How Does Inflammation Affect the Aging Brain? Research Study Investigates Aging, Memory, and Immune Function.
The University of Colorado Anschutz Medical Campus is looking for interested adults 60 and over to participate in a research study examining how inflammation influences brain health. Data gathered from this study will be used to better understand how inflammation may or may not disrupt thi...
Protocol #: 18-2607
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ImTAB
Immunity, mTBI, and Alzheimer's Biomarkers
You may qualify if you are:
- 65 years or older
- Have had a concussion within the past 5 years
- Saw a doctor within 1 week of your concussion
- Have not been diagnosed with a memory disorder
Participants will receive:
-Snacks and refreshments
-Medical screening (neurological e...
Protocol #: 19-1423
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University of Colorado Alzheimer's and Cognition Center Longitudinal Biomarker and Clinical Phenotyping Study (Bio-AD Study)
This study will establish a large bank of samples and data for future research into the causes of and treatments for Alzheimer’s disease (AD), Down Syndrome (DS) and other diseases that cause thinking and memory problems....
Protocol #: 15-1774
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Calibrating free-living physical activity characteristics across functionally-limited populations using machine-learned accelerometer approaches
Regular physical activity is known to have positive effects on many health outcomes. In research, physical activity is often measured using activity monitors worn on the hip, wrist or ankle. These instruments determine how much physical activity a person does based on the amount of movemen...
Protocol #: 16-2706
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Unraveling the early phases of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL).
Protocol #: 22-0235
Location: Brain Imaging Center (BIC), CTRC Inpatient, University of Colorado Hospital
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Rocky Mountain Multiple Sclerosis Center (RMMSC) Biorepository for the Study of Neuroimmunological Disorders
Protocol #: 12-0968
Location: University of Colorado Hospital
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Stereotactic Laser Ablation for Temporal Lobe Epilepsy (SLATE) Study
Protocol #: 17-0873
Location: Lone Tree Medical Center, University of Colorado Hospital
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Using Next Generation Sequencing to Unravel the Pathogenesis of Sporadic Inclusion Body Myositis (IBM) - The International IBM Consortium Genetic Study
Protocol #: 17-1132
Location: University of Colorado Hospital
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The modified Atkins diet in patients with drug resistant epilepsy and the responsive neurostimulator 09Aug2017
Protocol #: 17-0888
Location: University of Colorado Hospital
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Risk factors in Early Multiple Sclerosis (RisE-MS)
Protocol #: 17-1884
Location: Outpatient CTRC, University of Colorado Hospital
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Validation of a performance-based assessment of functional ability related to cognition in Parkinson's disease
Protocol #: 15-0170
Location: Colorado Research Center, Department Specific Free Standing Clinic, Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
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Perceived palliative care needs of Huntington's disease patients
Protocol #: 18-0216
Location: University of Colorado Hospital
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Diet and Relapses in Pediatric Multiple Sclerosis
Protocol #: 18-0393
Location: Childrens Hospital Colorado, Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
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Automatic measurement of hand movements toward development of an objective assessment of primary motor symptoms in Parkinson?s disease
Protocol #: 15-1041
Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
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Ruptured Aneurysms Treated with Hydrogel Coils
Protocol #: 18-6052
Location: Memorial Hospital Central
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COG ANBL1531 - A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or ALK Inhibitor Therapy Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma (NBL) (IND# 134379)
Protocol #: 18-0971
Location: Childrens Hospital Colorado
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Neurologic Music Therapy for enhancing fine motor control in Parkinson's Disease 16Apr2018
Protocol #: 16-2308
Location: University of Colorado Hospital
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More than a Movement Disorder: Applying Palliative Care to Parkinson?s Disease v: 12/06/2017
Protocol #: 16-1400
Location: Colorado Research Center, Department Specific Free Standing Clinic
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Conversational Speech in the Diagnosis of Neurocognitive Disorders
Protocol #: 18-0456
Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
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Peripheral Inflammatory Cytokine Levels in Parkinson Disease
Protocol #: 18-1356
Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
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Clinical Outcome Measures in Friedreich's Ataxia
Protocol #: 18-1641
Location: Outpatient CTRC, University of Colorado Hospital
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Determining the Effectiveness of early Intensive
Versus Escalation approaches for the treatment of Relapsing-Remitting Multiple Sclerosis (DELIVERMS)
Protocol #: 18-1633
Location: University of Colorado Hospital
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Identifying relevant seizure biomarkers from RNS? System recorded electrocorticography for the development of optimized seizure detection algorithms
Protocol #: 18-2089
Location: University of Colorado Hospital
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Association of depth recordings from the temporal cortex with sleep pattern detection and characterization of sleep dysfunction in patients with refractory epilepsy.
