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Multiple Sclerosis (MS) is a health condition that affects the nervous system. It can cause muscle weakness, balance problems, and difficulty walking. Exercise is often recommended to help manage MS symptoms, but little is known about the effects of strength training in people who need walking support or use a wheelchair. Before joining the study, you will visit the clinic for an exam with a physical therapist and fill out health questionnaires. If you qualify and choose to participate, you will be randomly assigned to one of two groups. One group will exercise while wearing a blood flow restriction (BFR) device on the leg, which limits blood flow during exercise. The other group will do the same exercise program without the device. Everyone in the study will attend strength training sessions with a physical therapist twice a week for 10 weeks, for a total of 20 sessions. You will also complete strength and mobility tests before the program begins, after it ends, and again eight weeks later. Throughout the study, ultrasound images of your leg muscles will be collected. Your participation in this study will last up to 20 weeks. You may earn up to $250 for completing all study visits.

Who can Participate

You may qualify for this study if you are 18 to 70 years old, have multiple sclerosis (MS), and use an aid, like a cane, walker, or wheelchair at least some of the time. You may not qualify if your MS does not affect your ability to walk on your own.

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