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Novel Evaluations of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Women Compared to Age Group-Matched Cisgender Adults

Primary Objective

This study is examining how gender-affirming hormone therapy affects the health of blood vessels and impacts cardiovascular disease risk in transgender women.

Study category: Diabetes & Hormone Disorders

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Do you qualify? • Transgender women (i. e., assigned male at birth but identify as female) taking estradiol and spironolactone o Ages 18 to 40 or 50 to 75 years o In good general health o Have been on hormones for at least 1 year o No history of gonadectomy o No history of cancer, diabetes or heart disease o Non-smoker (or quit at least one year ago)

Main Procedures Involved: • Blood tests for hormones, cholesterol, clotting factor and other labs • Blood vessel cell collection • Dietary analysis • Physical activity monitor • Questionnaires • Ultrasound of the blood vessels • Measurements of bone mineral density and body composition • Compensation provided


Type of Study





Compensation provided


Anschutz Health and Wellness
Outpatient CTRC
Rocky Mountain Regional VA Medical Center
University of Colorado Hospital

Principal Investigator
Sean Iwamoto,  MD

Sean Iwamoto, MD

Study ID

Protocol Number: 18-2258

More information available at NCT04066283

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