Safety, Tolerability, and Impact of Oral TLR8 Agonist Selgantolimod on HBsAg in Participants with both Chronic Hepatitis B and HIV
CTRC Inpatient, Outpatient CTRC, University of Colorado Hospital A5394 is a phase II, double-blinded, placebo-controlled trial. Forty-eight study participants will be randomized 3:1 to receive SLGN or its placebo (36 active and 12 placebo), and randomization will be stratified by HBeAg status. One-half of the study participants will be HBeAg positive (n... |
Giving Standardized Estradiol Therapy in Transgender Women to Research Interactions with HIV Therapy: the GET IT RIgHT Study
Outpatient CTRC, University of Colorado Hospital Transgender women (TW) are the fastest-growing group of people with HIV (PWH). Historically, TW have had few opportunities to participate in research, and often experience barriers to engaging in care. More research is needed to help providers when it comes to choosing HIV medication in TW... |
A Double-Blind, Randomized, Placebo-Controlled Clinical Trial of Combination HIV-Specific Broadly Neutralizing Monoclonal Antibodies Combined with ART Initiation during Acute HIV Infection to Induce HIV Remission
Outpatient CTRC, University of Colorado Hospital Scientists are looking for ways to minimize the distribution of HIV-1 in the body, especially where anti-HIV medications (ART) are unable to reach. Starting ART as soon as possible following a diagnosis of Acute HIV Infection (AHI) has been shown to better preserve the immune system. Broad... |
PHACS Health Outcomes around Pregnancy and Exposure to HIV/ARVs (HOPE)
Childrens Hospital Colorado, University of Colorado Hospital The study is designed to evaluate the health outcomes of women living with HIV over time. Women who elect to participate in this study complete a combination of online surveys, clinical assessments, and interviews, with a blood draw and other samples collected at the time a person enrolls ... |
How Gut Bacteria Affect the Gut Lining in Men with HIV and Metabolic Syndrome who have Sex with Men
Outpatient CTRC, University of Colorado Hospital This study plans to learn more about metabolic syndrome in people living with HIV, especially men who have sex with men. Metabolic syndrome is common in people living with HIV and linked to gut health. We want to find out what causes metabolic syndrome in men who have sex with men and peop... |
A Study Testing the Safety and Effectiveness of Antibodies for Treating Early Stages of COVID-19 in Non-hospitalized Patients
CTRC Inpatient, University of Colorado Hospital If you have been recently diagnosed with COVID-19, we want to find out if a single dose of antibodies can help prevent your disease from getting worse as compared to a placebo. Antibodies are protective proteins made by the immune system. A placebo is an inactive product that looks the sam... |
A Phase 3, Randomized, Open-Label, Active-Controlled Study to Evaluate a Switch to an Oral Weekly Islatravir/Lenacapavir Regimen in People With HIV-1 Who Are Virologically Suppressed on Standard of Care
Adult Infectious Disease Clinical Trials Center, Outpatient CTRC, University of Colorado Hospital The goal of this clinical study is to learn more about the safety and efficacy of switching to a once weekly tablet of islatravir/lenacapavir (ISL/LEN) regimen versus continuing standard of care treatment in people with human immunodeficiency virus (PWH) who are virologically suppressed (H... |
An Open_label, Randomized Controlled Trial of Pramipexole versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD with Mild Neurocognitive Disorder (MND) in Persons with HIV
Outpatient CTRC, University of Colorado Hospital The purpose of this research study is to evaluate the safety and efficacy of pramipexole extended release (ER) versus escitalopram for the treatment of major depressive disorder (MDD) and mild neurocognitive disorder (MND) in people living with HIV (PWH).... |