Protocol #: 18-2806
Location: University of Colorado Hospital
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Gene Expression of Cerebral Aneurysms
In this study, we will collect tissue and blood from participants during their epilepsy surgery. ...
Protocol #: 19-0182
Location: University of Colorado Hospital
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Investigating cortical networks disruption and rehabilitation after traumatic brain injury
Protocol #: 19-0049
Location: Colorado Research Center, Department Specific Free Standing Clinic
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GORE? CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients with Patent Foramen Ovale (PFO): the REDUCE Post Approval Study
This study will assess the safety and effectiveness of GORE? CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a post-market setting....
Protocol #: 19-6030
Location: Harmony Campus, Medical Center of the Rockies
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A Natural History Study of CMT1B, CMT2A, CMT4A and CMT4C
Protocol #: 18-2537
Location: University of Colorado Hospital
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AMPLATZERTM PFO Occluder Post
Approval Study
This is a single arm, multi-center study to confirm the safety and effectiveness of the AMPLATZERTM PFO Occluder in the post approval setting...
Protocol #: 19-6502
Location: Memorial Hospital Central
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A Phase I/II Study of Nivolumab Plus or Minus Ipilimumab in Combination with Multi-Fraction Stereotactic Radiosurgery for Recurrent High-Grade Radiation-Relapsed Meningioma
Protocol #: 19-0423
Location: University of Colorado Hospital
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Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3
Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for
Severe Cerebral Edema following Large Hemispheric Infarction
Protocol #: 19-0675
Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital
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A Two-year Prospective Natural History Study Examining the Use of Neuronal Injury Biomarkers in Autoimmune Encephalitis as a Potential Biomarker for Disease Activity and Severity
Protocol #: 19-0889
Location: Brain Imaging Center (BIC), Childrens Hospital Colorado, Colorado Research Center, University of Colorado Hospital
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Natural History of Rett Syndrome and Related Disorders
Protocol #: 15-2332
Location: Childrens Hospital Colorado
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Neurophysiological Correlates V: 31Jan18
Protocol #: 16-1480
Location: Childrens Hospital Colorado
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Comparative Effectiveness Research for Infantile Spasms V: 12Jan2017
Protocol #: 16-2408
Location: Childrens Hospital Colorado
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Feasibility of the Multiple Sclerosis Performance Test for assessment of functional performance measures in patients with Multiple Sclerosis
Protocol #: 19-1192
Location: University of Colorado Hospital
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GBM AGILE Global Adaptive Trial Master Protocol: An International, Seamless Phase II/III Response Adaptive Randomization Platform Trial Designed To Evaluate Multiple Regimens In Newly Diagnosed and Recurrent GBM (GCAR-7213)
Protocol #: 19-0744
Location: University of Colorado Hospital
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A Study of the Pipeline Flex Embolization DeVice with Shield Technology for EndovAscular TreatmeNt of Wide-NeCked Intracranial AnEurysms
Protocol #: 19-1399
Location: University of Colorado Hospital
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GRASP-LGMD RESEARCH PROTOCOL; Project 1a Defining Clinical Endpoints in LGMD
Protocol #: 19-0506
Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
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A Multicenter Randomized Controlled Trial of Best Available Therapy versus Autologous Hematopoietic Stem Cell Transplant for Treatment-Resistant Relapsing Multiple Sclerosis
Protocol #: 19-1621
Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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GORE? CARDIOFORM Septal Occluder Migraine Clinical Study (RELIEF
Clinical Study): A Study to evaluate the safety and efficacy of transcatheter
closure of patent foramen ovale for relief of migraine headaches
Protocol #: 20-6000
Location: Harmony Campus, Medical Center of the Rockies
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Perceived Palliative Care Needs in Early-Onset Dementia
Protocol #: 19-2134
Location: Outpatient CTRC, UCHealth Central Park Medical Center, University of Colorado Hospital
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A Phase 3, External Placebo-Controlled, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Patients with Neuromyelitis OpticavSpectrum Disorder (NMOSD)
Protocol #: 19-2038
Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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A Prospective Study of Acute Flaccid Myelitis (AFM) to Define Natural History, Risk Factors, and Pathogenic Mechanisms
Protocol #: 19-2357
Location: Childrens Hospital Colorado
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A Room Temperature Atomic Magnetrode System for Telemetry of Epileptic Seizures
Protocol #: 19-2363
Location: University of Colorado Hospital
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A MULTICENTER, LONGITUDINAL, OPEN-LABEL, SINGLE-ARM STUDY DESCRIBING COGNITIVE PROCESSING SPEED CHANGES IN RELAPSING MULTIPLE SCLEROSIS SUBJECTS TREATED WITH OZANIMOD (RPC-1063)
Protocol #: 19-2420
Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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An Open Label Extension Study of Ublituximab in Subjects with Relapsing Multiple Sclerosis
Protocol #: 19-2378
Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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Lipoic acid for Treatment of Progressive Multiple Sclerosis
Protocol #: 19-2525
Location: Brain Imaging Center (BIC), University of Colorado Hospital
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Platform Trial for the Treatment of Amyotrophic Lateral Sclerosis (ALS): A perpetual multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of ALS.
