Aquaman: Treatment of Exercise-Induced Pulmonary Vascular Dysfunction After Pulmonary Thromboendoarterectomy

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This is a 3 month study to see if riociguat improves RHC measurements and exercise tolerance. There are 2 study visits - one at the beginning and one at the end - during which the subject will undergo a 6 MWT as well as a resting RHC and an exercise RHC. Study drug will be uptitrated at week 2, 4 and 6 via the telephone.




1) Men and Women 18-80 years of age 2) Women cannot be pregnant or nursing and must be willing to use 2 forms of birth control during the study 3) Participants must have undergone PTE surgery for a diagnosis of CTEPH at least 6 months prior to screening and report having continued exercise limitation post PTE surgery. 4) Patients with known residual PH by RHC will be excluded (mP AP > 25 mmHg or a mPAP >30 mmHg and a PVR > 3.00 wu). 5) Patient cannot be currently using revatio or tadalafil

Type of Study



Outpatient CTRC
University of Colorado Hospital

Principal Investigator
Photograph of Todd Bull,  MD

Todd Bull, MD

Study ID

Protocol Number: 17-2349

More information available at NCT03409588

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