Your search for "Brain and Nervous System" found 108 matches:
University of Colorado Alzheimer's and Cognition Center Longitudinal Biomarker and Clinical Phenotyping Study (Bio-AD Study)

This study will establish a large bank of samples and data for future research into the causes of and treatments for Alzheimer’s disease (AD), Down Syndrome (DS) and other diseases that cause thinking and memory problems....

Protocol #15-1774

Calibrating free-living physical activity characteristics across functionally-limited populations using machine-learned accelerometer approaches

Regular physical activity is known to have positive effects on many health outcomes. In research, physical activity is often measured using activity monitors worn on the hip, wrist or ankle. These instruments determine how much physical activity a person does based on the amount of movemen...

Protocol #16-2706

Conversational Speech in the Diagnosis of Neurocognitive Disorders

Using elements of conversational speech such as tone of voice and duration of speaking is a cheap, non-invasive way to gather information, which can be used to direct medical interventions that will help slow or prevent the progression of neurological disease. ...

Protocol #18-0456

Effect of Hormones on Frequency of Headache and Brain Structure and Function in Puberty

This research studies how hormones impact headache and how different parts of the brain talk to each other. You are invited to participate if you are (or your child is): • 9 years to 20 years of age • With or without history of headache • Male sex, male gender identity • Health...

Protocol #20-1824

Phase II Trial to Evaluate Safety and Efficacy of GM-CSF/Sargramostim in Alzheimer's Disease (SESAD).

Sargramostim is an investigational drug, meaning it has not been approved by the FDA to treat Alzheimer’s. Sargramostim has been approved by the FDA for the past thirty years to treat patients who have had chemotherapy to boost the body’s innate immune system. This research study hopes to ...

Protocol #19-2727

Teen Brain Imaging Study

Irritability in youth is associated with anxiety, depression and suicidality later in life. Treating irritability early may prevent negative outcomes. A promising way to treat irritability is to address negative bias. Understanding biased social judgments has become a major focus of soci...

Protocol #20-2633

Location: CU Anschutz non-hospital research facilities

Please help us learn more about autism!

Study participants will complete MRI Scans, blood draws, tests of cognitive abilities, such as memory and attention, questionnaires about physical activity and emotions, and may be asked to participate in 10 weeks of exercise or social gaming....

Protocol #14-1282

Location: CU Anschutz non-hospital research facilities

ExCITES-PD: Exercise-Induced Cognitive Improvement Through Enhanced Sleep in Parkinson’s Disease

The purpose of this study is to examine the impact of exercise on sleep and cognition in Parkinson’s Disease. Inclusion criteria, Parkinson’s Disease (PD) group: • 45 years of age or older • Diagnosis of Parkinson’s • No contraindications to exercise Exclusion criteria, PD group:...

Protocol #22-1685

Location: CTRC-adult

Bipolar Prediction Brain Imaging Study

Adults age 18-40 with diagnoses of Bipolar Disorder or Major Depressive Disorder are being recruited for this study. ...

Protocol #22-1159

Location: CU Anschutz non-hospital research facilities

Neurologic Music Therapy for Enhancing fine motor control in Parkinson’s Disease

The study involves 2 visits on the Anschutz campus and a 5-week therapy fine motor training regimen (music therapy or occupational therapy). The Anschutz visits include quality of life and motor assessments, and a type of non-invasive brain scan called magnetoencephalography (MEG). Therap...

Protocol #16-2308

Unraveling the early phases of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL).

