This study wants to learn more about the heart and brain health of people with and without endometriosis.
This phase II trial tests how well tailoring therapy in post-surgery works in patients with low-risk endometrial cancer. The usual approach for patients with low-risk endometrial cancer is treatment with surgery. In this study, tissue that is removed as part of the surgical procedure is analyzed in the pathology laboratory to help guide the doctor to decide whether or not additional treatment such...
This study looks at how choline supplements and exposure to cannabis-based products affect pregnancy and child health.
Measure the preliminary effect of psilocybin assisted psychotherapy on fear of recurrence.
This is a study wants to find out if the birth control pill Slynd affects bone health in adolescent girls ages 14 to 17.
This research study is designed to learn more about racial inequities in Obstetric and Gynecologic care.
This research is designed to determine if experimental treatment with Antibody-drug conjugate, AZD5335, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced tumors
Patients will be registered prior to, during or at the completion of neoadjuvant chemotherapy (Paclitaxel 175 mg/m2 IV over 3 hours and Carboplatin AUC 6 IV on Day 1 every 21 days for 3-4 cycles). Registered patients who progress during neoadjuvant chemotherapy will not be eligible for iCRS and will be removed from the study. Following completion of neoadjuvant chemotherapy, interval cytoreduct...
This study wants to see how blood sugar changes with sex hormones during regular menstrual cycles or when using hormonal birth control. We also want to learn how exercise and hormonal birth control affect blood sugar.
This is a first-in-human phase I/II study to examine the safety, tolerability and preliminary efficacy of VLS-1488 in subjects with advanced cancers.
We want to learn how estrogen levels during menopause might affect artery health, body fat, and risk of heart disease in women with regular periods.
This study wants to learn how working at night or outside normal daytime hours affects women’s heart and reproductive health in women. We are looking for women who work night shifts, both day and night shifts, or only daytime shifts to see how different work hours may affect heart and reproductive health.
The purpose of the dose escalation phase is to evaluate the safety profile of escalating doses and dose schedules of NXP800. In the expansion phase the preliminary efficacy in subjects with ARID1a mutated ovarian clear cell and ovarian endometrioid cancers will be estimated.
This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine in participants with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma, and urothelial carcinoma based on Acrivon's OncoSignature® test status.
This study is looking at the short-term effect of equol supplementation (1, 2, and 3 hours after ingestion) on blood vessel function in women with and without chronic kidney disease. Equol is a dietary supplement. Equol is a metabolite of soy that is produced by the gut microbiome.
This is a Phase 1b open-label, multicenter study, evaluating the safety, tolerability, preliminary clinical activity, pharmacokinetics (PK), and pharmacodynamics of ZN-c3 in combination with other drugs.
This study will provide pilot data examining suction as a mechanism of IUD displacement with menstrual cup use. We hypothesize that manufacturer-recommended menstrual cup insertion and removal by breaking the seal will result in 15% rate of IUD displacement/expulsion. We will also use this data to explore variables associated with IUD displacement and menstrual cup use. By examining the role of su...
Our research team wants to learn how birth control pills affect the brain and emotional wellbeing.
This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study m...
This study wants to collect medical information from individuals with Turner Syndrome at clinics across the country to learn more about the condition. We are gathering this data in a national registry to help improve the health and care for people with Turner Syndrome in the future.
This is a first-in-human study to learn about the study drug called BG-C9074 alone and in combination with tislelizumab in participants with advanced solid tumors.
This study wants to learn how a type of fat in the blood, called triglycerides, affects how the fetus grows.
In this study we want to learn if a medicine approved for diabetes and weight loss called Ozempic® and Wegovy® (semaglutide) can help improve the frequency of periods and the way the body uses sugar in women with polycystic ovary syndrome (PCOS).
This study wants to find out how well a monthly, non-hormonal vaginal ring is at preventing pregnancy.
The overall objective of this study is to ultimately develop an improved standard of cancer care by facilitating new clinical trials, new technology, new informatics solutions and "personalized medicine".
IMGN151-1001 is a Phase 1, first in human, open-label dose-escalation and expansion study in adult patients with recurrent endometrial cancer, recurrent, high-grade serous epithelial ovarian, primary peritoneal, or fallopian tube cancers.
This is a clinical trial to test letrozole in patients with uterine leiomyosarcoma. The main question is will treatment with letrozole extend progression-free survival in patients. Patients will receive 2/5 mg of letrozole daily.
This phase II/III trial tests whether adding trastuzumab and hyaluronidase-oysk (Herceptin Hylecta [TM]) or pertuzumab, trastuzumab and hyaluronidase-zzxf (Phesgo [TM]) to the usual chemotherapy (paclitaxel and carboplatin) works to shrink tumors in patients with HER2 positive endometrial cancer. Trastuzumab and pertuzumab are monoclonal antibodies and forms of targeted therapy that attach to spec...
We want to learn how stimulating the vagus nerve while moving the hand can help improve fine motor control in people with relapsing-remitting multiple sclerosis (MS), who have trouble moving their hands and arms.
The primary objective of this study is to determine whether individuals with the CYP3A7*1C variant have increased metabolism of both DSG and EE while taking this combined oral contraceptive pill.