Clonal hematopoiesis, mild cognitive impairment and kidney function decline.
We will recruit 50 adult patients with stage IIIb-IV Chronic Kidney Disease (eGFR 15-45 mL/min/1.73 m2) with clonal hematopoiesis (CH) and 50 adult patients with stage IIIb-IV CKD without CH. All patients will undergo MRI scanning of the upper leg and lowe
Why this Research Matters
CH is a common aging-associated biological state that predisposes to subsequent cardiovascular death, however, whether it plays a role in MCI, dementia and kidney disease progression is unknown and understanding this novel risk factor may uncover new way
Who can Participate
The study plans to enroll up to 100 people, age 55 -99 years, over the next 5 years. Other criteria for the study include: -a diagnosis of chronic kidney disease (CKD) -GFR 15 - 45 mL/min/1.73 m2 -no history of blood cell cancer, chemotherapy or radiati
Study ID
Protocol Number: 22-0288
Meet the Team
Principal Investigator