Perceptions of the esthetics of the anterior-posterior position of maxillary central incisors in individuals of four ethnicities as evaluated by orthodontists and four ethnicities of laypersonProtocol #: 19-0741 Location: Dental Clinic |
Disordered Eating, Energy Availability, and Quality of Life in Adolescent AthletesParticipants will receive a DEXA scan and will wear a FitBit for a week to track HR, sleep, and exercise. The participant will also log their food intake for the week. Compensation included. Protocol #: 20-1681 Location: Childrens Hospital Colorado |
Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth (PUBERTY)This study will involve 6 research visits at 3 timepoints for transgender individuals (before starting estrogen and 6 and 12 months after starting estrogen). No medications are given as a part of this study. Cisgender (non-transgender) participants will have 4 visits at two timepoints (baseline and 12 months later). Research visits will include a physical exam, questionnaires, a blood draw, drinking a sugary drink, ultrasounds of the head, neck and arm, riding an exercise bike and a body scan. Protocol #: 19-1226 Locations: Childrens Hospital Colorado; University of Colorado Hospital |
Colorado Nurses Experience with COVID-19The purpose of the study is to find out the experiences of nurses who cared or prepared to care for COVID-19 patients. If you join the study you will help us learn about what nurses are going through during this pandemic time. You will provide insight to how nurses can improve or change the delivery of care to patients during a pandemic. Protocol #: 20-6039 Locations: Boulder Health Center; Broomfield Hospital; Cherry Creek Medical Center; Grandview Hospital; Greeley Campus; Harmony Campus; Highlands Ranch Hospital; Lone Tree Medical Center; Long's Peak Hospital; Medical Center of the Rockies; Memorial Hospital Central; Memorial Hospital North; Pikes Peak Regional Hospital; Poudre Valley Hospital; Steadman Hawkins Clinic - Denver; UCHealth Central Park Medical Center; UCHealth Internal Medical Clinic - Lowry; UCHealth Inverness; University of Colorado Hospital; Yampa Valley Medical Center |
Validation of the Apollo EE Device, Indirect CalorimetryProtocol #: 20-0317 Locations: Anschutz Health and Wellness; University of Colorado Hospital |
The HPV 9-10 Trial: Early Initiation of HPV VaccinationProtocol #: 19-3006 Locations: CHOC ? Children?s Hospital of Orange County; UCLA - University of California; UCLA, Jonsson Cancer Center; University of Colorado Hospital |
The impact of feminizing gender-affirming hormone therapy on biomarkers of coagulation and thrombosis in transgender womenProtocol #: 20-0104 Location: University of Colorado Hospital |
Novel Evaluations of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Men Compared to Age Group-Matched Transgender Women and Cisgender AdultsTransgender men (i.e., assigned female at birth but identify as male) taking testosterone o Ages 18 to 40 or 50 to 75 years o In good general health o Have been on hormones for at least 1 year o No history of gonadectomy o No history of cancer, diabetes or heart disease o Non-smoker (or quit at least one year ago) This study is examining how gender-affirming hormone therapy affects the health of blood vessels and impacts cardiovascular disease risk in transgender men. Protocol #: 19-2323 Locations: Anschutz Health and Wellness; University of Colorado Hospital |
Microfluidic models of bleeding and thrombosisThis study plans to learn more about how blood composition affects the formation of blood clots and to identify how individuals respond to commons drugs like anticoagulants and hormone treatments. Protocol #: 19-2408 Locations: Department Specific Free Standing Clinic; University of Colorado Hospital |
Gait Analysis of Femoroacetabular Impingement Patientsi. To compare differences in muscle recruitment, gait patterns (kinematics & kinetics), spaciotemporal variables, functional movements (squats, lunges, sit-to-stand, and single leg steps), and pelvic tilt between patients with femoroacetabular impingement (FAI) and age-matched morphologically normal controls. ii. To compare differences in muscle recruitment, gait patterns, spaciotemporal variables, functional movements, and pelvic tilt between symptomatic and asymptomatic patients with FAI morphology. iii. To compare changes in muscle recruitment, gait patterns, spaciotemporal variables, functional movements, and pelvic tilt pre- and post-intra-articular hip injection in symptomatic FAI patients. iv. To test if anatomical variables (alpha angle, center edge angle, FAI version) are predictors of change in gait and movement patterns. Protocol #: 16-1934 Location: Childrens Hospital Colorado |
