University of Colorado Alzheimer's and Cognition Center Longitudinal Biomarker and Clinical Phenotyping Study (Bio-AD Study)
This study will establish a large bank of samples and data for future research into the causes of and treatments for Alzheimer’s disease (AD), Down Syndrome (DS) and other diseases that cause thinking and memory problems....
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Calibrating free-living physical activity characteristics across functionally-limited populations using machine-learned accelerometer approaches
Regular physical activity is known to have positive effects on many health outcomes. In research, physical activity is often measured using activity monitors worn on the hip, wrist or ankle. These instruments determine how much physical activity a person does based on the amount of movemen...
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Effect of Hormones on Frequency of Headache and Brain Structure and Function in Puberty
This research studies how hormones impact headache and how different parts of the brain talk to each other.
You are invited to participate if you are (or your child is):
• 9 years to 20 years of age
• With or without history of headache
• Male sex, male gender identity
• Health...
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Phase II Trial to Evaluate Safety and Efficacy of GM-CSF/Sargramostim in Alzheimer's Disease (SESAD).
Sargramostim is an investigational drug, meaning it has not been approved by the FDA to treat Alzheimer’s. Sargramostim has been approved by the FDA for the past thirty years to treat patients who have had chemotherapy to boost the body’s innate immune system. This research study hopes to ...
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Please help us learn more about autism!
CU Anschutz non-hospital research facilities
Study participants will complete MRI Scans, blood draws, tests of cognitive abilities, such as memory and attention, questionnaires about physical activity and emotions, and may be asked to participate in 10 weeks of exercise or social gaming....
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ExCITES-PD: Exercise-Induced Cognitive Improvement Through Enhanced Sleep in Parkinson’s Disease
CTRC-adult
The purpose of this study is to examine the impact of exercise on sleep and cognition in Parkinson’s Disease....
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Bipolar Prediction Brain Imaging Study
CU Anschutz non-hospital research facilities
We are studying the mental health history and brain imaging of young adults with mood disorders. Our goal is to create a model that will be able to predict which youth will later develop Bipolar disorder. With this model, we can develop treatments and interventions to help these youth so...
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A 2-Part, Multicenter, Randomized, Blinded, Active-Controlled Phase 2
Study to Sequentially Evaluate the Safety and Efficacy of BIIB091 Monotherapy and BIIB091
Combination Therapy With Diroximel Fumarate in Participants With Relapsing Forms of Multiple
Sclerosis
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CBD for Individuals with Mild Cognitive Impairment and at Risk for Alzheimer's Disease
CU Anschutz non-hospital research facilities
This study plans to learn more about different types of CBD in reducing symptoms of MCI (sleep and cognitive dysfunction, anxiety, and inflammation)....
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Unraveling the early phases of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL).
Brain Imaging Center (BIC), CTRC Inpatient, University of Colorado Hospital
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A PHASE I, MULTICENTER, OPEN-LABEL,UNCONTROLLED STUDY TO EVALUATE PHARMACOKINETICS, PHARMACODYNAMICS, SAFETY, AND TOLERABILITY OFSATRALIZUMAB IN ADULT PATIENTS WITH AQP4 ANTIBODYPOSITIVE NEUROMYELITIS OPTICA SPECTRUM DISORDER WITH BODYWEIGHT 100 KG
Outpatient CTRC, University of Colorado Hospital
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LONG-TERM FOLLOW-UP STUDY OF PATIENTS WITH SPINAL MUSCULAR ATROPHY RECEIVING RISDIPLAM TREATMENT
Outpatient CTRC, University of Colorado Hospital
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MECHANISTIC INVESTIGATION OF THERAPIES FOR DOWN SYNDROME REGRESSION DISORDER
Childrens Hospital Colorado
Individuals with Down syndrome (DS) have an increased risk of numerous co-occurring conditions, including the neuropsychiatric condition known as Down Syndrome Regression Disorder (DSRD). A DSRD diagnosis often includes a sub-acute onset of catatonia, mutism, depersonalization, loss of abi...
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A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Determine the Efficacy and Safety of BIIB122 in Participants with Parkinson's Disease
Outpatient CTRC, University of Colorado Hospital
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Mindfulness-Based Intervention for Adolescents with Chronic Migraine
Childrens Hospital Colorado
Learning from YOU will help us improve a program that can help teens with chronic migraine live a better life!