Protocol #22-0235

Location: Brain Imaging Center (BIC), CTRC Inpatient, University of Colorado Hospital

A PHASE I, MULTICENTER, OPEN-LABEL,UNCONTROLLED STUDY TO EVALUATE PHARMACOKINETICS, PHARMACODYNAMICS, SAFETY, AND TOLERABILITY OFSATRALIZUMAB IN ADULT PATIENTS WITH AQP4 ANTIBODYPOSITIVE NEUROMYELITIS OPTICA SPECTRUM DISORDER WITH BODYWEIGHT  100 KG

Protocol #22-1981

Location: Outpatient CTRC, University of Colorado Hospital

A Randomized, Double-Blind, Placebo-Controlled, Two-Part Study in Parkinson's Disease Patients With Dyskinesia to Assess the Efficacy and Safety/Tolerability of Fixed Dose Combinations of JM-010 and its Individual Components

Protocol #22-1962

Location: Outpatient CTRC, University of Colorado Hospital

LONG-TERM FOLLOW-UP STUDY OF PATIENTS WITH SPINAL MUSCULAR ATROPHY RECEIVING RISDIPLAM TREATMENT

Protocol #22-0296

Location: Outpatient CTRC, University of Colorado Hospital

MECHANISTIC INVESTIGATION OF THERAPIES FOR DOWN SYNDROME REGRESSION DISORDER

Individuals with Down syndrome (DS) have an increased risk of numerous co-occurring conditions, including the neuropsychiatric condition known as Down Syndrome Regression Disorder (DSRD). A DSRD diagnosis often includes a sub-acute onset of catatonia, mutism, depersonalization, loss of abi...

Protocol #22-1992

Location: Childrens Hospital Colorado

A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Determine the Efficacy and Safety of BIIB122 in Participants with Parkinson's Disease

Protocol #22-0285

Location: Outpatient CTRC, University of Colorado Hospital

Rocky Mountain Multiple Sclerosis Center (RMMSC) Biorepository for the Study of Neuroimmunological Disorders

Protocol #12-0968

Location: University of Colorado Hospital

Mindfulness-Based Intervention for Adolescents with Chronic Migraine

Learning from YOU will help us improve a program that can help teens with chronic migraine live a better life! We would like to interview you and your parent for 1 hour each. Interviews can be over Zoom or in person. Interviews will help us understand your experience living with migr...

Protocol #22-2359

Location: Childrens Hospital Colorado

Trial Readiness and Endpoint Assessment in LGMD R1

Protocol #23-1472

Location: Brain Imaging Center - BIC, Department Specific Free Standing Clinic, University of Colorado Hospital

A Phase 2 Multicenter, Randomized, Double-blind, Placebo-controlled Study of BOTOX? (Botulinum Toxin Type A) Purified Neurotoxin Complex for the Treatment of Upper Limb Essential Tremor

Protocol #22-0016

Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital

A Phase 2 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of EDG-5506 on Safety, Biomarkers, Pharmacokinetics, and Functional Measures in Adults and Adolescents with Becker Muscular Dystrophy

Protocol #22-0354

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

Risk factors in Early Multiple Sclerosis (RisE-MS)

Protocol #17-1884

Location: Brain Imaging Center - BIC, Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

Prospective Evaluation of De-Escalation from antiCD-20 Therapies to Diroximel Fumarate

Protocol #21-4993

Location: Brain Imaging Center (BIC), Brain Imaging Center - BIC, University of Colorado Hospital

Diet and Relapses in Pediatric Multiple Sclerosis

Protocol #18-0393

Location: Childrens Hospital Colorado, Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

Automatic measurement of hand movements toward development of an objective assessment of primary motor symptoms in Parkinson?s disease

Protocol #15-1041

Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

A PHASE III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER BASKET STUDY TO EVALUATE THE EFFICACY, SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF SATRALIZUMAB IN PATIENTS WITH ANTIN-METHYL-D ASPARTIC ACID RECEPTOR (NMDAR) OR ANTILEUCINE-RICH GLIOMA-INACTIVATED 1 (LGI1) ENCEPHALITIS

Protocol #22-0449

Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital

Peripheral Inflammatory Cytokine Levels in Parkinson Disease

Protocol #18-1356

Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

Clinical Outcome Measures in Friedreich's Ataxia

Protocol #18-1641

Location: Outpatient CTRC, University of Colorado Hospital

Determining the Effectiveness of early Intensive Versus Escalation approaches for the treatment of Relapsing-Remitting Multiple Sclerosis (DELIVERMS)

