Discontinuation of Disease Modifying Therapies (DMTs) in Multiple Sclerosis (MS): Extension of the DISCOMS Study
Protocol #: 20-2772
Location: University of Colorado Hospital
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Sleep assessed by actigraphy and direct recordings of the subthalamic nucleus in Parkinson's Disease.
Protocol #: 20-2508
Locations: Lone Tree Medical Center; University of Colorado Hospital
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A RANDOMIZED, DOUBLE-BLIND, MULTICENTER, PLACEBO-CONTROLLED PHASE 3 STUDY WITH OPEN-LABEL PERIOD TO EVALUATE THE EFFICACY AND SAFETY OF INEBILIZUMAB IN ADULTS WITH MYASTHENIA GRAVIS
Protocol #: 20-1787
Location: University of Colorado Hospital
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Genetics of CMT - Modifiers of CMT1A, New Causes of CMT
Protocol #: 20-1525
Location: University of Colorado Hospital
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A double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of intravenous ganaxolone in status epilepticus
Status Epilepticus is a serious condition that needs fast treatment to stop the seizures and prevent permanent brain damage. Ganaxolone is an investigational drug, which means that it is not approved by the US FDA. The study drug will be added on to the usual care patients will already be ...more >
Protocol #: 20-1641
Location: University of Colorado Hospital
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Patient Preferences in Deep Brain Stimulation Products
Protocol #: 19-3015
Location: University of Colorado Hospital
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The Parkinson's Progression Markers Initiative (PPMI) 2.0 Clinical - Establishing a Deeply Phenotyped PD Cohort
Protocol #: 20-1204
Locations: Brain Imaging Center (BIC); University of Colorado Hospital
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A single-arm, prospective, multicentre, open-label study to evaluate ofatumumab treatment effectiveness and patientreported outcomes in patients with relapsing multiple sclerosis transitioning from dimethyl fumarate or fingolimod therapy (COMB157G23101)
Protocol #: 20-0705
Locations: Brain Imaging Center (BIC); University of Colorado Hospital
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A Phase 2, Randomized, Placebo-Controlled Study to Evaluate Safety, Tolerability, and
Efficacy of TAK-079 in Patients With Generalized Myasthenia Gravis
Protocol #: 20-0609
Location: University of Colorado Hospital
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A Phase 1, Two-part, Open-label Dose-escalation and Double-blind, Placebo-controlled Dose-expansion Study with an Open-label Extension to Evaluate the Safety and Efficacy of ATA188 in Subjects with Progressive Multiple Sclerosis (ATA188-MS-101
Protocol #: 20-0454
Locations: Brain Imaging Center (BIC); University of Colorado Hospital
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Phase 3b Open-Label, Multicenter, Safety Study of BIIB037 (aducanumab) in Subjects with Alzheimer's disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205
Protocol #: 20-0571
Locations: Brain Imaging Center (BIC); University of Colorado Hospital
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A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Parallel Group, Multicenter Study With an Open-Label Extension to Evaluate the Efficacy and Safety of Ravulizumab in Patients With Amyotrophic Lateral Sclerosis (ALS)
Protocol #: 20-0404
Location: University of Colorado Hospital
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Deep sleep in Parkinson disease and its relationship to cognition, neuroinflammation and neurodegeneration
Protocol #: 20-0347
Locations: Brain Imaging Center (BIC); University of Colorado Hospital
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ALS toolkit project
Protocol #: 20-0127
Location: University of Colorado Hospital
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A Phase 4 Multicenter Observational Study to Evaluate the Effectiveness of Patisiran in Patients with Polyneuropathy of Hereditary Transthyretin-Mediated (hATTR) Amyloidosis with a V122I or T60A Mutation
Protocol #: 19-3061
Location: University of Colorado Hospital
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Biomarker Development in LGMD 2i
Protocol #: 19-2943
Location: University of Colorado Hospital
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A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL GROUP, MULTICENTER TRIAL OF CVL-865 AS ADJUNCTIVE THERAPY IN ADULTS WITH DRUG-RESISTANT FOCAL ONSET SEIZURES (REALIZE TRIAL)
Protocol #: 19-2898
Location: University of Colorado Hospital
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Platform Trial for the Treatment of Amyotrophic Lateral Sclerosis (ALS): A perpetual multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of ALS.
