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Precision Approach to PPI Therapy in Gastroesophageal reflux disease

Study category: Digestive Health

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Description

Over the past 25 years, RALS has been increasingly, and often incorrectly, diagnosed and has emerged as a point of controversy and confusion. Despite the limitations of current diagnostic tests and therapeutic strategies, recent advances in gastoresophageal reflux disease offer tremendous potential for RALS diagnosis and treatment. Newer diagnostic tools are able to assess physiologic properties of RALS. Thus, this study will address three crucial gaps impacting the clinical approach to RALS: 1) Paucity of diagnostic tests that predict clinically relevant outcomes, 2) undefined clinical role of UES augmentation, and 3) deficiency or cost-effective and personalized approaches.

Details
Age

Adult

Eligibility

18 years and older Willing to be on PPI >8 weeks if symptoms

Detailed Eligibility: Subjects diagnosed with reflux associated laryngeal symptoms

Phase

Pilot - A pilot Study is used to obtain information, and work out the logistics and management, deemed necessary for further Research Studies.

Type of Study

Outcomes Research

Location

University of Colorado Hospital

Principal Investigator
Rena Yadlapti,  MD, MHS

Rena Yadlapti, MD, MHS

Study ID

Protocol Number: 18-0205

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