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A Phase 1, Open-Label, Multicenter, Dose-Escalation Study of RMC-4630 Monotherapy in Adult Participants with Relapsed/Refractory Solid Tumors. Protocol v.1.3

Study category: Cancer

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In Expansion Arm, participants must have one of the following genotypic mutations: RTK mutation, amplification or re-arrangement; KRAS-G12, BRAF Class 3 or NF1 LOF mutation.


I - Research Studies that focus on the safety of a drug. The goal is to determine the drug's most frequent and serious adverse events and, often, how the drug is broken down and excreted by the body. These studies usually involve a small number of participants.

Type of Study



University of Colorado Hospital

Principal Investigator
Jose Pacheco,  MD

Jose Pacheco, MD

Study ID

Protocol Number: 18-1150

More information available at NCT03634982

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