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If you want to join this study, the first step is to see if you qualify. This is called the screening period and lasts about 8 weeks. During this time, you will have several tests and activities. The study team will review your medical and family history and check your vital signs, such as blood pressure and heart rate. You will have a physical exam, and a heart test called an ECG. You will also give a blood sample from a vein in your arm. If you qualify for the study, you will be placed into one of two groups by chance, like flipping a coin. One group will get the study drug, muvalaplin. The other group will get a placebo. A placebo looks the same as the study drug but has no active medicine. You and the study team will not know what group you are in. During this part of the study, you will take the study drug or placebo by mouth every day. You will also have study visits where the study team will do a physical exam, check your vitals, and do another ECG. You will also have your blood drawn at each visit and fill out questionnaires about your health and lifestyle. The study drug and study procedures will be provided at no cost to you. You and your insurance will need to pay for your routine medical care. You may have up to 20 study visits. Your participation in the study will last about 63 months, which is a little over 5 years.

Who can Participate

You may be able to join this study if you are 18 years old or older and have a lipoprotein level of 175 nmol/L or higher. You must have had a heart or blood vessel related event at least 3 months ago but no more than 10 years ago. This can include heart disease, stroke, or disease of the blood vessels in the arms or legs. If you have not had one of these events, you may still qualify if you have one or more risk factors for heart or blood vessel disease, such as hypertension, diabetes, a high coronary artery calcium, or reduced kidney function. The study team will review all study requirements with you to see if you qualify.

Study ID