The goal of this study is to evaluate the efficacy and safety of Veverimer in adults with CKD and metabolic acidosis
After your eligibility has been confirmed you will move on to the Study Treatment period and consume study drug every day for 24 weeks. This 24-week study treatment period has two parts, Part A and Part B. Veverimer is a powder that is mixed with liquid and taken with food. Some study visits will include testing of physical strength, others will just be coming to clinic to check in. Compensation is provided.
You must be at least 18 years of age and diagnosed with chronic kidney disease (CKD) with a lower-than-normal level of bicarbonate in your blood to participate in this study. You must also be willing to maintain similar food consumption (including type and amount of food) throughout the study, since this can impact the amount of acid in your body. To take part in this study you cannot have participated in another study involving another study drug within 28 days prior to the first study visit during screening, nor while you are participating in this study. You also cannot be in this study if you are currently on a GLP-1 medication (for example, Ozempic, Wegovy, Mounjaro, Zepbound, etc.) or have taken a GLP-1 medication within 6 months prior to the first study visit during screening. Also, you cannot participate in this study if you are a current or regular user of cannabis or THC products (inhaled or ingested). You must be completely honest with the study doctor about your health status and history, or it might not be safe for you to participate in this study.
Protocol Number: 25-2612
Principal Investigator