Search Results | Research Studies | School of Medicine


How Does Inflammation Affect the Aging Brain? Research Study Investigates Aging, Memory, and Immune Function. The University of Colorado Anschutz Medical Campus is looking for interested adults 60 and over to participate in a research study examining how inflammation influences brain health. Data gathered from this study will be used to better understand how inflammation may or may not disrupt thi... Protocol #: 18-2607
ImTAB Immunity, mTBI, and Alzheimer's Biomarkers You may qualify if you are: - 65 years or older - Have had a concussion within the past 5 years - Saw a doctor within 1 week of your concussion - Have not been diagnosed with a memory disorder Participants will receive: -Snacks and refreshments -Medical screening (neurological e... Protocol #: 19-1423
University of Colorado Alzheimer's and Cognition Center Longitudinal Biomarker and Clinical Phenotyping Study (Bio-AD Study) This study will establish a large bank of samples and data for future research into the causes of and treatments for Alzheimer’s disease (AD), Down Syndrome (DS) and other diseases that cause thinking and memory problems.... Protocol #: 15-1774
Calibrating free-living physical activity characteristics across functionally-limited populations using machine-learned accelerometer approaches Regular physical activity is known to have positive effects on many health outcomes. In research, physical activity is often measured using activity monitors worn on the hip, wrist or ankle. These instruments determine how much physical activity a person does based on the amount of movemen... Protocol #: 16-2706
Conversational Speech in the Diagnosis of Neurocognitive Disorders Using elements of conversational speech such as tone of voice and duration of speaking is a cheap, non-invasive way to gather information, which can be used to direct medical interventions that will help slow or prevent the progression of neurological disease. ... Protocol #: 18-0456
Effect of Hormones on Frequency of Headache and Brain Structure and Function in Puberty This research studies how hormones impact headache and how different parts of the brain talk to each other. You are invited to participate if you are (or your child is): • 11 years to 20 years of age • With or without history of headache • Male sex, male gender identity • Healt... Protocol #: 20-1824
Phase 2, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of SAR443820 in adult participants with amyotrophic lateral sclerosis, followed by an open-label extension Protocol #: 22-0037 Location: Outpatient CTRC, University of Colorado Hospital
Unraveling the early phases of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). Protocol #: 22-0235 Location: Brain Imaging Center (BIC), CTRC Inpatient, University of Colorado Hospital
An Investigator-initiated, Prospective, Multi-center, Controlled Feasibility Study of Direct Brain Recording and Stimulation for Memory Enhancement Protocol #: 22-0332 Location: Brain Imaging Center (BIC), University of Colorado Hospital
LONG-TERM FOLLOW-UP STUDY OF PATIENTS WITH SPINAL MUSCULAR ATROPHY RECEIVING RISDIPLAM TREATMENT Protocol #: 22-0296 Location: Outpatient CTRC, University of Colorado Hospital
A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Determine the Efficacy and Safety of BIIB122 in Participants with Parkinson's Disease Protocol #: 22-0285 Location: Outpatient CTRC, University of Colorado Hospital
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose Range Finding Clinical Trial to Evaluate the Tolerability, Safety, and Efficacy of PRAX-944 in the Treatment of Adults with Essential Tremor Protocol #: 22-0519 Location: Outpatient CTRC, University of Colorado Hospital
Slow wave sleep as a biomarker of rehabilitation-induced cognitive improvement in Parkinson's disease Protocol #: 22-1685 Location: Brain Imaging Center (BIC), CTRC Inpatient, Outpatient CTRC
Rocky Mountain Multiple Sclerosis Center (RMMSC) Biorepository for the Study of Neuroimmunological Disorders Protocol #: 12-0968 Location: University of Colorado Hospital
Stereotactic Laser Ablation for Temporal Lobe Epilepsy (SLATE) Study Protocol #: 17-0873 Location: Lone Tree Medical Center, University of Colorado Hospital
Using Next Generation Sequencing to Unravel the Pathogenesis of Sporadic Inclusion Body Myositis (IBM) - The International IBM Consortium Genetic Study Protocol #: 17-1132 Location: University of Colorado Hospital
A Phase 2 Multicenter, Randomized, Double-blind, Placebo-controlled Study of BOTOX? (Botulinum Toxin Type A) Purified Neurotoxin Complex for the Treatment of Upper Limb Essential Tremor Protocol #: 22-0016 Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital
The modified Atkins diet in patients with drug resistant epilepsy and the responsive neurostimulator 09Aug2017 Protocol #: 17-0888 Location: University of Colorado Hospital
Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate Efficacy, Safety, and Tolerability of IMU-838 in Patients with Progressive Multiple Sclerosis Protocol #: 22-1607 Location: Brain Imaging Center (BIC), University of Colorado Hospital
A Phase 2 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of EDG-5506 on Safety, Biomarkers, Pharmacokinetics, and Functional Measures in Adults and Adolescents with Becker Muscular Dystrophy Protocol #: 22-0354 Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
Risk factors in Early Multiple Sclerosis (RisE-MS) Protocol #: 17-1884 Location: Brain Imaging Center - BIC, Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
Prospective Evaluation of De-Escalation from antiCD-20 Therapies to Diroximel Fumarate Protocol #: 21-4993 Location: Brain Imaging Center (BIC), Brain Imaging Center - BIC, University of Colorado Hospital
Perceived palliative care needs of Huntington's disease patients Protocol #: 18-0216 Location: University of Colorado Hospital
Diet and Relapses in Pediatric Multiple Sclerosis Protocol #: 18-0393 Location: Childrens Hospital Colorado, Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
Automatic measurement of hand movements toward development of an objective assessment of primary motor symptoms in Parkinson?s disease Protocol #: 15-1041 Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
COG ANBL1531 - A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or ALK Inhibitor Therapy Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma (NBL) (IND# 134379) Protocol #: 18-0971 Location: Childrens Hospital Colorado