Protocol #18-1633

Location: University of Colorado Hospital

Phase II Trial to Evaluate GM-CSF Applications in Down Syndrome (EGADS)

Protocol #22-1301

Location: Brain Imaging Center - BIC, Outpatient CTRC, University of Colorado Hospital

Identifying relevant seizure biomarkers from RNS? System recorded electrocorticography for the development of optimized seizure detection algorithms

Protocol #18-2089

Location: University of Colorado Hospital

Association of depth recordings from the temporal cortex with sleep pattern detection and characterization of sleep dysfunction in patients with refractory epilepsy.

Protocol #18-2806

Location: University of Colorado Hospital

Gene Expression of Cerebral Aneurysms

In this study, we will collect tissue and blood from participants during their epilepsy surgery. ...

Protocol #19-0182

Location: University of Colorado Hospital

Investigating cortical networks disruption and rehabilitation after traumatic brain injury

Protocol #19-0049

Location: Colorado Research Center, Department Specific Free Standing Clinic

REDUCE Post Approval Study - GORE CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients with Patent Foramen Ovale (PFO)

This study will assess the safety and effectiveness of GORE? CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a post-market setting....

Protocol #19-6030

Location: Harmony Campus, Medical Center of the Rockies

A Natural History Study of CMT1B, CMT2A, CMT4A and CMT4C

Protocol #18-2537

Location: University of Colorado Hospital

A Two-year Prospective Natural History Study Examining the Use of Neuronal Injury Biomarkers in Autoimmune Encephalitis as a Potential Biomarker for Disease Activity and Severity

Protocol #19-0889

Location: Brain Imaging Center (BIC), Childrens Hospital Colorado, Colorado Research Center, University of Colorado Hospital

Comparative Effectiveness Research for Infantile Spasms V: 12Jan2017

Protocol #16-2408

Location: Childrens Hospital Colorado

GRASP-LGMD RESEARCH PROTOCOL; Project 1a Defining Clinical Endpoints in LGMD

Protocol #19-0506

Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

A Multicenter Randomized Controlled Trial of Best Available Therapy versus Autologous Hematopoietic Stem Cell Transplant for Treatment-Resistant Relapsing Multiple Sclerosis

Protocol #19-1621

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

RELIEF- GORE CARDIOFORM Septal Occluder Migraine Clinical Study

Protocol #20-6000

Location: Harmony Campus, Medical Center of the Rockies

A Phase 3, External Placebo-Controlled, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Patients with Neuromyelitis OpticavSpectrum Disorder (NMOSD)

Protocol #19-2038

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

A Room Temperature Atomic Magnetrode System for Telemetry of Epileptic Seizures

Protocol #19-2363

Location: University of Colorado Hospital

Lipoic acid for Treatment of Progressive Multiple Sclerosis

Protocol #19-2525

Location: Brain Imaging Center (BIC), University of Colorado Hospital

Deep sleep in Parkinson disease and its relationship to cognition, neuroinflammation and neurodegeneration

Protocol #20-0347

Location: Brain Imaging Center (BIC), Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

The Parkinson's Progression Markers Initiative (PPMI) 2.0 Clinical - Establishing a Deeply Phenotyped PD Cohort

Protocol #20-1204

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

Patient Preferences in Deep Brain Stimulation Products

Protocol #19-3015

Location: University of Colorado Hospital

Endovascular treatment of acutely ruptured shallow intradural aneurysms not amendable to clipping and coiling with the pipeline vantage embolization device

Protocol #20-1254

Location: University of Colorado Hospital

Embolization of the Middle Meningeal Artery with ONYX(TM) Liquid Embolic System in the Treatment of Subactue and Chronic Subdural Hematoma (EMBOLISE)

The purpose of this study is to evaluate the safety (short and long term side effects) and effectiveness (how well it helps) of Onyx Liquid Embolic System(LES) (study device) embolization of the middle meningeal artery when used in addition to the standard treatment that is used to treat a...

