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Relationship between Cardiac Health and Exercise Capacity in Men and Women with and without Type 2 Diabetes
CTRC-adult, University of Colorado Hospital Participants will undergo baseline testing of their heart, blood vessel, and skeletal muscle function, and perform tests to determine exercise ability. Participants will then do exercise training for 15 weeks, and all testing will be repeated.... |
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BURST2D Study: Breaking up sedentary time to improve glucose control in a population at risk for developing type 2 diabetes
The purpose of the study is to compare two different physical activity groups to learn about their effects on blood sugar and metabolism. Participants will be randomly assigned to one of two groups. The first will complete 45-minutes of brisk walking at least 5 days per week and the second... |
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PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life - The PROMISE Study
The environment during pregnancy may contribute to the risk of islet autoimmunity (IA) in the baby. Having IA increases the risk of type 1 diabetes (T1D) in the child. Illnesses such as viruses could contribute to IA and T1D risk. Pregnancy history may also influence IA and T1D risk. Ha... |
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Volunteers needed for research study on changing eating behaviors
Study volunteers will be asked to complete an MRI scan, during which they will watch pictures of foods. Participants will also complete a 12-week intervention that involves viewing food or food images, with once-weekly study visits. After the intervention, we will ask volunteers to complet... |
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Integrated Lifestyle Intervention to Promote Weight Loss Study (COMIRB 23-1154)
If you join the study, you will undergo 2-3 screening visits to see if you are eligible to be in the study. If you are eligible to be in the study, you will receive a 6-month integrated lifestyle intervention program. This integrated program includes PreventT2 (formally known as the Diabet... |
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Effect of weight loss on intermuscular adipose tissue (IMAT) signaling
Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss. After 12 weeks, this will be followed by the same testing and biopsies that were complete... |
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Treating Early Type 2 Diabetes by Reducing Postprandial Glucose Excursions: A Paradigm Shift in Lifestyle Modification
The study is looking for 200 adults diagnosed with T2D within the last 12 months. CU will enroll 100 of those participants. Participants will be assigned to one of two groups. The first group will receive individualized routine care. The second group will receive individualized routine car... |
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A Study Evaluating an Intermittent Fasting Intervention in Adults with Breast Cancer and Overweight or Obesity
If you decide to participate in the study, you will be on an intermittent fasting diet three days per week to reduce what you are eating for 6 months. On the intermittent fasting diet days, you will only eat about 500 calories per day. On the other four non-fasting diet days per week, you ... |
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How When you Eat and Exercise Affect Metabolism in Adults
As a participant in this study, you will be assigned to 4 different diet and exercise groups where the time of your meals and when you exercise will be different. This will last for 4 consecutive days, and you will be provided meals on 2-3 of the days. On the 5th day of each exercise and d... |
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The Balanced and Empowered EaTing (BEET) in Diabetes Feasibility Trial
The study is currently recruiting integrated behavioral health providers in clinical settings with patients with type 2 diabetes. Once integrated behavioral health providers are recruited, they will be randomized and trained to deliver and test the implementation of one of two behavior cha... |
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JAK Inhibitors to Preserve C-Peptide Production in New Onset T1D: A Phase 2 Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Subtype-Selective JAK Inhibitors for Preservation of Pancreatic β Cell Function in Newly Diagnosed Type 1 Diabetes Mellitus
Barbara Davis Center, University of Colorado Hospital This phase 2 trial is a double-blind, randomized, placebo-controlled clinical trial in male and female adolescent and adult participants (ages 12-35 years) with newly diagnosed Stage 3 T1D (within 100 days of diagnosis). Enrollment into abrocitinib and ritlecitinib arms and the shared ... |
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Role of semaglutide in restoring ovulation in youth and adults with polycystic ovary syndrome (PCOS) (RESTORE Study)
Childrens Hospital Colorado, Outpatient CTRC For this study, participants will complete a screening visit to determine eligibility. They will collect 4-months of daily urine to determine rates of ovulation prior to starting semaglutide treatment. They will complete an oral sugar tolerance test (drink a sugary drink) to measure their ... |
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Surgical or Medical Treatment for Pediatric Type 2 Diabetes
Childrens Hospital Colorado, University of Colorado Hospital Surgical or Medical Treatment for Pediatric Type 2 Diabetes (STOMP-T2D) is a prospective, open-label, controlled clinical trial funded by the National Institutes of Health for a period of 5 years. We propose to study 90 participants who are 13-19 years of age and have type 2 diabetes (T2D)... |
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Mindfulness-Based Intervention for Depression and Insulin Resistance in Adolescents
Children's Hospital National (CHN), Children's Hospital National (CHN), Childrens Hospital Colorado, Colorado State University, Uniformed Services University of Health Sciences (USUHS), Uniformed Services University of Health Sciences (USUHS) |
