Your search for "Diabetes & Hormone Disorders" found 53 matches:
Does When You Exercise Matter? A Randomized Trial Comparing the Effect of Morning versus Evening Aerobic Exercise on Weight Loss and Compensatory Behaviors

If you join the study, you will undergo screening evaluations to see if you are eligible to be in the study. If you are eligible to be in the study, you will be randomized to one of two study groups. Which group you are assigned to will be chosen by chance by a procedure similar to the t...

Protocol #: 21-3094

Impact of SARS CoV2 on Post-Hospital Recovery of Carbohydrate and Muscle Metabolism: Role of Endothelial Injury

Protocol #: 21-3711

REACH - Role of microvascular insulin resistance and cardiorespiratory fitness in diabetes

Participants will undergo baseline testing of heart and blood vessel function as well as skeletal muscle function and exercise ability. Participants will then do cardiovascular exercise for 15 weeks, and all testing will be repeated....

Protocol #: 20-2723

Prolonged Sedentary Behavior in Older Women with and without Type 2 Diabetes: Knowledge, Engagement, and Relationship to Cardiometabolic Risk

Are you interested in participating in a research study to understand the health effects of the time we spend sitting? The ACTIVE Research Lab is looking for: • Women • 60 to 75 years of age • Non-smoker • If Type 2 Diabetes, not being treated with insulin • BMI 25-40 kg/m2 (check ...

Protocol #: 19-2758

NightWare Therapeutic Platform for improving Cardiovascular Health in Adults With Nightmares Associated with PTSD

We are recruiting individuals who experience PTSD-associated nightmares to participate in a research study to help us understand if improving sleep quality, by reducing the impact of nightmares can improve cardiovascular health....

Protocol #: 21-5027

A Randomized Parallel Comparison of Semaglutide versus Placebo on Intestinal Barrier (SIB)

Participants will complete 7-8 visits. Some participants will be asked to split screening into 2 visits. After screening, participants will be given either semaglutide or a placebo and will be asked to self-administer the medication once weekly. Four visits will include blood draws and thr...

Protocol #: 21-2774

Location: CU Anschutz non-hospital research facilities

MitoQ supplementation for restoring aerobic exercise training effects on endothelial function in postmenopausal women

The purpose of this research study is to see if we can improve exercise training responses on heart health in postmenopausal women....

Protocol #: 22-1521

BURST2D Study: Breaking up sedentary time to improve glucose control in a population at risk for developing type 2 diabetes

The purpose of the study is to compare two different physical activity interventions (BREAK or ONE) to learn about their effects on blood sugar and metabolism. Participants will be randomized to one of two interventions: ONE (45-minutes of brisk walking at least 5 days per week) and BREAK ...

Protocol #: 20-1900

uHoWL Research Study

Are you interested in a research study on women's reproductive hormones? We are conducting a study among women aged 18-40 who have regular menstrual cycles, are not using hormonal birth control, and have a body mass index between 27-45. ...

Protocol #: 21-3957

PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life - The PROMISE Study

The environment during pregnancy may contribute to the risk of islet autoimmunity (IA) in the baby. Having IA increases the risk of type 1 diabetes (T1D) in the child. Illnesses such as viruses could contribute to IA and T1D risk. Pregnancy history may also influence IA and T1D risk. Ha...

Protocol #: 22-1840

Neuronal and behavioral effects of an implicit priming approach to improve eating behaviors in obesity

What is involved: -A 12-week intervention involving viewing food or food images (study visits once per week) -Study days before and after the intervention to measure brain responses to food images -Measures of body composition, mood, physical activity, and eating behaviors St...

Protocol #: 20-2821

SIB: A Randomized Parallel Comparison of Semaglutide versus Placebo on Intestinal Barrier Function in Type 2 Diabetes Mellitus

Volunteers needed for a research study examining the effects of once weekly semaglutide on intestinal barrier function in type 2 diabetics who are being treated with metformin only. Main procedures involve blood draws, lactulose mannitol ratio (urine) test, stool samples, and once-weekly s...

