Women living with HIV often have more frequent and severe hot flashes and night sweats than women without HIV. Hormone therapy is one of the most effective treatments for these symptoms in healthy women. However, it has not been well studied in women living with HIV. This study will help researchers learn: if hormone therapy reduces hot flashes and night sweats, improves memory, mood, and sleep, improves quality of life, supports bone health, reduces inflammation, and is safe for women living with HIV. If you join this study, you will be randomly placed into one of two groups, like flipping a coin. One group will receive hormone therapy and the other group will receive a placebo (a pill with no medication). You will not know which group you are in. At most visits blood will be drawn. You may also have a physical exam, provide a urine sample, complete questionnaires, and complete a daily diary. There will be about 5 study visits over 5 months. You will be paid up to $325 if you complete all visits.

Who can Participate

You may be able to join this study if you are a woman living with HIV, 40-60 years old, and experiencing hot flashes and night sweats. Compensation is provided.

Study ID

More information available at ClinicalTrials.gov: NCT06856174