Protocol #20-1390

Location: University of Colorado Hospital

A double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of intravenous ganaxolone in status epilepticus

Status Epilepticus is a serious condition that needs fast treatment to stop the seizures and prevent permanent brain damage. Ganaxolone is an investigational drug, which means that it is not approved by the US FDA. The study drug will be added on to the usual care patients will already be ...

Protocol #20-1641

Location: University of Colorado Hospital

Genetics of CMT - Modifiers of CMT1A, New Causes of CMT

Protocol #20-1525

Location: Outpatient CTRC, University of Colorado Hospital

A Multi-Center, Controlled Study to Evaluate use of CereGate Therapy to Reduce Freezing of Gait in Participants diagnosed with Parkinson's Disease

Protocol #21-5060

Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital

Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1 (END-DM1)

Protocol #21-4907

Location: University of Colorado Hospital

A PHASE IIIB MULTICENTER, RANDOMIZED, DOUBLE-BLIND, CONTROLLED STUDY TO EVALUATE THE EFFICACY, SAFETY AND PHARMACOKINETICS OF A HIGHER DOSE OF OCRELIZUMAB IN ADULTS WITH PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS

Protocol #20-1852

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

A PHASE III MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PARALLEL-GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FENEBRUTINIB COMPARED WITH TERIFLUNOMIDE IN ADULT PATIENTS WITH RELAPSING MULTIPLE SCLEROSIS

Protocol #20-2036

Location: Brain Imaging Center (BIC), University of Colorado Hospital

A Phase 2 Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of NS-089/NCNP-02 in Boys with Duchenne Muscular Dystrophy (DMD)

Treatment of Duchenne muscular dystrophy (DMD) with dystrophin deletion amenable to exon 44 skipping...

Protocol #22-0121

Location: Childrens Hospital Colorado

ALZHEIMER'S CLINICAL TRIAL CONSORTIUM FOR DOWN SYNDROME (ACTC-DS) TRIAL-READY COHORT - DOWN SYNDROME (TRC-DS)

TRC-DS is part of a larger movement working with people with Down syndrome to advance Alzheimer's disease therapies and potential cures for this population. The Alzheimer's Clinical Trials Consortium-Down Syndrome (ACTC-DS) is a large collaboration of researchers conducting clinical trials...

Protocol #20-2692

Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

Treatment for Alcohol Use Disorder: Emotion Regulation and Brain Function

This study plans to learn more about the brain's role alcohol use problems and recovery. Prominent theories about alcohol use disorder suggest that it is a disorder of the brain. However, it remains unclear what parts of the brain work differently in alcohol use disorder. This study intend...

Protocol #20-3000

Location: Brain Imaging Center (BIC), University of Colorado Hospital

A PHASE III, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PARALLEL-GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FENEBRUTINIB, COMPARED WITH OCRELIZUMAB IN ADULT PATIENTS WITH PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS.

Protocol #21-2663

Location: Brain Imaging Center (BIC), University of Colorado Hospital

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER, PHASE 2 STUDY TO EVALUATE THE EFFICACY, SAFETY, AND PHARMACOKINETICS OF ROZANOLIXIZUMAB IN ADULT STUDY PARTICIPANTS WITH LEUCINE-RICH GLIOMA INACTIVATED 1 AUTOIMMUNE ENCEPHALITIS

Protocol #21-2955

Location: Brain Imaging Center (BIC), Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

ALLFTD: ARTFL-LEFFTDS LONGITUDINAL FRONTOTEMPORAL LOBAR DEGENERATION

Protocol #21-2833

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

A PHASE III MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY STUDY TO EVALUATE SAFETY AND EFFICACY OF OCRELIZUMAB IN CHILDREN AND ADOLESCENTS WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS

Protocol #20-2614

Location: Childrens Hospital Colorado

BIOREPOSITORY FOR CENTRAL VEIN SIGN: A DIAGNOSTIC BIOMARKER IN MULTIPLE SCLEROSIS

Protocol #21-3715

Location: Department Specific Free Standing Clinic, Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

Influence of NT5c1A antibodies on disease progression, clinical phenotype and blood and muscle biomarkers in sporadic Inclusion Body Myositis - A prospective evaluation

Protocol #21-3383

Location: University of Colorado Hospital

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER, PHASE 3, PIVOTAL STUDY WITH AN OPEN-LABEL EXTENSION PERIOD TO EVALUATE THE EFFICACY AND SAFETY OF ROZANOLIXIZUMAB IN ADULT PARTICIPANTS WITH MYELIN OLIGODENDROCYTE GLYCOPROTEIN (MOG) ANTIBODY-ASSOCIATED DISEASE (MOG-AD)

Protocol #21-3747

Location: Brain Imaging Center (BIC), University of Colorado Hospital

NAVEG test administration for Cerebral Vision Impairment (CVI) in premature infants

Protocol #21-3043

Location: Childrens Hospital Colorado

Automated Seizure Detection for Home Seizure Monitoring with Epilog Sensors

Protocol #21-3574

Location: University of Colorado Hospital

SPHERES Neuromyelitis Optica Spectrum Disorder (NMOSD) Registry

Protocol #21-3763

Location: University of Colorado Hospital

A Prospective, Multicenter Study to Evaluate the Performance and Safety of the CerebroFlo EVD Catheter

Protocol #21-4725

Location: University of Colorado Hospital

AGNOS: An 18-month, Open-label, Multi-Center Study to Assess the Effect of fatumumab 20mg SC Monthly in Treatment Naive, Very Early Relapsing Remitting Multiple Sclerosis Patients Benchmarked Against Healthy Controls on Select Outcomes.

Protocol #21-4783

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

A randomized, double-blind, double-dummy, parallel-group study, comparing the efficacy and safety of remibrutinib 100 mg b.i.d. versus teriflunomide 14 mg q.d. in participants with relapsing multiple sclerosis, followed by extended treatment with open-label remibrutinib

Protocol #21-4825

Location: Brain Imaging Center (BIC), CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital

An Open-Label Uncontrolled Multicenter Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Activity of Nipocalimab in Children Aged 2 to less than 18 years with Generalized Myasthenia Gravis

Protocol #21-4875

Location: Childrens Hospital Colorado

A First-in-human (FIH), Multicenter, Open Label, Single Arm, Dose Escalation Study of Inhibitory Interneurons (NRTX-1001) in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE)

Protocol #21-3486

Location: Brain Imaging Center (BIC), University of Colorado Hospital

Naturalistic sleep assessed by wearable devices in Parkinson's disease

Wear a wrist activity monitor and headband at night to monitor sleep....

Protocol #22-0393

Location: Boulder Health Center, Lone Tree Medical Center, University of Colorado Hospital

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 2, 6-MONTH STUDY TO EVALUATE THE SAFETY, TOLERABILITY AND EXPLORATORY EFFICACY OF CT1812 IN SUBJECTS WITH MILD TO MODERATE DEMENTIA WITH LEWY BODIES

Protocol #22-0669

Location: Brain Imaging Center - BIC, Outpatient CTRC, University of Colorado Hospital

Neuroliten MVP System Clinical Observation Study

Protocol #22-1062

Location: Harmony Campus, Medical Center of the Rockies

A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL TO ASSESS SAFETY AND EFFICACY OF SLS-005 (TREHALOSE INJECTION, 90.5 MG/ML FOR INTRAVENOUS INFUSION) FOR THE TREATMENT OF ADULTS WITH SPINOCEREBELLAR ATAXIA

Protocol #22-1127

Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital

A Multi-center, Noninterventional Study Evaluating Variability, Reliability, and Compliance for the Parkinson's Disease Diary