Protocol #: 19-2645
Location: Outpatient CTRC, University of Colorado Hospital
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Deep sleep in Parkinson disease and its relationship to cognition, neuroinflammation and neurodegeneration
Protocol #: 20-0347
Location: Brain Imaging Center (BIC), Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
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A Phase 1, Two-part, Open-label Dose-escalation and Double-blind, Placebo-controlled Dose-expansion Study with an Open-label Extension to Evaluate the Safety and Efficacy of ATA188 in Subjects with Progressive Multiple Sclerosis (ATA188-MS-101
Protocol #: 20-0454
Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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A single-arm, prospective, multicentre, open-label study to evaluate ofatumumab treatment effectiveness and patientreported outcomes in patients with relapsing multiple sclerosis transitioning from dimethyl fumarate or fingolimod therapy (COMB157G23101)
Protocol #: 20-0705
Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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The Parkinson's Progression Markers Initiative (PPMI) 2.0 Clinical - Establishing a Deeply Phenotyped PD Cohort
Protocol #: 20-1204
Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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Patient Preferences in Deep Brain Stimulation Products
Protocol #: 19-3015
Location: University of Colorado Hospital
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Endovascular treatment of acutely ruptured shallow intradural aneurysms not amendable to clipping and coiling with the pipeline vantage embolization device
Protocol #: 20-1254
Location: University of Colorado Hospital
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Embolization of the Middle Meningeal Artery with ONYX(TM) Liquid Embolic System in the Treatment of Subactue and Chronic Subdural Hematoma (EMBOLISE)
The purpose of this study is to evaluate the safety (short and long term side effects) and effectiveness (how well it helps) of Onyx Liquid Embolic System(LES) (study device) embolization of the middle meningeal artery when used in addition to the standard treatment that is used to treat a...
Protocol #: 20-1390
Location: University of Colorado Hospital
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A double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of intravenous ganaxolone in status epilepticus
Status Epilepticus is a serious condition that needs fast treatment to stop the seizures and prevent permanent brain damage. Ganaxolone is an investigational drug, which means that it is not approved by the US FDA. The study drug will be added on to the usual care patients will already be ...
