The Bone, Exercise, Alendronate, and Caloric Restriction (BEACON) Trial
Outpatient CTRC The purpose of this research study is to identify strategies that minimize bone loss that occurs when older adults lose weight. Your participation in this research study will involve a groupmediated weight loss intervention and may involve resistance training and/or 70 mg of weekly oral al... |
Effects of early as compared to late time restricted eating on weight loss and metabolic outcomes in adults with obesity
Anschutz Health and Wellness, Outpatient CTRC Volunteers needed for a 12 month weight loss research study who are willing to try time restricted eating (eating only during an assigned 8 hour time window each day) in order to lose weight. ... |
How When you Eat and Exercise Affect Metabolism in Adults
CTRC Inpatient As a participant in this study, you will be assigned to 4 different diet and exercise groups where the time of your meals and when you exercise will be different. This will last for 4 consecutive days, and you will be provided meals on 2-3 of the days. On the 5th day of each exercise and d... |
Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes (T1-DISCO)
Anschutz Health and Wellness, Barbara Davis Center, Brain Imaging Center (BIC), CTRC Inpatient, CU-RIC, Outpatient CTRC, University of Colorado Hospital Randomized clinical trial to assess the effects of 8 months of once-weekly subcutaneous semaglutide vs. once-weekly placebo injection. ... |
JAK Inhibitors to Preserve C-Peptide Production in New Onset T1D: A Phase 2 Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Subtype-Selective JAK Inhibitors for Preservation of Pancreatic β Cell Function in Newly Diagnosed Type 1 Diabetes Mellitus
Barbara Davis Center, University of Colorado Hospital This phase 2 trial is a double-blind, randomized, placebo-controlled clinical trial in male and female adolescent and adult participants (ages 12-35 years) with newly diagnosed Stage 3 T1D (within 100 days of diagnosis). Enrollment into abrocitinib and ritlecitinib arms and the shared ... |
Intermuscular adipose tissue (IMAT) - protagonist in sarcopenia and insulin resistance in humans
Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital Participants will be asked to complete a screening visit prior to their procedure which will include a fasted OGTT, DEXA scan, muscle strength testing, and MRI of the abdomen and thigh. During surgery, the research team will perform a muscle biopsy of the vastus lateralis, and the surgeon ... |
Role of semaglutide in restoring ovulation in youth and adults with polycystic ovary syndrome (PCOS) (RESTORE Study)
Childrens Hospital Colorado, Outpatient CTRC For this study, participants will complete a screening visit to determine eligibility. They will collect 4-months of daily urine to determine rates of ovulation prior to starting semaglutide treatment. They will complete an oral sugar tolerance test (drink a sugary drink) to measure their ... |
BURST2D Study: Breaking Up Sedentary Time to Improve Glucose Control in a Population At-Risk for Developing Type 2 Diabetes
Outpatient CTRC, University of Colorado Hospital The purpose of the study is to compare two different physical activity groups to learn about their effects on blood sugar and how your body breaks down food. If you decide to volunteer for this study, you will be randomly assigned to one of two groups. This means you will not get to choose... |
Volunteers needed for research study on changing eating behaviors
Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital Our food perceptions are linked to our eating habits, and if we understand how we think and feel about food better, then we will understand people’s eating behaviors more. ... |
Relationship between Cardiac Health and Exercise Capacity in Men and Women with and without Type 2 Diabetes
CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital This study will test how exercise impacts heart health, blood vessel function, and how the body uses sugar, among adults with and without T2D. ... |
Does when you exercise matter? Healthy adults needed for study looking at differences between morning exercise and nighttime exercise.
Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital You will be asked to attend several screening visits to make sure you are eligible to be in the research study and that it is safe for you to participate. Research study participants will be randomized to exercise either in the morning or the evening. Randomization is like flipping a coin,... |
GALAXY: Generating Advancements through Longitudinal Analysis in X and Y Syndromes
Childrens Hospital Colorado, Outpatient CTRC Participants who join the GALAXY Registry are agreeing to have their medical records be used for research. There are no additional study visits, etc. – participants just continue with their usual clinical care. If participants are seen outside of Children’s Colorado, they can sign a Releas... |
PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life - The PROMISE Study
Barbara Davis Center, University of Colorado Hospital A baby’s health before birth may affect their chances of getting islet autoimmunity (IA), which can lead to type 1 diabetes (T1D) in the child. Illnesses like viruses and pregnancy history might play a role in IA and T1D risk. A child is less likely to develop T1D if their mother has it co... |
TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes
Barbara Davis Center, University of Colorado Hospital This study will be a multicenter, double-blind, placebo-controlled, 2:1 random assigned, phase II clinical trial for individuals with recent onset type 1 diabetes. We are conducting a double masked placebo-controlled intention to treat study enrolling persons with new onset T1D with docu... |
A Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter Trial to Evaluate the Efficacy and Safety of Diamyd® to Preserve Endogenous Beta Cell Function in Adolescents and Adults with Recently Diagnosed Type 1 Diabetes, Carrying the Genetic HLA DR3-DQ2 Haplotype
Barbara Davis Center, Childrens Hospital Colorado A Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter Trial to Evaluate the Efficacy and Safety of Diamyd® to Preserve Endogenous Beta Cell Function in Adolescents and Adults with Recently Diagnosed Type 1 Diabetes, Carrying the Genetic HLA DR3-DQ2 Haplotype... |
Treating Early Type 2 Diabetes by Reducing Postprandial Glucose Excursions: A Paradigm Shift in Lifestyle Modification
Department Specific Free Standing Clinic, Outpatient CTRC, University of Colorado Hospital The study is looking for 200 adults diagnosed with T2D within the last 12 months. CU will enroll 100 of those participants. Participants will be assigned to one of two groups. The first group will receive individualized routine care. The second group will receive individualized routine car... |
A multi-national, multi-centre, prospective, single-arm, observational, non-interventional post-authorisation safety study to investigate long-term safety of Sogroya (somapacitan) in adults with growth hormone deficiency (AGHD) under normal routine practice (REAL 7)
University of Colorado Hospital We are doing this study to collect information about how safe and effective Sogroya (somapacitan) is, when used for treatment of people with Adult Growth Hormone Deficiency (AGHD). This study has a special focus on neoplasms and diabetes mellitus type 2. Sogroya (somapacitan), which is p... |
A 52-week randomized, double-blind, placebocontrolled,
multi-center Phase 2b study with a 52-week blinded extension
assessing safety and efficacy of frexalimab, a
CD40Lantagonist
monoclonal antibody, for preservation of
pancreatic β-cell function in adults and adolescents with newly
diagnosed type 1 diabetes on insulin therapy
Barbara Davis Center, Outpatient CTRC, University of Colorado Hospital DRI17476 is a Phase 2, multicenter, randomized, double-blind, placebo-controlled study to assess the safety, efficacy, and tolerability of frexalimab in participants with newly diagnosed T1D on insulin therapy: adults (18-35 y.o.)... |
Effect of GLP-1 Agonist Therapy on Insulin Secretion in Adults with Pancreatic Insufficient Cystic Fibrosis and Abnormal Glucose Tolerance: a randomized, open-label, cross-over trial
Childrens Hospital Colorado This research is being done to better understand Cystic-Fibrosis Related Diabetes (CFRD) and to see the effects of GLP-1 (dulaglutide) in individuals with abnormal glucose tolerance. GLP-1 (dulaglutide) helps the pancreas release insulin, which controls blood sugar levels from getting too... |