Protocol #22-1234

Location: Outpatient CTRC, University of Colorado Hospital

Distinguishing REM Sleep Behavior Disorder from Trauma Associated Sleep Disorder

Protocol #22-1244

Location: Outpatient CTRC, University of Colorado Hospital

Defining Endpoints in Becker Muscular Dystrophy

Protocol #22-1278

Location: Outpatient CTRC, University of Colorado Hospital

A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel, Multicenter Study to Evaluate the Safety and Efficacy of ALXN1720 in Adults with Generalized Myasthenia Gravis

Protocol #22-1330

Location: Outpatient CTRC, University of Colorado Hospital

NRG-BN011, A Phase III Trial of Lomustine-Temozolomide Combination Therapy Versus Standard Temozolomide in Patients With Methylated MGMT Promoter Glioblastoma (NCT 05095376)

Protocol #22-1113

Location: Greeley Campus, Harmony Campus, Medical Center of the Rockies, Memorial Hospital Central, Memorial Hospital North, Poudre Valley Hospital

Detecting depression and anxiety in people with adult-onset idiopathic dystonia: a diagnostic accuracy study

Protocol #22-1129

Location: Outpatient CTRC, University of Colorado Hospital

A PHASE II, MULTICENTER, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND STUDY TO EVALUATE THE PHARMACODYNAMICS, SAFETY, TOLERABILITY, PHARMACOKINETICS, AND EFFICACY OF RO7204239 IN PARTICIPANTS WITH FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY

Protocol #22-1495

Location: Brain Imaging Center (BIC), Department Specific Free Standing Clinic, Outpatient CTRC, University of Colorado Hospital

A 2-part Phase 2 Study of Safety, Pharmacokinetics and Biomarkers in Children with Duchenne Muscular Dystrophy including a Randomized, Double-Blind, Placebo-Controlled Part A, Followed by an Open-Label Part B

This is a 2-part multi-center, Phase 2 study to evaluate the effect of EDG-5506 on safety, PK and biomarkers of muscle damage in approximately 27 children with DMD treated with oral, once daily EDG-5506 for 12 months. Part A will include a 12-week, randomized, double-blind, placebo-contr...

Protocol #22-1823

Location: Childrens Hospital Colorado

A Phase 3, Multi-center, Randomized, Quadruple-blind, Placebo-controlled Study to Assess the Efficacy and Safety of Batoclimab as Induction and Maintenance Therapy in Adult Participants with Generalized Myasthenia Gravis (gMG)

Protocol #22-2391

Location: Outpatient CTRC

A 2-Part, Multicenter, Randomized, Blinded, Active-Controlled Phase 2 Study to Sequentially Evaluate the Safety and Efficacy of BIIB091 Monotherapy and BIIB091 Combination Therapy With Diroximel Fumarate in Participants With Relapsing Forms of Multiple Sclerosis

Protocol #22-2421

Location: Brain Imaging Center (BIC), Outpatient CTRC

A Phase 3, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, for Stroke Prevention after an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack

Protocol #23-0053

Location: Outpatient CTRC, University of Colorado Hospital

A Phase II/III Randomized, Double-blind, Placebo-controlled, Multicenter Study to Determine the Efficacy and Safety of ABC008 in the Treatment of Subjects with Inclusion Body Myositis

Protocol #23-0008

Location: Outpatient CTRC

An Observational Pregnancy Safety Study in Women with Neuromyelitis Optica Spectrum Disorder (NMOSD) Exposed to UPLIZNA? (inebilizumab-cdon) during Pregnancy

Protocol #23-0315

Location: Department Specific Free Standing Clinic

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in Subjects With Parkinson's Disease With a Pathogenic Variant in the Glucocerebrosidase (GBA1) Gene

Protocol #23-0328

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

A Randomized, Double-blind, Placebo-Controlled, Multicenter Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Focal-Onset Seizures