Protocol #: 19-2645
Location: University of Colorado Hospital
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Lipoic acid for Treatment of Progressive Multiple Sclerosis
Protocol #: 19-2525
Locations: Brain Imaging Center (BIC); University of Colorado Hospital
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Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of 36 Weeks of Treatment with NLY01 in Early-stage Parkinson's Disease
Protocol #: 19-2471
Location: University of Colorado Hospital
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A Phase 3, Multi-center, Open-label, Safety Study of Oral Edaravone Administered over 48 Weeks in Subjects with Amyotrophic Lateral Sclerosis (ALS)
Protocol #: 19-2377
Location: University of Colorado Hospital
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An Open Label Extension Study of Ublituximab in Subjects with Relapsing Multiple Sclerosis
Protocol #: 19-2378
Locations: Brain Imaging Center (BIC); University of Colorado Hospital
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A MULTICENTER, LONGITUDINAL, OPEN-LABEL, SINGLE-ARM STUDY DESCRIBING COGNITIVE PROCESSING SPEED CHANGES IN RELAPSING MULTIPLE SCLEROSIS SUBJECTS TREATED WITH OZANIMOD (RPC-1063)
Protocol #: 19-2420
Locations: Brain Imaging Center (BIC); University of Colorado Hospital
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A RANDOMIZED, OPEN-LABEL EXTENSION STUDY TO INVESTIGATE THE LONG-TERM SAFETY, TOLERABILITY, AND EFFICACY OF ROZANOLIXIZUMAB IN ADULT PATIENTS WITH GENERALIZED MYASTHENIA GRAVIS
Protocol #: 19-1929
Location: University of Colorado Hospital
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A Room Temperature Atomic Magnetrode System for Telemetry of Epileptic Seizures
Protocol #: 19-2363
Location: University of Colorado Hospital
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An open-label, non-randomized trial to investigate the efficacy and safety of early versus delayed start of arimoclomol in patients with sporadic inclusion body myositis who have completed the IBM4809 trial
Protocol #: 19-1598
Location: University of Colorado Hospital
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CLadribine Tablets: Collaborative Study to Evaluate the Impact On Central Nervous System BiomarKers in Multiple Sclerosis (CLOCK-MS)
Protocol #: 19-1980
Locations: Brain Imaging Center (BIC); University of Colorado Hospital
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A Prospective Study of Acute Flaccid Myelitis (AFM) to Define Natural History, Risk Factors, and Pathogenic Mechanisms
Protocol #: 19-2357
Location: Childrens Hospital Colorado
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A Phase 3, External Placebo-Controlled, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Patients with Neuromyelitis OpticavSpectrum Disorder (NMOSD)
Protocol #: 19-2038
Locations: Brain Imaging Center (BIC); University of Colorado Hospital
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Perceived Palliative Care Needs in Early-Onset Dementia
Protocol #: 19-2134
Locations: UCHealth Central Park Medical Center; University of Colorado Hospital
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A Multicenter Randomized Controlled Trial of Best Available Therapy versus Autologous Hematopoietic Stem Cell Transplant for Treatment-Resistant Relapsing Multiple Sclerosis
Protocol #: 19-1621
Locations: Brain Imaging Center (BIC); University of Colorado Hospital
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A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess
the Efficacy, Safety, and Tolerability of Valbenazine for the Treatment of
Chorea Associated with Huntington's Disease
Protocol #: 19-1840
Location: University of Colorado Hospital
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Neurological Screening of Controls in an Age-Related Macular Degeneration Registry
Protocol #: 19-1925
Location: University of Colorado Hospital
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A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY EVALUATING EFFICACY AND SAFETY OF ROZANOLIXIZUMAB IN ADULT PATIENTS WITH GENERALIZED MYASTHENIA GRAVIS