A PHASE III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER BASKET STUDY TO EVALUATE THE EFFICACY, SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF SATRALIZUMAB IN PATIENTS WITH ANTIN-METHYL-D ASPARTIC ACID RECEPTOR (NMDAR) OR ANTILEUCINE-RICH GLIOMA-INACTIVATED 1 (LGI1) ENCEPHALITIS Protocol #: 22-0449 Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital
Neurologic Music Therapy for enhancing fine motor control in Parkinson's Disease 16Apr2018 Protocol #: 16-2308 Location: University of Colorado Hospital
More than a Movement Disorder: Applying Palliative Care to Parkinson?s Disease v: 12/06/2017 Protocol #: 16-1400 Location: Colorado Research Center, Department Specific Free Standing Clinic
Peripheral Inflammatory Cytokine Levels in Parkinson Disease Protocol #: 18-1356 Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
Clinical Outcome Measures in Friedreich's Ataxia Protocol #: 18-1641 Location: Outpatient CTRC, University of Colorado Hospital
Determining the Effectiveness of early Intensive Versus Escalation approaches for the treatment of Relapsing-Remitting Multiple Sclerosis (DELIVERMS) Protocol #: 18-1633 Location: University of Colorado Hospital
Identifying relevant seizure biomarkers from RNS? System recorded electrocorticography for the development of optimized seizure detection algorithms Protocol #: 18-2089 Location: University of Colorado Hospital
Association of depth recordings from the temporal cortex with sleep pattern detection and characterization of sleep dysfunction in patients with refractory epilepsy. Protocol #: 18-2806 Location: University of Colorado Hospital
Gene Expression of Cerebral Aneurysms In this study, we will collect tissue and blood from participants during their epilepsy surgery. ... Protocol #: 19-0182 Location: University of Colorado Hospital
Investigating cortical networks disruption and rehabilitation after traumatic brain injury Protocol #: 19-0049 Location: Colorado Research Center, Department Specific Free Standing Clinic
REDUCE Post Approval Study - GORE CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients with Patent Foramen Ovale (PFO) This study will assess the safety and effectiveness of GORE? CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a post-market setting.... Protocol #: 19-6030 Location: Harmony Campus, Medical Center of the Rockies
A Natural History Study of CMT1B, CMT2A, CMT4A and CMT4C Protocol #: 18-2537 Location: University of Colorado Hospital
AMPLATZERTM PFO Occluder Post Approval Study This is a single arm, multi-center study to confirm the safety and effectiveness of the AMPLATZERTM PFO Occluder in the post approval setting... Protocol #: 19-6502 Location: Memorial Hospital Central
A Phase I/II Study of Nivolumab Plus or Minus Ipilimumab in Combination with Multi-Fraction Stereotactic Radiosurgery for Recurrent High-Grade Radiation-Relapsed Meningioma Protocol #: 19-0423 Location: University of Colorado Hospital
Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema following Large Hemispheric Infarction Protocol #: 19-0675 Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital
A Two-year Prospective Natural History Study Examining the Use of Neuronal Injury Biomarkers in Autoimmune Encephalitis as a Potential Biomarker for Disease Activity and Severity Protocol #: 19-0889 Location: Brain Imaging Center (BIC), Childrens Hospital Colorado, Colorado Research Center, University of Colorado Hospital
Comparative Effectiveness Research for Infantile Spasms V: 12Jan2017 Protocol #: 16-2408 Location: Childrens Hospital Colorado
A Study of the Pipeline Flex Embolization DeVice with Shield Technology for EndovAscular TreatmeNt of Wide-NeCked Intracranial AnEurysms Protocol #: 19-1399 Location: University of Colorado Hospital
GRASP-LGMD RESEARCH PROTOCOL; Project 1a Defining Clinical Endpoints in LGMD Protocol #: 19-0506 Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
A Multicenter Randomized Controlled Trial of Best Available Therapy versus Autologous Hematopoietic Stem Cell Transplant for Treatment-Resistant Relapsing Multiple Sclerosis Protocol #: 19-1621 Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
RELIEF- GORE CARDIOFORM Septal Occluder Migraine Clinical Study Protocol #: 20-6000 Location: Harmony Campus, Medical Center of the Rockies
Perceived Palliative Care Needs in Early-Onset Dementia Protocol #: 19-2134 Location: Outpatient CTRC, UCHealth Central Park Medical Center, University of Colorado Hospital
A Phase 3, External Placebo-Controlled, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Patients with Neuromyelitis OpticavSpectrum Disorder (NMOSD) Protocol #: 19-2038 Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
A Prospective Study of Acute Flaccid Myelitis (AFM) to Define Natural History, Risk Factors, and Pathogenic Mechanisms Protocol #: 19-2357 Location: Childrens Hospital Colorado
A Room Temperature Atomic Magnetrode System for Telemetry of Epileptic Seizures Protocol #: 19-2363 Location: University of Colorado Hospital
Lipoic acid for Treatment of Progressive Multiple Sclerosis Protocol #: 19-2525 Location: Brain Imaging Center (BIC), University of Colorado Hospital
Platform Trial for the Treatment of Amyotrophic Lateral Sclerosis (ALS): A perpetual multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of ALS. Protocol #: 19-2645 Location: Outpatient CTRC, University of Colorado Hospital
Deep sleep in Parkinson disease and its relationship to cognition, neuroinflammation and neurodegeneration Protocol #: 20-0347 Location: Brain Imaging Center (BIC), Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
A Phase 1, Two-part, Open-label Dose-escalation and Double-blind, Placebo-controlled Dose-expansion Study with an Open-label Extension to Evaluate the Safety and Efficacy of ATA188 in Subjects with Progressive Multiple Sclerosis (ATA188-MS-101 Protocol #: 20-0454 Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
The Parkinson's Progression Markers Initiative (PPMI) 2.0 Clinical - Establishing a Deeply Phenotyped PD Cohort Protocol #: 20-1204 Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
Patient Preferences in Deep Brain Stimulation Products Protocol #: 19-3015 Location: University of Colorado Hospital
Endovascular treatment of acutely ruptured shallow intradural aneurysms not amendable to clipping and coiling with the pipeline vantage embolization device Protocol #: 20-1254 Location: University of Colorado Hospital