Protocol #23-0395

Location: Outpatient CTRC, University of Colorado Hospital

A Randomized, Double-blind, Placebo-Controlled, Multicenter, Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

Protocol #23-0396

Location: Outpatient CTRC, University of Colorado Hospital

A Phase 2b Clinical Study of the P38 Alpha Kinase Inhibitor Neflamapimod in Patients with Dementia with Lewy Bodies (DLB)

Protocol #23-0426

Location: Brain Imaging Center (BIC), Outpatient CTRC

A Phase 3 Randomized, Placebo-controlled, Double-blind Study to Evaluate the Efficacy and Safety of BBP-418 (ribitol) in Patients with Limb Girdle Muscular Dystrophy 2I (LGMD2I)

Protocol #23-0309

Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital

A PHASE III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY TO EVALUATE THE EFFICACY, SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF SATRALIZUMAB AS MONOTHERAPY OR IN ADDITION TO BASELINE THERAPY IN PATIENTS WITH MYELIN OLIGODENDROCYTE GLYCOPROTEIN ANTIBODY-ASSOCIATED DISEASE (MOGAD)

Protocol #23-0648

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

A 17-week, Phase 2, Randomized, Double-blind, Placebo-controlled, Flexible-dosing, Parallel-group, Multicenter Study of the Efficacy and Safety of Suvecaltamide in the Treatment of Moderate to Severe Residual Tremor in Participants with Parkinson's Disease

Protocol #23-0784

Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital

Biomarkers in Pediatric and Young-Adult Autoimmune Encephalitis and Epilepsy

Protocol #22-2311

Location: Childrens Hospital Colorado, University of Colorado Hospital

Validation of Instruments Measuring Caregiver Experiences (Caregiver VOICE Study)

Attention, Dementia Caregiving Dementia caregivers have important roles in supporting someone with Dementia. We are interested in hearing the voices of those caregivers. Participation in this telephone based study will take approx. 30-45 minutes. We are interested in your perspective o...

Protocol #23-0854

Location: Lone Tree Medical Center, University of Colorado Hospital

A Long-Term, Prospective, Observational, Registry of Patients with Anti-Aquaporin 4 Antibody-Positive (AQP4+) Neuromyelitis Optica Spectrum Disorder (NMOSD) Treated with Alexion Complement Component 5 (C5) Inhibitor Therapies (ALXN-C5IT)

Protocol #23-0935

Location: University of Colorado Hospital

A Phase 2b, Multi-center, Randomized, Quadruple-blind, Placebo-controlled Study of Batoclimab Treatment in Adult Participants with Active Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Protocol #23-0692

Location: University of Colorado Hospital

Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study

Protocol #23-1196

Location: Outpatient CTRC, University of Colorado Hospital

Table Tennis as neurologic rehabilitation (NeuroPongTM Program) in people with Multiple Sclerosis

Protocol #23-1355

Location: University of Colorado Hospital

A Phase III, Randomised, Double-blind, Placebo-controlled, Multicentre, Parallel-group Study with Extension Phase to Evaluate the Efficacy and Safety of Dysport? for the Prevention of Chronic Migraine in Adult Participants

Protocol #23-1244

Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital

The ME&MG digital solution for autonomous assessment of Myasthenia Gravis: a validation study

Protocol #23-1307

Location: Department Specific Free Standing Clinic, Outpatient CTRC, University of Colorado Hospital

A Phase 2/3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy, Safety and Tolerability of BHV-7000 in Subjects with Refractory Focal Onset Epilepsy

Protocol #23-1919

Location: Brain Imaging Center - BIC, Department Specific Free Standing Clinic, Outpatient CTRC, University of Colorado Hospital

NIH-K01: Investigating Cognitive-Motor Variability to Predict Driving Performance in Stroke Survivors with MCI

Protocol #23-2556

Location: University of Colorado Hospital

An Interactive Decision Aid to Improve Shared Decision-Making for Women with Parkinson's Disease

Protocol #23-2390

Location: University of Colorado Hospital