Protocol #: 19-1597
Location: University of Colorado Hospital
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AN OBSERVATIONAL STUDY OF OCRELIZUMAB TREATED PATIENTS WITH MULTIPLE SCLEROSIS TO DETERMINE THE INCIDENCE AND MORTALITY RATES OF BREAST CANCER AND ALL MALIGNANCIES (VERISMO STUDY)
Protocol #: 19-1600
Location: University of Colorado Hospital
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A Post-Market Study Evaluating the Safety of Infinity DBS System with MR Conditional Labeling
Protocol #: 19-1566
Location: University of Colorado Hospital
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GRASP-LGMD RESEARCH PROTOCOL; Project 1a Defining Clinical Endpoints in LGMD
Protocol #: 19-0506
Location: University of Colorado Hospital
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A Phase III Study to Evaluate the Efficacy, Safety, and Tolerability of Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase (HYQVIA/HyQvia) and Immune Globulin Infusion (Human), 10% (GAMMAGARD LIQUID/KIOVIG) for the Treatment of Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
Protocol #: 19-1455
Location: University of Colorado Hospital
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ImTAB
Immunity, mTBI, and Alzheimer's Biomarkers
You may qualify if you are:
- 65 years or older
- Have had a concussion within the past 5 years
- Saw a doctor within 1 week of your concussion
- Have not been diagnosed with a memory disorder
Participants will receive:
-Snacks and refreshments
-Medical screening (neurological e...more >
Protocol #: 19-1423
Location: University of Colorado Hospital
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GBM AGILE Global Adaptive Trial Master Protocol: An International, Seamless Phase II/III Response Adaptive Randomization Platform Trial Designed To Evaluate Multiple Regimens In Newly Diagnosed and Recurrent GBM (GCAR-7213)
Protocol #: 19-0744
Location: University of Colorado Hospital
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Feasibility of the Multiple Sclerosis Performance Test for assessment of functional performance measures in patients with Multiple Sclerosis
Protocol #: 19-1192
Location: University of Colorado Hospital
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Comparative Effectiveness Research for Infantile Spasms V: 12Jan2017
Protocol #: 16-2408
Location: Childrens Hospital Colorado
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Neurophysiological Correlates V: 31Jan18
Protocol #: 16-1480
Location: Childrens Hospital Colorado
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Natural History of Rett Syndrome and Related Disorders
Protocol #: 15-2332
Location: Childrens Hospital Colorado
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Gamma band neural stimulation and its effects on resting state networks
Protocol #: 19-1251
Locations: Brain Imaging Center (BIC); Department Specific Free Standing Clinic
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A Two-year Prospective Natural History Study Examining the Use of Neuronal Injury Biomarkers in Autoimmune Encephalitis as a Potential Biomarker for Disease Activity and Severity
Protocol #: 19-0889
Locations: Brain Imaging Center (BIC); Childrens Hospital Colorado; Colorado Research Center; University of Colorado Hospital
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Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3
Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for
Severe Cerebral Edema following Large Hemispheric Infarction
Protocol #: 19-0675
Location: University of Colorado Hospital
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A Multi-center, Prospective, Longitudinal, Digital Assessment Study of Disease Progression in Subjects with Early, Untreated Parkinson Disease (PD)
Protocol #: 19-0865
Location: University of Colorado Hospital
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A PHASE Ib, OPEN-LABEL, MULTICENTER STUDY TO INVESTIGATE THE PHARMACOKINETICS, SAFETY, AND TOLERABILITY OF SUBCUTANEOUS OCRELIZUMAB ADMINISTRATION IN PATIENTS WITH MULTIPLE SCLEROSIS
Protocol #: 19-1040
Location: University of Colorado Hospital
