The purpose of this study is to learn more about the effects of how many hours a day we eat in adults with autosomal dominant polycystic kidney disease (ADPKD) who are overweight or obese and how feasible it is to restrict eating to 8 hours a day.
We want to study how feasible it is to restrict eating to 8 hours a day. Both groups will participate in a group-based, behavioral dietary intervention for 1 year (initially weekly, then monthly meetings). We will also look at changes in markers in the blood and both the size of the kidneys and amount of fat tissue in the abdomen by MRI. The results of this study will help design a larger study where we can test if restricting hours of eating can slow progression of ADPKD.
1) Age 18-65 2) ADPKD diagnosis 3) BMI 25-45 kg/m2 4) CKD-EPI eGFR greater than or equal to 30 mL/min/1.73m2 5) Access to the internet with video chat capabilities and a smart phone 6) Typical eating duration more than 12 hrs/day Exclusion criteria: 1) Diabetes mellitus 2) Current nicotine use of history of use in past 12 months 3) Alcohol/substance abuse 4) History of hospitalization or major surgery in last 3 months 5) Untreated dyslipidemia 6) Uncontrolled blood pressure (>160/100) 7) Pregnancy, lactation, or unwillingness to use adequate contraception 8) Significant GI disorders 9) History of a clinically diagnosed eating disorder 10) Weight loss of >5% in the past 3 months for any reason except post-partum weight loss 11) Current severe depression or history of severe depression in the last year 12) History of other significant psychiatric illness 13) Inability to cooperate with/clinical contraindications for MRI
Principal Investigator