Your search for "Brain and Nervous System" found 85 matches:
Evaluation of COVID-19 humoral and cellular immune response in immunosuppressed patients with autoimmune neurological conditions

Protocol #: 21-4092

Locations: Department Specific Free Standing Clinic; University of Colorado Hospital

Efficacy and Safety Study of Nipocalimab IV Infusions for Adults With Generalized Myasthenia Gravis

Protocol #: 21-3289

Locations: CTRC Inpatient; University of Colorado Hospital

ALLFTD: ARTFL-LEFFTDS LONGITUDINAL FRONTOTEMPORAL LOBAR DEGENERATION

Protocol #: 21-2833

Locations: Brain Imaging Center (BIC); Outpatient CTRC; University of Colorado Hospital

THE EVALUATION OF IMMUNE RESPONSES TO SARS-COV-2 MRNA VACCINES IN MULTIPLE SCLEROSIS PATIENTS ON OCRELIZUMAB

Protocol #: 21-3126

Locations: Outpatient CTRC; University of Colorado Hospital

A PHASE III, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PARALLEL-GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FENEBRUTINIB, COMPARED WITH OCRELIZUMAB IN ADULT PATIENTS WITH PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS.

Protocol #: 21-2663

Locations: Brain Imaging Center (BIC); University of Colorado Hospital

Persistent Abnormal Cerebrovascular Reactivity and Vessel Wall Enhancement in Individuals Recovered from COVID-19 Infection

Protocol #: 21-2881

Location: University of Colorado Hospital

Phase II Trial to Evaluate Safety and Efficacy of GM-CSF/Sargramostim in Alzheimer's Disease (SESAD)

Protocol #: 19-2727

Locations: Brain Imaging Center (BIC); C-TRIC; Outpatient CTRC; University of Colorado Hospital

Discontinuation of Disease Modifying Therapies (DMTs) in Multiple Sclerosis (MS): Extension of the DISCOMS Study

Protocol #: 20-2772

Location: University of Colorado Hospital

Sleep assessed by actigraphy and direct recordings of the subthalamic nucleus in Parkinson's Disease.

Protocol #: 20-2508

Locations: Lone Tree Medical Center; University of Colorado Hospital

Cerebrospinal fluid-biomarkers-based diagnostic and prognostic models for multiple sclerosis (SPINCOMS)

Protocol #: 20-1025

Locations: Brain Imaging Center (BIC); University of Colorado Hospital

A Phase 3b, Multicenter, Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Oral Edaravone Administered for a Period of 48 Weeks in Subjects with Amyotrophic Lateral Sclerosis (ALS)

Protocol #: 20-2340

Location: University of Colorado Hospital

A single-arm, prospective, multi-center, study to explore maintained efficacy with ofatumumab therapy in patients with relapsing Multiple Sclerosis who discontinue intravenously delivered anti-CD20 monoclonal antibody (aCD20 mAb) therapy (OLIKOS)

Protocol #: 20-2135

Locations: Brain Imaging Center (BIC); Outpatient CTRC; University of Colorado Hospital

A PHASE III MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PARALLEL-GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FENEBRUTINIB COMPARED WITH TERIFLUNOMIDE IN ADULT PATIENTS WITH RELAPSING MULTIPLE SCLEROSIS

Protocol #: 20-2036

Locations: Brain Imaging Center (BIC); University of Colorado Hospital

A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PEGCETACOPLAN IN SUBJECTS WITH AMYOTROPHIC LATERAL SCLEROSIS (ALS)

Protocol #: 20-2005

Locations: CTRC Inpatient; Outpatient CTRC; University of Colorado Hospital

A PHASE IIIB MULTICENTER, RANDOMIZED, DOUBLE-BLIND, CONTROLLED STUDY TO EVALUATE THE EFFICACY, SAFETY AND PHARMACOKINETICS OF A HIGHER DOSE OF OCRELIZUMAB IN ADULTS WITH PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS