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A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Safety and Efficacy of Ravulizumab in Complement-Inhibitor-Naive Adult Patients With Generalized Myasthenia Gravis
Protocol #: 19-0772
Location: University of Colorado Hospital
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An Open-label Extension Study of MOM-M281-004 to Evaluate the
Safety, Tolerability, and Efficacy of M281 Administered to Patients
with Generalized Myasthenia Gravis
Protocol #: 19-0150
Location: University of Colorado Hospital
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A Phase 3, 22-week, Multi-center, Randomized Withdrawal Study of TD˗9855 in Treating Symptomatic Neurogenic Orthostatic Hypotension in Subjects with Primary Autonomic Failure
Protocol #: 19-0520
Location: University of Colorado Hospital
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Instrumentation of Huntington's Disease Motor Function Assessment
Protocol #: 19-0212
Location: University of Colorado Hospital
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A Phase 3, 4-week, Multicenter, Randomized, Double-blind, Placebocontrolled,
Parallel-group Study of TD-9855 in Treating Symptomatic Neurogenic Orthostatic Hypotension in Subjects With Primary Autonomic Failure
Protocol #: 19-0414
Location: University of Colorado Hospital
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A Phase I/II Study of Nivolumab Plus or Minus Ipilimumab in Combination with Multi-Fraction Stereotactic Radiosurgery for Recurrent High-Grade Radiation-Relapsed Meningioma
Protocol #: 19-0423
Location: University of Colorado Hospital
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AMPLATZERTM PFO Occluder Post
Approval Study
This is a single arm, multi-center study to confirm the safety and effectiveness of the AMPLATZERTM PFO Occluder in the post approval setting...more >
Protocol #: 19-6502
Location: Memorial Hospital Central
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Detection and Risk in Early MS
Protocol #: 19-0393
Locations: Brain Imaging Center (BIC); University of Colorado Hospital
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A Natural History Study of CMT1B, CMT2A, CMT4A and CMT4C
Protocol #: 18-2537
Location: University of Colorado Hospital
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GORE? CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients with Patent Foramen Ovale (PFO): the REDUCE Post Approval Study
This study will assess the safety and effectiveness of GORE? CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a post-market setting....more >
Protocol #: 19-6030
Locations: Harmony Campus; Medical Center of the Rockies
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Bedside Resources to Gauge Intravascular Volume Status in Hypovolemic Infants in the Operating Room
Protocol #: 18-2513
Location: Childrens Hospital Colorado
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Investigating cortical networks disruption and rehabilitation after traumatic brain injury
Protocol #: 19-0049
Locations: Colorado Research Center; Department Specific Free Standing Clinic
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Gene Expression of Cerebral Aneurysms
In this study, we will collect tissue and blood from participants during their epilepsy surgery. ...more >
Protocol #: 19-0182
Location: University of Colorado Hospital
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How Does Inflammation Affect the Aging Brain? Research Study Investigates Aging, Memory, and Immune Function.
The University of Colorado Anschutz Medical Campus is looking for interested adults 60 and over to participate in a research study examining how inflammation influences brain health. Data gathered from this study will be used to better understand how inflammation may or may not disrupt thi...more >
Protocol #: 18-2607
Location: University of Colorado Hospital
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Association of depth recordings from the temporal cortex with sleep pattern detection and characterization of sleep dysfunction in patients with refractory epilepsy.