The Balanced and Empowered EaTing (BEET) in Diabetes Feasibility Trial
Denver Health and Hospital Authority, Outpatient CTRC, University of Colorado Hospital The study is currently recruiting integrated behavioral health providers in clinical settings with patients with type 2 diabetes. Once integrated behavioral health providers are recruited, they will be randomized and trained to deliver and test the implementation of one of two behavior cha... |
Impact of MEnstruation on glycemic Response and exercise In females with Type 1 diabetes
Barbara Davis Center, Outpatient CTRC We will enroll 180 women ages 18 to 45, including 120 with regular menstrual cycles and 60 women using hormonal birth control. We plan to enroll an equal number of sedentary women and habitually active women. ... |
BEGIN Substudy: Continuous Glucose Monitoring in Healthy Children
Childrens Hospital Colorado This data is being collected as a sub-study of a larger study, which is looking at blood sugars in children with Cystic Fibrosis (CF). A device called a continuous glucose monitor (CGM) will be used to collect data for this study. The device brand is the Dexcom G6 and it is an FDA-approv... |
A Study Evaluating an Intermittent Fasting Intervention in Adults with Breast Cancer and Overweight or Obesity
Anschutz Health and Wellness, Outpatient CTRC, University of Colorado Hospital If you decide to participate in the study, you will be on an intermittent fasting diet three days per week to reduce what you are eating for 6 months. On the intermittent fasting diet days, you will only eat about 500 calories per day. On the other four non-fasting diet days per week, you ... |
Clinical validation of islet autoantibody measurement in self-collected dried blood spot specimens
Barbara Davis Center Accessible testing of islet autoantibody may improve the clinical management of type 1 diabetes. We propose to validate the detection of islet autoantibodies for type 1 diabetes in self-collected capillary dried blood spot samples. Capillary blood spots do not require a visit to the doctor... |
DISCOVERY of Risk Factors for Type 2 Diabetes in Youth
Childrens Hospital Colorado, Denver Health and Hospital Authority Longitudinal studies are needed to identify early contributors to insulin resistance and β-cell dysfunction in youth with obesity, and to explore the interrelationships between the transition through puberty and the evolution of dysglycemia, particularly in the context of psychosocial fact... |
CONtiNuous glucosE monitoring (CGM) in people wiTh type 2 diabetes not on insulin: The CONNECT Study
Anschutz Health and Wellness, Boulder Health Center, Lone Tree Medical Center, Outpatient CTRC, UCHealth Central Park Medical Center, UCHealth Family Practice - Westminster This multi-center study is a 26-week randomized controlled trial (RCT) in which adults (>17 years) with type 2 diabetes (T2D) not using insulin and managed in a primary-care setting will be randomly assigned 1:1 to either use of real-time continuous glucose monitoring (CGM) or routine care... |
A Phase 2, Randomized, Human Growth Hormone-Controlled, Multicenter, Basket Study of Vosoritide in Children with Turner Syndrome, Short Stature Homeobox-Containing Gene Deficiency, and Noonan Syndrome with an Inadequate Response to Human Growth Hormone
Childrens Hospital Colorado Phase 2, Randomized, Human Growth Hormone-Controlled, Multicenter, Basket Study... |
Protocol 24-1819 (Thermogenic responses to fasting and overfeeding in women: a potential mechanism contributing to postmenopausal weight gain)
CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital During and after menopause, women are prone to increased weight gain. The increase in weight and body fat with menopause may be due to changes in metabolism related to the loss of estrogen. This research study plans to compare how the metabolism of premenopausal and postmenopausal women re... |
A PHASE 2A, RANDOMIZED, DOUBLE-BLIND, SPONSOR-OPEN, PLACEBO-CONTROLLED, PARALLEL GROUP, DOSE-RANGING STUDY OF PF-07976016 TO ASSESS SAFETY AND EFFICACY IN ADULT PARTICIPANTS WITH OBESITY
Anschutz Health and Wellness, Outpatient CTRC To study effectiveness, safety and tolerability of a new investigational medication (PF-07976016) in adults with obesity... |