Allen CU-UCSD Transition to RA Project: Blood and FluProtocol #: 19-1150 Locations: Barbara Davis Center; University of Colorado Hospital |
Sex effects on the neurobiology of eating behaviors in Veterans with overweight/obesityVeterans are needed for a study that aims to learn more about how men and women differ in the way their brains respond to food and hunger. It also plans to learn more about how hormones and the menstrual cycle affect these responses. Protocol #: 19-0940 Locations: Rocky Mountain Regional VA Medical Center; University of Colorado Hospital |
Neurophysiological Correlates V: 31Jan18Protocol #: 16-1480 Location: Childrens Hospital Colorado |
The contributions of age related changes in the sound localization pathway to central hearing lossThis study plans to learn more about how age affects the way we process sounds we hear. If you join the study, you will come into our Auditory Lab on the Anschutz Medical Campus 4-6 times and complete hearing assessments and questionnaires. To learn more about how age affects the way we process sounds we hear. Protocol #: 19-1213 Location: Department Specific Free Standing Clinic |
The Neural Underpinnings of Disinhibited Eating Behavior in Adolescents with and without ObesityProtocol #: 19-1171 Location: University of Colorado Hospital |
Sex-based differences in the neuronal mechanisms of food intake behaviorThis study aims to learn more about how men and women differ in the way their brains respond to food and hunger. It also plans to learn more about how hormones and the menstrual cycle affect these responses. Protocol #: 19-1148 Location: University of Colorado Hospital |
Cardiopulmonary and Right Ventricular Function in Health and DiseaseThe primary objective of this research protocol is to advance the understanding of cardiopulmonary and right ventricular (RV) performance among individuals with cardiomyopathy (heart failure with reduced ejection fraction [HFrEF], heart failure with preserved ejection fraction [HFpEF]), as well as athletes engaging in endurance/prolonged exercise, who are at a high risk of an acquired cardiomyopathy during/following completion of an endurance event. Examine the heart function of elite athletes and heart failure patients utilizing a novel catheter system. Protocol #: 19-1141 Location: University of Colorado Hospital |
Molecular Transducers of Physical Activity Consortium (MoTrPAC) - AdultProtocol #: 18-0220 Location: University of Colorado Hospital |
Multiomics Investigation of Marijuana UseThis research study seeks to learn more about biomarkers and biological pathways associated with marijuana use. We are enrolling adults who are marijuana users or non-users. The study involves filling out online surveys and one on-campus visit to give a blood, urine, and hair sample. If you want to learn more about the study please contact Kristen Raymond at kristen.raymond@cuanschutz.edu. The specific aims of the project are to: 1) Discover biomarkers associated with marijuana use. 2) Discover biological pathways associated with marijuana use. 3) Exploratory Aim: Test whether peripheral endocannabinoid levels vary with marijuana use and predict marijuana craving. Protocol #: 18-0853 Location: University of Colorado Hospital |
Bioenergetic and Metabolic Consequences of the Loss of Gonadal Function- 2018This research study is investigating the roles of estrogen (female sex hormone) and FSH, or follicle-stimulating hormone, on cortisol (a stress hormone), fat gain, and disease risk. Protocol #: 18-2483 Location: University of Colorado Hospital |
Novel Evaluations of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Women Compared to Age- and BMI-Matched Cisgender AdultsDo you qualify? • Transgender women (i.e., assigned male at birth but identify as female) taking estradiol and spironolactone o Ages 18 to 40 or 50 to 75 years o In good general health o Have been on hormones for at least 1 year o No history of gonadectomy o No history of cancer, diabetes or heart disease o Non-smoker (or quit at least one year ago) This study is examining how gender-affirming hormone therapy affects the health of blood vessels and impacts cardiovascular disease risk in transgender women. Protocol #: 18-2258 Locations: Anschutz Health and Wellness; Rocky Mountain Regional VA Medical Center; University of Colorado Hospital |