Embolization of the Middle Meningeal Artery with ONYX(TM) Liquid Embolic System in the Treatment of Subactue and Chronic Subdural Hematoma (EMBOLISE) The purpose of this study is to evaluate the safety (short and long term side effects) and effectiveness (how well it helps) of Onyx Liquid Embolic System(LES) (study device) embolization of the middle meningeal artery when used in addition to the standard treatment that is used to treat a... Protocol #: 20-1390 Location: University of Colorado Hospital
A double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of intravenous ganaxolone in status epilepticus Status Epilepticus is a serious condition that needs fast treatment to stop the seizures and prevent permanent brain damage. Ganaxolone is an investigational drug, which means that it is not approved by the US FDA. The study drug will be added on to the usual care patients will already be ... Protocol #: 20-1641 Location: University of Colorado Hospital
Genetics of CMT - Modifiers of CMT1A, New Causes of CMT Protocol #: 20-1525 Location: Outpatient CTRC, University of Colorado Hospital
A Multi-Center, Controlled Study to Evaluate use of CereGate Therapy to Reduce Freezing of Gait in Participants diagnosed with Parkinson's Disease Protocol #: 21-5060 Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital
Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1 (END-DM1) Protocol #: 21-4907 Location: University of Colorado Hospital
A RANDOMIZED, DOUBLE-BLIND, MULTICENTER, PLACEBO-CONTROLLED PHASE 3 STUDY WITH OPEN-LABEL PERIOD TO EVALUATE THE EFFICACY AND SAFETY OF INEBILIZUMAB IN ADULTS WITH MYASTHENIA GRAVIS Protocol #: 20-1787 Location: University of Colorado Hospital
A PHASE IIIB MULTICENTER, RANDOMIZED, DOUBLE-BLIND, CONTROLLED STUDY TO EVALUATE THE EFFICACY, SAFETY AND PHARMACOKINETICS OF A HIGHER DOSE OF OCRELIZUMAB IN ADULTS WITH PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS Protocol #: 20-1852 Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
A PHASE III MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PARALLEL-GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FENEBRUTINIB COMPARED WITH TERIFLUNOMIDE IN ADULT PATIENTS WITH RELAPSING MULTIPLE SCLEROSIS Protocol #: 20-2036 Location: Brain Imaging Center (BIC), University of Colorado Hospital
A Phase 3b, Multicenter, Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Oral Edaravone Administered for a Period of 48 Weeks in Subjects with Amyotrophic Lateral Sclerosis (ALS) Protocol #: 20-2340 Location: University of Colorado Hospital
Sleep assessed by actigraphy and direct recordings of the subthalamic nucleus in Parkinson's Disease. Protocol #: 20-2508 Location: Lone Tree Medical Center, University of Colorado Hospital
ALZHEIMER'S CLINICAL TRIAL CONSORTIUM FOR DOWN SYNDROME (ACTC-DS) TRIAL-READY COHORT - DOWN SYNDROME (TRC-DS) TRC-DS is part of a larger movement working with people with Down syndrome to advance Alzheimer's disease therapies and potential cures for this population. The Alzheimer's Clinical Trials Consortium-Down Syndrome (ACTC-DS) is a large collaboration of researchers conducting clinical trials... Protocol #: 20-2692 Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
Phase II Trial to Evaluate Safety and Efficacy of GM-CSF/Sargramostim in Alzheimer's Disease (SESAD) Protocol #: 19-2727 Location: Brain Imaging Center (BIC), C-TRIC, Outpatient CTRC, University of Colorado Hospital
Treatment for Alcohol Use Disorder: Emotion Regulation and Brain Function This study plans to learn more about the brain's role alcohol use problems and recovery. Prominent theories about alcohol use disorder suggest that it is a disorder of the brain. However, it remains unclear what parts of the brain work differently in alcohol use disorder. This study intend... Protocol #: 20-3000 Location: Brain Imaging Center (BIC), University of Colorado Hospital
A Phase 3, Randomized, Double-Blind, Trial of Pamrevlumab (FG-3019) or Placebo in Combination with Systemic Corticosteroids in ambulatory subjects with Duchenne Muscular Dystrophy (DMD) Protocol #: 20-2929 Location: Childrens Hospital Colorado
A PHASE 3, MULTI-CENTER, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF RELDESEMTIV IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS (ALS) Protocol #: 21-2598 Location: University of Colorado Hospital
A PHASE III, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PARALLEL-GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FENEBRUTINIB, COMPARED WITH OCRELIZUMAB IN ADULT PATIENTS WITH PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS. Protocol #: 21-2663 Location: Brain Imaging Center (BIC), University of Colorado Hospital
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER, PHASE 2 STUDY TO EVALUATE THE EFFICACY, SAFETY, AND PHARMACOKINETICS OF ROZANOLIXIZUMAB IN ADULT STUDY PARTICIPANTS WITH LEUCINE-RICH GLIOMA INACTIVATED 1 AUTOIMMUNE ENCEPHALITIS Protocol #: 21-2955 Location: Brain Imaging Center (BIC), Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
ALLFTD: ARTFL-LEFFTDS LONGITUDINAL FRONTOTEMPORAL LOBAR DEGENERATION Protocol #: 21-2833 Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
Efficacy and Safety Study of Nipocalimab IV Infusions for Adults With Generalized Myasthenia Gravis Protocol #: 21-3289 Location: CTRC Inpatient, University of Colorado Hospital
A PHASE III MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY STUDY TO EVALUATE SAFETY AND EFFICACY OF OCRELIZUMAB IN CHILDREN AND ADOLESCENTS WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS Protocol #: 20-2614 Location: Childrens Hospital Colorado
BIOREPOSITORY FOR CENTRAL VEIN SIGN: A DIAGNOSTIC BIOMARKER IN MULTIPLE SCLEROSIS Protocol #: 21-3715 Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
Influence of NT5c1A antibodies on disease progression, clinical phenotype and blood and muscle biomarkers in sporadic Inclusion Body Myositis - A prospective evaluation Protocol #: 21-3383 Location: University of Colorado Hospital
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER, PHASE 3, PIVOTAL STUDY WITH AN OPEN-LABEL EXTENSION PERIOD TO EVALUATE THE EFFICACY AND SAFETY OF ROZANOLIXIZUMAB IN ADULT PARTICIPANTS WITH MYELIN OLIGODENDROCYTE GLYCOPROTEIN (MOG) ANTIBODY-ASSOCIATED DISEASE (MOG-AD) Protocol #: 21-3747 Location: Brain Imaging Center (BIC), University of Colorado Hospital
NAVEG test administration for Cerebral Vision Impairment (CVI) in premature infants Protocol #: 21-3043 Location: Childrens Hospital Colorado