We would like to interview you and your parent for 1 hour each. Interviews can be over Zoom or in person.
Interviews will help us understand your experience living with migr...
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A Phase 2 Multicenter, Randomized, Double-blind, Placebo-controlled Study of BOTOX? (Botulinum Toxin Type A) Purified Neurotoxin Complex for the Treatment of Upper Limb Essential Tremor
CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital
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A Phase 2 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of EDG-5506 on Safety, Biomarkers, Pharmacokinetics, and Functional Measures in Adults and Adolescents with Becker Muscular Dystrophy
Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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Risk factors in Early Multiple Sclerosis (RisE-MS)
Brain Imaging Center (BIC) - Scan Read, Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
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Prospective Evaluation of De-Escalation from antiCD-20 Therapies to Diroximel Fumarate
Brain Imaging Center (BIC), Brain Imaging Center (BIC) - Scan Read, University of Colorado Hospital
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Diet and Relapses in Pediatric Multiple Sclerosis
Childrens Hospital Colorado, Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
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Automatic measurement of hand movements toward development of an objective assessment of primary motor symptoms in Parkinson?s disease
Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
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A PHASE III, RANDOMIZED, DOUBLE-BLIND,
PLACEBO-CONTROLLED, MULTICENTER BASKET STUDY TO EVALUATE THE EFFICACY,
SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF SATRALIZUMAB IN
PATIENTS WITH ANTIN-METHYL-D ASPARTIC ACID RECEPTOR (NMDAR) OR ANTILEUCINE-RICH GLIOMA-INACTIVATED 1 (LGI1) ENCEPHALITIS
CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital
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Peripheral Inflammatory Cytokine Levels in Parkinson Disease
Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
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Clinical Outcome Measures in Friedreich's Ataxia
Outpatient CTRC, University of Colorado Hospital
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Determining the Effectiveness of early Intensive
Versus Escalation approaches for the treatment of Relapsing-Remitting Multiple Sclerosis (DELIVERMS)
University of Colorado Hospital
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Phase II Trial to Evaluate GM-CSF Applications in Down Syndrome (EGADS)
Brain Imaging Center (BIC) - Scan Read, Outpatient CTRC, University of Colorado Hospital
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Identifying relevant seizure biomarkers from RNS? System recorded electrocorticography for the development of optimized seizure detection algorithms
University of Colorado Hospital
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Association of depth recordings from the temporal cortex with sleep pattern detection and characterization of sleep dysfunction in patients with refractory epilepsy.
University of Colorado Hospital
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Gene Expression of Cerebral Aneurysms
University of Colorado Hospital
In this study, we will collect tissue and blood from participants during their epilepsy surgery. ...
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Investigating cortical networks disruption and rehabilitation after traumatic brain injury
Colorado Research Center, Department Specific Free Standing Clinic
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REDUCE Post Approval Study - GORE CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients with Patent Foramen Ovale (PFO)
Harmony Campus, Medical Center of the Rockies
This study will assess the safety and effectiveness of GORE? CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a post-market setting....
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A Natural History Study of CMT1B, CMT2A, CMT4A and CMT4C
University of Colorado Hospital
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A Two-year Prospective Natural History Study Examining the Use of Neuronal Injury Biomarkers in Autoimmune Encephalitis as a Potential Biomarker for Disease Activity and Severity
Brain Imaging Center (BIC), Childrens Hospital Colorado, Colorado Research Center, University of Colorado Hospital
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Comparative Effectiveness Research for Infantile Spasms V: 12Jan2017
Childrens Hospital Colorado
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GRASP-LGMD RESEARCH PROTOCOL; Project 1a Defining Clinical Endpoints in LGMD
Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
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A Multicenter Randomized Controlled Trial of Best Available Therapy versus Autologous Hematopoietic Stem Cell Transplant for Treatment-Resistant Relapsing Multiple Sclerosis
Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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A Phase 3, External Placebo-Controlled, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Patients with Neuromyelitis OpticavSpectrum Disorder (NMOSD)
Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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A Room Temperature Atomic Magnetrode System for Telemetry of Epileptic Seizures
University of Colorado Hospital
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Lipoic acid for Treatment of Progressive Multiple Sclerosis
Brain Imaging Center (BIC), University of Colorado Hospital
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The Parkinson's Progression Markers Initiative (PPMI) 2.0 Clinical - Establishing a Deeply Phenotyped PD Cohort
Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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Patient Preferences in Deep Brain Stimulation Products
University of Colorado Hospital
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Endovascular treatment of acutely ruptured shallow intradural aneurysms not amendable to clipping and coiling with the pipeline vantage embolization device
University of Colorado Hospital
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Embolization of the Middle Meningeal Artery with ONYX(TM) Liquid Embolic System in the Treatment of Subactue and Chronic Subdural Hematoma (EMBOLISE)
University of Colorado Hospital
The purpose of this study is to evaluate the safety (short and long term side effects) and effectiveness (how well it helps) of Onyx Liquid Embolic System(LES) (study device) embolization of the middle meningeal artery when used in addition to the standard treatment that is used to treat a...
