Defining Molecular Phenotypes of Exacerbation-Prone Asthmatics (ENIGMA)

Primary Objective

The objective of this study is to learn more about the effects of the environment (pollutants, allergens, viruses) on asthma exacerbations in children

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We want to learn more about asthma and how stuff in the air, like pollution and allergens, can make asthma worse in children. To do this we want to look at kids with and without asthma. If you join the study, you will participate in a remote consent visit, a clinic visit and a remote home visit. (Remote visits take place by video chat or phone.) Study activities include: breathing tests, surveys, blood draw, nasal cell and mucus collection, urine collection, sputum collection, home environmental testing, and wearing a small air monitor. The risks are minimal for participating in this research study. If needed, transportation to and from the clinic visit can be provided. You will be paid for your time and effort.




To take part in this study, you need to be 8 to 17 years old and Have asthma with severe asthma attack in the last 12 months

Type of Study





Childrens Hospital Colorado

Principal Investigator
Photograph of Andrew Liu,  MD

Andrew Liu, MD

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