In this study we are testing a new drug called teplizumab to see if it can help protect the cells that make insulin in people with type 1 diabetes. We want to know if it can improve blood sugar levels, reduce the need for extra insulin, and lower the risk of low blood sugar.
This study wants to see if a new drug called SAB-142 in addition to regular insulin therapy can help slow down Type 1 Diabetes (T1D) in people who were diagnosed in the last 100 days.
This study looks at whether mothers with viral infections during pregnancy experience inflammation that might affect the baby.
In this study, we want to learn how teens handle stress, deal with feelings of depression, and manage habits like eating, exercise, and sleep. We will use what we learn to make a Digital App that helps teens struggling with these challenges.
In this study we want to learn more about how common health problems like high blood pressure, vision problems, and kidney disease are in people with cystic fibrosis-related diabetes (CFRD).
In this study we want to see if improving the amount and quality of sleep will help improve the overall health of adolescents that have type 1 diabetes (TID).
The goal of this study is to compare how well the iLet Bionic Pancreas works in people with Cystic Fibrosis Related Diabetes compared to others with the same condition using their regular care.
In this study we want to gather information about Stargardt Disease Type 1 (STGD1) and learn how it develops over time. We hope to use this information to help scientists come up with treatments or a cure for STGD1 in the future.
To estimate the effect of ATG therapy based on responder status with and without verapamil in patients recently diagnosed with stage 3 T1D.
This study will test a new medicine called DMX-200 to see if it can lower protein in the urine and slow kidney damage in people with focal segmental glomerulosclerosis (FSGS) who are already taking an ARB medicine. Researchers will also look at how safe DMX-200 is, how well people can handle it, how it affects kidney health and quality of life, and how the body uses the medicine.
In this study we want to determine the best intervention for improving sleep quality in people recovering from a concussion. To do this we are comparing two sleep interventions and seeing how the impact the recovery time for a concussion.
In this study we want to learn more about the safety and effectiveness of a drug called frexalimab to treat people with newly diagnosed type 1 diabetes.
In this study we want to standardize the type of data we collect during a treatment called embolization for people with pulmonary arteriovenous malformations (PAVMs). We will then use this data to compare other treatment methods for PAVMs and learn how they impact patient health and healing.
In this study, we want to learn if eating meals together as a family can help improve your child’s health, and the health of other family members too!
In this study, we want to compare two methods for treating teens who have substance use disorder (SUD) and symptoms of post-traumatic stress disorder (PTSD). We want to see if Risk Reduction Through Family Therapy (RRFT) or Encompass Treatment is more helpful for treating teens with these mental health problems.
In this study we want to learn more about a new treatment called CD19x22 CAR T cells. We want to see how well it works as a treatment for B-cell Acute Lymphoblastic Leukemia (B-ALL) when the cancer has come back after treatment or hasn’t responded to previous treatments.
In this study, we want to better understand how the environment and things that happen early in children’s lives—even before they are born—affect their development, health, and well-being.
To assess the pharmacodynamic and clinical efficacy of CNP-103
In this study we want to learn more about achondroplasia and the genetic factors and health outcomes linked to it. To do this, we are collecting DNA (from saliva samples) from people who have achondroplasia and their family members.
This study wants to learn if taking a protein supplement drink twice a day for 8 weeks can help lower the amount of fat that is stored in the liver.
We are studying how a type of chemotherapy called doxorubicin affects the heart and arteries. We are looking for lymphoma survivors and healthy adults to join this study.
This study looks at how choline supplements and exposure to cannabis-based products affect pregnancy and child health.
In this study, we want to see if two anti-rejection drugs (belatacept and sirolimus) can better protect your new kidney after kidney transplant, compared to the currently used drugs (tacrolimus and MMF).
This study wants to know if a new drug called Diamyd®, can safely and effectively treat type 1 diabetes.
In this study, we want to learn more about a new drug called iptacopan to see if it can help treat a rare kidney disease called IC-MPGN (immune complex mediated membranoproliferative glomerulonephritis).
This study wants to learn more about how exposures during pregnancy like infections, diet and growth, can affect a baby’s chances of developing type 1 diabetes later in life.
We want to find better ways to treat bipolar disorders. We are looking for children, teens, and young adults, aged 9 to 21 years old, to join our study.
This study will collect data from health records about people that have variations in their X & Y chromosomes to learn about their health. We also ask if people are willing to join future studies about X & Y variations.
We are looking for couples that have had two or more pregnancy losses with no known cause. We want to find out if genetics might be a reason for recurrent pregnancy loss (RPL).
This study wants to learn more about hearing loss using samples from a child, both of their biological parents, and/or other family members. We will use the samples to study heritable risk factors for hearing loss and changes in gene expression that lead to hearing loss and/or ear abnormalities.
This study wants to learn more about how COVID-19 and diabetes are connected.
This study wants to collect medical information from people with Turner Syndrome at clinics across the country to learn more about the condition. We are gathering this data in a national registry to help improve the health and care for people with Turner Syndrome in the future.
This study wants to learn how a type of fat in the blood, called triglycerides, affects how the fetus grows.
In this study we want to learn if a medicine approved for diabetes and weight loss called Ozempic® and Wegovy® (semaglutide) can help improve the frequency of periods and the way the body uses sugar in women with polycystic ovary syndrome (PCOS).
Our team is here to find out if taking part in a cognitive-behavioral therapy group, exercise training group, or combination of therapy and exercise training lowers stress, improves mood, raises physical activity and fitness, and lowers diabetes risk among teen girls at risk for diabetes.
This study wants to find a new combination of drugs that is safe and effective to treat people who have bone cancer that has come back or not responded to other treatments.
Our goal is to determine if 12 sessions of Parent Management Training can reduce anger outbursts and irritable moods in children aged 10 to 14 years old. We are also looking at body responses, like heart rate, that might be used to develop better treatments for irritability.
This study wants to better understand Down syndrome and related health problems by comparing blood and saliva samples from people with and without Down syndrome. Right now, we are mainly looking for people who do not have Down syndrome but do have chronic constipation to join our study.
In this study we want to find out how the body’s immune system reacts to nuts and other foods and causes allergies. We also want to check how well a new test works that may help predict allergic reactions to peanuts