Protocol #: 20-1852

Locations: Brain Imaging Center (BIC); Outpatient CTRC; University of Colorado Hospital

A RANDOMIZED, DOUBLE-BLIND, MULTICENTER, PLACEBO-CONTROLLED PHASE 3 STUDY WITH OPEN-LABEL PERIOD TO EVALUATE THE EFFICACY AND SAFETY OF INEBILIZUMAB IN ADULTS WITH MYASTHENIA GRAVIS

Protocol #: 20-1787

Location: University of Colorado Hospital

Genetics of CMT - Modifiers of CMT1A, New Causes of CMT

Protocol #: 20-1525

Locations: Outpatient CTRC; University of Colorado Hospital

A double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of intravenous ganaxolone in status epilepticus

Status Epilepticus is a serious condition that needs fast treatment to stop the seizures and prevent permanent brain damage. Ganaxolone is an investigational drug, which means that it is not approved by the US FDA. The study drug will be added on to the usual care patients will already be ...more >

Protocol #: 20-1641

Location: University of Colorado Hospital

Patient Preferences in Deep Brain Stimulation Products

Protocol #: 19-3015

Location: University of Colorado Hospital

The Parkinson's Progression Markers Initiative (PPMI) 2.0 Clinical - Establishing a Deeply Phenotyped PD Cohort

Protocol #: 20-1204

Locations: Brain Imaging Center (BIC); Outpatient CTRC; University of Colorado Hospital

A Phase 3, randomized, double-blind efficacy and safety study comparing SAR442168 to teriflunomide (Aubagio?) in participants with relapsing forms of multiple sclerosis (GEMINI 1)

Protocol #: 20-1101

Locations: Brain Imaging Center (BIC); University of Colorado Hospital

A single-arm, prospective, multicentre, open-label study to evaluate ofatumumab treatment effectiveness and patientreported outcomes in patients with relapsing multiple sclerosis transitioning from dimethyl fumarate or fingolimod therapy (COMB157G23101)

Protocol #: 20-0705

Locations: Brain Imaging Center (BIC); Outpatient CTRC; University of Colorado Hospital

A Phase 2, Randomized, Placebo-Controlled Study to Evaluate Safety, Tolerability, and Efficacy of TAK-079 in Patients With Generalized Myasthenia Gravis

Protocol #: 20-0609

Locations: Outpatient CTRC; University of Colorado Hospital

A Phase 1, Two-part, Open-label Dose-escalation and Double-blind, Placebo-controlled Dose-expansion Study with an Open-label Extension to Evaluate the Safety and Efficacy of ATA188 in Subjects with Progressive Multiple Sclerosis (ATA188-MS-101

Protocol #: 20-0454

Locations: Brain Imaging Center (BIC); Outpatient CTRC; University of Colorado Hospital

Deep sleep in Parkinson disease and its relationship to cognition, neuroinflammation and neurodegeneration

Protocol #: 20-0347

Locations: Brain Imaging Center (BIC); Outpatient CTRC; University of Colorado Hospital

ALS toolkit project

Protocol #: 20-0127

Location: University of Colorado Hospital

Platform Trial for the Treatment of Amyotrophic Lateral Sclerosis (ALS): A perpetual multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of ALS.

Protocol #: 19-2645

Locations: Outpatient CTRC; University of Colorado Hospital

Lipoic acid for Treatment of Progressive Multiple Sclerosis

Protocol #: 19-2525

Locations: Brain Imaging Center (BIC); University of Colorado Hospital

Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of 36 Weeks of Treatment with NLY01 in Early-stage Parkinson's Disease

Protocol #: 19-2471

Locations: Outpatient CTRC; University of Colorado Hospital

An Open Label Extension Study of Ublituximab in Subjects with Relapsing Multiple Sclerosis

Protocol #: 19-2378

Locations: Brain Imaging Center (BIC); Outpatient CTRC; University of Colorado Hospital

