Study to improve dEployment related Asthma by using L-citrulline Supplementation (SEALS)

Primary Objective

1. Determine if L-citrulline supplementation improves deployment related asthma control and increases FeNO (co-primary outcomes). Subjects will receive either 15 g L-citrulline/day or matched placebo for 7 weeks followed by a 4-6 week washout and then 7 weeks of the opposite treatment.

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Description

2. This is a proof-of-concept, randomized, double blinded, placebo controlled study to determine if adding on L-citrulline for deployment related asthmatics: a) improves asthma control, and b) increases FeNO levels.

Details
Age
Adult
Eligibility
1. Post 9/11 Deployment-Related Asthma diagnosis 2. Not currently smoking in past 3 months 3. Male and female patients, 18 - 70 years old, inclusive N/A
Locations

Outpatient CTRC
Rocky Mountain Regional VA Medical Center
University of Colorado Hospital

Principal Investigator
Photograph of Fernando Holguin

Fernando Holguin

Study ID

Protocol Number: 21-2804

More information available at ClinicalTrials.gov: NCT05259904

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