Determine whether patients undergoing prophylactic nail placement return to at least their preoperative pain interference (PI) and physical function (PF) scores by 6 weeks post operatively.
This is a phase III, randomized, open-label, multicenter, global study to determine the efficacy and safety of Volrustomig (MEDI5752) + Carboplatin + Pemetrexed vs the investigator's choice of platinum + Pemetrexed or Nivolumab + Ipilimumab in participants with unresectable pleural mesothelioma.
The WeCanWork research study at the University of Colorado Cancer Center wants to learn how a cancer diagnosis impacts work, finances, and general well-being for employed people undergoing treatment. The research team hopes to find ways to lessen the negative impact of cancer on employment by focusing on working patients.
The primary objective of this screening study is to test patient specimens to determine eligibility for participation in the biomarker-driven and non-matched sub-studies included within the Lung-MAP umbrella protocol.
A comparison of baseline tumor characteristics in oncogene-driven cancers to tumor characteristics after early response to TKI targeted treatment will allow identification of early adaptive mechanisms of cell survival. This will facilitate targeting and termination of these survival/ resistance pathways before they develop with rational combinations of therapeutic agents to improve outcomes.
The overall objective of this study is to ultimately develop an improved standard of cancer care by facilitating new clinical trials, new technology, new informatics solutions and "personalized medicine".
The primary objective of the BISON-PRO Database is to establish a prospective repository of real-world, longitudinally-collected patient-reported outcomes (PRO) and quality-of-life data for patients with both malignant and non-neoplastic blood disorders to support patient-centered research.