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Genetics of CMT - Modifiers of CMT1A, New Causes of CMT
Outpatient CTRC, University of Colorado Hospital
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A Multi-Center, Controlled Study to Evaluate use of CereGate Therapy to Reduce Freezing of Gait in Participants diagnosed with Parkinson's Disease
CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital
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Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1 (END-DM1)
University of Colorado Hospital
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A PHASE IIIB MULTICENTER, RANDOMIZED, DOUBLE-BLIND, CONTROLLED STUDY TO EVALUATE THE EFFICACY, SAFETY AND PHARMACOKINETICS OF A HIGHER DOSE OF OCRELIZUMAB IN ADULTS WITH PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS
Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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A PHASE III MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PARALLEL-GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FENEBRUTINIB COMPARED WITH TERIFLUNOMIDE IN ADULT PATIENTS WITH RELAPSING MULTIPLE SCLEROSIS
Brain Imaging Center (BIC), University of Colorado Hospital
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A Phase 2 Study to Assess the Efficacy, Safety, Tolerability, and
Pharmacokinetics of NS-089/NCNP-02 in Boys with Duchenne
Muscular Dystrophy (DMD)
Childrens Hospital Colorado
Treatment of Duchenne muscular dystrophy (DMD) with dystrophin
deletion amenable to exon 44 skipping...
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ALZHEIMER'S CLINICAL TRIAL CONSORTIUM FOR DOWN SYNDROME (ACTC-DS)
TRIAL-READY COHORT - DOWN SYNDROME (TRC-DS)
Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
TRC-DS is part of a larger movement working with people with Down syndrome to advance Alzheimer's disease therapies and potential cures for this population. The Alzheimer's Clinical Trials Consortium-Down Syndrome (ACTC-DS) is a large collaboration of researchers conducting clinical trials...
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Treatment for Alcohol Use Disorder: Emotion Regulation and Brain Function
Brain Imaging Center (BIC), University of Colorado Hospital
This study plans to learn more about the brain's role alcohol use problems and recovery. Prominent theories about alcohol use disorder suggest that it is a disorder of the brain. However, it remains unclear what parts of the brain work differently in alcohol use disorder. This study intend...
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A PHASE III, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PARALLEL-GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FENEBRUTINIB, COMPARED WITH OCRELIZUMAB IN ADULT PATIENTS WITH PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS.