Protocol #: 21-2774

Location: CTRC-adult

The Bone, Exercise, Alendronate, and Caloric Restriction (BEACON) Trial

Protocol #: 22-2041

Integrated Lifestyle Intervention to Promote Weight Loss Study (COMIRB 23-1154)

If you join the study, you will undergo 2-3 screening visits to see if you are eligible to be in the study. If you are eligible to be in the study, you will receive a 6-month integrated lifestyle intervention program. This integrated program includes PreventT2 (formally known as the Diabet...

Protocol #: 23-1154

Effect of weight loss on intermuscular adipose tissue (IMAT) signaling

Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss. After 12 weeks, this will be followed by the same testing and biopsies that were complete...

Protocol #: 23-0545

Effects of early as compared to late time restricted eating on weight loss and metabolic outcomes in adults with obesity

Protocol #: 22-1829

Location: Anschutz Health and Wellness, Outpatient CTRC

A T cell phenotype signature driven dose finding study with siplizumab in type 1 diabetes mellitus

Open label study in subjects age 8-45 with T1D diagnosis within 18 months to identify a safe and metabolically favorable dosing regimen of siplizumab. ...

Protocol #: 22-0999

Location: Barbara Davis Center, University of Colorado Hospital

Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes (T1-DISCO)

Protocol #: 22-0794

Location: Anschutz Health and Wellness, Barbara Davis Center, Brain Imaging Center (BIC), CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital

Copeptin and Nonalcoholic Fatty Liver Disease

See above...

Protocol #: 17-1160

Locations: Anschutz Health and Wellness, Outpatient CTRC, UCD Anschutz Health & Wellness Center, University of Colorado Hospital

JAK Inhibitors to Preserve C-Peptide Production in New Onset T1D: A Phase 2 Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Subtype-Selective JAK Inhibitors for Preservation of Pancreatic β Cell Function in Newly Diagnosed Type 1 Diabetes Mellitus

This phase 2 trial is a double-blind, randomized, placebo-controlled clinical trial in male and female adolescent and adult participants (ages 12-35 years) with newly diagnosed Stage 3 T1D (within 100 days of diagnosis). Enrollment into abrocitinib and ritlecitinib arms and the shared ...

Protocol #: 23-0996

Location: Barbara Davis Center, University of Colorado Hospital

Feasibility and Preliminary Efficacy of a Reverse Diet as a Novel Weight Loss Maintenance Strategy for Weight-Reduced Adults with Overweight/Obesity

In this study, we will be evaluating the effects of a reverse-diet compared to standard weight loss maintenance advice....

Protocol #: 17-1726

Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

Expanded Access Program of Palopegteriparatide in Patients with Hypoparathyroidism

Protocol #: 23-0912

Location: University of Colorado Hospital

Targeting Leukotrienes in Kidney Disease: A Pilot Study

Protocol #: 22-0187

Location: Department Specific Free Standing Clinic, Renal Research Center

Intermuscular adipose tissue (IMAT) - protagonist in sarcopenia and insulin resistance in humans

Protocol #: 18-0582

Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

Metabolic and Renal Effects of Automated Insulin Delivery Systems in Youth with Type 1 Diabetes Mellitus

Protocol #: 18-1558

Location: Childrens Hospital Colorado

The Neural Underpinnings of Disinhibited Eating Behavior in Adolescents with and without Obesity

Protocol #: 19-1171

Location: Brain Imaging Center - BIC, Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

Role of semaglutide in restoring ovulation in youth and adults with polycystic ovary syndrome (PCOS) (RESTORE Study)

Protocol #: 21-4941

Location: Childrens Hospital Colorado, Outpatient CTRC

Adjunctive Anti-Obesity Pharmacotherapy in Adolescents and Young Adults after Bariatric Surgery: A Randomized Controlled Pilot Study

Protocol #: 18-2793

Location: Childrens Hospital Colorado, Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

Surgical or Medical Treatment for Pediatric Type 2 Diabetes

Surgical or Medical Treatment for Pediatric Type 2 Diabetes (STOMP-T2D) is a prospective, open-label, controlled clinical trial funded by the National Institutes of Health for a period of 5 years. We propose to study 90 participants who are 13-19 years of age and have type 2 diabetes (T2D)...

