SPOT Study: The Impact of Auditory Access on the Development of Speech Perception
Childrens Hospital Colorado, CU Anschutz non-hospital research facilities The goal of our research is to improve services for children who are at risk for language learning (i.e., hearing loss, reading difficulties). We do this by measuring how infants tell the difference between speech sounds. A child’s ability to differentiate between speech sounds predicts th... |
Effects of Exercise and Social Gaming on the Brain in Autism Spectrum Disorders
CU Anschutz non-hospital research facilities If you join this study, you will take part in a 10-week exercise program or social gaming program. This will help us learn more about how exercise and social games affect the brain. You will be randomly assigned to one of the programs, like flipping a coin. You don’t get to choose what pro... |
Mindfulness-Based Intervention for Adolescents with Chronic Migraine
Childrens Hospital Colorado If eligible, your teen would participate in a 6-week virtual group program with other teens with migraine. Your teen would also complete questionnaires before and after the group program. Possible benefits of the study include learning mindfulness-based skills, feeling less stressed, p... |
CBD for Individuals with Mild Cognitive Impairment and at Risk for Alzheimer's Disease
Outpatient CTRC, University of Colorado Hospital This study wants to learn if different types of CBD can reduce MCI symptoms like trouble sleeping, memory problems, cognitive dysfunction, anxiety, and inflammation.... |
A Phase I/II Study of Nivolumab Plus or Minus Ipilimumab in Combination with Multi-Fraction Stereotactic Radiosurgery for Recurrent High-Grade Radiation-Relapsed Meningioma
University of Colorado Hospital This phase I/II trial studies the side effects and best dose of nivolumab when given together with multi-fraction stereotactic radiosurgery and to see how well they work with or without ipilimumab in treating patients with grade II-III meningioma that has come back (recurrent). Immunothera... |
GBM AGILE Global Adaptive Trial Master Protocol: An International, Seamless Phase II/III Response Adaptive Randomization Platform Trial Designed To Evaluate Multiple Regimens In Newly Diagnosed and Recurrent GBM (GCAR-7213)
Cherry Creek Medical Center, CTRC Inpatient, Highlands Ranch Hospital, Longs Peak Hospital, University of Colorado Hospital Glioblastoma (GBM) adaptive, global, innovative learning environment (GBM AGILE) is an international, seamless Phase II/III response adaptive randomization platform trial designed to evaluate multiple therapies in newly diagnosed (ND) and recurrent GBM. Its goals are to identify effective ... |
Endovascular treatment of acutely ruptured shallow intradural aneurysms not amendable to clipping and coiling with the pipeline vantage embolization device
University of Colorado Hospital The purpose of this study is to assess the safety (short and long term side effects) and effectiveness (how well it stops the blood flow into the aneurysm) of the study device for the treatment of adults (22 – 80 years of age) with acutely ruptured, intradural (inside the head) aneurysms t... |
The Effects of Aerobic Exercise on Parkinson's Disease
Outpatient CTRC, University of Colorado Hospital This is an exercise research study for people who have been recently diagnosed with Parkinson's disease. Aerobic exercise is a vital treatment for people living with Parkinson's disease. Although anti-parkinsonian medication helps alleviate Parkinson's symptoms, it is not known to slow ... |
ALZHEIMER'S CLINICAL TRIAL CONSORTIUM FOR DOWN SYNDROME (ACTC-DS)
TRIAL-READY COHORT - DOWN SYNDROME (TRC-DS)
Outpatient CTRC, Outpatient CTRC, University of Colorado Hospital TRC-DS is part of a larger movement working with people with Down syndrome to advance Alzheimer's disease therapies and potential cures for this population. The Alzheimer's Clinical Trials Consortium-Down Syndrome (ACTC-DS) is a large collaboration of researchers conducting clinical trials... |
Evaluation of Safety and Efficacy of Sargramostim in Alzheimer's Disease
Brain Imaging Center (BIC), CU-RIC, Outpatient CTRC, University of Colorado Hospital The purpose of this research study is to learn more about the safety and effectiveness of a drug called sargramostim for improving cognitive function and memory in people with Alzheimer’s disease. This research study hopes to find out more about how sargramostim works within the body over ... |
Teen Brain Imaging Study on Irritability and Social Information Processing
Brain Imaging Center (BIC), Brain Imaging Center (BIC) - Scan Read Interested in how irritability affects how teens interpret social situations? Our goal is to learn more about how teens think and feel about unclear social situations and how irritable mood may relate to negative thoughts and feelings about these social situations.... |
A 2-part Phase 2 Study of Safety, Pharmacokinetics and Biomarkers
in Children with Duchenne Muscular Dystrophy including a Randomized, Double-Blind, Placebo-Controlled Part A, Followed by an Open-Label Part B
Childrens Hospital Colorado This is a 2-part multi-center, Phase 2 study to evaluate the effect of EDG-5506 on safety, PK and biomarkers of muscle damage in approximately 27 children with DMD treated with oral, once daily EDG-5506 for 12 months. Part A will include a 12-week, randomized, double-blind, placebo-contr... |
Validation of Instruments Measuring Caregiver Experiences (Caregiver VOICE Study)
Lone Tree Medical Center, University of Colorado Hospital Attention, Dementia Caregiving Dementia caregivers have important roles in supporting someone with Dementia. We are interested in hearing the voices of those caregivers. Participation in this telephone based study will take approx. 30-45 minutes. We are interested in your perspective o... |
A Phase 1/2, First in Human, Multiple-dose, 2-part Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NS-050/NCNP-03 in Boys with Duchenne Muscular Dystrophy (DMD)
Childrens Hospital Colorado This is a Phase 1/2, first in human, multicenter, two-part study of MAD levels for 12 weeks of treatment followed by 24 weeks of open-label treatment with a selected dose of NS-050/NCNP-03 administered once weekly to ambulant boys with DMD, who have a DMD mutation amenable to exon 50 sk... |
A PHASE IV OPEN-LABEL STUDY EVALUATING THE EFFECTIVENESS AND SAFETY OF
RISDIPLAM ADMINISTERED IN PEDIATRIC PATIENTS WITH SPINAL MUSCULAR ATROPHY
WHO EXPERIENCED A PLATEAU OR DECLINE IN FUNCTION AFTER GENE THERAPY
Childrens Hospital Colorado This is a Phase IV, open-label, single-arm, multicenter clinical study to evaluate the effectiveness and safety of risdiplam (Evrysdi®) administered in pediatric patients with SMA who previously received onasemnogene abeparvovec and experience a plateau or decline in function. Patients t... |
A PHASE IV OPEN-LABEL STUDY EVALUATING THE EFFECTIVENESS AND SAFETY OF RISDIPLAM ADMINISTERED AS AN EARLY INTERVENTION IN PEDIATRIC PATIENTS WITH SPINAL MUSCULAR ATROPHY AFTER GENE THERAPY
Childrens Hospital Colorado This is a Phase IV, open-label, single-arm, multicenter clinical study to evaluate the effectiveness and safety of risdiplam (Evrysdi®) administered as an early intervention in pediatric patients with SMA who previously received onasemnogene abeparvovec. Patients to be enrolled are chil... |