A Phase 3, Multicenter, Open-Label Study of a Levonorgestrel 52 mg Intrauterine System for the Treatment of Heavy Menstrual BleedingThe study is a multicenter, open-label, evaluation of the efficacy and safety of LNG20 IUS for treatment of heavy menstrual bleeding. Primary objective: Assess the efficacy of a levonorgestrel 52 mg intrauterine system (LNG20 IUS) as a treatment for heavy menstrual bleeding. Secondary objectives: Assess safety, tolerability, bleeding patterns, and continuation rates of LNG20 IUS in women using LNG20 IUS for heavy menstrual bleeding. Protocol #: 18-2249 Locations: Comprehensive Women's Health Center; Comprehensive Womens Health Center; University of Colorado Hospital |
The Effect of Exercise on Sleep Quality and Nocturnal Fat Oxidation in Individuals with Metabolic SyndromeProtocol #: 18-0369 Location: University of Colorado Hospital |
CU Faces of Hope-Genetics of Craniofacial and Dental Development Research StudyThis study plans to collect samples to create a database of patients with various syndromes that affect the way bones of the face are formed, termed “craniofacial”. These samples will support a new research program, named CU Faces of Hope, which involves a team of researchers and doctors who will work together toward a goal of better understanding facial development and gain knowledge about your specific syndrome. Samples, such as blood, DNA, and cells, will be stored for future approved research. The reason for collecting both health information and blood/tooth samples from the same person is to look at relationships between physical symptoms, behavior, genes, and parts of the blood. We are also asking parents and siblings of people with these various craniofacial associated syndromes to join the study. Having information available from family members can help researchers look at differences between people who have a syndrome and those who do not. Protocol #: 18-1916 Location: Childrens Hospital Colorado |
The Associations between EIT and Clinical Measures during Standard of Care Procedures in Patients with Respiratory Disease: A Preliminary StudyPrimary outcome: EIT imaging maps that provide regional information regarding ventilation and perfusion of the lung. These images will be analyzed both visually for qualitative abnormalities and through quantitative pixel analysis that can provide information regarding lung volume, blood volume, and changes in either based on respiratory cycle, cardiac cycle, or intervention. Areas of low ventilation (atelectasis and consolidation) will be identified. Secondary outcomes: Regional conductivity changes due to ventilation Waveform for a mesh element Regional conductivity changes due to perfusion Regional pulsatile perfusion imaging at the end of systole Power waveform (computed as the inner product of measured voltages and applied currents) Protocol #: 18-1843 Location: Childrens Hospital Colorado |
Identifying Predictors of Poor Health-Related Quality-of-Life among Pediatric Hematopoietic Stem Cell DonorsProtocol #: 18-1997 Location: Childrens Hospital Colorado |
My Transgender Brain Study (MyT "Mighty" Brain) - ColoradoProtocol #: 18-1740 Locations: Anschutz Health and Wellness; UCD Anschutz Health & Wellness Center; University of Colorado Hospital |
Strategy to Prevent the Onset of Clinically-Apparent Rheumatoid Arthritis (StopRA)Protocol #: 15-1868 Locations: Barbara Davis Center; UCD Barbara Davis Center; University of Colorado Hospital |
A multi-center, single-blind, randomized clinical trial to compare two copper IUDs:Mona Lisa NT Cu380 Mini and ParaGardA randomized, single-blind, phase IIb/III controlled clinical trial to measure contraceptive efficacy of Mona Lisa NT Cu380 Mini. To measure contraceptive efficacy of the test product Protocol #: 17-0225 Locations: Comprehensive Women's Health Center; Comprehensive Womens Health Center; University of Colorado Hospital |
Identifying Environmental Triggers of Smoking Behaviors in Low-income CommunitiesProtocol #: 18-0052 Locations: Department Specific Free Standing Clinic; University of Colorado Cancer Center; University of Colorado Hospital |
PLACENTAL PROTEINS AND PREMATURITY (P3 STUDY)This study plans to learn more about why babies born prematurely sometimes can have problems with infections, breathing, feeding, vision, and brain function. Protocol #: 18-0637 Location: University of Colorado Hospital |
Precision Approach to PPI Therapy in Gastroesophageal reflux diseaseOver the past 25 years, RALS has been increasingly, and often incorrectly, diagnosed and has emerged as a point of controversy and confusion. Despite the limitations of current diagnostic tests and therapeutic strategies, recent advances in gastoresophageal reflux disease offer tremendous potential for RALS diagnosis and treatment. Newer diagnostic tools are able to assess physiologic properties of RALS. Thus, this study will address three crucial gaps impacting the clinical approach to RALS: 1) Paucity of diagnostic tests that predict clinically relevant outcomes, 2) undefined clinical role of UES augmentation, and 3) deficiency or cost-effective and personalized approaches. Protocol #: 18-0205 Location: University of Colorado Hospital |