Protocol #: 20-1641
Location: University of Colorado Hospital
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Genetics of CMT - Modifiers of CMT1A, New Causes of CMT
Protocol #: 20-1525
Location: Outpatient CTRC, University of Colorado Hospital
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A Multi-Center, Controlled Study to Evaluate use of CereGate Therapy to Reduce Freezing of Gait in Participants diagnosed with Parkinson's Disease
Protocol #: 21-5060
Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital
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A RANDOMIZED, DOUBLE-BLIND, MULTICENTER, PLACEBO-CONTROLLED PHASE 3 STUDY WITH OPEN-LABEL PERIOD TO EVALUATE THE EFFICACY AND SAFETY OF INEBILIZUMAB IN ADULTS WITH MYASTHENIA GRAVIS
Protocol #: 20-1787
Location: University of Colorado Hospital
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A PHASE IIIB MULTICENTER, RANDOMIZED, DOUBLE-BLIND, CONTROLLED STUDY TO EVALUATE THE EFFICACY, SAFETY AND PHARMACOKINETICS OF A HIGHER DOSE OF OCRELIZUMAB IN ADULTS WITH PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS
Protocol #: 20-1852
Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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A PHASE III MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PARALLEL-GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FENEBRUTINIB COMPARED WITH TERIFLUNOMIDE IN ADULT PATIENTS WITH RELAPSING MULTIPLE SCLEROSIS
Protocol #: 20-2036
Location: Brain Imaging Center (BIC), University of Colorado Hospital
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A single-arm, prospective, multi-center, study to explore maintained efficacy with ofatumumab therapy in patients with relapsing Multiple Sclerosis who discontinue
intravenously delivered anti-CD20 monoclonal antibody (aCD20 mAb) therapy (OLIKOS)
Protocol #: 20-2135
Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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A Phase 3b, Multicenter, Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Oral Edaravone Administered for a Period of 48 Weeks in Subjects with Amyotrophic Lateral Sclerosis (ALS)
Protocol #: 20-2340
Location: University of Colorado Hospital
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Cerebrospinal fluid-biomarkers-based diagnostic and prognostic models for multiple sclerosis (SPINCOMS)
Protocol #: 20-1025
Location: Brain Imaging Center (BIC), University of Colorado Hospital
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Sleep assessed by actigraphy and direct recordings of the subthalamic nucleus in Parkinson's Disease.
Protocol #: 20-2508
Location: Lone Tree Medical Center, University of Colorado Hospital
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ALZHEIMER'S CLINICAL TRIAL CONSORTIUM FOR DOWN SYNDROME (ACTC-DS)
TRIAL-READY COHORT - DOWN SYNDROME (TRC-DS)
TRC-DS is part of a larger movement working with people with Down syndrome to advance Alzheimer's disease therapies and potential cures for this population. The Alzheimer's Clinical Trials Consortium-Down Syndrome (ACTC-DS) is a large collaboration of researchers conducting clinical trials...
Protocol #: 20-2692
Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
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Discontinuation of Disease Modifying Therapies (DMTs) in Multiple Sclerosis (MS): Extension of the DISCOMS Study
Protocol #: 20-2772
Location: University of Colorado Hospital
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Phase II Trial to Evaluate Safety and Efficacy of GM-CSF/Sargramostim in Alzheimer's Disease (SESAD)
Protocol #: 19-2727
Location: Brain Imaging Center (BIC), C-TRIC, Outpatient CTRC, University of Colorado Hospital
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Treatment for Alcohol Use Disorder: Emotion Regulation and Brain Function
This study plans to learn more about the brain's role alcohol use problems and recovery. Prominent theories about alcohol use disorder suggest that it is a disorder of the brain. However, it remains unclear what parts of the brain work differently in alcohol use disorder. This study intend...
Protocol #: 20-3000
Location: Brain Imaging Center (BIC), University of Colorado Hospital
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A Phase 3, Randomized, Double-Blind, Trial of Pamrevlumab (FG-3019) or Placebo in Combination with Systemic Corticosteroids in ambulatory subjects with Duchenne Muscular Dystrophy (DMD)
Protocol #: 20-2929
Location: Childrens Hospital Colorado
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A PHASE 3, MULTI-CENTER, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF RELDESEMTIV IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Protocol #: 21-2598
Location: University of Colorado Hospital
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A PHASE III, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PARALLEL-GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FENEBRUTINIB, COMPARED WITH OCRELIZUMAB IN ADULT PATIENTS WITH PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS.