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Glucose Monitoring in Youth with Cystic Fibrosis During Pulmonary Exacerbations (GeM-PEx)
Childrens Hospital Colorado The purpose of this study is to determine if pulmonary exacerbations in youth with cystic fibrosis cause blood sugars to vary during and after an exacerbation. Blood sugars will be monitored using a continuous glucose monitor (CGM) for 2 weeks both during and 6 weeks after an exacerbation... |
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GALAXY: Generating Advancements through Longitudinal Analysis in X and Y Syndromes
Childrens Hospital Colorado, Outpatient CTRC Participants who join the GALAXY Registry are agreeing to have their medical records be used for research. There are no additional study visits, etc. – participants just continue with their usual clinical care. If participants are seen outside of Children’s Colorado, they can sign a Releas... |
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DiEtary Sodium Intake effects on ertugliflozin-induced changes in GFR, reNal oxygenation and systemic hemodynamics: the DESIGN study, a randomized, placebo-controlled, cross-over study with ertugliflozin in people with type 2 diabetes
Outpatient CTRC, University of Colorado Hospital If you choose to participate, you will take the study medication, ertugliflozin, or placebo over 4 so-called treatment blocks of 20 days each. You will be recommended foods based on a sodium-controlled diet for approximately 23 weeks. There will be 5 study visits total over 23 weeks, which... |
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TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes
Barbara Davis Center, University of Colorado Hospital This study will be a multicenter, double-blind, placebo-controlled, 2:1 random assigned, phase II clinical trial for individuals with recent onset type 1 diabetes. We are conducting a double masked placebo-controlled intention to treat study enrolling persons with new onset T1D with docu... |
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A Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter Trial to Evaluate the Efficacy and Safety of Diamyd? to Preserve Endogenous Beta Cell Function in Adolescents and Adults with Recently Diagnosed Type 1 Diabetes, Carrying the Genetic HLA DR3-DQ2 Haplotype
Barbara Davis Center, Childrens Hospital Colorado A Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter Trial to Evaluate the Efficacy and Safety of Diamyd? to Preserve Endogenous Beta Cell Function in Adolescents and Adults with Recently Diagnosed Type 1 Diabetes, Carrying the Genetic HLA DR3-DQ2 Haplotype... |
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Examining the Effects of Morning and Evening Exercise on Glucose Regulation in Adults with Prediabetes
Anschutz Health and Wellness, Outpatient CTRC Baseline (no exercise) will be performed first with testing done on the fourth day of this condition. Testing will include a full day at the Anschutz Health Science Building Clinical and Translational Research Core clinic and will involve direct measurements of insulin action on the body, ... |
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A multi-national, multi-centre, prospective, single-arm, observational, non-interventional post-authorisation safety study to investigate long-term safety of Sogroya? (somapacitan) in adults with growth hormone deficiency (AGHD) under normal routine practice (REAL 7)
University of Colorado Hospital We are doing this study to collect information about how safe and effective Sogroya ? (somapacitan) is, when used for treatment of people with Adult Growth Hormone Deficiency (AGHD) such as yourself. Sogroya ? (somapacitan), which is prescribed to you by your doctor. It is commercially ava... |
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A 52-week randomized, double-blind, placebocontrolled,
multi-center Phase 2b study with a 52-week blinded extension
assessing safety and efficacy of frexalimab, a
CD40Lantagonist
monoclonal antibody, for preservation of
pancreatic β-cell function in adults and adolescents with newly
diagnosed type 1 diabetes on insulin therapy
Barbara Davis Center, Outpatient CTRC, University of Colorado Hospital DRI17476 is a Phase 2, multicenter, randomized, double-blind, placebo-controlled study to assess the safety, efficacy, and tolerability of frexalimab in participants with newly diagnosed T1D on insulin therapy: adults (18-35 y.o.)... |
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Effect of GLP-1 Agonist Therapy on Insulin Secretion in Adults with Pancreatic Insufficient Cystic Fibrosis and Abnormal Glucose Tolerance: a randomized, open-label, cross-over trial
Childrens Hospital Colorado This research is being done to better understand Cystic-Fibrosis Related Diabetes (CFRD) and to see the effects of GLP-1 (dulaglutide) in individuals with abnormal glucose tolerance. GLP-1 (dulaglutide) helps the pancreas release insulin, which controls blood sugar levels from getting too... |
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BEGIN Substudy: Continuous Glucose Monitoring in Healthy Children
Childrens Hospital Colorado This data is being collected as a sub-study of a larger study, which is looking at blood sugars in children with Cystic Fibrosis (CF). A device called a continuous glucose monitor (CGM) will be used to collect data for this study. The device brand is the Dexcom G6 and it is an FDA-approv... |
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CONtiNuous glucosE monitoring (CGM) in people wiTh type 2 diabetes not on insulin: The CONNECT Study
Anschutz Health and Wellness, Boulder Health Center, Lone Tree Medical Center, Outpatient CTRC, UCHealth Central Park Medical Center, UCHealth Family Practice - Westminster This multi-center study is a 26-week randomized controlled trial (RCT) in which adults (>17 years) with type 2 diabetes (T2D) not using insulin and managed in a primary-care setting will be randomly assigned 1:1 to either use of real-time continuous glucose monitoring (CGM) or routine care... |