EA1151: Tomosynthesis Mammographic Imaging Screening Trial (TMIST)Participants in this trial will be randomized to receive either 2D or 3D mammograms for the first 5 years of the research study, either ever year or every other year depending on personal risk factors. Information will be collected on breast cancer status for 8 years in total. To compare the proportions of participants in the Tomosynthesis (TM) and Digital Mammography (DM) study arms experiencing the occurrence of an advanced breast cancer at any time during a period of 4.5 years from randomization, including the period of active screening and a period of clinical follow-up after the last screen (T4). To assess the potential effect of age, menopausal and hormonal status, breast density, and family cancer history on the primary endpoint difference between the two arms. Protocol #: 18-0392 Locations: Highlands Ranch Hospital; University of Colorado Hospital |
Mitochondrial targeted antioxidant supplementation and diastolic function in healthy men and womenAs we get older, our cardiovascular health worsens. This can lead to high blood pressure and heart disease. In this study we want to find out what causes cardiovascular health to worsen in older men and women. Also we want to find out what happens to the cardiovascular system when we take a dietary antioxidant supplement for a short period of time. Specifically, we want to see if the antioxidant supplement will improve cardiovascular health in older men and women because of damage to mitochondria. Mitochondria are the main power supply of the cells in our body. The results from this study will help to understand whether improvements in mitochondrial function will also improve cardiovascular health in older men and women. Protocol #: 17-1782 Location: University of Colorado Hospital |
Electronic Cigarette Use During PregnancyProtocol #: 17-2033 Locations: CU John C. Hobbins Perinatal Center; CU Parker Perinatal Center; Denver Health Medical Center; Department Specific Free Standing Clinic; University of Colorado Hospital |
Rapid measurements of water isotopes in human breath and saliva for doubly labeled water analysis V: 04/03/18Protocol #: 16-2203 Location: University of Colorado Hospital |
The effect of topiramate on etonogestrel concentrations in contraceptive implant usersProtocol #: 17-1047 Locations: Comprehensive Women's Health Center; Comprehensive Womens Health Center; University of Colorado Hospital |
Effects of Ovarian Hormone Suppression on Vascular and Cognitive FunctionProtocol #: 17-0092 Location: University of Colorado Hospital |
Validation of a method for isotopic analysis in human plasma samples V:04/20/2018Protocol #: 16-2739 Location: University of Colorado Hospital |
Human Trisome ProjectAdditional information about this study can be found at www.trisome.org. Designed to be the largest and most comprehensive study of its kind, The Human Trisome Project will help us understand why individuals with Down syndrome (caused by trisomy of chromosome 21) are protected from some medical conditions, such as cancer, while highly predisposed to others, such as Alzheimer's disease and autoimmune disorders. Protocol #: 15-2170 Locations: Childrens Hospital Colorado; University of Colorado Hospital |
Appetite Regulation in Older-Aged Obese IndividualsParticipants needed for a research study that plans to examine the effects of age and body weight on food intake, appetite regulation, and brain responses to food. Protocol #: 15-1511 Location: University of Colorado Hospital |
Tissue-specific effects of insufficient sleepThe proposed project is a within-subject consecutive design examining 14 healthy individuals after baseline and after 4 nights of insufficient sleep. Following 7 days of at-home habitual sleep of 9 hours/night and a 3-day lead-in energy balanced diet, participants will be admitted for a 6-night inpatient stay at the UC Denver. Sleep schedules will be verified via sleep logs, time-stamped voice-recorder of bed and wake times, and wrist actigraphy recordings. On the morning after the 1st night in the lab, subjects will undergo including saliva sampling, endothelial function testing, muscle biopsy, fat biopsy, hyperinsulinemic euglycemic clamp. Protocol #: 17-0533 Locations: CTRC-UC Boulder; University of Colorado Hospital |