Automated Seizure Detection for Home Seizure Monitoring with Epilog Sensors Protocol #: 21-3574 Location: University of Colorado Hospital
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Pitolisant on Excessive Daytime Sleepiness and Other Non-Muscular Symptoms in Patients with Myotonic Dystrophy Type 1, Followed by an Open-Label Extension Protocol #: 21-3397 Location: UCHealth Central Park Medical Center, University of Colorado Hospital
A Randomized, Double-Blind, Placebo-Controlled, Phase 1/2 Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple-Doses of AOC 1001 Administered Intravenously to Adult Myotonic Dystrophy Type 1 (DM1) Patients Protocol #: 21-3032 Location: Brain Imaging Center (BIC), CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital
SPHERES Neuromyelitis Optica Spectrum Disorder (NMOSD) Registry Protocol #: 21-3763 Location: University of Colorado Hospital
SAKURABONSAI: CLINICAL, IMAGING AND BIOMARKER OPEN-LABEL STUDY IN NEUROMYELITIS OPTICA SPECTRUM DISORDER (NMOSD) WITH SATRALIZUMAB AS AN INTERVENTION Protocol #: 21-4079 Location: Brain Imaging Center (BIC), University of Colorado Hospital
A Comparative Study of Levodopa and Carbidopa Bioavailability Following Foslevodopa/foscarbidopa Infusion at Different Subcutaneous Sites in Parkinson's Disease Patients Protocol #: 21-4448 Location: University of Colorado Hospital
Aneurysmal SubArachnoid Hemorrhage - Red Blood Cell Transfusion And Outcome (SAHaRA): A Randomized Controlled Trial Protocol #: 21-4692 Location: University of Colorado Hospital
A Prospective, Multicenter Study to Evaluate the Performance and Safety of the CerebroFlo EVD Catheter Protocol #: 21-4725 Location: University of Colorado Hospital
AGNOS: An 18-month, Open-label, Multi-Center Study to Assess the Effect of fatumumab 20mg SC Monthly in Treatment Naive, Very Early Relapsing Remitting Multiple Sclerosis Patients Benchmarked Against Healthy Controls on Select Outcomes. Protocol #: 21-4783 Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
A randomized, double-blind, double-dummy, parallel-group study, comparing the efficacy and safety of remibrutinib 100 mg b.i.d. versus teriflunomide 14 mg q.d. in participants with relapsing multiple sclerosis, followed by extended treatment with open-label remibrutinib Protocol #: 21-4825 Location: Brain Imaging Center (BIC), CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital
A First-in-human (FIH), Multicenter, Open Label, Single Arm, Dose Escalation Study of Inhibitory Interneurons (NRTX-1001) in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE) Protocol #: 21-3486 Location: Brain Imaging Center (BIC), University of Colorado Hospital
Integrating Home-Based Video Teleneuropsychology into Clinical Practice: Typical Versus Atypical Alzheimer's Disease Protocol #: 21-5037 Location: Department Specific Free Standing Clinic, Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital
Naturalistic sleep assessed by wearable devices in Parkinson's disease Wear a wrist activity monitor and headband at night to monitor sleep.... Protocol #: 22-0393 Location: Boulder Health Center, Lone Tree Medical Center, University of Colorado Hospital
A PHASE IV MULTICENTER, OPEN-LABEL STUDY EVALUATING B CELL LEVELS IN INFANTS OF LACTATING WOMEN WITH CIS OR MS RECEIVING OCRELIZUMAB Protocol #: 22-0387 Location: Outpatient CTRC, University of Colorado Hospital
A PHASE IV MULTICENTER, OPEN-LABEL STUDY EVALUATING B CELL LEVELS IN INFANTS POTENTIALLY EXPOSED TO OCRELIZUMAB DURING PREGNANCY - THE MINORE STUDY Protocol #: 22-0386 Location: Outpatient CTRC, University of Colorado Hospital
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 2, 6-MONTH STUDY TO EVALUATE THE SAFETY, TOLERABILITY AND EXPLORATORY EFFICACY OF CT1812 IN SUBJECTS WITH MILD TO MODERATE DEMENTIA WITH LEWY BODIES Protocol #: 22-0669 Location: Brain Imaging Center - BIC, Outpatient CTRC, University of Colorado Hospital
A Phase 3b/4 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Verify the Clinical Benefit of Aducanumab (BIIB037) in Participants with Alzheimer's Disease Protocol #: 22-0776 Location: Brain Imaging Center (BIC), C-TRIC, Outpatient CTRC, University of Colorado Hospital
Neuroliten MVP System Clinical Observation Study Protocol #: 22-1062 Location: Harmony Campus, Medical Center of the Rockies
A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL TO ASSESS SAFETY AND EFFICACY OF SLS-005 (TREHALOSE INJECTION, 90.5 MG/ML FOR INTRAVENOUS INFUSION) FOR THE TREATMENT OF ADULTS WITH SPINOCEREBELLAR ATAXIA Protocol #: 22-1127 Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital
A Multi-center, Noninterventional Study Evaluating Variability, Reliability, and Compliance for the Parkinson's Disease Diary Protocol #: 22-1234 Location: Outpatient CTRC, University of Colorado Hospital
A Phase 3 Global, Randomized, Double-Blind, Placebo-Controlled, 48-Week, Parallel-Group Study of the Efficacy and Safety of Losmapimod in Treating Patients with Facioscapulohumeral Muscular Dystrophy Protocol #: 22-1143 Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital
A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Determine the Efficacy and Safety of BIIB122/DNL151 in Participants with Parkinson's Disease and Pathogenic LRRK2 Variants Protocol #: 22-1259 Location: Outpatient CTRC, University of Colorado Hospital
Distinguishing REM Sleep Behavior Disorder from Trauma Associated Sleep Disorder Protocol #: 22-1244 Location: Outpatient CTRC, University of Colorado Hospital
Defining Endpoints in Becker Muscular Dystrophy Protocol #: 22-1278 Location: Outpatient CTRC, University of Colorado Hospital
NRG-BN011, A Phase III Trial of Lomustine-Temozolomide Combination Therapy Versus Standard Temozolomide in Patients With Methylated MGMT Promoter Glioblastoma (NCT 05095376) Protocol #: 22-1113 Location: Greeley Campus, Harmony Campus, Medical Center of the Rockies, Memorial Hospital Central, Memorial Hospital North, Poudre Valley Hospital
Detecting depression and anxiety in people with adult-onset idiopathic dystonia: a diagnostic accuracy study Protocol #: 22-1129 Location: Outpatient CTRC, University of Colorado Hospital
A PHASE II, MULTICENTER, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND STUDY TO EVALUATE THE PHARMACODYNAMICS, SAFETY, TOLERABILITY, PHARMACOKINETICS, AND EFFICACY OF RO7204239 IN PARTICIPANTS WITH FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY Protocol #: 22-1495 Location: Brain Imaging Center (BIC), Department Specific Free Standing Clinic, Outpatient CTRC, University of Colorado Hospital