A MULTICENTER, LONGITUDINAL, OPEN-LABEL, SINGLE-ARM STUDY DESCRIBING COGNITIVE PROCESSING SPEED CHANGES IN RELAPSING MULTIPLE SCLEROSIS SUBJECTS TREATED WITH OZANIMOD (RPC-1063)

Protocol #: 19-2420

Locations: Brain Imaging Center (BIC); Outpatient CTRC; University of Colorado Hospital

A Room Temperature Atomic Magnetrode System for Telemetry of Epileptic Seizures

Protocol #: 19-2363

Location: University of Colorado Hospital

CLadribine Tablets: Collaborative Study to Evaluate the Impact On Central Nervous System BiomarKers in Multiple Sclerosis (CLOCK-MS)

Protocol #: 19-1980

Locations: Brain Imaging Center (BIC); Outpatient CTRC; University of Colorado Hospital

A Prospective Study of Acute Flaccid Myelitis (AFM) to Define Natural History, Risk Factors, and Pathogenic Mechanisms

Protocol #: 19-2357

Location: Childrens Hospital Colorado

A Phase 3, External Placebo-Controlled, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Patients with Neuromyelitis OpticavSpectrum Disorder (NMOSD)

Protocol #: 19-2038

Locations: Brain Imaging Center (BIC); Outpatient CTRC; University of Colorado Hospital

Perceived Palliative Care Needs in Early-Onset Dementia

Protocol #: 19-2134

Locations: Outpatient CTRC; UCHealth Central Park Medical Center; University of Colorado Hospital

A Multicenter Randomized Controlled Trial of Best Available Therapy versus Autologous Hematopoietic Stem Cell Transplant for Treatment-Resistant Relapsing Multiple Sclerosis

Protocol #: 19-1621

Locations: Brain Imaging Center (BIC); Outpatient CTRC; University of Colorado Hospital

AN OBSERVATIONAL STUDY OF OCRELIZUMAB TREATED PATIENTS WITH MULTIPLE SCLEROSIS TO DETERMINE THE INCIDENCE AND MORTALITY RATES OF BREAST CANCER AND ALL MALIGNANCIES (VERISMO STUDY)

Protocol #: 19-1600

Location: University of Colorado Hospital

A Post-Market Study Evaluating the Safety of Infinity DBS System with MR Conditional Labeling

Protocol #: 19-1566

Location: University of Colorado Hospital

GRASP-LGMD RESEARCH PROTOCOL; Project 1a Defining Clinical Endpoints in LGMD

Protocol #: 19-0506

Location: University of Colorado Hospital

ImTAB Immunity, mTBI, and Alzheimer's Biomarkers

You may qualify if you are: - 65 years or older - Have had a concussion within the past 5 years - Saw a doctor within 1 week of your concussion - Have not been diagnosed with a memory disorder Participants will receive: -Snacks and refreshments -Medical screening (neurological e...more >

Protocol #: 19-1423

Locations: Outpatient CTRC; University of Colorado Hospital

GBM AGILE Global Adaptive Trial Master Protocol: An International, Seamless Phase II/III Response Adaptive Randomization Platform Trial Designed To Evaluate Multiple Regimens In Newly Diagnosed and Recurrent GBM (GCAR-7213)

Protocol #: 19-0744

Location: University of Colorado Hospital

Feasibility of the Multiple Sclerosis Performance Test for assessment of functional performance measures in patients with Multiple Sclerosis

Protocol #: 19-1192

Location: University of Colorado Hospital

Comparative Effectiveness Research for Infantile Spasms V: 12Jan2017

Protocol #: 16-2408

Location: Childrens Hospital Colorado

Neurophysiological Correlates V: 31Jan18

Protocol #: 16-1480

Location: Childrens Hospital Colorado

Natural History of Rett Syndrome and Related Disorders

Protocol #: 15-2332

Location: Childrens Hospital Colorado

A Two-year Prospective Natural History Study Examining the Use of Neuronal Injury Biomarkers in Autoimmune Encephalitis as a Potential Biomarker for Disease Activity and Severity

