A Multicenter, Open-label, Phase 2 Basket Study to Evaluate the Safety and Efficacy of MK-2140 as a Monotherapy and in Combination in Participants with Aggressive and Indolent B-cell Malignancies
Primary Objective
-(Cohort D): To evaluate the safety and tolerability of zilovertamab vedotin -(Cohort C): To evaluate the safety and tolerability of zilovertamab vedotin in combination with nemtabrutinib -To evaluate zilovertamab vedotin with respect to objective response rate: Cohorts A, B, D (FL), and E: per Lugano, Response Criteria as assessed by BICR, Cohorts D (CLL) and F: per iwCLL, Criteria as assessed by investigate -To evaluate zilovertamab vedotin in combination with nemtabrutinib with respect to objective response rate: Cohort C: per Lugano Response Criteria as assessed by investigator
![](https://researchstudies.cuanschutz.edu/Content/images/study-category-images/cancer.jpg)
Details
Adult
Locations
CTRC Inpatient
University of Colorado Hospital
Principal Investigator
![Photograph of Steven Bair](https://som.ucdenver.edu/FIMS/Content/faculty/30486/CU-Doctors-30486.jpg)
Steven Bair
Study ID
Protocol Number: 22-1252
More information available at ClinicalTrials.gov: NCT05458297
Categories
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