How Does Inflammation Affect the Aging Brain? Research Study Investigates Aging, Memory, and Immune Function.

The University of Colorado Anschutz Medical Campus is looking for interested adults 60 and over to participate in a research study examining how inflammation influences brain health. Data gathered from this study will be used to better understand how inflammation may or may not disrupt thi...

Protocol #: 18-2607

ImTAB Immunity, mTBI, and Alzheimer's Biomarkers

You may qualify if you are: - 65 years or older - Have had a concussion within the past 5 years - Saw a doctor within 1 week of your concussion - Have not been diagnosed with a memory disorder Participants will receive: -Snacks and refreshments -Medical screening (neurological e...

Protocol #: 19-1423

University of Colorado Alzheimer's and Cognition Center Longitudinal Biomarker and Clinical Phenotyping Study (Bio-AD Study)

This study will establish a large bank of samples and data for future research into the causes of and treatments for Alzheimer’s disease (AD), Down Syndrome (DS) and other diseases that cause thinking and memory problems....

Protocol #: 15-1774

Calibrating free-living physical activity characteristics across functionally-limited populations using machine-learned accelerometer approaches

Regular physical activity is known to have positive effects on many health outcomes. In research, physical activity is often measured using activity monitors worn on the hip, wrist or ankle. These instruments determine how much physical activity a person does based on the amount of movemen...

Protocol #: 16-2706

Conversational Speech in the Diagnosis of Neurocognitive Disorders

Using elements of conversational speech such as tone of voice and duration of speaking is a cheap, non-invasive way to gather information, which can be used to direct medical interventions that will help slow or prevent the progression of neurological disease. ...

Protocol #: 18-0456

Effect of Hormones on Frequency of Headache and Brain Structure and Function in Puberty

This research studies how hormones impact headache and how different parts of the brain talk to each other. You are invited to participate if you are (or your child is): • 11 years to 20 years of age • With or without history of headache • Male sex, male gender identity • Healt...

Protocol #: 20-1824

Phase 2, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of SAR443820 in adult participants with amyotrophic lateral sclerosis, followed by an open-label extension

Protocol #: 22-0037

Location: Outpatient CTRC, University of Colorado Hospital

Unraveling the early phases of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL).

Protocol #: 22-0235

Location: Brain Imaging Center (BIC), CTRC Inpatient, University of Colorado Hospital

An Investigator-initiated, Prospective, Multi-center, Controlled Feasibility Study of Direct Brain Recording and Stimulation for Memory Enhancement

Protocol #: 22-0332

Location: Brain Imaging Center (BIC), University of Colorado Hospital

LONG-TERM FOLLOW-UP STUDY OF PATIENTS WITH SPINAL MUSCULAR ATROPHY RECEIVING RISDIPLAM TREATMENT

Protocol #: 22-0296

Location: Outpatient CTRC, University of Colorado Hospital

A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Determine the Efficacy and Safety of BIIB122 in Participants with Parkinson's Disease

Protocol #: 22-0285

Location: Outpatient CTRC, University of Colorado Hospital

A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose Range Finding Clinical Trial to Evaluate the Tolerability, Safety, and Efficacy of PRAX-944 in the Treatment of Adults with Essential Tremor

Protocol #: 22-0519

Location: Outpatient CTRC, University of Colorado Hospital

Slow wave sleep as a biomarker of rehabilitation-induced cognitive improvement in Parkinson's disease

Protocol #: 22-1685

Location: Brain Imaging Center (BIC), CTRC Inpatient, Outpatient CTRC

Rocky Mountain Multiple Sclerosis Center (RMMSC) Biorepository for the Study of Neuroimmunological Disorders

Protocol #: 12-0968

Location: University of Colorado Hospital

Stereotactic Laser Ablation for Temporal Lobe Epilepsy (SLATE) Study

Protocol #: 17-0873

Location: Lone Tree Medical Center, University of Colorado Hospital

Using Next Generation Sequencing to Unravel the Pathogenesis of Sporadic Inclusion Body Myositis (IBM) - The International IBM Consortium Genetic Study

Protocol #: 17-1132

Location: University of Colorado Hospital

A Phase 2 Multicenter, Randomized, Double-blind, Placebo-controlled Study of BOTOX? (Botulinum Toxin Type A) Purified Neurotoxin Complex for the Treatment of Upper Limb Essential Tremor

Protocol #: 22-0016

Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital

The modified Atkins diet in patients with drug resistant epilepsy and the responsive neurostimulator 09Aug2017

Protocol #: 17-0888

Location: University of Colorado Hospital

Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate Efficacy, Safety, and Tolerability of IMU-838 in Patients with Progressive Multiple Sclerosis

Protocol #: 22-1607

Location: Brain Imaging Center (BIC), University of Colorado Hospital

A Phase 2 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of EDG-5506 on Safety, Biomarkers, Pharmacokinetics, and Functional Measures in Adults and Adolescents with Becker Muscular Dystrophy

Protocol #: 22-0354

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

Risk factors in Early Multiple Sclerosis (RisE-MS)

Protocol #: 17-1884

Location: Brain Imaging Center - BIC, Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

Prospective Evaluation of De-Escalation from antiCD-20 Therapies to Diroximel Fumarate

Protocol #: 21-4993

Location: Brain Imaging Center (BIC), Brain Imaging Center - BIC, University of Colorado Hospital

Perceived palliative care needs of Huntington's disease patients

Protocol #: 18-0216

Location: University of Colorado Hospital

Diet and Relapses in Pediatric Multiple Sclerosis

Protocol #: 18-0393

Location: Childrens Hospital Colorado, Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

Automatic measurement of hand movements toward development of an objective assessment of primary motor symptoms in Parkinson?s disease

Protocol #: 15-1041

Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

COG ANBL1531 - A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or ALK Inhibitor Therapy Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma (NBL) (IND# 134379)

Protocol #: 18-0971

Location: Childrens Hospital Colorado

A PHASE III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER BASKET STUDY TO EVALUATE THE EFFICACY, SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF SATRALIZUMAB IN PATIENTS WITH ANTIN-METHYL-D ASPARTIC ACID RECEPTOR (NMDAR) OR ANTILEUCINE-RICH GLIOMA-INACTIVATED 1 (LGI1) ENCEPHALITIS

Protocol #: 22-0449

Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital

Neurologic Music Therapy for enhancing fine motor control in Parkinson's Disease 16Apr2018

Protocol #: 16-2308

Location: University of Colorado Hospital

More than a Movement Disorder: Applying Palliative Care to Parkinson?s Disease v: 12/06/2017

Protocol #: 16-1400

Location: Colorado Research Center, Department Specific Free Standing Clinic

Peripheral Inflammatory Cytokine Levels in Parkinson Disease

Protocol #: 18-1356

Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

Clinical Outcome Measures in Friedreich's Ataxia

Protocol #: 18-1641

Location: Outpatient CTRC, University of Colorado Hospital

Determining the Effectiveness of early Intensive Versus Escalation approaches for the treatment of Relapsing-Remitting Multiple Sclerosis (DELIVERMS)

Protocol #: 18-1633

Location: University of Colorado Hospital

Identifying relevant seizure biomarkers from RNS? System recorded electrocorticography for the development of optimized seizure detection algorithms

Protocol #: 18-2089

Location: University of Colorado Hospital

Association of depth recordings from the temporal cortex with sleep pattern detection and characterization of sleep dysfunction in patients with refractory epilepsy.