Protocol #: 19-0889

Locations: Brain Imaging Center (BIC); Childrens Hospital Colorado; Colorado Research Center; University of Colorado Hospital

Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema following Large Hemispheric Infarction

Protocol #: 19-0675

Locations: CTRC Inpatient; Outpatient CTRC; University of Colorado Hospital

A Phase I/II Study of Nivolumab Plus or Minus Ipilimumab in Combination with Multi-Fraction Stereotactic Radiosurgery for Recurrent High-Grade Radiation-Relapsed Meningioma

Protocol #: 19-0423

Location: University of Colorado Hospital

AMPLATZERTM PFO Occluder Post Approval Study

This is a single arm, multi-center study to confirm the safety and effectiveness of the AMPLATZERTM PFO Occluder in the post approval setting...more >

Protocol #: 19-6502

Location: Memorial Hospital Central

A Natural History Study of CMT1B, CMT2A, CMT4A and CMT4C

Protocol #: 18-2537

Location: University of Colorado Hospital

GORE? CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients with Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

This study will assess the safety and effectiveness of GORE? CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a post-market setting....more >

Protocol #: 19-6030

Locations: Harmony Campus; Medical Center of the Rockies

Bedside Resources to Gauge Intravascular Volume Status in Hypovolemic Infants in the Operating Room

Protocol #: 18-2513

Location: Childrens Hospital Colorado

Investigating cortical networks disruption and rehabilitation after traumatic brain injury

Protocol #: 19-0049

Locations: Colorado Research Center; Department Specific Free Standing Clinic

Gene Expression of Cerebral Aneurysms

In this study, we will collect tissue and blood from participants during their epilepsy surgery. ...more >

Protocol #: 19-0182

Location: University of Colorado Hospital

How Does Inflammation Affect the Aging Brain? Research Study Investigates Aging, Memory, and Immune Function.

The University of Colorado Anschutz Medical Campus is looking for interested adults 60 and over to participate in a research study examining how inflammation influences brain health. Data gathered from this study will be used to better understand how inflammation may or may not disrupt thi...more >

Protocol #: 18-2607

Location: University of Colorado Hospital

Association of depth recordings from the temporal cortex with sleep pattern detection and characterization of sleep dysfunction in patients with refractory epilepsy.

Protocol #: 18-2806

Location: University of Colorado Hospital

Identifying relevant seizure biomarkers from RNS? System recorded electrocorticography for the development of optimized seizure detection algorithms

Protocol #: 18-2089

Location: University of Colorado Hospital

Determining the Effectiveness of early Intensive Versus Escalation approaches for the treatment of Relapsing-Remitting Multiple Sclerosis (DELIVERMS)

Protocol #: 18-1633

Location: University of Colorado Hospital

Clinical Outcome Measures in Friedreich's Ataxia

Protocol #: 18-1641

Locations: Outpatient CTRC; University of Colorado Hospital

A Phase 3, Randomized, Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur After Irradiation and Adjuvant Temozolomide Chemotherapy STELLAR Study

Protocol #: 18-1336

Location: University of Colorado Hospital

Peripheral Inflammatory Cytokine Levels in Parkinson Disease

Protocol #: 18-1356

Locations: Outpatient CTRC; University of Colorado Hospital

Conversational Speech in the Diagnosis of Neurocognitive Disorders

Protocol #: 18-0456

Locations: Outpatient CTRC; University of Colorado Hospital

More than a Movement Disorder: Applying Palliative Care to Parkinson?s Disease v: 12/06/2017

Protocol #: 16-1400

Locations: Colorado Research Center; Department Specific Free Standing Clinic

Neurologic Music Therapy for enhancing fine motor control in Parkinson's Disease 16Apr2018

