To establish whether or not nicotinamide riboside will improve large artery stiffness in patients with stage III and IV chronic kidney disease.
This is a 3 month study to determine if nicotinamide riboside (a B vitamin) will improve vascular function. During this study labs, vascular function, ambulatory BP, and office BP will be measured before taking the study drug (nicotinamide riboside/placebo) and again 3 months after daily doses of the study drug. During the 3 month study period there are every 2 week visits to evaluate blood pressure. Optional testing includes cerebral artery testing and cognitive testing before after daily doses of nicotinamide riboside.
Age 35-80 Chronic kidney disease stage III or IV Blood pressure controlled to < 140/90 in the past 3 months Body mass index < 40 kg/m2 Weight stable in prior 3 months
Principal Investigator