Brain Imaging Center (BIC), University of Colorado Hospital
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ALLFTD: ARTFL-LEFFTDS LONGITUDINAL FRONTOTEMPORAL LOBAR DEGENERATION
Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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A PHASE III MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY STUDY TO EVALUATE SAFETY AND EFFICACY OF OCRELIZUMAB IN CHILDREN AND ADOLESCENTS WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS
Childrens Hospital Colorado
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BIOREPOSITORY FOR CENTRAL VEIN SIGN: A DIAGNOSTIC BIOMARKER IN MULTIPLE SCLEROSIS
Department Specific Free Standing Clinic, Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
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Influence of NT5c1A antibodies on disease progression, clinical phenotype and blood and muscle biomarkers in sporadic Inclusion Body Myositis - A prospective evaluation
University of Colorado Hospital
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A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER, PHASE 3, PIVOTAL STUDY WITH AN OPEN-LABEL EXTENSION PERIOD TO EVALUATE THE
EFFICACY AND SAFETY OF ROZANOLIXIZUMAB IN ADULT
PARTICIPANTS WITH MYELIN OLIGODENDROCYTE GLYCOPROTEIN (MOG)
ANTIBODY-ASSOCIATED DISEASE (MOG-AD)
Brain Imaging Center (BIC), University of Colorado Hospital
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NAVEG test administration for Cerebral Vision Impairment (CVI) in premature infants
Childrens Hospital Colorado
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Automated Seizure Detection for Home Seizure Monitoring with Epilog Sensors
University of Colorado Hospital
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SPHERES Neuromyelitis Optica Spectrum Disorder (NMOSD) Registry
University of Colorado Hospital
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A Prospective, Multicenter Study to Evaluate the Performance and Safety of the CerebroFlo EVD Catheter
University of Colorado Hospital
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AGNOS: An 18-month, Open-label, Multi-Center Study to Assess the Effect of fatumumab 20mg SC Monthly in Treatment Naive, Very Early Relapsing Remitting Multiple
Sclerosis Patients Benchmarked Against Healthy Controls on Select Outcomes.
Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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A randomized, double-blind, double-dummy, parallel-group study, comparing the efficacy and safety of remibrutinib 100 mg b.i.d. versus teriflunomide 14 mg q.d. in participants with relapsing multiple sclerosis, followed by extended treatment with open-label remibrutinib
Brain Imaging Center (BIC), CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital
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An Open-Label Uncontrolled Multicenter Study to Evaluate the Pharmacokinetics,
Pharmacodynamics, Safety and Activity of Nipocalimab in Children Aged 2 to less than 18 years with Generalized Myasthenia Gravis
Childrens Hospital Colorado
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A First-in-human (FIH), Multicenter, Open Label, Single Arm, Dose Escalation Study of Inhibitory Interneurons (NRTX-1001) in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE)
Brain Imaging Center (BIC), University of Colorado Hospital
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Naturalistic sleep assessed by wearable devices in Parkinson's disease
Boulder Health Center, Lone Tree Medical Center, University of Colorado Hospital
Wear a wrist activity monitor and headband at night to monitor sleep....
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Neuroliten MVP System Clinical Observation Study
Harmony Campus, Medical Center of the Rockies
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Distinguishing REM Sleep Behavior Disorder from Trauma Associated Sleep Disorder
Outpatient CTRC, University of Colorado Hospital
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Defining Endpoints in Becker Muscular Dystrophy
Outpatient CTRC, University of Colorado Hospital
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A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel, Multicenter Study to Evaluate the Safety and Efficacy of ALXN1720 in Adults with Generalized Myasthenia Gravis
Outpatient CTRC, University of Colorado Hospital
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NRG-BN011, A Phase III Trial of Lomustine-Temozolomide Combination Therapy Versus Standard Temozolomide in Patients With Methylated MGMT Promoter Glioblastoma (NCT 05095376)
Greeley Campus, Harmony Campus, Medical Center of the Rockies, Memorial Hospital Central, Memorial Hospital North, Poudre Valley Hospital
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A 2-part Phase 2 Study of Safety, Pharmacokinetics and Biomarkers
in Children with Duchenne Muscular Dystrophy including a Randomized, Double-Blind, Placebo-Controlled Part A, Followed by an Open-Label Part B
Childrens Hospital Colorado
This is a 2-part multi-center, Phase 2 study to evaluate the effect of EDG-5506 on safety, PK and biomarkers of muscle damage in approximately 27 children with DMD treated with oral, once daily
EDG-5506 for 12 months. Part A will include a 12-week, randomized, double-blind,
placebo-contr...
