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People living with HIV can be affected by major depressive disorder (MDD) and mild neurocognitive disorder (MND). Depression is often missed or not fully treated in this population. At the same time, there is no standard treatment available for MND in people living with HIV. This study looks at how pramipexole and escitalopram are and how well they work to treat MDD and MND in people living with HIV. We will also study the side effects of both medications and see if there are any differences. If you join this study, you will be randomly placed into one of two groups, like flipping a coin. You will know which group you are in. In both groups, you will start a low dose of the study drug. The dose may slowly increase over time based on how you feel. At most visits, blood will be drawn from a vein in your arm. You will also have a physical exam and complete questionnaires and thinking and memory tests. At some visits, you will provide a urine sample and have electrocardiogram (ECG), which is a test that measures your heart rhythm. You will have about 13 study visits over 6 months. You will be paid up to $650 if you complete all visits.

Who can Participate

You may be able to join this study if you are living with HIV, 18-70 years old, and feeling depressed. Compensation provided.

Study ID

More information available at ClinicalTrials.gov: NCT06705478