Protocol #: 18-2806

Location: University of Colorado Hospital

Gene Expression of Cerebral Aneurysms

In this study, we will collect tissue and blood from participants during their epilepsy surgery. ...

Protocol #: 19-0182

Location: University of Colorado Hospital

Investigating cortical networks disruption and rehabilitation after traumatic brain injury

Protocol #: 19-0049

Location: Colorado Research Center, Department Specific Free Standing Clinic

REDUCE Post Approval Study - GORE CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients with Patent Foramen Ovale (PFO)

This study will assess the safety and effectiveness of GORE? CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a post-market setting....

Protocol #: 19-6030

Location: Harmony Campus, Medical Center of the Rockies

A Natural History Study of CMT1B, CMT2A, CMT4A and CMT4C

Protocol #: 18-2537

Location: University of Colorado Hospital

AMPLATZERTM PFO Occluder Post Approval Study

This is a single arm, multi-center study to confirm the safety and effectiveness of the AMPLATZERTM PFO Occluder in the post approval setting...

Protocol #: 19-6502

Location: Memorial Hospital Central

A Phase I/II Study of Nivolumab Plus or Minus Ipilimumab in Combination with Multi-Fraction Stereotactic Radiosurgery for Recurrent High-Grade Radiation-Relapsed Meningioma

Protocol #: 19-0423

Location: University of Colorado Hospital

Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema following Large Hemispheric Infarction

Protocol #: 19-0675

Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital

A Two-year Prospective Natural History Study Examining the Use of Neuronal Injury Biomarkers in Autoimmune Encephalitis as a Potential Biomarker for Disease Activity and Severity

Protocol #: 19-0889

Location: Brain Imaging Center (BIC), Childrens Hospital Colorado, Colorado Research Center, University of Colorado Hospital

Comparative Effectiveness Research for Infantile Spasms V: 12Jan2017

Protocol #: 16-2408

Location: Childrens Hospital Colorado

A Study of the Pipeline Flex Embolization DeVice with Shield Technology for EndovAscular TreatmeNt of Wide-NeCked Intracranial AnEurysms

Protocol #: 19-1399

Location: University of Colorado Hospital

GRASP-LGMD RESEARCH PROTOCOL; Project 1a Defining Clinical Endpoints in LGMD

Protocol #: 19-0506

Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

A Multicenter Randomized Controlled Trial of Best Available Therapy versus Autologous Hematopoietic Stem Cell Transplant for Treatment-Resistant Relapsing Multiple Sclerosis

Protocol #: 19-1621

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

RELIEF- GORE CARDIOFORM Septal Occluder Migraine Clinical Study

Protocol #: 20-6000

Location: Harmony Campus, Medical Center of the Rockies

Perceived Palliative Care Needs in Early-Onset Dementia

Protocol #: 19-2134

Location: Outpatient CTRC, UCHealth Central Park Medical Center, University of Colorado Hospital

A Phase 3, External Placebo-Controlled, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Patients with Neuromyelitis OpticavSpectrum Disorder (NMOSD)

Protocol #: 19-2038

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

A Prospective Study of Acute Flaccid Myelitis (AFM) to Define Natural History, Risk Factors, and Pathogenic Mechanisms

Protocol #: 19-2357

Location: Childrens Hospital Colorado

A Room Temperature Atomic Magnetrode System for Telemetry of Epileptic Seizures

Protocol #: 19-2363

Location: University of Colorado Hospital

Lipoic acid for Treatment of Progressive Multiple Sclerosis

Protocol #: 19-2525

Location: Brain Imaging Center (BIC), University of Colorado Hospital

Platform Trial for the Treatment of Amyotrophic Lateral Sclerosis (ALS): A perpetual multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of ALS.

Protocol #: 19-2645

Location: Outpatient CTRC, University of Colorado Hospital

Deep sleep in Parkinson disease and its relationship to cognition, neuroinflammation and neurodegeneration

Protocol #: 20-0347

Location: Brain Imaging Center (BIC), Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

A Phase 1, Two-part, Open-label Dose-escalation and Double-blind, Placebo-controlled Dose-expansion Study with an Open-label Extension to Evaluate the Safety and Efficacy of ATA188 in Subjects with Progressive Multiple Sclerosis (ATA188-MS-101

Protocol #: 20-0454

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

The Parkinson's Progression Markers Initiative (PPMI) 2.0 Clinical - Establishing a Deeply Phenotyped PD Cohort

Protocol #: 20-1204

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

Patient Preferences in Deep Brain Stimulation Products

Protocol #: 19-3015

Location: University of Colorado Hospital

Endovascular treatment of acutely ruptured shallow intradural aneurysms not amendable to clipping and coiling with the pipeline vantage embolization device

Protocol #: 20-1254

Location: University of Colorado Hospital

Embolization of the Middle Meningeal Artery with ONYX(TM) Liquid Embolic System in the Treatment of Subactue and Chronic Subdural Hematoma (EMBOLISE)

The purpose of this study is to evaluate the safety (short and long term side effects) and effectiveness (how well it helps) of Onyx Liquid Embolic System(LES) (study device) embolization of the middle meningeal artery when used in addition to the standard treatment that is used to treat a...

Protocol #: 20-1390

Location: University of Colorado Hospital

A double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of intravenous ganaxolone in status epilepticus

Status Epilepticus is a serious condition that needs fast treatment to stop the seizures and prevent permanent brain damage. Ganaxolone is an investigational drug, which means that it is not approved by the US FDA. The study drug will be added on to the usual care patients will already be ...

