participation to those of high school girls who do not participate in organized sport over a 9 month period.
Aim 1: To compare pain and function in patients undergoing operative versus non-operative treatment of atraumatic rotator cuff tears at 12 months of follow-up. Aim 2: To assess effects of rotator cuff tear size and age on comparative outcomes (measured by SPADI) in operative versus non-operative treatments for atraumatic rotator cuff tears.
This is an international phase III trial, with a Bayesian design, incorporating two sequential randomisations. It efficiently examines a series of questions that routinely arise in the sequencing of treatment. The study design has evolved from lengthy international consultation that has enabled us to build consensus over which questions arise from current knowledge and practice. It will enable pot...
The primary objective of this study is to evaluate the efficacy of subtypeselective Janus kinase (JAK) inhibitors in the preservation of β cell function in participants with recent onset Stage 3 T1D (diagnosed within 100 days)
Determine if copeptin levels, a marker of vasopressin, correlates with presence and severity of fatty liver disease.
This study wants to find out how well a monthly, non-hormonal vaginal ring is at preventing pregnancy.
The purpose of this research study is to learn more about how cannabidiol (CBD) may affect cannabis use, effects, mood, and cognitive function.
To longitudinally study individuals at risk for spondyloarthritis and spondyloarthritis associated diseases.
We are looking for people aged 25 to 55 who smoke and/or vape cannabis, and people aged 25 to 55 who do not smoke cannabis, to see how cannabis use affects lung health over time.
To evaluate the best overall response rate (BOR) of recurrent/metastatic androgen receptor positive (AR+) salivary gland cancer (SGC) patients within one year of darolutamide and androgen deprivation therapy (ADT
To determine the maximum tolerated dose of temozolomide followed by selinexor in recurrent glioblastoma patients as determined by dose-limiting toxicities (DLTs) and the total toxicity profile. (Phase I) II. To evaluate the efficacy of sequentially administering temozolomide and selinexor in recurrent glioblastoma as determined by progression-free survival (PFS). (Phase 2)
This phase Ib/II trial tests the safety, side effects, best dose, and effectiveness of the combination of ipatasertib with megestrol acetate to megestrol acetate alone in patients with endometrial cancer that has come back (recurrent) or has spread to other places in the body (metastatic). Ipatasertib may stop the growth of tumor cells and may kill them by blocking some of the enzymes needed for c...
This study plans to learn more about cannabidiol (CBD) as a potential treatment in patients that have Traumatic Brain Injury (TBI)-related symptoms. CBD is a chemical found in the cannabis (or hemp) plant that can be used as a medication.
Designed to be the largest and most comprehensive study of its kind, The Human Trisome Project will help us understand why individuals with Down syndrome (caused by trisomy of chromosome 21) are protected from some medical conditions, such as cancer, while highly predisposed to others, such as Alzheimer's disease and autoimmune disorders. De-identified samples and information are then available to...
We want to learn how to help teens with migraine live a better life!
An Open-label Extension Study for Participants who Completed Study IMVT-1401-3201 or Study IMVT-1401-3202 to Assess the Efficacy and Safety of Batoclimab for the Treatment of Thyroid Eye Disease (TED)
This study is designed to assess whether broad spectrum CBD and full spectrum CBD, compared to placebo, is effective in reducing alcohol drinking in participants with an alcohol use disorder. If eligible for the study, participants will be randomly chosen to receive one of the study conditions for 12 weeks.
To test CAR T cell therapy (a type of therapy made from one's own immune cells) for refractory lupus nephritis
The purpose of this study is to learn more about the effects of an investigational drug called semaglutide as a safe and effective means of improving cardiovascular function, kidney function, and insulin sensitivity in adults with type 1 diabetes.
We are looking for people aged 25 to 55 who drink alcohol heavily to see how alcohol use affects lung health over time.
The purpose of this study is to determine how the body's immune system interacts with nuts and other foods to cause allergic reaction. This study also plans to validate a test that is being developed to help predict reactions to peanuts.
This study plans to learn more about how safe the investigational study drug CB-03-10 is, and to see how your body tolerates CB-03-10 and how your body reacts to the drug
Develop a database of subjects with inflammatory renal disease. Develop a data and biobank containing securely stored data, blood, urine, stool, endothelial cell samples, and kidney biopsy tissue.
The goal of this clinical trial is to test an experimental treatment (immunotherapy) in pancreatic cancer patients. The main research objectives are: to evaluate if the KISIMA-02 treatment is safe and well-tolerated (first part) to evaluate if the KISIMA-02 treatment has an impact on the time to observe a possible reappearance of the tumor (second part) Participants will receive: i) a ther...
The purpose of this study is to examine the impact of exercise on sleep and cognition in Parkinson’s Disease.
The goal of this study is to see how when you eat and when you exercise (morning or evening) affects metabolism.
A comparison of baseline tumor characteristics in oncogene-driven cancers to tumor characteristics after early response to TKI targeted treatment will allow identification of early adaptive mechanisms of cell survival. This will facilitate targeting and termination of these survival/ resistance pathways before they develop with rational combinations of therapeutic agents to improve outcomes.
The overall objective of this study is to ultimately develop an improved standard of cancer care by facilitating new clinical trials, new technology, new informatics solutions and "personalized medicine".
IMGN151-1001 is a Phase 1, first in human, open-label dose-escalation and expansion study in adult patients with recurrent endometrial cancer, recurrent, high-grade serous epithelial ovarian, primary peritoneal, or fallopian tube cancers.
This is a clinical trial to test letrozole in patients with uterine leiomyosarcoma. The main question is will treatment with letrozole extend progression-free survival in patients. Patients will receive 2/5 mg of letrozole daily.