Protocol #: 19-1978

Location: Childrens Hospital Colorado, University of Colorado Hospital

Mindfulness-Based Intervention for Depression and Insulin Resistance in Adolescents

Protocol #: 20-2649

Location: Children's Hospital National (CHN), Children's Hospital National (CHN), Childrens Hospital Colorado, Colorado State University, Uniformed Services University of Health Sciences (USUHS), Uniformed Services University of Health Sciences (USUHS)

A phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of 400 mg twice a day oral ladarixin in patients with new-onset type 1 diabetes and a low residual β-cell function at baseline.

A phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of 400 mg twice a day oral ladarixin in patients with new-onset type 1 diabetes and a low residual β-cell function at baseline. It has been designed to further evaluate whether la...

Protocol #: 21-2474

Location: Barbara Davis Center, University of Colorado Hospital

Multicentric Carpotarsal Osteolysis (MCTO): Natural History Study

Protocol #: 21-2606

Location: Childrens Hospital Colorado

REMODEL - Renal mode of action of semaglutide in patients with type 2 diabetes and chronic kidney disease

Protocol #: 21-2645

Location: Barbara Davis Center, Childrens Hospital Colorado, Outpatient CTRC, University of Colorado Hospital

Evaluating the peripheral vascular blood flow and oxygenation responses to exercise in type 2 diabetes with time-resolved, quantitative MRI

Protocol #: 21-3080

Location: Brain Imaging Center (BIC), Outpatient CTRC

MANATEE-T1D: Metformin ANd AutomaTEd insulin delivery system Effects on renal vascular resistance, insulin sensitivity, and cardiometabolic function in youth with Type 1 Diabetes

Protocol #: 21-3483

Location: Barbara Davis Center, Childrens Hospital Colorado

Identifying novel therapeutic targets in MCTO by unbiased proteomics of patient plasma

Protocol #: 21-3367

Location: Childrens Hospital Colorado, Department Specific Free Standing Clinic

Glucose Monitoring in Youth with Cystic Fibrosis During Pulmonary Exacerbations (GeM-PEx)

The purpose of this study is to determine if pulmonary exacerbations in youth with cystic fibrosis cause blood sugars to vary during and after an exacerbation. Blood sugars will be monitored using a continuous glucose monitor (CGM) for 2 weeks both during and 6 weeks after an exacerbation...

Protocol #: 21-3666

Location: Childrens Hospital Colorado

CLINICAL AND RADIOLOGICAL CHARACTERISTICS OF HYPOPHOSPHATASIA IN ADULTS WITH TYPE 1 DIABETES

Protocol #: 21-3876

Location: Childrens Hospital Colorado, University of Colorado Hospital

Effects of SGLT2 inhibition on early diabetic kidney disease: interrogation of renal energetics by functional imaging and single-cell transcriptomics- an ancillary study to the ATTEMPT trial (COMIRB #19-2947)

Protocol #: 21-4373

Location: Childrens Hospital Colorado

Randomized, sham-controlled, multicenter, pragmatic, trial with open-label extension of PHOENIX to improve glycemic control in adults with type 2 diabetes in a real-world setting BRIGHT - Digital therapeutic Based Randomized Investigation to improve Glycemic control in patients with type 2 diabetes and residual Hyperglycemia on stable medical Therapy

Randomized, sham-controlled, multicenter, pragmatic, pivotal trial with open-label extension evaluating the hypothesis that PHOENIX, an investigational digital therapeutic intended to help patients with type 2 diabetes improve their glycemic control, will lower hemoglobin A1c (HbA1c) compa...