Protocol #: 20-1641

Location: University of Colorado Hospital

Genetics of CMT - Modifiers of CMT1A, New Causes of CMT

Protocol #: 20-1525

Location: Outpatient CTRC, University of Colorado Hospital

A Multi-Center, Controlled Study to Evaluate use of CereGate Therapy to Reduce Freezing of Gait in Participants diagnosed with Parkinson's Disease

Protocol #: 21-5060

Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital

Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1 (END-DM1)

Protocol #: 21-4907

Location: University of Colorado Hospital

A RANDOMIZED, DOUBLE-BLIND, MULTICENTER, PLACEBO-CONTROLLED PHASE 3 STUDY WITH OPEN-LABEL PERIOD TO EVALUATE THE EFFICACY AND SAFETY OF INEBILIZUMAB IN ADULTS WITH MYASTHENIA GRAVIS

Protocol #: 20-1787

Location: University of Colorado Hospital

A PHASE IIIB MULTICENTER, RANDOMIZED, DOUBLE-BLIND, CONTROLLED STUDY TO EVALUATE THE EFFICACY, SAFETY AND PHARMACOKINETICS OF A HIGHER DOSE OF OCRELIZUMAB IN ADULTS WITH PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS

Protocol #: 20-1852

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

A PHASE III MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PARALLEL-GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FENEBRUTINIB COMPARED WITH TERIFLUNOMIDE IN ADULT PATIENTS WITH RELAPSING MULTIPLE SCLEROSIS

Protocol #: 20-2036

Location: Brain Imaging Center (BIC), University of Colorado Hospital

A Phase 3b, Multicenter, Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Oral Edaravone Administered for a Period of 48 Weeks in Subjects with Amyotrophic Lateral Sclerosis (ALS)

Protocol #: 20-2340

Location: University of Colorado Hospital

Sleep assessed by actigraphy and direct recordings of the subthalamic nucleus in Parkinson's Disease.

Protocol #: 20-2508

Location: Lone Tree Medical Center, University of Colorado Hospital

ALZHEIMER'S CLINICAL TRIAL CONSORTIUM FOR DOWN SYNDROME (ACTC-DS) TRIAL-READY COHORT - DOWN SYNDROME (TRC-DS)

TRC-DS is part of a larger movement working with people with Down syndrome to advance Alzheimer's disease therapies and potential cures for this population. The Alzheimer's Clinical Trials Consortium-Down Syndrome (ACTC-DS) is a large collaboration of researchers conducting clinical trials...

Protocol #: 20-2692

Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

Phase II Trial to Evaluate Safety and Efficacy of GM-CSF/Sargramostim in Alzheimer's Disease (SESAD)

Protocol #: 19-2727

Location: Brain Imaging Center (BIC), C-TRIC, Outpatient CTRC, University of Colorado Hospital

Treatment for Alcohol Use Disorder: Emotion Regulation and Brain Function

This study plans to learn more about the brain's role alcohol use problems and recovery. Prominent theories about alcohol use disorder suggest that it is a disorder of the brain. However, it remains unclear what parts of the brain work differently in alcohol use disorder. This study intend...

Protocol #: 20-3000

Location: Brain Imaging Center (BIC), University of Colorado Hospital

A Phase 3, Randomized, Double-Blind, Trial of Pamrevlumab (FG-3019) or Placebo in Combination with Systemic Corticosteroids in ambulatory subjects with Duchenne Muscular Dystrophy (DMD)

Protocol #: 20-2929

Location: Childrens Hospital Colorado

A PHASE 3, MULTI-CENTER, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF RELDESEMTIV IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS (ALS)

Protocol #: 21-2598

Location: University of Colorado Hospital

A PHASE III, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PARALLEL-GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FENEBRUTINIB, COMPARED WITH OCRELIZUMAB IN ADULT PATIENTS WITH PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS.

Protocol #: 21-2663

Location: Brain Imaging Center (BIC), University of Colorado Hospital

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER, PHASE 2 STUDY TO EVALUATE THE EFFICACY, SAFETY, AND PHARMACOKINETICS OF ROZANOLIXIZUMAB IN ADULT STUDY PARTICIPANTS WITH LEUCINE-RICH GLIOMA INACTIVATED 1 AUTOIMMUNE ENCEPHALITIS

Protocol #: 21-2955

Location: Brain Imaging Center (BIC), Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

ALLFTD: ARTFL-LEFFTDS LONGITUDINAL FRONTOTEMPORAL LOBAR DEGENERATION

Protocol #: 21-2833

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

Efficacy and Safety Study of Nipocalimab IV Infusions for Adults With Generalized Myasthenia Gravis

Protocol #: 21-3289

Location: CTRC Inpatient, University of Colorado Hospital

A PHASE III MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY STUDY TO EVALUATE SAFETY AND EFFICACY OF OCRELIZUMAB IN CHILDREN AND ADOLESCENTS WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS

Protocol #: 20-2614

Location: Childrens Hospital Colorado

BIOREPOSITORY FOR CENTRAL VEIN SIGN: A DIAGNOSTIC BIOMARKER IN MULTIPLE SCLEROSIS

Protocol #: 21-3715

Location: Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

Influence of NT5c1A antibodies on disease progression, clinical phenotype and blood and muscle biomarkers in sporadic Inclusion Body Myositis - A prospective evaluation

Protocol #: 21-3383

Location: University of Colorado Hospital

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER, PHASE 3, PIVOTAL STUDY WITH AN OPEN-LABEL EXTENSION PERIOD TO EVALUATE THE EFFICACY AND SAFETY OF ROZANOLIXIZUMAB IN ADULT PARTICIPANTS WITH MYELIN OLIGODENDROCYTE GLYCOPROTEIN (MOG) ANTIBODY-ASSOCIATED DISEASE (MOG-AD)

Protocol #: 21-3747

Location: Brain Imaging Center (BIC), University of Colorado Hospital

NAVEG test administration for Cerebral Vision Impairment (CVI) in premature infants

Protocol #: 21-3043

Location: Childrens Hospital Colorado

Automated Seizure Detection for Home Seizure Monitoring with Epilog Sensors

Protocol #: 21-3574

Location: University of Colorado Hospital

A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Pitolisant on Excessive Daytime Sleepiness and Other Non-Muscular Symptoms in Patients with Myotonic Dystrophy Type 1, Followed by an Open-Label Extension

Protocol #: 21-3397

Location: UCHealth Central Park Medical Center, University of Colorado Hospital

A Randomized, Double-Blind, Placebo-Controlled, Phase 1/2 Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple-Doses of AOC 1001 Administered Intravenously to Adult Myotonic Dystrophy Type 1 (DM1) Patients

