This study trains outpatient clinicians to implement Facing Your Fears: Intellectual and Developmental Disabilities (FYF:IDD), a 14-week group CBT intervention for autistic teens with intellectual development disability and interfering anxiety.
In this study we want to learn more about a new treatment called CD19x22 CAR T cells. We want to see how well it works as a treatment for B-cell Acute Lymphoblastic Leukemia (B-ALL) when the cancer has come back after treatment or hasn’t responded to previous treatments.
To study how cycles of Carfilzomib and Belatacept impact antibody composition and strength for patients who are highly sensitized.
We are inviting people who are pregnant, at least 16 years old, and less than 20 weeks pregnant to join the Mile High ECHO Study. The study follows people during pregnancy and after their baby is born to learn what helps children grow and stay healthy.
To assess the pharmacodynamic and clinical efficacy of CNP-103
In this study we want to learn more about achondroplasia and the genetic factors and health outcomes linked to it. To do this, we are collecting DNA (from saliva samples) from people who have achondroplasia and their family members.
This study wants to learn if taking a protein supplement drink twice a day for 8 weeks can help lower the amount of fat that is stored in the liver.
To discover the efficacy of a multidimensional sleep health intervention on concussion symptom resolution time and sleep health assessments following adolescent concussion, compared to SOC sleep health guidance. To discover the efficacy of a multidimensional sleep health intervention on concussion symptom resolution time and sleep health assessments following adolescent concussion, compared to SOC...
This study plans to learn more about psychological interventions that can be used to address anxiety for youth with at high risk for type 1 diabetes and their caregivers. Anxiety is a common reaction to learning you or a loved one are at risk for type 1 diabetes.
We are studying how a type of chemotherapy called doxorubicin affects the heart and arteries. We are looking for lymphoma survivors and healthy adults to join this study.
This study looks at how choline supplements and exposure to cannabis-based products affect pregnancy and child health.
To determine the safety of targeted immunotherapy with daratumumab (DARA) IV after total body irradiation (TBI)-based myeloablative conditioning and allogeneic hematopoietic cell transplantation (HCT) for children, adolescents, and young adults (CAYA) with high-risk T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LLy).
This is a study wants to find out if the birth control pill Slynd affects bone health in adolescent girls ages 14 to 17.
This study will evaluate the effectiveness and safety of risdiplam (Evrysdi®) administered to patients under 2 years of age genetically diagnosed with spinal muscular atrophy (SMA) and 2 SMN2 copies who have previously received onasemnogene abeparvovec.
In this study, we want to see if two anti-rejection drugs (belatacept and sirolimus) can better protect your new kidney after kidney transplant, compared to the currently used drugs (tacrolimus and MMF).
Primary objective: To assess the persistence rate of patients undergoing pulmonary arteriovenous malformation (PAVM) embolization at multiple hereditary hemorrhagic telangiectasias (HHT) centers of excellence in the United States using standardized reports. Second objective: To assess the impact of technical factors like the type of embolic device and embolization technique (feeding artery vs. ve...
To demonstrate the efficacy of different doses of frexalimab in comparison with placebo and in addition to standard of care (SOC) on endogenous insulin secretion in participants (12-21 y.o.) with newly diagnosed T1D over a 52-week period
This study wants to know if a new drug called Diamyd®, can safely and effectively treat type 1 diabetes.
In this study, we want to learn more about a new drug called iptacopan to see if it can help treat a rare kidney disease called IC-MPGN (immune complex mediated membranoproliferative glomerulonephritis).
• Examine the clinical efficacy of 1000 mg/m2 /day of oral DFMO to stabilize or improve loss of β cell function in persons with recent onset T1D. Our primary endpoint defining clinical efficacy will be based on mixed-meal stimulated C-peptide AUC in the treatment group compared to placebo after 6 months of DFMO treatment. • Examine the safety and tolerability of 1000 mg/m2 /day of oral DFMO i...
