This research study is being conducted to examine the effects of montelukast therapy on kidney function and blood vessel function in young adults with type two diabetes. We are studying the effects/impact of montelukast (an asthma/allergy medication) on: Kidney function Protein in the urine Blood vessel function. The main procedures done in the study are: Physical exam and medical history Blood pressure Blood draw Urine collection Kidney function measures Blood vessel function testing Study drug will be taken for 6 months. There are approximately 4 study visits where the above procedures will be conducted over 6 months. The study takes place at the CU Medicine Building. Participants will receive information regarding their overall health status; including testing for blood pressure, kidney function levels and urine results. Compensation is provided. For more information, please contact Dr. Angelina Dixon at: Angelina.dixon@cuanschutz.edu

Who can Participate

Age 14-24 years History of type 2 diabetes Diabetes onset <18 years of age A1c <10% Diabetes onset <18 years of age and <10 years duration prior to study start Blood pressure <140/90 mm Hg prior to randomization Stable blood pressure medications for at least one month prior to randomization BMI < 40 kg/m2 If on SGLT2 inhibitor, ACEi/ARB or GLP-1RA, stable dose for 4 weeks No T1D No episode of diabetic ketoacidosis or hyperosmolar hyperglycemia within 60 days No uncontrolled hypertension eGFR >30 ml/min/1.73m2 No macroalbuminuria with urine albumin to creatinine ratio >300 mg/g No current participation in another research study No pregnancy or planning to become pregnant or currently breastfeeding No allergy to aspirin No severe liver impairment No history of major psychiatric disorder (higher risk of neuropsychiatric reaction) No use of inhaled or systemic corticosteroids or long-acting beta agonists No Iodine or shellfish allergy

Study ID