Physical activity and sedentary time will be measured via accelerometry (ActiGraph wGT3X-BT) for 7 days in patients with ADPKD and healthy controls.
This phase II/III trial tests whether adding trastuzumab and hyaluronidase-oysk (Herceptin Hylecta [TM]) or pertuzumab, trastuzumab and hyaluronidase-zzxf (Phesgo [TM]) to the usual chemotherapy (paclitaxel and carboplatin) works to shrink tumors in patients with HER2 positive endometrial cancer. Trastuzumab and pertuzumab are monoclonal antibodies and forms of targeted therapy that attach to spec...
This study wants to learn more about the best times of day to eat that lead to weight loss for adults with overweight or obesity.
The purpose of this research is to identify strategies that minimize bone loss that occurs when older adults lose weight
The study aims to assess safety and tolerability of oral toll-like receptor (TLR) 8 agonist Selgantolimod (SLGN) administered for 24 weeks in participants with both CHB and HIV who have been receiving suppressive antiviral therapy for both viruses for ≥5 years and have qHBsAg level >1000 (3 log10) IU/mL at screening. The study will also evaluate if TLR8 stimulation with SLGN will reduce hepatitis ...
The primary objective of the BISON-PRO Database is to establish a prospective repository of real-world, longitudinally-collected patient-reported outcomes (PRO) and quality-of-life data for patients with both malignant and non-neoplastic blood disorders to support patient-centered research.
This is a first-in-human, phase 1/2 to learn about the study drug SNS-101.
We want to learn how stimulating the vagus nerve while moving the hand can help improve fine motor control in people with relapsing-remitting multiple sclerosis (MS), who have trouble moving their hands and arms.
OKI-219-101 is a Phase 1a/1b, open-label, multicenter, dose-escalation study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PDx), and efficacy of OKI-219 as monotherapy and in combination with fulvestrant or trastuzumab. Phase 1a (Part A) will investigate escalating doses of OKI-219 monotherapy, and Phase 1b will investigate OKI-219 (at a tolerated dose det...
To measure distant recurrence free interval from end of treatment stratified by landmark (4-12 weeks post-treatment) and serial post-treatment ctDNA detection status (detected vs. not detected). The purpose of ORACLE is to demonstrate the ability of a novel ctDNA assay developed by Guardant Health to detect recurrence in individuals treated for early-stage solid tumors. It is necessary that ctD...
Primary objective is to evaluate the effectiveness of cenerimod 4mg at reducing disease activity compared to placebo. The secondary objective is to evaluate the effect of cenerimod 4mg to control the disease compared to placebo. The safety objective is to evaluate the safety and tolerability of cenerimod 4mg.
The primary objective of this study is to determine whether primary PC is non-inferior to specialty PC for improving quality of life (QOL) in patients with AML.
The goal of this clinical trial is to test ELVN-002 in people with cancers that have an abnormal HER2 gene. The main question the trial aims to answer is if ELVN-002 is safe and tolerable at different doses. A second main question is to evaluate the concentration of ELVN-002 in the blood at different doses and to see how this correlates with safety and see how the concentration of drug changes ove...
We are recruiting adult women with regular periods to learn more about how reproductive hormones are impacted by two different diets. We also will look at how women's hormones influence weight and metabolism.
To collect data on the recurrence rate and outcomes of benign and primary/metastatic malignant tumors seen in Orthopaedic patients at the University of Colorado Hospital.
To collect prospectively (after informed consent) fresh, excess surgical tissues, blood and other bodily fluids, and saliva from patients with HNC slated to undergo biopsy or surgical resection, and to collect prospectively optional samples from patients with HNC slated to undergo other therapies
This study wants to learn which physical therapy treatments are most helpful to individuals with chronic neck pain including parts of treatment outside of the treatment itself such as the patient and therapist relationship. The study will compare two different treatments, resistance exercise and manual therapy. Resistance exercise builds muscle strength by making your muscles work against a weight...
This study is testing a virtual physical activity program to improve the health and wellness of older family care partners. The virtual physical activity program will use Zoom to deliver exercise sessions, track physical activity and sleep using a Fitbit, and send motivational and encouraging text messages. The goal is to help older family care partners to improve their physical and mental health ...
To study how infants’ ability to differentiate speech sounds develops and how this ability affects other measures of auditory development.
We are looking for teens with autism, ages 13-19, to help us study how exercise and social gaming affect brain responses.
We are studying how sleep affects memory in people with traumatic brain injuries. We need healthy people that do not have any neurological conditions to join our study!
This complimentary online program will teach you to notice and prevent work-related stress injuries and learn how to hold supportive talks with peers. This training will provide you with the tools to create a better caring community at work.
With our community partner, the Gyedi Project, we want to see how different levels of goal-setting exercises can encourage physical activity in the Black community. We also want to see how this program affects sticking to exercise and attitudes toward exercise.
This study wants to see if gut problems are worse in men with and without HIV that have sex with men who have metabolic syndrome compared to those without metabolic syndrome. We are looking for men that do not have HIV.
We are looking for adults with a glioma brain tumor (grades 2, 3, or 4) to share their ideas on a new program to improve health and well-being for brain cancer survivors.
We are recruiting healthy individuals in need of an exercise program, aged 30 to 55, to help us test how exercise affects heart health, blood vessels, and blood sugar.
Is this your first time using hearing aids? We want to learn how they affect your daily life through three short online surveys.
We are looking for Hispanic or Latino adults with a low-grade glioma brain tumor (grades 2 or 3) to join a new health education program. In this program, we will talk about what low-grade glioma and how genes affect it, how to get ready for a doctor visits, how to find help in your community, what are quality of life needs, and how to take part in research.
This study wants to learn how age and sex affect how our blood vessels age and how exercise (both short-term and long-term) changes the body.