Cardiovascular Mechanisms of Exercise Intolerance in Diabetes and the Role of SexThis study will define the relationship of cardiac, vascular function and skeletal muscle blood flow (individually and together) to cardiovascular exercise capacity in in men and women with and without type 2 diabetes (T2DM). Identification of differences in the effects of exercise training on the integrated cardiovascular system and metabolism in men and women with and without T2DM will reveal specific adaptive responses to exercise. This study will evaluate & compare exercise function in a total of 60 subjects from the Denver area (30 people with T2DM and 30 overweight control subjects). Protocol #: 17-0356 Location: University of Colorado Hospital |
Myeloid to Adipocyte Transdifferentiation in Human cellsIf you join the study, you will complete the following research procedures over the course of 2 study visits: Informed consent, physical exam and medical history, body composition test, blood draw and fat biopsy. This research study plans to learn more about where the fat cells in your body come from. Understanding the origin of fat cells is important because it may help to determine the health of fat cells and why fat that is stored in some places of your body is more "unhealthy" than other fat. Protocol #: 15-1779 Location: University of Colorado Hospital |
Dysregulation of FSH in Obesity: Functional and Statistical AnalysisThis study plans to learn more about the relationship between fertility and obesity. Protocol #: 15-0474 Location: University of Colorado Hospital |
Reprometabolic Syndrome Mediates Subfertility in ObesityProtocol #: 15-1052 Location: University of Colorado Hospital |
The effect of isotretinoin on the etonogestrel contraceptive implantProtocol #: 16-0614 Locations: Comprehensive Women's Health Center; Comprehensive Womens Health Center |
The impact of estrogen status on the biological function of brown adipose tissue in women measured using quantitative PET/CTThe physiological relevance of brown adipose tissue in humans is largely unknown. We have shown that suppressing ovarian function in premenopausal women reduces resting energy expenditure (REE), and this is prevented by adding back estradiol (E2). Our preliminary data suggest that this may be due, in part, to reduced brown adipose tissue (BAT) activity. However, whether E2 status affects BAT activity in women has not been studied. In this research, we will study 1) the contribution of BAT to REE under basal (room temperature) and stimulated conditions (mild cold-exposure); and 2) whether these responses are modulated by E2 status. Protocol #: 16-1479 Locations: CTRC-adult; University of Colorado Hospital |
Effect of Mechanical Circulatory Support on Exercise Capacity in Heart FailureProtocol #: 16-1635 Locations: Colorado Research Center; CTRC-adult; University of Colorado Hospital |
Cardiovascular consequences of hypogonadism in menProtocol #: 15-1162 Locations: Rocky Mountain Regional VA Medical Center; University of Colorado Hospital |
Is disruption of the human gut microbial environment associated with cognitive impairment following chemotherapy for breast cancer?Protocol #: 16-2138 Location: University of Colorado Hospital |
A double-blind, placebo-controlled crossover study comparing the analgesic efficacy of cannabis versus oxycodonePRIMARY AIMS: (1) To compare the effects of cannabis versus oxycodone versus placebo on spontaneous chronic spine pain relief, as measured by change in score on the 10-point Numeric Rating Scale (NRS); (2) To compare the effects of cannabis versus oxycodone versus placebo on experimental pain analgesia, as measured by change in Experimental Pain Threshold (EPTh), in both patients with chronic spine pain and healthy controls. SECONDARY AIMS: (1) To compare the effects of cannabis versus oxycodone versus placebo on chronic spine pain, as measured by the Patient Global Impression of Change (PGIC) scale; (2) To compare the effects of cannabis versus oxycodone versus placebo on subjective reports of drug effects, psychoactive effects, and mood; (3) To compare the effects of cannabis versus oxycodone versus placebo on tests of neurocognitive functioning (Wechsler Adult Intelligence Scale (WAIS-III) Digit Symbol Test, the Hopkins Verbal Learning Test Revised (HVLT), and the Grooved Pegboard Test); (4) To compare the effects of cannabis versus oxycodone versus placebo on Standardized Field Sobriety Tests (SFST). Protocol #: 14-1909 Locations: CTRC-adult; University of Colorado Hospital |
Total Cancer Care Protocol: A Lifetime Partnership with Patients Who Have or May be at Risk of Having Cancer (ORIEN)Protocol #: 15-1110 Locations: Memorial Hospital Central; Memorial Hospital North; Poudre Valley Hospital; University of Colorado Hospital |