To evaluate the efficacy of IMVT-1402 compared to placebo in participants with CLE as assessed by changes in the Cutaneous Lupus Erythematosus Disease area and Severity Index activity (CLASI-A) score
This study aims to evaluate the efficacy and safety of subcutaneous (SC) anifrolumab versus placebo in adult participants with cutaneous lupus erythematosus (CLE)
Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus
To assess the real-world use and effectiveness of belimumab in routine practice for the treatment of adults with active lupus nephritis. Aims to provide the first long-term assessment of renal function preservation in patients treated with belimumab.
We are looking for adults to join a national study to help us learn more about how rheumatoid arthritis (RA) develops.
This study looks at changes in the fluid in your knee, your knee MRI scans, and your physical abilities before and after Genicular Artery Embolization (GAE). GAE is a treatment that can give long‑lasting pain relief to adults with osteoarthritis.
To evaluate the safety and tolerability of benralizumab
This study wants to collect health and growth information about children with hypochondroplasia. This information will help us understand their basic health and see if they can join future studies about hypochondroplasia.
This study wants to learn if breathing tests (called spirometry) performed in an outpatient clinic give results that are as reliable and accurate as spirometry that is done in a specialized lung function lab.
Evaluate safety and tolerability of SC291; and, to evaluate clinical response to SC291.
The goal of the Accelerating Medicines Partnership (AMP) research study is to better understand the molecular and cellular characteristics of Rheumatoid Arthritis (RA) to help develop better therapies for people with RA.
To evaluate the efficacy of GS-5718 versus placebo-to-match (PTM) in reducing skin disease activity for participants with CLE with or without systemic lupus erythematosus. To evaluate the efficacy of GS-5718 versus PTM in reducing skin disease activity for participants with CLE with or without SLE. To evaluate the safety and tolerability of GS-5178 in participants with CLE with or without SLE.
For Period 1, the primary objective is to evaluate the efficacy and safety of upadacitinib and adalimumab, in adult subjects on background MTX, following an inadequate response or intolerance to a single TNFi. For Period 2, the objective is to evaluate the long-term safety, tolerability, and efficacy of upadacitinib and adalimumab in subjects who have completed Period 1.
In this study, we plan to learn about the causes of rheumatoid arthritis (RA) and about lung disease in RA. RA is an autoimmune disease that can cause arthritis, and in some people, RA can also be related to lung disease called ‘interstitial lung disease’ (or ILD).
This study aims to understand how topical cannabis products (creams, salves, balms, etc.) could help relieve the symptoms of joint pain.
To evaluate the safety and effectiveness of the Spinal Kinetics M6-C™ artificial cervical disc in patients with contiguous twolevel symptomatic cervical radiculopathy with or without cord compression.
Assess effectiveness of post-op ACL physical therapy modification to increase quad strength during recovery.
To evaluate the efficacy of VIB4920 antoagonism of CD40L in achieving a complete renal response in active lupus nephritis
Use of blood flow restriction cuffs in post surgical hip patients.
To learn more about lung disease and risk of lung disease in early RA.
We are looking for healthy men & women to study the effects of sleep disruption on bone. Please click on the "Let's Get Started!" button below to determine your eligibility.
This study involves chimeric antigen receptor (CAR) T cell therapy, which is a relatively new therapeutic approach that uses a patient's own immune cells to treat their disease. In autoimmune diseases such as rheumatoid arthritis (RA), certain parts of the immune system are overactive, leading to inflammation. A subtype of immune cells, called regulatory T cells (Tregs), normally help to reduce ...
The primary objective of the current study is to validate the performance of the current ASAS classification criteria in a prospective, combined cohort of patients presenting with undiagnosed current back pain.
The primary objective of this study is to demonstrate efficacy of BIIB059 compared with placebo in participants with active systemic lupus erythematosus (SLE), who are receiving background lupus standard of care (SOC) therapy in reducing disease activity.
This study wants to learn about how total joint replacements affect the lives and physical abilities of children and young adults as they grow older.
To fully characterize safety and efficacy when the coflex® device is used in the intended subject population under the actual conditions of use”
The purpose of this study is to investigate high frequency ultrasound as a future modality for the diagnosis of chronic exertional compartment syndrome (CECS).
Aim 1: To compare pain and function in patients undergoing operative versus non-operative treatment of atraumatic rotator cuff tears at 12 months of follow-up. Aim 2: To assess effects of rotator cuff tear size and age on comparative outcomes (measured by SPADI) in operative versus non-operative treatments for atraumatic rotator cuff tears.
To longitudinally study individuals at risk for spondyloarthritis and spondyloarthritis associated diseases.
We hope to learn how safe and effective the Neuroport array plus stimulation is in controlling computer generated images and real-world objects, such as a robotic arm, using imagined movements of the arms and hands.
Primary objective is to evaluate the effectiveness of cenerimod 4mg at reducing disease activity compared to placebo. The secondary objective is to evaluate the effect of cenerimod 4mg to control the disease compared to placebo. The safety objective is to evaluate the safety and tolerability of cenerimod 4mg.
This study wants to learn which physical therapy treatments are most helpful to individuals with chronic neck pain including parts of treatment outside of the treatment itself such as the patient and therapist relationship. The study will compare two different treatments, resistance exercise and manual therapy. Resistance exercise builds muscle strength by making your muscles work against a weight...