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Individualizing Treatment of Asthma in Primary Care (iTREAT-PC)

This study wants to see how safe and how well two different ways to treat asthma (adding an inhaled corticosteroid or using an antibiotic) work when compared to usual care. By figuring out which treatment decreases the number of asthma attacks and reduces the need for emergency care, we hope to improve people’s symptoms and quality of life.

Why this Research Matters

People with asthma need new ways to manage their symptoms and improve their quality of life. This study will test which guideline-approved treatment works best for different individuals.

What to Expect

If you choose to take part, you will be randomly placed into one of four groups. The first group will use their regular asthma medication and track their symptoms. The second group will add an inhaled corticosteroid to their rescue inhaler. The third group will take an antibiotic three times per week. The fourth group will add an inhaled corticosteroid to their rescue inhaler and take an antibiotic three times per week. You will take a short survey when you start the study, and then every two months. You can do it online or by phone. The survey will ask about your asthma symptoms and medication use. You may be asked to complete an optional blood draw and a brief interview about your experience.

Study Duration

You will be in the study for 16 months.

Who can Participate

13 to 75

You may be able to join this study if you:

  • Are between 13 and 75 years of age
  • Have asthma for at least on year
  • Are taking a daily inhaled corticosteroid
  • Have either had an asthma flare-up (attack) in the past year OR your asthma is not well controlled
  • Do not have a person living in your home already enrolled in the study
  • Do not have an allergy to macrolides (e.g., azithromycin)
  • Do not have a history of certain liver or heart rhythm conditions (prolonged QT interval) or other lung diseases like cystic fibrosis or bronchiectasis
  • Do not take oral steroids every day or every other day
If you have COPD, you  may be able to join the study if you have never smoked and have normal diffusing capacity.

Study ID

Protocol Number: 25-0667

Compensation Information

Compensation
Study Payment: You and your insurance will need to pay for your routine medical care. You can earn up to $160 in gift cards for completing the enrollment process and surveys.

Meet the Team

Image of Principal Investigator

Jill Vanwyk, MD

Principal Investigator

More Information

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