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A Phase 3, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to
Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, for Stroke
Prevention after an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack
Outpatient CTRC, University of Colorado Hospital
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A Phase II/III Randomized, Double-blind, Placebo-controlled, Multicenter
Study to Determine the Efficacy and Safety of ABC008 in the Treatment of
Subjects with Inclusion Body Myositis
Outpatient CTRC
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An Observational Pregnancy Safety Study in Women with Neuromyelitis Optica Spectrum Disorder (NMOSD) Exposed to UPLIZNA? (inebilizumab-cdon) during Pregnancy
Department Specific Free Standing Clinic
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A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in Subjects With Parkinson's Disease With a Pathogenic Variant in the Glucocerebrosidase (GBA1) Gene
Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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A Randomized, Double-blind, Placebo-Controlled, Multicenter Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Focal-Onset Seizures
Outpatient CTRC, University of Colorado Hospital
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A Randomized, Double-blind, Placebo-Controlled, Multicenter, Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
Outpatient CTRC, University of Colorado Hospital
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A Phase 3 Randomized, Placebo-controlled, Double-blind Study to Evaluate the Efficacy and Safety of BBP-418 (ribitol) in Patients with Limb Girdle Muscular Dystrophy 2I (LGMD2I)
CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital
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A PHASE III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY TO EVALUATE THE EFFICACY, SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF SATRALIZUMAB AS MONOTHERAPY OR IN ADDITION TO BASELINE THERAPY IN PATIENTS WITH MYELIN OLIGODENDROCYTE GLYCOPROTEIN ANTIBODY-ASSOCIATED DISEASE (MOGAD)
Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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Biomarkers in Pediatric and Young-Adult Autoimmune Encephalitis and Epilepsy
Childrens Hospital Colorado, University of Colorado Hospital
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Validation of Instruments Measuring Caregiver Experiences (Caregiver VOICE Study)
Lone Tree Medical Center, University of Colorado Hospital
Attention, Dementia Caregiving
Dementia caregivers have important roles in supporting someone with Dementia. We are interested in hearing the voices of those caregivers. Participation in this telephone based study will take approx. 30-45 minutes. We are interested in your perspective o...
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A Phase 2b, Multi-center, Randomized, Quadruple-blind, Placebo-controlled Study of Batoclimab Treatment in Adult Participants with Active Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
University of Colorado Hospital
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A Phase 1/2a Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered ION717 in Patients with Prion Disease
Brain Imaging Center (BIC) - Scan Read, Outpatient CTRC, University of Colorado Hospital
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Prospective Evaluation of De-Escalation from antiCD-20 Therapies to Ozanimod
Brain Imaging Center (BIC) - Scan Read, Outpatient CTRC, University of Colorado Hospital
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T cell responses to common antigens in individuals with Parkinson disease and Heathy controls
Outpatient CTRC, University of Colorado Hospital
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A Two Part, Observational, Basket Study to Determine Usability, Validity and Biomarker Discovery for Mobile EEG, Wearable and Device Collected Objective Measurement of Disturbed Sleep and Neurologic Disorders (LEARNS)
Outpatient CTRC, University of Colorado Hospital
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A Phase 2/3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy, Safety and Tolerability of BHV-7000 in Subjects with Refractory Focal Onset Epilepsy
Brain Imaging Center (BIC) - Scan Read, Department Specific Free Standing Clinic, Outpatient CTRC, University of Colorado Hospital
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A Phase 1, Multicenter, Single-arm, Dose-escalation Study of CC-97540
(BMS-986353), CD19-Targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells,
Evaluating Safety and Tolerability in Participants with Relapsing Forms of Multiple
Sclerosis (RMS) or Progressive Forms of Multiple Sclerosis (PMS)
Brain Imaging Center (BIC) - Scan Read, Outpatient CTRC, University of Colorado Hospital
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A randomized, double-blind, Phase 3 study comparing
efficacy and safety of frexalimab (SAR441344) to
placebo in adult participants with nonrelapsing
secondary progressive multiple sclerosis
Brain Imaging Center (BIC) - Scan Read, Department Specific Free Standing Clinic, Outpatient CTRC, University of Colorado Hospital
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NIH-K01: Investigating Cognitive-Motor Variability to Predict Driving Performance in Stroke Survivors with MCI
Greeley Campus, Harmony Campus, Medical Center of the Rockies, Poudre Valley Hospital, University of Colorado Hospital
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Master protocol of two independent, randomized,
double-blind, Phase 3 studies comparing efficacy and
safety of frexalimab (SAR441344) to teriflunomide in
adult participants with relapsing forms of multiple
sclerosis
Brain Imaging Center (BIC) - Scan Read, Department Specific Free Standing Clinic, Outpatient CTRC, University of Colorado Hospital
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Double-blind, Randomized Controlled Trial to Demonstrate Efficacy of Celeste? Specialized Phototherapy in Treating Symptoms of Parkinson's Disease.
University of Colorado Hospital
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