Protocol #: 18-2806
Location: University of Colorado Hospital
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Identifying relevant seizure biomarkers from RNS? System recorded electrocorticography for the development of optimized seizure detection algorithms
Protocol #: 18-2089
Location: University of Colorado Hospital
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Genomic Translation for ALS Care
Protocol #: 18-1768
Location: University of Colorado Hospital
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A RANDOMIZED CONTROLLED STUDY TO COMPARE THE SAFETY AND EFFICACY OF IPX203 WITH IMMEDIATE-RELEASE CARBIDOPA-LEVODOPA IN PARKINSON'S DISEASE PATIENTS WITH MOTOR FLUCTUATIONS
Protocol #: 18-2047
Location: University of Colorado Hospital
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Determining the Effectiveness of early Intensive
Versus Escalation approaches for the treatment of Relapsing-Remitting Multiple Sclerosis (DELIVERMS)
Protocol #: 18-1633
Location: University of Colorado Hospital
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Clinical Outcome Measures in Friedreich's Ataxia
Protocol #: 18-1641
Location: University of Colorado Hospital
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A Phase 3, Randomized, Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur After Irradiation and Adjuvant Temozolomide Chemotherapy STELLAR Study
Protocol #: 18-1336
Location: University of Colorado Hospital
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Peripheral Inflammatory Cytokine Levels in Parkinson Disease
Protocol #: 18-1356
Location: University of Colorado Hospital
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Conversational Speech in the Diagnosis of Neurocognitive Disorders
Protocol #: 18-0456
Location: University of Colorado Hospital
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More than a Movement Disorder: Applying Palliative Care to Parkinson?s Disease v: 12/06/2017
Protocol #: 16-1400
Locations: Colorado Research Center; Department Specific Free Standing Clinic
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Microburst VNS Therapy Feasibility Study in Patients with Refractory Epilepsy
Protocol #: 18-0995
Location: University of Colorado Hospital
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Neurologic Music Therapy for enhancing fine motor control in Parkinson's Disease 16Apr2018
Protocol #: 16-2308
Location: University of Colorado Hospital
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COG ANBL1531 - A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or Crizotinib Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma (NBL) (IND# 134379)
Protocol #: 18-0971
Location: Childrens Hospital Colorado
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Ruptured Aneurysms Treated with Hydrogel Coils
Protocol #: 18-6052
Location: Memorial Hospital Central
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A Randomized, Placebo Surgery Controlled, Double-blinded, Multi-center, Phase 2 Clinical Trial, Evaluating the Efficacy and Safety of VY-AADC02 in Advanced Parkinson's Disease with Motor Fluctuations
Study is double blind and placebo controlled....more >
Protocol #: 18-0829
Location: University of Colorado Hospital
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Automatic measurement of hand movements toward development of an objective assessment of primary motor symptoms in Parkinson?s disease
Protocol #: 15-1041
Location: University of Colorado Hospital
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Diet and Relapses in Pediatric Multiple Sclerosis
Protocol #: 18-0393
Locations: Childrens Hospital Colorado; University of Colorado Hospital
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Application of transcranial alternating current stimulation for modulation of sleep and cognitive performance
Protocol #: 16-1875
Locations: Colorado Research Center; Department Specific Free Standing Clinic; University of Colorado Hospital
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Perceived palliative care needs of Huntington's disease patients
Protocol #: 18-0216
Location: University of Colorado Hospital
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Clinical Trial Readiness for SCA1 and SCA3
Protocol #: 18-0020
Location: University of Colorado Hospital
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Validation of a performance-based assessment of functional ability related to cognition in Parkinson's disease
Protocol #: 15-0170
Locations: Colorado Research Center; Department Specific Free Standing Clinic; University of Colorado Hospital
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Determining the Optimal Treatment Strategy for Patients who have Chronic Migraine with Medication Overuse
Protocol #: 16-2179
Location: University of Colorado Hospital
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Risk factors in Early Multiple Sclerosis (RisE-MS)
Protocol #: 17-1884
Location: University of Colorado Hospital
