Study to See if Alendronate can affect hidden HIV in people living with HIV.
This study will look at whether a medication called alendronate can reduce the amount of hidden HIV (called the HIV reservoir) in people living with HIV. Alendronate is a medication used to strengthen bones.
Why this Research Matters
The study will look at whether alendronate helps make hidden HIV active so it can be removed from the body while you continue taking your antiretroviral therapy (ART). If you join this study, you will be randomly placed into one of two groups, like flipping a coin. One group will get the alendronate , and the other group will get a placebo (a pill with no medication). You will not know which group you are in. At most visits, some blood will be taken from a vein in your arm and you may also have a physical exam. There will be about 10 study visits over 11 months. You will be paid up to $500 if you complete all visits. You can also choose to have a sigmoidoscopy at the beginning and end of the study. A sigmoidoscopy is a procedure that examines your lower large intestines and is done by a specialized doctor. You will be paid $300 for each sigmoidoscopy procedure that you complete.
Who can Participate
You may be able to join this study if you are living with HIV, 18-65 years old, and on stable, antiretroviral therapy (ART). Compensation provided.
Study ID
Protocol Number: 25-2431
More information available at ClinicalTrials.gov: NCT07216794
Compensation Information
Meet the Team
Principal Investigator