Protocol #: 16-2308

Location: University of Colorado Hospital

COG ANBL1531 - A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or Crizotinib Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma (NBL) (IND# 134379)

Protocol #: 18-0971

Location: Childrens Hospital Colorado

Ruptured Aneurysms Treated with Hydrogel Coils

Protocol #: 18-6052

Location: Memorial Hospital Central

Automatic measurement of hand movements toward development of an objective assessment of primary motor symptoms in Parkinson?s disease

Protocol #: 15-1041

Locations: Outpatient CTRC; University of Colorado Hospital

Diet and Relapses in Pediatric Multiple Sclerosis

Protocol #: 18-0393

Locations: Childrens Hospital Colorado; University of Colorado Hospital

Perceived palliative care needs of Huntington's disease patients

Protocol #: 18-0216

Location: University of Colorado Hospital

Clinical Trial Readiness for SCA1 and SCA3

Protocol #: 18-0020

Location: University of Colorado Hospital

Validation of a performance-based assessment of functional ability related to cognition in Parkinson's disease

Protocol #: 15-0170

Locations: Colorado Research Center; Department Specific Free Standing Clinic; Outpatient CTRC; University of Colorado Hospital

Risk factors in Early Multiple Sclerosis (RisE-MS)

Protocol #: 17-1884

Locations: Outpatient CTRC; University of Colorado Hospital

A randomized, double blind, placebo-controlled parallel study of tolerability and efficacy of Cannabidiol (CBD) on tremor in Parkinson's disease

Protocol #: 17-2318

Location: University of Colorado Hospital

Topiramate as a disease altering therapy for Cryptogenic Sensory Peripheral Neuropathy (CSPN)

Protocol #: 17-1751

Location: University of Colorado Hospital

Transcranial electrical stimulation for the treatment of cervical dystonia

Protocol #: 17-1322

Locations: Colorado Research Center; Department Specific Free Standing Clinic

Calibrating free-living physical activity characteristics across functionally-limited populations using machine-learned accelerometer approaches

Regular physical activity is known to have positive effects on many health outcomes. In research, physical activity is often measured using activity monitors worn on the hip, wrist or ankle. These instruments determine how much physical activity a person does based on the amount of movemen...more >

Protocol #: 16-2706

Locations: CTRC-adult; Outpatient CTRC; University of Colorado Hospital

The modified Atkins diet in patients with drug resistant epilepsy and the responsive neurostimulator 09Aug2017

Protocol #: 17-0888

Location: University of Colorado Hospital

Using Next Generation Sequencing to Unravel the Pathogenesis of Sporadic Inclusion Body Myositis (IBM) - The International IBM Consortium Genetic Study

Protocol #: 17-1132

Location: University of Colorado Hospital

Stereotactic Laser Ablation for Temporal Lobe Epilepsy (SLATE) Study

Protocol #: 17-0873

Locations: Lone Tree Medical Center; University of Colorado Hospital

Rocky Mountain Multiple Sclerosis Center (RMMSC) Biorepository for the Study of Neuroimmunological Disorders

Protocol #: 12-0968

Location: University of Colorado Hospital

University of Colorado Alzheimer's and Cognition Center Longitudinal Biomarker and Clinical Phenotyping Study (Bio-AD Study)

This study will establish a large bank of samples and data for future research into the causes of and treatments for Alzheimer’s disease (AD), Down Syndrome (DS) and other diseases that cause thinking and memory problems....more >

Protocol #: 15-1774

Location: University of Colorado Hospital

A Phase IV Trial of Neuroprotection with ACTH in Acute Optic Neuritis

Protocol #: 13-0388

Location: University of Colorado Hospital

NAtalizumab for Prevention of Post-partum Relapses in patients with Multiple Sclerosis 09May2016

Protocol #: 16-0156

Location: University of Colorado Hospital

Collaborative International Research in Clinical and Longitudinal Experience for Neuromyelitis Optica (NMO) Studies

Protocol #: 13-3181

Location: University of Colorado Hospital