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A randomized, double blind, placebo-controlled parallel study of tolerability and efficacy of Cannabidiol (CBD) on tremor in Parkinson's disease
Protocol #: 17-2318
Location: University of Colorado Hospital
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American Registry for Migraine Research
Protocol #: 17-2165
Locations: Lone Tree Medical Center; UCHealth Internal Medical Clinic - Lowry; University of Colorado Hospital
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Phase 2 Study of Allogeneic Umbilical Cord Blood Infusion for Adults with Ischemic Stroke - CoBIS 2
Protocol #: 17-2136
Location: University of Colorado Hospital
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A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Safety, Pharmacokinetics, and Pharmacodynamics of BIIB054 in Subjects with Parkinson's Disease
Protocol #: 17-1532
Location: University of Colorado Hospital
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Topiramate as a disease altering therapy for Cryptogenic Sensory Peripheral Neuropathy (CSPN)
Protocol #: 17-1751
Location: University of Colorado Hospital
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Transcranial electrical stimulation for the treatment of cervical dystonia
Protocol #: 17-1322
Locations: Colorado Research Center; Department Specific Free Standing Clinic
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Calibrating free-living physical activity characteristics across functionally-limited populations using machine-learned accelerometer approaches
Regular physical activity is known to have positive effects on many health outcomes. In research, physical activity is often measured using activity monitors worn on the hip, wrist or ankle. These instruments determine how much physical activity a person does based on the amount of movemen...more >
Protocol #: 16-2706
Locations: CTRC-adult; University of Colorado Hospital
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The modified Atkins diet in patients with drug resistant epilepsy and the responsive neurostimulator 09Aug2017
Protocol #: 17-0888
Location: University of Colorado Hospital
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BEnefits of Stroke Treatment Delivered Using a Mobile Stroke Unit Compared to Standard Management by Emergency Medical Services: The BEST-MSU Study
Protocol #: 15-2114
Locations: Memorial Hospital Central; University of Colorado Hospital
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Using Next Generation Sequencing to Unravel the Pathogenesis of Sporadic Inclusion Body Myositis (IBM) - The International IBM Consortium Genetic Study
Protocol #: 17-1132
Location: University of Colorado Hospital
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Stereotactic Laser Ablation for Temporal Lobe Epilepsy (SLATE) Study
Protocol #: 17-0873
Locations: Lone Tree Medical Center; University of Colorado Hospital
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Diagnostic and Rating Tools for Blepharospasm
Protocol #: 16-0017
Location: University of Colorado Hospital
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Dystonia Coalition Project 1: Natural History and Biospecimen Repository for Dystonia
Protocol #: 11-0647
Location: University of Colorado Hospital
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10-1311
DoneSave
Functional connectivity of the motor network in two major subtypes of Parkinson Disease December 24,2015
Protocol #: 10-1311
Location: University of Colorado Hospital
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Deep Brain Stimulation (DBS) of the Rostral Zona Incerta (rZI) for Parkinson's Disease (PD): Stereotactic Targeting and Clinical Efficacy
Protocol #: 16-1443
Location: University of Colorado Hospital
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Rocky Mountain Multiple Sclerosis Center (RMMSC) Biorepository for the Study of Neuroimmunological Disorders
Protocol #: 12-0968
Location: University of Colorado Hospital
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Rocky Mountain Alzheimer's Disease Center at the University of Colorado School of Medicine (RMADC at UCSOM) Longitudinal Biomarker and Clinical Phenotyping Study
Protocol #: 15-1774
Location: University of Colorado Hospital
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A Phase IV Trial of Neuroprotection with ACTH in Acute Optic Neuritis
Protocol #: 13-0388
Location: University of Colorado Hospital
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Wireless electroencephalography for continuous monitoring in the EEG LTM unit 12Apr2018
Protocol #: 15-0449
Location: University of Colorado Hospital
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NAtalizumab for Prevention of Post-partum Relapses in patients with
Multiple Sclerosis 09May2016
Protocol #: 16-0156
Location: University of Colorado Hospital
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Collaborative International Research in Clinical and Longitudinal Experience for Neuromyelitis Optica (NMO) Studies
Protocol #: 13-3181
Location: University of Colorado Hospital
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