Protocol #: 21-3032

Location: Brain Imaging Center (BIC), CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital

SPHERES Neuromyelitis Optica Spectrum Disorder (NMOSD) Registry

Protocol #: 21-3763

Location: University of Colorado Hospital

SAKURABONSAI: CLINICAL, IMAGING AND BIOMARKER OPEN-LABEL STUDY IN NEUROMYELITIS OPTICA SPECTRUM DISORDER (NMOSD) WITH SATRALIZUMAB AS AN INTERVENTION

Protocol #: 21-4079

Location: Brain Imaging Center (BIC), University of Colorado Hospital

A Comparative Study of Levodopa and Carbidopa Bioavailability Following Foslevodopa/foscarbidopa Infusion at Different Subcutaneous Sites in Parkinson's Disease Patients

Protocol #: 21-4448

Location: University of Colorado Hospital

Aneurysmal SubArachnoid Hemorrhage - Red Blood Cell Transfusion And Outcome (SAHaRA): A Randomized Controlled Trial

Protocol #: 21-4692

Location: University of Colorado Hospital

A Prospective, Multicenter Study to Evaluate the Performance and Safety of the CerebroFlo EVD Catheter

Protocol #: 21-4725

Location: University of Colorado Hospital

AGNOS: An 18-month, Open-label, Multi-Center Study to Assess the Effect of fatumumab 20mg SC Monthly in Treatment Naive, Very Early Relapsing Remitting Multiple Sclerosis Patients Benchmarked Against Healthy Controls on Select Outcomes.

Protocol #: 21-4783

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

A randomized, double-blind, double-dummy, parallel-group study, comparing the efficacy and safety of remibrutinib 100 mg b.i.d. versus teriflunomide 14 mg q.d. in participants with relapsing multiple sclerosis, followed by extended treatment with open-label remibrutinib

Protocol #: 21-4825

Location: Brain Imaging Center (BIC), CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital

A First-in-human (FIH), Multicenter, Open Label, Single Arm, Dose Escalation Study of Inhibitory Interneurons (NRTX-1001) in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE)

Protocol #: 21-3486

Location: Brain Imaging Center (BIC), University of Colorado Hospital

Integrating Home-Based Video Teleneuropsychology into Clinical Practice: Typical Versus Atypical Alzheimer's Disease

Protocol #: 21-5037

Location: Department Specific Free Standing Clinic, Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital

Naturalistic sleep assessed by wearable devices in Parkinson's disease

Wear a wrist activity monitor and headband at night to monitor sleep....

Protocol #: 22-0393

Location: Boulder Health Center, Lone Tree Medical Center, University of Colorado Hospital

A PHASE IV MULTICENTER, OPEN-LABEL STUDY EVALUATING B CELL LEVELS IN INFANTS OF LACTATING WOMEN WITH CIS OR MS RECEIVING OCRELIZUMAB

Protocol #: 22-0387

Location: Outpatient CTRC, University of Colorado Hospital

A PHASE IV MULTICENTER, OPEN-LABEL STUDY EVALUATING B CELL LEVELS IN INFANTS POTENTIALLY EXPOSED TO OCRELIZUMAB DURING PREGNANCY - THE MINORE STUDY

Protocol #: 22-0386

Location: Outpatient CTRC, University of Colorado Hospital

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 2, 6-MONTH STUDY TO EVALUATE THE SAFETY, TOLERABILITY AND EXPLORATORY EFFICACY OF CT1812 IN SUBJECTS WITH MILD TO MODERATE DEMENTIA WITH LEWY BODIES

Protocol #: 22-0669

Location: Brain Imaging Center - BIC, Outpatient CTRC, University of Colorado Hospital

A Phase 3b/4 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Verify the Clinical Benefit of Aducanumab (BIIB037) in Participants with Alzheimer's Disease

Protocol #: 22-0776

Location: Brain Imaging Center (BIC), C-TRIC, Outpatient CTRC, University of Colorado Hospital

Neuroliten MVP System Clinical Observation Study

Protocol #: 22-1062

Location: Harmony Campus, Medical Center of the Rockies

A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL TO ASSESS SAFETY AND EFFICACY OF SLS-005 (TREHALOSE INJECTION, 90.5 MG/ML FOR INTRAVENOUS INFUSION) FOR THE TREATMENT OF ADULTS WITH SPINOCEREBELLAR ATAXIA

Protocol #: 22-1127

Location: CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital

A Multi-center, Noninterventional Study Evaluating Variability, Reliability, and Compliance for the Parkinson's Disease Diary

Protocol #: 22-1234

Location: Outpatient CTRC, University of Colorado Hospital

A Phase 3 Global, Randomized, Double-Blind, Placebo-Controlled, 48-Week, Parallel-Group Study of the Efficacy and Safety of Losmapimod in Treating Patients with Facioscapulohumeral Muscular Dystrophy

Protocol #: 22-1143

Location: Brain Imaging Center (BIC), Outpatient CTRC, University of Colorado Hospital

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Determine the Efficacy and Safety of BIIB122/DNL151 in Participants with Parkinson's Disease and Pathogenic LRRK2 Variants

Protocol #: 22-1259

Location: Outpatient CTRC, University of Colorado Hospital

Distinguishing REM Sleep Behavior Disorder from Trauma Associated Sleep Disorder

Protocol #: 22-1244

Location: Outpatient CTRC, University of Colorado Hospital

Defining Endpoints in Becker Muscular Dystrophy

Protocol #: 22-1278

Location: Outpatient CTRC, University of Colorado Hospital

NRG-BN011, A Phase III Trial of Lomustine-Temozolomide Combination Therapy Versus Standard Temozolomide in Patients With Methylated MGMT Promoter Glioblastoma (NCT 05095376)

Protocol #: 22-1113

Location: Greeley Campus, Harmony Campus, Medical Center of the Rockies, Memorial Hospital Central, Memorial Hospital North, Poudre Valley Hospital

Detecting depression and anxiety in people with adult-onset idiopathic dystonia: a diagnostic accuracy study

Protocol #: 22-1129

Location: Outpatient CTRC, University of Colorado Hospital

A PHASE II, MULTICENTER, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND STUDY TO EVALUATE THE PHARMACODYNAMICS, SAFETY, TOLERABILITY, PHARMACOKINETICS, AND EFFICACY OF RO7204239 IN PARTICIPANTS WITH FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY

Protocol #: 22-1495

Location: Brain Imaging Center (BIC), Department Specific Free Standing Clinic, Outpatient CTRC, University of Colorado Hospital