Protocol #: 21-2663
Location: Brain Imaging Center (BIC), University of Colorado Hospital
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A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER, PHASE 2 STUDY TO EVALUATE THE EFFICACY, SAFETY, AND PHARMACOKINETICS OF ROZANOLIXIZUMAB IN ADULT STUDY PARTICIPANTS WITH LEUCINE-RICH GLIOMA INACTIVATED 1 AUTOIMMUNE ENCEPHALITIS
Protocol #: 21-2955
Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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THE EVALUATION OF IMMUNE RESPONSES TO SARS-COV-2 MRNA VACCINES IN MULTIPLE SCLEROSIS PATIENTS ON OCRELIZUMAB
Protocol #: 21-3126
Location: Outpatient CTRC, University of Colorado Hospital
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ALLFTD: ARTFL-LEFFTDS LONGITUDINAL FRONTOTEMPORAL LOBAR DEGENERATION
Protocol #: 21-2833
Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
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Efficacy and Safety Study of Nipocalimab IV Infusions for Adults With Generalized Myasthenia Gravis
Protocol #: 21-3289
Location: CTRC Inpatient, University of Colorado Hospital
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A PHASE III MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY STUDY TO EVALUATE SAFETY AND EFFICACY OF OCRELIZUMAB IN CHILDREN AND ADOLESCENTS WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS
Protocol #: 20-2614
Location: Childrens Hospital Colorado
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BIOREPOSITORY FOR CENTRAL VEIN SIGN: A DIAGNOSTIC BIOMARKER IN MULTIPLE SCLEROSIS
Protocol #: 21-3715
Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
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Influence of NT5c1A antibodies on disease progression, clinical phenotype and blood and muscle biomarkers in sporadic Inclusion Body Myositis - A prospective evaluation
Protocol #: 21-3383
Location: University of Colorado Hospital
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A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER, PHASE 3, PIVOTAL STUDY WITH AN OPEN-LABEL EXTENSION PERIOD TO EVALUATE THE
EFFICACY AND SAFETY OF ROZANOLIXIZUMAB IN ADULT
PARTICIPANTS WITH MYELIN OLIGODENDROCYTE GLYCOPROTEIN (MOG)
ANTIBODY-ASSOCIATED DISEASE (MOG-AD)
Protocol #: 21-3747
Location: Brain Imaging Center (BIC), University of Colorado Hospital
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Automated Seizure Detection for Home Seizure Monitoring with Epilog Sensors
Protocol #: 21-3574
Location: University of Colorado Hospital
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A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Pitolisant on Excessive Daytime Sleepiness and Other Non-Muscular Symptoms in Patients with Myotonic Dystrophy Type 1, Followed by an Open-Label Extension
Protocol #: 21-3397
Location: UCHealth Central Park Medical Center, University of Colorado Hospital
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SPHERES Neuromyelitis Optica Spectrum Disorder (NMOSD) Registry
Protocol #: 21-3763
Location: University of Colorado Hospital
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Evaluation of COVID-19 humoral and cellular immune response in immunosuppressed patients with autoimmune neurological conditions
Protocol #: 21-4092
Location: Department Specific Free Standing Clinic, University of Colorado Hospital
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SAKURABONSAI: CLINICAL, IMAGING AND BIOMARKER OPEN-LABEL STUDY IN
NEUROMYELITIS OPTICA SPECTRUM DISORDER (NMOSD) WITH SATRALIZUMAB AS AN INTERVENTION
Protocol #: 21-4079
Location: Brain Imaging Center (BIC), University of Colorado Hospital
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A Comparative Study of Levodopa and Carbidopa
Bioavailability Following Foslevodopa/foscarbidopa Infusion at Different
Subcutaneous Sites in Parkinson's Disease Patients
Protocol #: 21-4448
Location: University of Colorado Hospital
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Aneurysmal SubArachnoid Hemorrhage - Red Blood Cell Transfusion And Outcome (SAHaRA): A Randomized Controlled Trial
Protocol #: 21-4692
Location: University of Colorado Hospital
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A Prospective, Multicenter Study to Evaluate the Performance and Safety of the CerebroFlo EVD Catheter
Protocol #: 21-4725
Location: University of Colorado Hospital
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Feasibility of Reducing Cardiovascular Disease Risk Factors in Hispanics through a Family-Based Community Intervention
Protocol #: 21-4605
Location: Medical Center of the Rockies
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A Phase 2a Open-Label Preliminary Safety, Efficacy, and Biomarker Study of WP-0512 in
Patients with Amyotrophic Lateral Sclerosis (ALS)
Protocol #: 21-4944
Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
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Integrating Home-Based Video Teleneuropsychology into Clinical Practice: Typical Versus Atypical Alzheimer's Disease
Protocol #: 21-5037
Location: Department Specific Free Standing Clinic, Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
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Naturalistic sleep assessed by wearable devices in Parkinson's disease
Wear a wrist activity monitor and headband at night to monitor sleep....
Protocol #: 22-0393
Location: Boulder Health Center, Lone Tree Medical Center, University of Colorado Hospital
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