This study wants to learn more about how exposures during pregnancy like infections, diet and growth, can affect a baby’s chances of developing type 1 diabetes later in life.
To evaluate the safety and effectiveness of the Spinal Kinetics M6-C™ artificial cervical disc in patients with contiguous twolevel symptomatic cervical radiculopathy with or without cord compression.
We want to find better ways to treat bipolar disorders. We are looking for children, teens, and young adults, aged 9 to 21 years old, to join our study.
This study seeks to better understand the effects of cannabis use during adolescence on decision making and reward responsivity and may identify biomarkers that help distinguish youth who experience impairments in decision making and are at higher risk of the negative effects of cannabis use.
This study is designed as a real-world evaluation of two integrated treatments for substance use and trauma, Risk Reduction Through Family Therapy (RRFT) or Encompass Treatment for adolescents with co-occurring Substance Use Disorder (SUD) and symptoms of Post-Traumatic Stress Disorder (PTSD).
This study will collect data from health records about people that have variations in their X & Y chromosomes to learn about their health. We also ask if people are willing to join future studies about X & Y variations.
The proposed project presents an opportunity to expand use cases for a social engagement virtual reality (VR) program. The purpose is to assess the feasibility, usability, and acceptability of VR for anxiety symptoms associated with social interactions in public places, using a technology developed by Rey (previously Oxford VR or OVR). This project is a first step toward understanding new populati...
We are looking for couples that have had two or more pregnancy losses with no known cause. We want to find out if genetics might be a reason for recurrent pregnancy loss (RPL).
This study wants to learn more about hearing loss using samples from a child, both of their biological parents, and/or other family members. We will use the samples to study heritable risk factors for hearing loss and changes in gene expression that lead to hearing loss and/or ear abnormalities.
This study wants to learn more about how COVID-19 and diabetes are connected.
This study wants to collect medical information from individuals with Turner Syndrome at clinics across the country to learn more about the condition. We are gathering this data in a national registry to help improve the health and care for people with Turner Syndrome in the future.
This study wants to learn how a type of fat in the blood, called triglycerides, affects how the fetus grows.
In this study we want to learn if a medicine approved for diabetes and weight loss called Ozempic® and Wegovy® (semaglutide) can help improve the frequency of periods and the way the body uses sugar in women with polycystic ovary syndrome (PCOS).
Our team is here to find out if taking part in a cognitive-behavioral therapy group, exercise training group, or combination of therapy and exercise training lowers stress, improves mood, raises physical activity and fitness, and lowers diabetes risk among teen girls at risk for diabetes.
This study wants to find a new combination of drugs that is safe and effective to treat people who have bone cancer that has come back or not responded to other treatments.
The purpose of this study is to investigate high frequency ultrasound as a future modality for the diagnosis of chronic exertional compartment syndrome (CECS).
Our goal is to determine if 12 sessions of Parent Management Training can reduce anger outbursts and irritable moods in children aged 10-14.
This study plans to learn how the physical, mental, and emotional well-being of adolescents who do or do not play sports or participate in other activities change over the course of a fall school semester (10-13 weeks).
The primary objective of this study is to evaluate the efficacy of subtypeselective Janus kinase (JAK) inhibitors in the preservation of β cell function in participants with recent onset Stage 3 T1D (diagnosed within 100 days)
This study wants to better understand Down syndrome and related health problems by comparing blood and saliva samples from people with and without Down syndrome. Right now, we are mainly looking for people who do not have Down syndrome but do have chronic constipation to join our study.
The purpose of this study is to determine how the body's immune system interacts with nuts and other foods to cause allergic reaction. This study also plans to validate a test that is being developed to help predict reactions to peanuts.
This study plans to learn more about how providing interventions in the home during family meals affects the health of children. We want to learn how we can best educate families about things that affect the health of children.
This study wants to learn about how total joint replacements affect the lives and physical abilities of children and young adults as they grow older.