Protocol #: 21-4891

Location: Boulder Health Center, Broomfield Hospital, Cherry Creek Medical Center, CTRC Inpatient, Highlands Ranch Hospital, Lone Tree Medical Center, Longs Peak Hospital, UCHealth Central Park Medical Center, UCHealth Internal Medical Clinic - Lowry, UCHealth Northfield Medical Center, UCHealth Steadman Hawkins Clinic - Denver (Inverness), University of Colorado Hospital

Libre 2 CGM plus Glycemic Excursion MIniMization (GEM) in the Treatment of PrEDiabeteE: The IMPEDE Study

For people with prediabetes, it may be possible to delay or prevent the progression to diabetes by reducing postprandial glucose (PPG). Our Glycemic Excursion Minimization (GEM) lifestyle intervention guide can reduce PPG in people with type 2 diabetes and has been studied in this populati...

Protocol #: 21-4931

Location: Outpatient CTRC

GALAXY: Generating Advancements through Longitudinal Analysis in X and Y Syndromes

Participants who join the GALAXY Registry are agreeing to have their medical records be used for research. There are no additional study visits, etc. – participants just continue with their usual clinical care. If participants are seen outside of Children’s Colorado, they can sign a Releas...

Protocol #: 20-0482

Location: Childrens Hospital Colorado, Outpatient CTRC

Autosomal Dominant Hypocalcemia Types 1 And 2 (ADH1/2) Disease Monitoring Study (DMS)

Protocol #: 22-0360

Location: Childrens Hospital Colorado

Pathogenesis of kidney disease in type 1 diabetes: a modern kidney biopsy cohort (The PANDA Study)

Protocol #: 22-0250

Location: Childrens Hospital Colorado, Outpatient CTRC

Molecular Mechanisms of SGLT2 inhibition in diabetic kidney disease

Protocol #: 22-0668

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

Effect of Montelukast on Kidney and Vascular Function in Type 1 Diabetes

Protocol #: 22-1027

Location: Outpatient CTRC, University of Colorado Hospital

DiEtary Sodium Intake effects on ertugliflozin-induced changes in GFR, reNal oxygenation and systemic hemodynamics: the DESIGN study, a randomized, placebo-controlled, cross-over study with ertugliflozin in people with type 2 diabetes

If you choose to participate, you will take the study medication, ertugliflozin, or placebo over 4 so-called treatment blocks of 20 days each. You will be recommended foods based on a sodium-controlled diet for approximately 23 weeks. There will be 5 study visits total over 23 weeks, which...

Protocol #: 22-0224

Location: Outpatient CTRC, University of Colorado Hospital

TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes

This study will be a multicenter, double-blind, placebo-controlled, 2:1 random assigned, phase II clinical trial for individuals with recent onset type 1 diabetes. We are conducting a double masked placebo-controlled intention to treat study enrolling persons with new onset T1D with docu...

Protocol #: 23-0398

Location: Barbara Davis Center, University of Colorado Hospital

Safety and Efficacy of the Omnipod? 5 Automated Insulin Delivery System in Adults with Type 2 Diabetes

This single-arm, multi-center, prospective study will evaluate the safety (primary) and efficacy (secondary) of the Omnipod? 5 Automated Insulin Delivery System in adults with type 2 diabetes requiring insulin therapy....

Protocol #: 23-0388

Location: Anschutz Health and Wellness, Barbara Davis Center, Lone Tree Medical Center

Evaluation of Basal Insulin Initialization and Titration in People with Type 2 Diabetes wearing a Dexcom G6 Sensor

Protocol #: 23-0393

Location: Anschutz Health and Wellness, Lone Tree Medical Center

Effects of Inspiratory muscle strength training on exercise capacity in Type 2 Diabetes

Protocol #: 23-0493

Location: Outpatient CTRC

Expanded Access Program of Palopegteriparatide in Patients with Hypoparathyroidism

Protocol #: 23-0510

Location: Greeley Campus

Efficacy and safety of cagrilintide 2.4 mg s.c. in combination with semaglutide 2.4 mg s.c. (CagriSema s.c. 2.4 mg/2.4 mg) once-weekly compared to tirzepatide 15 mg s.c. once-weekly in participants with obesity

Subjects will be randomly assigned to study medication and receive dietary counseling and be followed over 78 weeks....

Protocol #: 23-1695

Location: Anschutz Health and Wellness, Outpatient CTRC